Union members at the polls in diverse trade union landscapes

This article investigates to what extent social democratic parties still benefit from the support of union members at the polls. Not only are social democratic parties confronted with new competitors in the party systems, but also the union confederations of the socialist labour movement are in some countries losing their dominant position due to the rise of separate professional confederations. It is argued in the article that the effect of union membership on voting choice is conditioned by the structure of the trade union movement. The support of union members for social democracy is fostered by the strength of the confederations historically close to this party family, while it is hampered when strong separate (or politically unaffiliated) white-collar confederations exist. Using European Social Survey and Swedish Public Opinion data, the article shows that social democratic parties still enjoy important support from trade union members, but at the same time are under fierce competition from bourgeois and green parties among members of white-collar confederations. This reinforces the challenges for social democracy to build new voters’ coalitions in post-industrial societies

Characterisation and radioimmunotherapy of L19-SIP, an anti-angiogenic antibody against the extra domain B of fibronectin, in colorectal tumour models

Angiogenesis is a characteristic feature of tumours and other disorders. The human monoclonal antibody L19- SIP targets the extra domain B of fibronectin, a marker of angiogenesis expressed in a range of tumours. The aim of this study was to investigate whole body distribution, tumour localisation and the potential of radioimmunotherapy with the L19-small immunoprotein (SIP) in colorectal tumours. Two colorectal tumour models with highly different morphologies, the SW1222 and LS174T xenografts, were used in this study. Localisation and retention of the L19-SIP antibody at tumour vessels was demonstrated using immunohistochemistry and Cy3-labelled L19-SIP. Whole body biodistribution studies in both tumour models were carried out with 125I-labelled L19-SIP. Finally, 131I-labelled antibody was used to investigate the potential of radioimmunotherapy in SW1222 tumours. Using immunohistochemistry, we confirmed extra domain B expression in the tumour vasculature. Immunofluorescence demonstrated localisation and retention of injected Cy3-labelled L19-SIP at the abluminal side of tumour vessels. Biodistribution studies using a 125I-labelled antibody showed selective tumour uptake in both models. Higher recorded values for localisation were found in the SW1222 tumours than in the LS174T (7.9 vs 6.6 %ID g−1), with comparable blood clearance for both models. Based on these results, a radioimmunotherapy study was performed in the SW1222 xenograft using 131I-Labelled L19-SIP (55.5 MBq), which showed selective tumour uptake, tumour growth inhibition and improved survival. Radio- and fluorescence-labelled L19-SIP showed selective localisation and retention at vessels of two colorectal xenografts. Furthermore, 131I-L19-SIP shows potential as a novel treatment of colorectal tumours, and provides the foundation to investigate combined therapies in the same tumour models

Trade Unions in Western Europe since 1945

This comparative data handbook offers an empirical base to a long-term and comparative understanding of changes and variations in European union movements. It provides information on the context and history of union development, the changes in the structure of post-war unionism until today, the long-term trends in union membership and union density, and the shifts in the cross-sectional composition of union membership. Introduction and references are included, as well as standardised tables for each country and comparative indicators.This book is the result of many years of research by the authors in collaboration with an international research team, and provides an original source for comparative and national studies or individual enquiries. It offers cross-checked and often newly-calculated statistics from the project's unique comprehensive database on national union organisations and their membership series. An original, comprehensive and up-to-date data collection on postwar union movements, Trade Unions in Western Europe since 1945 will act as an indispensable tool for anyone comparing labour relations across Europe.Part I: Introduction 1 A Guide to the Handbook 2 A Comparative Profile Part II: Country Profiles and Tables 3 Austria 4 Belgium 5 Denmark 6 Finland 7 France 8 Germany 9 Ireland 10 Italy 11 Netherlands 12 Norway 13 Portugal 14 Spain 15 Sweden 16 Switzerland 17 United Kingdom Part III: Appendix 18 European Union Organizations 19 A Note on the CD-RO