Germán de Granda, Estudios de lingüística andina. Pontificia Universidad Católica del Perú, Lima, 2001; 359 pp.

Se reseñó el libro: Estudios de lingüística andina.

Voluntariado y Salud mental: perfil, formación y motivación del voluntario en la Fundación Rey Ardid de Zaragoza

En los últimos años se ha producido un incremento del número de personas con enfermedad mental y con ello una sociedad que tiende a la estigmatización y como consecuencia de ello, se han visto aumentadas las necesidades tanto de atención, y cuidado y la importancia del voluntariado para cubrir esas necesidades. El voluntario requiere de unos conocimientos y una motivación para realizarlo técnicas propias proporciona una atención integral, tanto a las personas afectadas como a sus familiares y siendo esta llevada a cabo desde las entidades del Tercer Sector, una de estas entidades es el objeto de nuestra investigación

The cirrhotic liver is depleted of docosahexaenoic acid (DHA), a key modulator of NF-κB and TGFβ pathways in hepatic stellate cells

Liver cirrhosis results from chronic hepatic damage and is characterized by derangement of the organ architecture with increased liver fibrogenesis and defective hepatocellular function. It frequently evolves into progressive hepatic insufficiency associated with high mortality unless liver transplantation is performed. We have hypothesized that the deficiency of critical nutrients such as essential omega-3 fatty acids might play a role in the progression of liver cirrhosis. Here we evaluated by LC-MS/MS the liver content of omega-3 docosahexaenoic fatty acid (DHA) in cirrhotic patients and investigated the effect of DHA in a murine model of liver injury and in the response of hepatic stellate cells (HSCs) (the main producers of collagen in the liver) to pro-fibrogenic stimuli. We found that cirrhotic livers exhibit a marked depletion of DHA and that this alteration correlates with the progression of the disease. Administration of DHA exerts potent anti-fibrogenic effects in an acute model of liver damage. Studies with HSCs show that DHA inhibits fibrogenesis more intensely than other omega-3 fatty acids. Data from expression arrays revealed that DHA blocks TGFβ and NF-κB pathways. Mechanistically, DHA decreases late, but not early, SMAD3 nuclear accumulation and inhibits p65/RelA-S536 phosphorylation, which is required for HSC survival. Notably, DHA increases ADRP expression, leading to the formation of typical quiescence-associated perinuclear lipid droplets. In conclusion, a marked depletion of DHA is present in the liver of patients with advanced cirrhosis. DHA displays anti-fibrogenic activities on HSCs targeting NF-κB and TGFβ pathways and inducing ADPR expression and quiescence in these cells

Crystallization and preliminary X-ray characterization of 1,3-propanediol dehydrogenase from the human pathogen Klebsiella pneumoniae

1,3-Propanediol dehydrogenase from K. pneumoniae has been overexpressed in E. coli, purified and crystallized. Diffraction data have been collected to 2.7 Å resolution

Disrupting Plasmodium UIS3–host LC3 interaction with a small molecule causes parasite elimination from host cells

© The Author(s) 2020. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.The malaria parasite Plasmodium obligatorily infects and replicates inside hepatocytes surrounded by a parasitophorous vacuole membrane (PVM), which is decorated by the host-cell derived autophagy protein LC3. We have previously shown that the parasite-derived, PVM-resident protein UIS3 sequesters LC3 to avoid parasite elimination by autophagy from hepatocytes. Here we show that a small molecule capable of disrupting this interaction triggers parasite elimination in a host cell autophagy-dependent manner. Molecular docking analysis of more than 20 million compounds combined with a phenotypic screen identified one molecule, C4 (4-{[4-(4-{5-[3-(trifluoromethyl) phenyl]-1,2,4-oxadiazol-3-yl}benzyl)piperazino]carbonyl}benzonitrile), capable of impairing infection. Using biophysical assays, we established that this impairment is due to the ability of C4 to disrupt UIS3–LC3 interaction, thus inhibiting the parasite’s ability to evade the host autophagy response. C4 impacts infection in autophagy-sufficient cells without harming the normal autophagy pathway of the host cell. This study, by revealing the disruption of a critical host–parasite interaction without affecting the host’s normal function, uncovers an efficient anti-malarial strategy to prevent this deadly disease.This work was supported by grants from Institut Mérieux (MRG_20052016 to M.M.M). S.S. and A.F.C. were recipients of Fundação para a Ciência e Tecnologia fellowships SFRH/BPD/116451/2016 and SFRH/BPD/112009/2015, respectively. H.R. and V.S. were supported by core funds from NCBS-TIFR. A.L. was supported by Sanofi-Institut Pasteur 2018 Prize to M.M.M.info:eu-repo/semantics/publishedVersio

Predicting the academic underachievement in high school in Spain over the next few years: A dynamic modelling approach

[EN] In this paper we propose a dynamic model to understand the evolution of the academic underachievement in a high school in Spain. This model is based on ideas of Christakis and Fowler where individual habits may be transmitted by social contact. Thus, to build the model we suppose that a student has academic failure when she/he gets into study habits transmitted by students with bad academic habits. From the available academic results of the Spanish high school educational system during the period 1999 2008, we fit the model to the data in order to obtain the parameters of the model. Then, we predict the academic underachievement evolution over the next few years.This work has been partially supported by the Spanish M.C.Y.T. grant MTM2009-08587 and the Universitat Politecnica de Valencia grant PAID06-09-2588Camacho Vidal, FJ.; Cortés, J.; Micle, RM.; Sánchez-Sánchez, A. (2013). Predicting the academic underachievement in high school in Spain over the next few years: A dynamic modelling approach. Mathematical and Computer Modelling. 57(7):1703-1708. https://doi.org/10.1016/j.mcm.2011.11.011S1703170857