11 research outputs found
Adverse effects of extra-articular corticosteroid injections: a systematic review
<p>Abstract</p> <p>Background</p> <p>To estimate the occurrence and type of adverse effects after application of an extra-articular (soft tissue) corticosteroid injection.</p> <p>Methods</p> <p>A systematic review of the literature was made based on a PubMed and Embase search covering the period 1956 to January 2010. Case reports were included, as were prospective and retrospective studies that reported adverse events of corticosteroid injection. All clinical trials which used extra-articular corticosteroid injections were examined. We divided the reported adverse events into major (defined as those needing intervention or not disappearing) and minor ones (transient, not requiring intervention).</p> <p>Results</p> <p>The search yielded 87 relevant studies:44 case reports, 37 prospective studies and 6 retrospective studies. The major adverse events included osteomyelitis and protothecosis; one fatal necrotizing fasciitis; cellulitis and ecchymosis; tendon ruptures; atrophy of the plantar fat was described after injecting a neuroma; and local skin effects appeared as atrophy, hypopigmentation or as skin defect. The minor adverse events effects ranged from skin rash to flushing and disturbed menstrual pattern. Increased pain or steroid flare after injection was reported in 19 studies. After extra-articular injection, the incidence of major adverse events ranged from 0-5.8% and that of minor adverse events from 0-81%. It was not feasible to pool the risk for adverse effects due to heterogeneity of study populations and difference in interventions and variance in reporting.</p> <p>Conclusion</p> <p>In this literature review it was difficult to accurately quantify the incidence of adverse effects after extra-articular corticosteroid injection. The reported adverse events were relatively mild, although one fatal reaction was reported.</p
Demographic, clinical and antibody characteristics of patients with digital ulcers in systemic sclerosis: data from the DUO Registry
OBJECTIVES: The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical and antibody characteristics, disease course and outcomes of patients with digital ulcers associated with systemic sclerosis (SSc).
METHODS: The DUO Registry is a European, prospective, multicentre, observational, registry of SSc patients with ongoing digital ulcer disease, irrespective of treatment regimen. Data collected included demographics, SSc duration, SSc subset, internal organ manifestations, autoantibodies, previous and ongoing interventions and complications related to digital ulcers.
RESULTS: Up to 19 November 2010 a total of 2439 patients had enrolled into the registry. Most were classified as either limited cutaneous SSc (lcSSc; 52.2%) or diffuse cutaneous SSc (dcSSc; 36.9%). Digital ulcers developed earlier in patients with dcSSc compared with lcSSc. Almost all patients (95.7%) tested positive for antinuclear antibodies, 45.2% for anti-scleroderma-70 and 43.6% for anticentromere antibodies (ACA). The first digital ulcer in the anti-scleroderma-70-positive patient cohort occurred approximately 5 years earlier than the ACA-positive patient group.
CONCLUSIONS: This study provides data from a large cohort of SSc patients with a history of digital ulcers. The early occurrence and high frequency of digital ulcer complications are especially seen in patients with dcSSc and/or anti-scleroderma-70 antibodies
Extracellular Sugar-Phosphates are Assimilated by Streptomyces in a PhoP-dependent Manner
Real-World Changes in Adolescents’ ADHD Symptoms within the Day and across School and Non-school Days
A biophysical model of the cortex-basal ganglia-thalamus network in the 6-OHDA lesioned rat model of Parkinson’s disease
Time-course of health-related adaptations in response to combined training in hypertensive elderly: immune and autonomic modulation interactions
Abstract Aims: This article is a methodological description of a randomized clinical trial (ClinicalTrials.gov U1111-1181-4455) aiming to evaluate the time-course (monthly) and associations between blood pressure changes and other health-related adaptations in response to exercise training in hypertensive elderly. Methods: The patients will be randomized to a control or combined training group interventions (aerobic and resistance exercise), with monthly assessments in four months. Although, the changes in baseline blood pressure is the primary clinical outcome, the secondary outcomes include: body composition, cardiorespiratory fitness, muscle strength, arterial stiffness, baroreceptor sensitivity, cardiovascular autonomic modulation, inflammatory markers, oxidative stress, growth factors, tissue remodeling markers, metabolic profile, renal function, cognitive function and quality of life. Results: To support the understanding of the blood pressure changes in hypertensive elderly, a time-course of exercise-induced adaptations including cardiovascular and immunological adaptations are fundamental for research in this field. Conclusion: To investigate the time-course of combined training-induced adaptations including all the diverse aspects of health in hypertensive elderly a well-controlled protocol design is necessary, mainly to clarify the relationship between cardiovascular and immunological exercise-induced adaptations
Time-course of health-related adaptations in response to combined training in hypertensive elderly: immune and autonomic modulation interactions
Functional impairment of systemic scleroderma patients with digital ulcerations: results from the DUO Registry
Objective. Digital ulcers (DUs) are frequent manifestations of systemic
scleroderma (SSc). This study assessed functional limitations due to DUs
among patients enrolled in the Digital Ulcer Outcome (DUO) Registry, an
international, multicentre, observational registry of SSc patients with
DU disease.
Methods. Patients completed at enrolment a DU-specific functional
assessment questionnaire with a 1-month recall period, measuring
impairment in work and daily activities, and hours of help needed from
others. Physician-reported clinical parameters were used to describe the
population. For patients who completed at least part of the
questionnaire, descriptive analyses were performed for overall results,
and stratified by number of DUs at enrolment.
Results. This study included 2327 patients who completed at least part
of the questionnaire. For patients with 0, 1-2, and DUs at enrolment,
mean overall work impairment during the prior month among
employed/self-employed patients was 28\%, 42\%, and 48\%, respectively.
Across all included patients, ability to perform daily activities was
impaired on average by 35\%, 54\%, and 63\%, respectively. Patients
required a mean of 2.0, 8.7, and 8.8 hours of paid help and 17.0, 35.9,
and 63.7 hours of unpaid help, respectively, due to DUs in the prior
month. Patients with DUs had more complications and medication use than
patients with no DUs.
Conclusion. With increasing number of DUs, SSc patients reported more
impairment in work and daily activities and required more support from
others