Quality control/quality assurance testing for longitudinal joint density and segregation of asphalt mixtures

AbstractLongitudinal joint quality control/assurance is essential to the successful performance of asphalt pavement and it has received considerable amount of attention in recent years. Five paving projects were selected for sampling and evaluation in Iowa. For each project, joint quality is compared with regard to the “center” of the pavement mat (6′ right of joint). Field densities and permeability test were made. Cores were obtained for subsequent lab permeability, density and indirect tensile (IDT) strength testing. Asphalt content and gradations were also obtained to determine the joint segregation.In general, this study found that methods providing the most reliable measurements of joint quality are the AASHTO T166, AASHTO T331 (CoreLok) density tests and the permeability test by Karol-Warner Permeameter. The minimum required joint density for quality control should be around 90.0% and 88.5% of theoretical maximum density based on the AASHTO T166 and AASHTO T331 method respectively. Based on various mix design and longitudinal joint construction methods, the joints show differences in asphalt content and level of segregation. Results of this study indicate that poor quality of longitudinal joint should be a combination of segregation, asphalt content variation and insufficient density

Tremor in multiple sclerosis

Tremor is estimated to occur in about 25 to 60 percent of patients with multiple sclerosis (MS). This symptom, which can be severely disabling and embarrassing for patients, is difficult to manage. Isoniazid in high doses, carbamazepine, propranolol and gluthetimide have been reported to provide some relief, but published evidence of effectiveness is very limited. Most trials were of small size and of short duration. Cannabinoids appear ineffective. Tremor reduction can be obtained with stereotactic thalamotomy or thalamic stimulation. However, the studies were small and information on long-term functional outcome is scarce. Physiotherapy, tremor reducing orthoses, and limb cooling can achieve some functional improvement. Tremor in MS remains a significant challenge and unmet need, requiring further basic and clinical research

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer

Notes for genera: basal clades of Fungi (including Aphelidiomycota, Basidiobolomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota)

Compared to the higher fungi (Dikarya), taxonomic and evolutionary studies on the basal clades of fungi are fewer in number. Thus, the generic boundaries and higher ranks in the basal clades of fungi are poorly known. Recent DNA based taxonomic studies have provided reliable and accurate information. It is therefore necessary to compile all available information since basal clades genera lack updated checklists or outlines. Recently, Tedersoo et al. (MycoKeys 13:1--20, 2016) accepted Aphelidiomycota and Rozellomycota in Fungal clade. Thus, we regard both these phyla as members in Kingdom Fungi. We accept 16 phyla in basal clades viz. Aphelidiomycota, Basidiobolomycota, Blastocladiomycota, Calcarisporiellomycota, Caulochytriomycota, Chytridiomycota, Entomophthoromycota, Glomeromycota, Kickxellomycota, Monoblepharomycota, Mortierellomycota, Mucoromycota, Neocallimastigomycota, Olpidiomycota, Rozellomycota and Zoopagomycota. Thus, 611 genera in 153 families, 43 orders and 18 classes are provided with details of classification, synonyms, life modes, distribution, recent literature and genomic data. Moreover, Catenariaceae Couch is proposed to be conserved, Cladochytriales Mozl.-Standr. is emended and the family Nephridiophagaceae is introduced

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Correction to: Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

The original version of this article unfortunately contained a mistake

Prevalence, associated factors and outcomes of pressure injuries in adult intensive care unit patients: the DecubICUs study

Funder: European Society of Intensive Care Medicine; doi: http://dx.doi.org/10.13039/501100013347Funder: Flemish Society for Critical Care NursesAbstract: Purpose: Intensive care unit (ICU) patients are particularly susceptible to developing pressure injuries. Epidemiologic data is however unavailable. We aimed to provide an international picture of the extent of pressure injuries and factors associated with ICU-acquired pressure injuries in adult ICU patients. Methods: International 1-day point-prevalence study; follow-up for outcome assessment until hospital discharge (maximum 12 weeks). Factors associated with ICU-acquired pressure injury and hospital mortality were assessed by generalised linear mixed-effects regression analysis. Results: Data from 13,254 patients in 1117 ICUs (90 countries) revealed 6747 pressure injuries; 3997 (59.2%) were ICU-acquired. Overall prevalence was 26.6% (95% confidence interval [CI] 25.9–27.3). ICU-acquired prevalence was 16.2% (95% CI 15.6–16.8). Sacrum (37%) and heels (19.5%) were most affected. Factors independently associated with ICU-acquired pressure injuries were older age, male sex, being underweight, emergency surgery, higher Simplified Acute Physiology Score II, Braden score 3 days, comorbidities (chronic obstructive pulmonary disease, immunodeficiency), organ support (renal replacement, mechanical ventilation on ICU admission), and being in a low or lower-middle income-economy. Gradually increasing associations with mortality were identified for increasing severity of pressure injury: stage I (odds ratio [OR] 1.5; 95% CI 1.2–1.8), stage II (OR 1.6; 95% CI 1.4–1.9), and stage III or worse (OR 2.8; 95% CI 2.3–3.3). Conclusion: Pressure injuries are common in adult ICU patients. ICU-acquired pressure injuries are associated with mainly intrinsic factors and mortality. Optimal care standards, increased awareness, appropriate resource allocation, and further research into optimal prevention are pivotal to tackle this important patient safety threat

Synthesis and characterization of metal complexes with a schiff base formed by condensation of S-benzyl dithiocarbazate with isatin (H₂IBD)

286-289Synthesis and characterization of Mn(II), Co(II), Ni(II)., Zn(II), Cd(II), Hg(II) and UO complexes of isatin- hydrazone-S-benzyldithiocarbazate (H2IBD) are reported. Elemental analysis, molar conductance, magnetic moment and spectral (IR, visible, NMR) data have been used to characterize the complexes. IR spectral data show that the ligand behaves in a bidentate, tridentate or tetradentate manner in different complexes. An octahedral structure is proposed for the Mn(II), Co(II) and Ni(II) complexes while a square-planar structure is proposed for Cu(II)complexes on the basis of magnetic and spectral measurements

Quality of life assessment in patients with duchenne muscular dystrophy

Background: Duchenne muscular dystrophy is associated with variable physical and psychosocial sequalae, to patients and their caregivers. Aim: This study aimed to assess quality of life in various dimensions in children with Duchenne Muscular Dystrophy (DMD) and in their caregivers. Patients and methods: This study included all children diagnosed with Duchene Muscular Dystrophy (DMD) registered in the Pediatric Neurology Clinic of Alexandria University Specialized Children’s Hospital. Pediatric Quality of Life (PedsQL ™ 3.0) Duchenne Muscular Dystrophy Module was applied to the children and their caregivers. Results: In toddler group, the mean score was 34.41 ± 26.84 SD for daily activity, 48.64 ± 21.41 SD for medications, 28.71 ± 20.70 SD for anxiety, 60.15 ± 21.01 SD for communication and 42.98 ± 15.41 SD and for total quality of life. In parents’ group, the mean scores were as following: 45.35 ± 30.66 SD for daily activity, 50.32 ± 18.79 SD for medications, 20.40 ± 19.32 SD for anxiety, 54.59 ± 20.92 SD communication and 42.55 ± 14.86 SD for total quality of life. Conclusion: Duchenne muscular dystrophy causes significant impairment in all aspects of quality of life in patients and their caregivers

Pharmacognostical study of Chorisia insignis HBK. grown in Egypt

AbstractChorisia insignis HBK. is a perennial deciduous plant native to South America. This study presents the macro and micromorphological features of the plant and the determination of its pharmacopoeial constants (Moisture=12.80%, Total ash=11.72%, Water soluble ash=9.24%, Acid insoluble ash=0.16% and Crude fibre=20.33%). Furthermore, the DNA of the plant was extracted from leaf samples and analyzed by polymerase chain reaction (PCR) using 12 decamer primers. The DNA fingerprint showed a total of 95 fragments. Protein electrophoresis was carried out using SDS–PAGE (sodium dodecyl sulphate polyacrylamide gel electrophoresis) technique to monitor the seed storage protein expressed by the active genes of the whole genomic DNA of C. insignis HBK. The data obtained revealed the presence of 20 sharp protein bands having a wide range of molecular weights. The percentage of protein in the seeds was found to be 26.83% as determined using micro-Kjeldahl method. Analysis of the total amino acids content of the seeds revealed the identification of 15 amino acids, mainly glutamic acid (26.71%), aspartic acid (11.98%) and glycine (11.00%)