Roles of estrogen receptor-alpha in mediating life span: the hypothalamic deregulation hypothesis.

In several species caloric restriction (CR) extends life span. In this paper we integrate data from studies on CR and other sources to articulate the hypothalamic deregulation hypothesis by which estrogen receptor-alpha (ER-α) signaling in the hypothalamus and limbic system affects life span under the stress of CR in mammals. ER-α is one of two principal estrogen-binding receptors differentially expressed in the amygdala, hippocampus, and several key hypothalamic nuclei: the arcuate nucleus (ARN), preoptic area (POA), ventromedial nucleus (VMN), antero ventral periventricular nucleus (AVPV), paraventricular nucleus (PVN), supraoptic nucleus (SON), and suprachiasmatic nucleus (SCN). Estradiol signaling via ER-α is essential in basal level functioning of reproductive cycle, sexually receptive behaviors, physiological stress responses, as well as sleep cycle, and other nonsexual behaviors. When an organism is placed under long-term CR, which introduces an external stress to this ER-α signaling, the reduction of ER-α expression is attenuated over time in the hypothalamus. This review paper seeks to characterize the downstream effects of ER-α in the hypothalamus and limbic system that affect normal endocrine functioning

Effect of heat treatment on in situ rumen degradability and in vitro gas production of full-fat soyabeans and soyabean meal

The objective of this study was to determine the effect of the heat treatment of full-fat soyabean (FFSB) and solvent extracted soyabean meal (SBM) on the in situ dry matter (DM) and protein degradability, and in vitro gas production kinetics of the protein sources. Ruminal disappearance of DM and crude protein (CP), and in vitro gas production were determined after 0, 4, 8, 16, 24, 48 and 72 h incubation using the in situ ruminal degradation and in vitro gas production techniques, respectively. In situ DM and CP disappearances were fitted to the exponential equation p = a + b (1-e-ct), where a is the rapid degradable fraction and b is the slow degradable fraction. In vitro gas production data were fitted to the equation, y = A {1 – exp [- b (t-T) – c (√t - √T)]}. Where b and c are the initial gas production rate constant (h-1) and later gas production rate constant (h-1/2), respectively. The two protein sources were heat treated both with steam pressure in an autoclave at 120 °C and in an oven at 150 °C for 20 min. Heat treatment had a significant effect on effective DM degradability (EDMD), effective CP degradability (ECPD) and in vitro gas production. Although the heat treatments reduced the EDMD, ECPD and the amount of gas produced, the results were inconsistent between protein sources. The heat treatments applied in the autoclave and the oven reduced the ECPD0.02 of FFSB by 12.5% and 10.9%, respectively. On the other hand, heat treatment applied through the autoclave decreased the ECPD0.02 of SBM by 13.9%, but by 18.7% when heat was applied through the oven. Heat treatment of SBM using the oven seemed to be more effective than using autoclaving. Heat treatments in the autoclave and oven reduced the total gas production from FFSB by 7.25 and 7.32%, respectively, and from SBM by 12.69 and 7.91%, respectively. It was concluded that heat treatment is an effective method of altering the rumen degradation characteristics of DM and CP in SBM and FFSB. Both methods could be used to increase the proportion of the rumen non-degradable protein fraction in protein sources which would then reach the small intestines unaffected by ruminal fermentation. Keywords: Full-fat soyabean; soyabean meal; heat treatment; in situ protein degradation; in vitro gas production South African Journal of Animal Sciences Vol. 35 (3) 2005: pp.186-19

Assessment of the wintering area of Red Knots in Maranhão, northern Brazil, in February 2005

To assess population size and the conservation status of the Red Knot Calidris canutus rufa population in Maranhão, N Brazil, an aerial census and field studies were conducted in February 2005. The aerial count showed a population of 7,575 Knots, which is down about 600 from a previous census in the 1980s. However, the count for all shorebird species combined was only 24,000 compared to 198,600 in the 1980s, paralleling a world-wide trend of population decline in shorebirds. Resightings of colour-banded knots confirmed that this is a separate population from the larger wintering population in Tierra del Fuego. All species of shorebirds captured in Maranhão were found to be infested with feather lice and mites. Body masses of knots in Maranhão were significantly lower than in Tierra del Fuego, and about half the birds were below the hypothesized fat-free mass of the species. Blood and feather samples were taken from 38 Knots for subsequent assessment of virus loads, and for detecting sites where primary feather moult had occurred. This will enable us to establish whether significant mortality is associated with pathogen loads and the energetic demands of delayed moulting. The small size of the Maranhão population and the loss of another 13,000 knots this winter from the Tierra del Fuego population means that both are now endangered. Brochures on the need for Red Knot conservation were designed and printed, and have been circulated among fishing communities and school classes in Maranhão.Fil: Baker,Allan J.. Royal Ontario Museum; CanadáFil: González, Patricia M.. Fundación Inalafquen; ArgentinaFil: Serrano, Ines L.. CEMAVE, Centro Nacional de Pesquisa para Conservação das Aves Silvestres; BrasilFil: Júnior, Wallace R. T.. CEMAVE, Centro Nacional de Pesquisa para Conservação das Aves Silvestres; BrasilFil: Efe, Marcio A.. Universidade Federal de Alagoas; BrasilFil: Rice, Susan. Eastern Shore of Virginia National Wildlife Refuge; Estados UnidosFil: D'amico, Veronica Laura. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico; ArgentinaFil: Rocha, Marcia C.. Belém, Pará; BrasilFil: Echave, María Eugenia. Fundación Inalafquen; Argentin

Evaluating functional capacity, and mortality effects in the presence of atrial electromechanical conduction delay in patients with systolic heart failure

Objective: Atrial functions are relatively suppressed in heart failure (HF). We aimed to investigate the associations of intra- and inter-atrial electromechanical conduction delay (EMCD) with functional class and mortality over a 12-month follow-up period. Methods: The prospective study included 65 patients with systolic HF and 65 healthy subjects with normal sinus rhythm. Left ventricular (LV) systolic functions and left atrial (LA) dimensions and volumes were evaluated by transthoracic echocardiography. Tissue Doppler imaging (TDI) signals at the lateral border of the mitral annulus (lateral PA’), septal mitral annulus (septal PA’), and tricuspid annulus (tricuspid PA’) were measured. Intra- and inter-atrial EMCD were calculated. Results: Mitral inflow velocities were studied using pulsed-wave Doppler after placing the sample volume at the leaflets’ tips. The peak early (E wave) and late (A wave) velocities were measured. The septal annular E/E’ ratio was relatively higher and lateral, septal, and right ventricular S, E’, and A’ waves were significantly lower in the HF group than in the control group (12.49±6.03 - 7.16±1.75, pE/E’ <0.0001). Intra-atrial EMCD was detected as 117.5 ms and inter-atrial EMCD as 127.5 ms in patients with prolonged atrial EMCD. A significant increase was found in prolonged intra- and inter-atrial EMCD according to functional capacity increase (p=0.012 and p=0.031, respectively). The incidence of mortality was significantly higher in patients with prolonged atrial EMCD (p=0.025), and 5 patients in the HF group died during the study over the 12-month follow-up period. Conclusions: In this study, we found a relationship between prolonged atrial conduction time and increased functional class and mortality in patients with systolic HF. © 2016 by Turkish Society of Cardiology

Alpha-induced cross sections of 106Cd for the astrophysical p-process

The 106Cd(alpha,gamma)110Sn reaction cross section has been measured in the energy range of the Gamow window for the astrophysical p-process scenario. The cross sections for 106Cd(alpha,n)109Sn and for 106Cd(alpha,p)109In below the (alpha,n) threshold have also been determined. The results are compared with predictions of the statistical model code NON-SMOKER using different input parameters. The comparison shows that a discrepancy for 106Cd(alpha,gamma)110Sn when using the standard optical potentials can be removed with a different alpha+106Cd potential. Some astrophysical implications are discussed.Comment: 10 pages, 9 figures, accepted for publication in Phys. Rev

Safety Evaluation of α-Lipoic Acid Supplementation: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Clinical Studies.

Alpha-lipoic acid (ALA) is a natural short-chain fatty acid that has attracted great attention in recent years as an antioxidant molecule. However, some concerns have been recently raised regarding its safety profile. To address the issue, we aimed to assess ALA safety profile through a systematic review of the literature and a meta-analysis of the available randomized placebo-controlled clinical studies. The literature search included EMBASE, PubMed Medline, SCOPUS, Google Scholar, and ISI Web of Science by Clarivate databases up to 15th August 2020. Data were pooled from 71 clinical studies, comprising 155 treatment arms, which included 4749 subjects with 2558 subjects treated with ALA and 2294 assigned to placebo. A meta-analysis of extracted data suggested that supplementation with ALA was not associated with an increased risk of any treatment-emergent adverse event (all p &gt; 0.05). ALA supplementation was safe, even in subsets of studies categorized according to smoking habit, cardiovascular disease, presence of diabetes, pregnancy status, neurological disorders, rheumatic affections, severe renal impairment, and status of children/adolescents at baseline

Short Paper: An Exploration of Code Diversity in the Cryptocurrency Landscape

Interest in cryptocurrencies has skyrocketed since their introduction a decade ago, with hundreds of billions of dollars now invested across a landscape of thousands of different cryptocurrencies. While there is significant diversity, there is also a significant number of scams as people seek to exploit the current popularity. In this paper, we seek to identify the extent of innovation in the cryptocurrency landscape using the open-source repositories associated with each one. Among other findings, we observe that while many cryptocurrencies are largely unchanged copies of Bitcoin, the use of Ethereum as a platform has enabled the deployment of cryptocurrencies with more diverse functionalities