273 research outputs found
Phase-fluctuation induced reduction of the kinetic energy at the superconducting transition
Recent reflectivity measurements provide evidence for a "violation" of the
in-plane optical integral in the underdoped high-T_c compound
Bi_2Sr_2CaCu_2O_{8+\delta} up to frequencies much higher than expected by
standard BCS theory. The sum rule violation may be related to a loss of
in-plane kinetic energy at the superconducting transition. Here, we show that a
model based on phase fluctuations of the superconducting order parameter can
account for this change of in-plane kinetic energy at T_c. The change is due to
a transition from a phase-incoherent Cooper-pair motion in the pseudogap regime
above T_c to a phase-coherent motion at T_c.Comment: 5 pages, 3 eps-figure
Characterization and evolution of cell division and cell wall synthesis genes in the bacterial phyla Verrucomicrobia, Lentisphaerae, Chlamydiae and Planctomycetes and phylogenetic comparison with rRNA genes
In the past, studies on the relationships of the bacterial phyla Planctomycetes, Chlamydiae, Lentisphaerae, and
Verrucomicrobia using different phylogenetic markers have been controversial. Investigations based on 16S
rRNA sequence analyses suggested a relationship of the four phyla, showing the branching order Planctomycetes,
Chlamydiae, Verrucomicrobia/Lentisphaerae. Phylogenetic analyses of 23S rRNA genes in this study also
support a monophyletic grouping and their branching orderâthis grouping is significant for understanding
cell division, since the major bacterial cell division protein FtsZ is absent from members of two of the phyla
Chlamydiae and Planctomycetes. In Verrucomicrobia, knowledge about cell division is mainly restricted to the
recent report of ftsZ in the closely related genera Prosthecobacter and Verrucomicrobium. In this study, genes of
the conserved division and cell wall (dcw) cluster (ddl, ftsQ, ftsA, and ftsZ) were characterized in all verrucomicrobial
subdivisions (1 to 4) with cultivable representatives (1 to 4). Sequence analyses and transcriptional
analyses in Verrucomicrobia and genome data analyses in Lentisphaerae suggested that cell division is based on
FtsZ in all verrucomicrobial subdivisions and possibly also in the sister phylum Lentisphaerae. Comprehensive
sequence analyses of available genome data for representatives of Verrucomicrobia, Lentisphaerae, Chlamydiae,
and Planctomycetes strongly indicate that their last common ancestor possessed a conserved, ancestral type of
dcw gene cluster and an FtsZ-based cell division mechanism. This implies that Planctomycetes and Chlamydiae
may have shifted independently to a non-FtsZ-based cell division mechanism after their separate branchings
from their last common ancestor with Verrucomicrobia
The correlations of glycated hemoglobin and carbohydrate metabolism parameters with heart rate variability in apparently healthy sedentary young male subjects
Introduction Sedentary lifestyle is a major risk factor for diabetes, cardiovascular and many other age-related diseases. Heart rate variability (HRV) reflects the function of regulatory systems of internal organs and may sensitively indicate early metabolic disturbances. We hypothesize that quantitative and qualitative changes of HRV in young subjects may reflect early metabolic derangements responsible for further development of clinically significant disease. Aim The aim of our study was to determine whether the parameters of carbohydrate metabolism (fasting blood glucose, HBA1c and surrogate insulin sensitivity/resistance indices) correlate with anthropometric data and HRV. Methods The study group consisted of 30 healthy sedentary male subjects aged 20â40, nonsmokers, mainly office and research employees, medical staff and students. Athletes, actively training more than one hour per week, severely obese and men of physical work were excluded from the study. HRV parameters were derived from short term ECG records (five minutes intervals) in supine position and during orthostatic test. Anthropometric data included height, weight, body mass index (BMI), age and body composition (estimation by bioelectric impedance method). The fasting blood glucose, insulin and C-peptide, homeostatic model assessment (HOMA-IR) index and glycated hemoglobin (HbA1c) were evaluated. Linear correlation coefficient (r) was calculated using Statistica 10.0 software. Results and discussion HOMA-IR index correlated positively with body weight, visceral fat and BMI (p=0.047, 0.027 and 0.017 respectively). In supine position pNN50 positively correlated with glucose/insulin ratio (p=0.011) and heart rate with HOMA-IR (p=0.006). In orthostatic test negative correlations of HBA1c with standard deviation, total and low frequency power were determined (p=0.034, 0.400 and 0.403 respectively), which indicates a gradual worsening of functional capacity of cardiovascular system with low-grade increase (under the conventional threshold) of HBA1c. Conclusions In apparently healthy sedentary subjects HRV reduction correlates with the age advancement, subclinical deteriorations of carbohydrate metabolism and excessive fat accumulation
Exact ground states for the four-electron problem in a two-dimensional finite Hubbard square system
We present exact explicit analytical results describing the exact ground
state of four electrons in a two dimensional square Hubbard cluster containing
16 sites taken with periodic boundary conditions. The presented procedure,
which works for arbitrary even particle number and lattice sites, is based on
explicitly given symmetry adapted base vectors constructed in r-space. The
Hamiltonian acting on these states generates a closed system of 85 linear
equations providing by its minimum eigenvalue the exact ground state of the
system. The presented results, described with the aim to generate further
creative developments, not only show how the ground state can be exactly
obtained and what kind of contributions enter in its construction, but
emphasize further characteristics of the spectrum. On this line i) possible
explications are found regarding why weak coupling expansions often provide a
good approximation for the Hubbard model at intermediate couplings, or ii)
explicitly given low lying energy states of the kinetic energy, avoiding double
occupancy, suggest new roots for pairing mechanism attracting decrease in the
kinetic energy, as emphasized by kinetic energy driven superconductivity
theories.Comment: 37 pages, 18 figure
Quality of life and clinical characteristics of self-improving congenital ichthyosis within the disease spectrum of autosomal recessive congenital ichthyosis
Background Autosomal-recessive congenital ichthyosis (ARCI) is a heterogeneous group of ichthyoses presenting at birth. Self-improving congenital ichthyosis (SICI) is a subtype of ARCI and is diagnosed when skin condition improves remarkably (within years) after birth. So far, there are sparse data on SICI and quality of life (QoL) in this ARCI subtype. This study aims to further delineate the clinical spectrum of SICI as a rather unique subtype of ARCI. Objectives This prospective study included 78 patients (median age: 15 years) with ARCI who were subdivided in SICI (n = 18) and non-SICI patients (nSICI, n = 60) by their ARCI phenotype. Methods Quality of life (QoL) was assessed using the (Children's) Dermatology Life Quality Index. Statistical analysis was performed with chi-squared and t-Tests. Results The genetically confirmed SICI patients presented causative mutations in the following genes: ALOXE3 (8/16; 50.0%), ALOX12B (6/16; 37.5%), PNPLA1 (1/16; 6.3%) and CYP4F22 (1/16; 6.3%). Hypo-/anhidrosis and insufficient vitamin D levels (<30 ng/mL) were often seen in SICI patients. Brachydactyly (a shortening of the 4th and 5th fingers) was statistically more frequent in SICI (P = 0.023) than in nSICI patients. A kink of the ear's helix was seen in half of the SICI patients and tends to occur more frequently in patients with ALOX12B mutations (P = 0.005). QoL was less impaired in patients under the age of 16, regardless of ARCI type. Conclusions SICI is an underestimated, milder clinical variant of ARCI including distinct features such as brachydactyly and kinking of the ears. Clinical experts should be aware of these features when seeing neonates with a collodion membrane. SICI patients should be regularly checked for clinical parameters such as hypo-/anhidrosis or vitamin D levels and monitored for changes in quality of life
Quantifying nitrous oxide emissions in the U.S. Midwest: a topâdown study using high resolution airborne inâsitu observations
The densely farmed U.S. Midwest is a prominent source of nitrous oxide (N2O) but topâdown and bottomâup N2O emission estimates differ significantly. We quantify Midwest N2O emissions by combining observations from the Atmospheric Carbon and TransportâAmerica campaign with model simulations to scale the Emissions Database for Global Atmospheric Research (EDGAR). In October 2017 we scaled agricultural EDGAR v4.3.2 and v5.0 emissions by factors of 6.3 and 3.5, respectively, resulting in 0.42ânmolâmâ2âsâ1 Midwest N2O emissions. In June/July 2019, a period when extreme flooding was occurring in the Midwest, agricultural scaling factors were 11.4 (v4.3.2) and 9.9 (v5.0), resulting in 1.06ânmolâmâ2âsâ1 Midwest emissions. Uncertainties are on the order of 50â%. Agricultural emissions estimated with the processâbased model DayCent (Daily version of the CENTURY ecosystem model) were larger than in EDGAR but still substantially smaller than our estimates. The complexity of N2O emissions demands further studies to fully characterize Midwest emissions
hiPSC-Derived Epidermal Keratinocytes from Ichthyosis Patients Show Altered Expression of Cornification Markers
Inherited ichthyoses represent a large heterogeneous group of skin disorders characterised by impaired epidermal barrier function and disturbed cornification. Current knowledge about disease mechanisms has been uncovered mainly through the use of mouse models or human skin organotypic models. However, most mouse lines suffer from severe epidermal barrier defects causing neonatal death and human keratinocytes have very limited proliferation ability in vitro. Therefore, the development of disease models based on patient derived human induced pluripotent stem cells (hiPSCs) is highly relevant. For this purpose, we have generated hiPSCs from patients with congenital ichthyosis, either non-syndromic autosomal recessive congenital ichthyosis (ARCI) or the ichthyosis syndrome trichothiodystrophy (TTD). hiPSCs were successfully differentiated into basal keratinocyte-like cells (hiPSC-bKs), with high expression of epidermal keratins. In the presence of higher calcium concentrations, terminal differentiation of hiPSC-bKs was induced and markers KRT1 and IVL expressed. TTD1 hiPSC-bKs showed reduced expression of FLG, SPRR2B and lipoxygenase genes. ARCI hiPSC-bKs showed more severe defects, with downregulation of several cornification genes. The application of hiPSC technology to TTD1 and ARCI demonstrates the successful generation of in vitro models mimicking the disease phenotypes, proving a valuable system both for further molecular investigations and drug development for ichthyosis patients
Ab initio screening methodology applied to the search for new permanent magnetic materials
In this paper a computational high-throughput screening (HTS) approach to the search for alternative permanent magnetic materials is presented. Systems considered for a start are binary intermetallic compounds composed of rare-earth (RE) and transition metal (TM) elements. With the tight-binding-linear muffin-tin-orbital-atomic-sphere-approximation (TBLMTO-ASA) method of density functional theory (DFT) a variety of REâTM intermetallic phases is investigated and their magnetic properties are obtained at rather low computational costs. Next, interstitial elements such as boron, carbon and nitrogen in these phases are considered. For promising candidate phases with high and stable spontaneous ferromagnetic polarization, the calculated local magnetic moments and exchange coupling parameters, as obtained from TB-LMTO-ASA calculations, are then used for Monte Carlo simulations to identify candidates with sufficiently high Curie temperatures (Tc). Finally, magnetocrystalline anisotropy constants (K1) of the most promising candidate phases are calculated with accurate, potential-shape-unrestricted DFT calculations using the Vienna ab initio simulation package. The computational HTS procedure is illustrated by results for a selection of hard-magnetic REâTM phases like RETM5, RE2TM17 and RE2TM14B
Kinetic Energy, Condensation Energy, Optical Sum Rule and Pairing Mechanism in High-Tc Cuprates
The mechanism of high-Tc superconductivity is investigated with interests on
the microscopic aspects of the condensation energy. The theoretical analysis is
performed on the basis of the FLEX approximation which is a microscopic
description of the spin-fluctuation-induced-superconductivity. Most of phase
transitions in strongly correlated electron system arise from the correlation
energy which is copmetitive to the kinetic energy. However, we show that the
kinetic energy cooperatively induces the superconductivity in the underdoped
region. This unusual decrease of kinetic energy below T_c is induced by the
feedback effect. The feedback effect induces the magnetic resonance mode as
well as the kink in the electronic dispersion, and alters the properties of
quasi-particles, such as mass renormalization and lifetime. The crossover from
BCS behavior to this unusual behavior occurs for hole dopings. On the other
hand, the decrease of kinetic energy below T_c does not occur in the
electron-doped region. We discuss the relation to the recent obserbation of the
violation of optical sum rule
Phonons and related properties of extended systems from density-functional perturbation theory
This article reviews the current status of lattice-dynamical calculations in
crystals, using density-functional perturbation theory, with emphasis on the
plane-wave pseudo-potential method. Several specialized topics are treated,
including the implementation for metals, the calculation of the response to
macroscopic electric fields and their relevance to long wave-length vibrations
in polar materials, the response to strain deformations, and higher-order
responses. The success of this methodology is demonstrated with a number of
applications existing in the literature.Comment: 52 pages, 14 figures, submitted to Review of Modern Physic
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