28 research outputs found
A biochemical marker panel in MRI-proven hyperacute ischemic stroke-a prospective study
- Author
- AI Qureshi
- Albert C Ludolph
- C Weimar
- Carolin Knauer
- CS Rivers
- Dietmar Bengel
- DL Nash
- DP Davis
- EC Jauch
- EC Sa de Camargo
- G Giannakoulas
- H Tomita
- Hans P MĂŒller
- HP Adams Jr
- I Sibon
- J Montaner
- K Iltumur
- Katharina Knauer
- M Mejdoubi
- M Ramos-Fernandez
- M Rodriguez-Yanez
- MH Kim
- PR Kamchatov
- R von Kummer
- Roman Huber
- S Prabhakaran
- S Vanni
- Susanne MĂŒller
- VN Thijs
- W Hacke
- W Hacke
- Publication venue
- BioMed Central
- Publication date
- 01/01/2012
- Field of study
Validation of <i>N</i>-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of <i>Trypanosoma cruzi</i>
- Author
- A Marques
- A Rassi Jr.
- AJ Roberts
- AJ Roberts
- AM Goldston
- Andres Santos
- Armando Varela-Ramirez
- BT Emmer
- C Panethymitaki
- Carlos Franco-Paredes
- Carolina Lema
- CJ Glover
- CL Epting
- DR Johnson
- E Mills
- E Ruge
- EC Gaffarogullari
- EP Camargo
- F Gazos-Lopes
- G Charron
- HP Price
- HP Price
- Ian H. Gilbert
- Igor C. Almeida
- J Gascon
- JA Brannigan
- JA Frearson
- JA Urbina
- JD Bangs
- JK Lodge
- JN Wingard
- Justin Harrison
- L Gaspar
- Lilian L. Nohara
- Linda J. Herrera
- LL Nohara
- M Masubuchi
- MD Rackham
- MT Bahia
- Neil R. Norcross
- NH Georgopapadakou
- NW Andrews
- PA Vigueira
- PW Bowyer
- PW Bowyer
- RA McIlhinney
- RJ Duronio
- Rosa A. Maldonado
- RS Bhatnagar
- S Brand
- S Brand
- SA Weston
- SM Mumby
- Stephen Brand
- Stephen Thompson
- TA Farazi
- V de Paulo Martins
- Victoria Smith
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 01/01/2016
- Field of study
BACKGROUND:Trypanosoma cruzi causes Chagas disease, an endemic and debilitating illness in Latin America. Lately, owing to extensive population movements, this neglected tropical disease has become a global health concern. The two clinically available drugs for the chemotherapy of Chagas disease have rather high toxicity and limited efficacy in the chronic phase of the disease, and may induce parasite resistance. The development of new anti-T. cruzi agents is therefore imperative. The enzyme N-myristoyltransferase (NMT) has recently been biochemically characterized, shown to be essential in Leishmania major, Trypanosoma brucei, and T. cruziž and proposed as promising chemotherapeutic target in these trypanosomatids. METHODOLOGY/PRINCIPAL FINDINGS:Here, using high-content imaging we assayed eight known trypanosomatid NMT inhibitors, against mammal-dwelling intracellular amastigote and trypomastigote stages and demonstrated that three of them (compounds 1, 5, and 8) have potent anti-proliferative effect at submicromolar concentrations against T. cruzi, with very low toxicity against human epithelial cells. Moreover, metabolic labeling using myristic acid, azide showed a considerable decrease in the myristoylation of proteins in parasites treated with NMT inhibitors, providing evidence of the on-target activity of the inhibitors. CONCLUSIONS/SIGNIFICANCE:Taken together, our data point out to the potential use of NMT inhibitors as anti-T. cruzi chemotherapy
PREVALENCE OF PARACOCCIDIOIDOMYCOSIS INFECTION BY INTRADERMAL REACTION IN RURAL AREAS IN ALFENAS, MINAS GERAIS, BRAZIL
- Author
- Abreu e Silva MA
- Bellisimo-Rodrigues F
- Cadavid D
- Cano LE
- Carla de FĂĄtima Ribeiro
- Carla Silva DĂąmaso
- Cermeño J
- Cermeño JR
- dos Santos WA
- Eric Batista Ferreira
- Evandro Monteiro de SĂĄ MagalhĂŁes
- Fava SC
- Fornajeiro N
- Hotez PJ
- Kalmar EM
- Karhawi AS
- Lacaz CS
- Liese B
- Luiz Cosme Cotta Malaquias
- Luiz Felipe Leomil Coelho
- Mamoni RL
- Mangiaterra ML
- Maria Rita Rodrigues
- Marques AP
- Marques SA
- Martinez R
- Moreira APV
- Oliveira SJ
- Ono MA
- Pinzan CF
- Restrepo A
- Restrepo A
- Restrepo A
- Restrepo A
- Roberta Ribeiro Silva
- Salazar ME
- Saraiva EC
- Sarti EC
- Shankar J
- Shikanai-Yasuda MA
- Silva-Vergara ML
- Stover EP
- Teixeira MM
- TĂąnia Regina GrĂŁo Velloso
- van Gelderen de Komaid A
- Zoilo Pires de Camargo
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
The global abundance of tree palms
- Author
- Affum-Baffoe K
- Aiba SI
- Alves LF
- Alvez-Valles CM
- Alvim Carvalho F
- Alzate Guarin F
- Andrade A
- AragĂŁo LEOC
- Araujo Murakami A
- Arroyo L
- Ashton PS
- Aymard Corredor GA
- Baker TR
- Baker WJ
- Balslev H
- Barbosa de Camargo P
- Barlow J
- Bastin JF
- Bengone NN
- Berenguer E
- Berry N
- Blanc L
- Bona D
- Bongers F
- Bradford M
- Brambach F
- Brearley FQ
- Brewer SW
- Böhning-Gaese K
- Camargo JLC
- Campbell DG
- Castilho CV
- Castro W
- Catchpole D
- CerĂłn MartĂnez CE
- Chen S
- Chhang P
- Cho P
- Chutipong W
- Clark C
- Collins M
- Comiskey JA
- Corrales Medina MN
- Costa FRC
- Couvreur TLP
- Culmsee H
- David-Higuita H
- Davidar P
- de Almeida EC
- de Almeida SS
- de Oliveira EA
- del Aguila-Pasquel J
- Derroire G
- Di Fiore A
- Doucet JL
- Dourdain A
- Drake DR
- Eiserhardt WL
- Emilio T
- Ensslin A
- Erwin T
- Ewango CEN
- Ewers RM
- Fauset S
- Feldpausch T
- Ferreira J
- Ferreira LL
- Fischer M
- Franklin J
- Fredriksson GM
- Gillespie TW
- Gilpin M
- Gonmadje C
- Gunatilleke AUN
- Hakeem KR
- Hall JS
- Hamer KC
- Harris DJ
- Harrison RD
- Hector A
- Hemp A
- Herault B
- Hidalgo Pizango CG
- Honorio Coronado EN
- Hubau W
- Hussain MS
- Ibrahim FH
- Imai N
- Joly CA
- Joseph S
- Kartawinata K
- Kassi J
- Killeen TJ
- Kitayama K
- KlitgÄrd BB
- Kooyman R
- LabriĂšre N
- Larney E
- Laumonier Y
- Laurance SG
- Laurance WF
- Lawes MJ
- Levesley A
- Lewis SL
- Lisingo J
- Lovejoy T
- Lovett J
- Lu X
- Lykke AM
- Magnusson WE
- Mahayani NPD
- Malhi Y
- Mansor A
- Marcelo Peña JL
- Marimon-Junior BH
- Marshall AR
- Melgaco K
- Mendoza Bautista C
- Mihindou V
- Millet J
- Milliken W
- Mohandass D
- Monteagudo Mendoza AL
- Morandi PS
- Mugerwa B
- Muscarella RE
- Nagamasu H
- Nagy L
- Naret Seuaturien
- Nascimento MT
- NazarĂ© O. de AraĂșjo R
- Neill DA
- Neto LM
- Nilus R
- Nurtjahya E
- NĂșñez Vargas MP
- Onrizal O
- Palacios WA
- Palacios-Ramos S
- Parren M
- Paudel E
- Pennington RT
- Phillips OL
- Pickavance G
- Pipoly III JJ
- Pitman NCA
- Poedjirahajoe E
- Poorter L
- Poulsen JR
- Prasad PRC
- Prieto A
- Puyravaud JP
- Qie L
- Quesada CA
- RamĂrez-Angulo H
- Razafimahaimodison JC
- Reitsma JM
- Requena-Rojas EJ
- Restrepo Correa Z
- Reynel Rodriguez C
- Roopsind A
- Rovero F
- Rozak A
- Rudas Lleras A
- Rutishauser E
- Rutten G
- Ruwan Punchi-Manage
- SalomĂŁo RP
- Sam HV
- Sarker SK
- Satdichanh M
- Schietti J
- Schmitt CB
- Schwantes Marimon B
- Senbeta F
- Sharma LN
- Sheil D
- Sierra R
- Silk F
- Silva-Espejo JE
- Silveira M
- Sonké B
- Steininger MK
- Steinmetz R
- Stevart T
- Sukumar R
- Sultana A
- Sunderland T
- Suresh HS
- Svenning JC
- Tang J
- Tanner E
- ter Steege H
- Terborgh JW
- Theilade I
- Timberlake J
- Torres-Lezama A
- Umunay P
- Uriarte M
- Valenzuela Gamarra L
- van de Bult M
- van der Hout P
- Van Do T
- Vasquez Martinez R
- Vieira ICG
- Vieira SA
- Vilanova E
- Villalobos Cayo J
- Wang O
- Webb CO
- Webb EL
- White L
- Whitfeld TJS
- Wich SA
- Willcock S
- Wiser SK
- Young KR
- Zakaria R
- Zang R
- Zartman CE
- Zo-Bi IC
- Ălvarez-DĂĄvila E
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- Field of study
Aim: Palms are an iconic, diverse and often abundant component of tropical ecosystems that provide many ecosystem services. Being monocots, tree palms are evolutionarily, morphologically and physiologically distinct from other trees, and these differences have important consequences for ecosystem services (e.g., carbon sequestration and storage) and in terms of responses to climate change. We quantified global patterns of tree palm relative abundance to help improve understanding of tropical forests and reduce uncertainty about these ecosystems under climate change.
Location: Tropical and subtropical moist forests.
Time period: Current.
Major taxa studied: Palms (Arecaceae).
Methods: We assembled a pantropical dataset of 2,548 forest plots (covering 1,191 ha) and quantified tree palm (i.e., â„10 cm diameter at breast height) abundance relative to coâoccurring nonâpalm trees. We compared the relative abundance of tree palms across biogeographical realms and tested for associations with palaeoclimate stability, current climate, edaphic conditions and metrics of forest structure.
Results: On average, the relative abundance of tree palms was more than five times larger between Neotropical locations and other biogeographical realms. Tree palms were absent in most locations outside the Neotropics but present in >80% of Neotropical locations. The relative abundance of tree palms was more strongly associated with local conditions (e.g., higher mean annual precipitation, lower soil fertility, shallower water table and lower plot mean wood density) than metrics of longâterm climate stability. Lifeâform diversity also influenced the patterns; palm assemblages outside the Neotropics comprise many nonâtree (e.g., climbing) palms. Finally, we show that tree palms can influence estimates of aboveâground biomass, but the magnitude and direction of the effect require additional work.
Conclusions: Tree palms are not only quintessentially tropical, but they are also overwhelmingly Neotropical. Future work to understand the contributions of tree palms to biomass estimates and carbon cycling will be particularly crucial in Neotropical forests
Prenatal exposures and exposomics of asthma
- Author
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- Bilbo SD
- Bilbo SD Schwarz JM
- Bjorkman S
- Borish L Culp JA
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- Publication venue
- 'American Institute of Mathematical Sciences (AIMS)'
- Publication date
- 01/01/2015
- Field of study
This review examines the causal investigation of preclinical development of childhood asthma using exposomic tools. We examine the current state of knowledge regarding early-life exposure to non-biogenic indoor air pollution and the developmental modulation of the immune system. We examine how metabolomics technologies could aid not only in the biomarker identification of a particular asthma phenotype, but also the mechanisms underlying the immunopathologic process. Within such a framework, we propose alternate components of exposomic investigation of asthma in which, the exposome represents a reiterative investigative process of targeted biomarker identification, validation through computational systems biology and physical sampling of environmental medi
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
- Abellan AN
- AbellĂĄn AN
- AbellĂĄn AN
- AbellĂĄn AN
- Abrams ST
- Ackerley C
- Acuña M
- Adda M
- Adhikari NK
- Adriano G
- Adrie C
- Affatato R
- Affatato R
- Afonso-Rivero D
- Agarossi A
- Agarwal LK
- Ageeva T
- Agrawal R
- Aguayo-DeHoyos E
- Aguilar AL
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguilar-Alonso E
- Aguirregabyria M
- Ahmadnia E
- Ahn C
- Ahn JY
- Ahn JY
- Ahn MY
- Ahn MY
- Aitken LM
- Akalaev R
- Akbarzadeh A
- Akcan-Arikan A
- Akhlagh SH
- Akhtar N
- AKI Research Group
- Akiduki N
- Akin S
- Akizuki N
- Akkoc T
- Ala-Kokko T
- Alanio A
- Albaiceta GM
- Albaladejo P
- Alberto F
- Albuisson E
- Alcala MA
- AlcĂĄzar L
- Aldabo-Pallas T
- Aldana NN
- Aldecoa C
- AlegrĂa L
- Alejandro R
- Alejo GC
- Alejos RM
- Alexandrova E
- Algarte R
- Algarte R
- Algieri I
- Algora-Weber A
- Alhamdi Y
- Aliaga FA
- Aliberti S
- Alkan A
- Almudena PM
- Almudevar PM
- Almudevar PM
- Almudévar PM
- Altıntas ND
- Alvarez J
- Alves SC
- Alzola LM
- Amargianitakis V
- Amaro R
- Amato MB
- Ambler M
- Amerongen MP
- Amininejad T
- Amor LL
- Amorim V
- Anand RK
- Andersen LW
- Andersson S
- Andoh K
- Andrade AH
- Andrade AH
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- Antonucci E
- AntĂłn DG
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- Appiani F
- Aquevedo A
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- Araujo NJ
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- ARIAM registry of adult cardiac surgery
- ARIAM-ANDALUCIA
- Arias CC
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- Arias-Verdu MD
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- Arslantas MK
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- Aslanian P
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- Asyralyyeva G
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- Ayala LY
- Aydin M
- Azevedo JC
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- Banderas-Bravo ME
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- Berthelsen RE
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- Brianti R
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- Campelo FA
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- Campos LM
- Cannesson M
- CAPCRI Study
- Capellier G
- Carbonara M
- Cardellino S
- Cardenas CL
- Cariou A
- Cariou A
- Carlesso E
- Carmona AF
- Carmona SA
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- Carpio D
- CarratalĂĄ A
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- Carrero-GĂłmez F
- Carreño ER
- Carreño R
- Carvalho JP
- Carvalho KV
- Casals XN
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- Cassina T
- Castañeda DP
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- Castellanos A
- Castellanos A
- Castillo-Lorente E
- Castillo-Lorente E
- Catalan M
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- Cavalcanti D
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- Cavalier E
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- Chaussard M
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- Chen YS
- Cheng CC
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- Cheng KC
- Cheng YJ
- Chernyshuk S
- Chevret S
- Chhor V
- Chiang CC
- Chiang CH
- Chiang CH
- Chiang CH
- Chiappa C
- Chiou KR
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- Chiu LC
- Chiumello D
- Chiurazzi C
- Chiurazzi C
- Cho Y
- Cho YJ
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- Cholley B
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- Chouvarda I
- Christopher KB
- Chrétien JM
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- Cinel I
- Cinnella G
- Citerio G
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- Clemente EA
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- Cohen Y
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- Colino L
- Collange O
- Colombo A
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- Combes A
- Concha P
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- Constan A
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- Conti G
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- Coombs M
- Cordeiro CP
- Cordero M
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- Cordovilla-Guardia S
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- Corona A
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- Corzo L
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- Curinga M
- Curtis A
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- Cutuli SL
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- da Silva VZ
- Daga-Ruiz D
- Dalhuisen A
- Dalorzo M
- Damas P
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- Das Neves A
- David H
- Davis C
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- De Backer A
- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
- de la Fuente MV
- De La Fuente-Martos C
- De La Fuente-Martos C
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- De la Torre MA
- De Maglie M
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- de Molina FJ
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- De Pascale G
- De Rosa S
- De Sanctis F
- De Silva AP
- De Sousa I
- de Vera AP
- de Wilde W
- De Zani D
- Deblier I
- DeBrunnar R
- Del Arco A
- Del Moral OL
- Del Olmo R
- Del Rosario CG
- Del Sorbo L
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- Delgado MJ
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- Demoule A
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- Dimopoulou IK
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- Dougall PC
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- Durrant J
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- E YY
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- Elbers PW
- Elgendy M
- Eliet J
- Emmanuel J
- Emmerich M
- Encina B
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- Engelberts D
- ENVIN-HELICS Study Group
- Erb J
- Erdogan M
- Eroles AA
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- EscĂłrcio S
- Eslami S
- Espinasse F
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- Esteban A
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- Facchin F
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- FernĂĄndez IF
- FernĂĄndez L
- FernĂĄndez MV
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- FernĂĄndez-Ortega JF
- Ferraz AB
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- Ferri F
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- FerrĂłn FR
- Fiks T
- Fiks T
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- Filho CA
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- FINNRESUSCI Study Group
- Fischer G
- Fleischmann E
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- Follin A
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- Fontaiña LP
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- Frithiof R
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- Hung WT
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- Hung WT
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- Ignacio ML
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- Kolnikova I
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- Kumbamu A
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- Kwon WY
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- Lin KC
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- Ălvarez JT
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Differing phagocytic function of monocytes and neutrophils in Chagas' cardiopathy according to the presence or absence of congestive heart failure
- Author
- Agoston I
- Blum A
- Braunwald E
- Camargo MM
- Campbell DE
- Cardoni RL
- Cassatella MA
- Celentano AM
- Chen T
- Cunha-Neto E
- Dutra WO
- Engman DM
- Ferreira GG
- Freischlag JA
- Futamura Y
- Georgiev VS
- Givertz MM
- Gotschlich EC
- Jackson G
- Junqueira Jr LF
- Junqueira Jr LF
- Junqueira Jr LF
- Kay J
- Kierszenbaum F
- Kierszenbaum F
- Krum H
- Köberle F
- Luiz Fernando Junqueira JĂșnior
- LĂcia Maria Mota
- Mancuso P
- Mann DL
- Mann DL
- Maria Imaculada Muniz-Junqueira
- Melo RC
- Miller WL
- Mills KHG
- Morato MJF
- Morris SA
- Muniz-Junqueira MI
- Muniz-Junqueira MI
- Muniz-Junqueira MI
- Muniz-Junqueira MI
- Nagy AM
- Ortiz-Ortiz L
- Prata A
- Prata A
- Rassi A Jr
- Rodrigo Barbosa Aires
- Schopf RE
- Sterin-Borda L
- Tarleton RL
- Torre-Amione G
- Underhill DM
- Voltarelli JC
- Wiedermann CJ
- World Health Organization
- Yamaoka-Tojo M
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Anti-Leishmania infantum IgG Antibody Avidity in Visceral Leishmaniasis
- Author
- Publication venue
- 'American Society for Microbiology'
- Publication date
- Field of study
Homeopatia no Sistema Ănico de SaĂșde: representaçÔes dos usuĂĄrios sobre o tratamento homeopĂĄtico
- Author
- AraĂșjo EC
- Bardin L
- Camargo Jr. KR
- Canguilhem G
- Caprara A
- Dalva de Andrade Monteiro
- Donangelo MCF
- Duprat H
- Fortes L
- Foucault M
- Hahnemann S
- Iriart JAB
- Jorge Alberto Bernstein Iriart
- Kleinman A
- Loyola MA
- Luz HS
- Luz MT
- Luz MT
- Luz MT
- Mendicelli VLLM
- Minayo MC
- Monteiro DA
- Monteiro DA
- Monteiro DA
- Montero P
- Paim J
- Queiroz MS
- Queiroz MS
- Salles SA
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Evaluation of Paracoccidioides brasiliensis Infection by gp 43 Intradermal Test in Rural Settlements in Central-West Brazil
- Author
- A Gelderen de Komaid van
- A Restrepo
- AMM Paniago
- Ana Paula da C. Marques
- Anamaria M. M. Paniago
- C Fava Netto
- CC Rodrigues
- CS Lacaz
- D Cadavid
- Dayane A. Melo
- DC Somensi
- E Brummer
- EC Saraiva
- ECFB Sarti
- EG Rodrigues
- Elenir Rose J. C. Pontes
- EM Kalmar
- GG Oliveira
- Grazielli R. Rezende
- ICG Vieira
- J Cermeño
- JE Mackinnon
- JR Cermeño
- L Carandina
- LH Silveira
- LH Silveira
- LR Travassos
- M Franco
- M Mangiaterra
- MA Ono
- Maria da GlĂłria Bonecini-Almeida
- MJ Diogenes
- MJS Mendes-Giannini
- ML Silva-Vergara
- N Fornajeiro
- PJ Hotez
- R Martinez
- R Puccia
- SA Marques
- Sandra Maria V. L. Oliveira
- SC Fava
- Sonia M. Fernandes-Fitts
- WA Santos
- ZF Coutinho
- Zoilo P. Camargo
- ZP Camargo
- ZP Camargo
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study