14,497 research outputs found
Less is more when analysts report bad news
Session 166: Sell-Side AnalystsTop Ten SessionThis study documents the existence of a positive-negative asymmetry in analysts’ consensus earnings forecast revisions. We find that upward revisions are more informative than downward revisions. After controlling for momentum, extreme downward revisions contain little incremental information compared with moderate downward revisions. The differential richness of information set in good and bad news revisions is more pronounced among bigger, more heavily covered stocks and stocks with higher institutional holding, i.e. stocks typically are more prone to the analyst agency problem. These findings are consistent with the claim that analysts systematically struggle with bad news reporting as conflicts are exacerbated with bad news but are attenuated with good news.postprin
Eye movement patterns during the recognition of three-dimensional objects: Preferential fixation of concave surface curvature minima
This study used eye movement patterns to examine how high-level shape information is used during 3D object recognition. Eye movements were recorded while observers either actively memorized or passively viewed sets of novel objects, and then during a subsequent recognition memory task. Fixation data were contrasted against different algorithmically generated models of shape analysis based on: (1) regions of internal concave or (2) convex surface curvature discontinuity or (3) external bounding contour. The results showed a preference for fixation at regions of internal local features during both active memorization and passive viewing but also for regions of concave surface curvature during the recognition task. These findings provide new evidence supporting the special functional status of local concave discontinuities in recognition and show how studies of eye movement patterns can elucidate shape information processing in human vision
EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF); Scientific Opinion on Flavouring Group Evaluation 220, Revision 1 (FGE.220Rev1): alpha,beta-Unsaturated ketones and precursors from chemical subgroup 4.4 of FGE.19: 3(2H)-Furanones.
Superpulsed low-level laser therapy protects skeletal muscle of mdx mice against damage, inflammation and morphological changes delaying dystrophy progression.
Aim: To evaluate the effects of preventive treatment with low-level laser therapy (LLLT) on progression of dystrophy in mdx mice. Methods: Ten animals were randomly divided into 2 experimental groups treated with superpulsed LLLT (904 nm, 15 mW, 700 Hz, 1 J) or placebo-LLLT at one point overlying the tibialis anterior muscle (bilaterally) 5 times per week for 14 weeks (from 6th to 20th week of age). Morphological changes, creatine kinase (CK) activity and mRNA gene expression were assessed in animals at 20th week of age. Results: Animals treated with LLLT showed very few morphological changes in skeletal muscle, with less atrophy and fibrosis than animals treated with placebo-LLLT. CK was significantly lower (p = 0.0203) in animals treated with LLLT (864.70 U.l−1, SEM 226.10) than placebo (1708.00 U.l−1, SEM 184.60). mRNA gene expression of inflammatory markers was significantly decreased by treatment with LLLT (p<0.05): TNF-α (placebo-control = 0.51 µg/µl [SEM 0.12], - LLLT = 0.048 µg/µl [SEM 0.01]), IL-1β (placebo-control = 2.292 µg/µl [SEM 0.74], - LLLT = 0.12 µg/µl [SEM 0.03]), IL-6 (placebo-control = 3.946 µg/µl [SEM 0.98], - LLLT = 0.854 µg/µl [SEM 0.33]), IL-10 (placebo-control = 1.116 µg/µl [SEM 0.22], - LLLT = 0.352 µg/µl [SEM 0.15]), and COX-2 (placebo-control = 4.984 µg/µl [SEM 1.18], LLLT = 1.470 µg/µl [SEM 0.73]). Conclusion: Irradiation of superpulsed LLLT on successive days five times per week for 14 weeks decreased morphological changes, skeletal muscle damage and inflammation in mdx mice. This indicates that LLLT has potential to decrease progression of Duchenne muscular dystrophy
Saturated phase densities of (CO2 + H2O) at temperatures from (293 to 450) K and pressures up to 64 MPa
An apparatus consisting of an equilibrium cell connected to two vibrating tube densimeters and two syringe pumps was used to measure the saturated phase densities of (CO2 + H2O) at temperatures from (293 to 450) K and pressures up to 64 MPa, with estimated average standard uncertainties of 1.5 kg · m−3 for the CO2-rich phase and 1.0 kg · m−3 for the aqueous phase. The densimeters were housed in the same thermostat as the equilibrium cell and were calibrated in situ using pure water, CO2 and helium. Following mixing, samples of each saturated phase were displaced sequentially at constant pressure from the equilibrium cell into the vibrating tube densimeters connected to the top (CO2-rich phase) and bottom (aqueous phase) of the cell. The aqueous phase densities are predicted to within 3 kg · m−3 using empirical models for the phase compositions and partial molar volumes of each component. However, a recently developed multi-parameter equation of state (EOS) for this binary mixture, Gernert and Span [32], was found to under predict the measured aqueous phase density by up to 13 kg · m−3. The density of the CO2-rich phase was always within about 8 kg · m−3 of the density for pure CO2 at the same pressure and temperature; the differences were most positive near the critical density, and became negative at temperatures above about 373 K and pressures below about 10 MPa. For this phase, the multi-parameter EOS of Gernert and Span describes the measured densities to within 5 kg · m−3, whereas the computationally-efficient cubic EOS model of Spycher and Pruess (2010), commonly used in simulations of subsurface CO2 sequestration, deviates from the experimental data by a maximum of about 8 kg · m−3
Methods to model and predict the ViewRay treatment deliveries to aid patient scheduling and treatment planning
Back reaction, emission spectrum and entropy spectroscopy
Recently, an interesting work, which reformulates the tunneling framework to
directly produce the Hawking emission spectrum and entropy spectroscopy in the
tunneling picture, has been received a broad attention. However, during the
emission process, most related observations have not incorporated the effects
of back reaction on the background spacetime, whose derivations are therefore
not the desiring results for the real physical process. With this point as a
central motivation, in this paper we suitably adapt the \emph{reformulated}
tunneling framework so that it can well accommodate the effects of back
reaction to produce the Hawking emission spectrum and entropy spectroscopy.
Consequently, we interestingly find that, when back reaction is considered, the
Parikh-Wilczek's outstanding observations that, an isolated radiating black
hole has an unitary-evolving emission spectrum that is \emph{not} precisely
thermal, but is related to the change of the Bekenstein-Hawking entropy, can
also be reproduced in the reformulated tunneling framework, meanwhile the
entropy spectrum has the same form as that without inclusion of back reaction,
which demonstrates the entropy quantum is \emph{independent} of the effects of
back reaction. As our final analysis, we concentrate on the issues of the black
hole information, but \emph{unfortunately} find that, even including the
effects of back reaction and higher-order quantum corrections, such tunneling
formalism can still not provide a mechanism for preserving the black hole
information.Comment: 16 pages, no figure, use JHEP3.cls. to be published in JHE
Quantum corrections and black hole spectroscopy
In the work \cite{BRM,RBE}, black hole spectroscopy has been successfully
reproduced in the tunneling picture. As a result, the derived entropy spectrum
of black hole in different gravity (including Einstein's gravity,
Einstein-Gauss-Bonnet gravity and Ho\v{r}ava-Lifshitz gravity) are all evenly
spaced, sharing the same forms as , where physical process is only
confined in the semiclassical framework. However, the real physical picture
should go beyond the semiclassical approximation. In this case, the physical
quantities would undergo higher-order quantum corrections, whose effect on
different gravity shares in different forms. Motivated by these facts, in this
paper we aim to observe how quantum corrections affect black hole spectroscopy
in different gravity. The result shows that, in the presence of higher-order
quantum corrections, black hole spectroscopy in different gravity still shares
the same form as , further confirming the entropy quantum is universal
in the sense that it is not only independent of black hole parameters, but also
independent of higher-order quantum corrections. This is a desiring result for
the forthcoming quantum gravity theory.Comment: 14 pages, no figure, use JHEP3.cls. to be published in JHE
Genome-wide signatures of convergent evolution in echolocating mammals
Evolution is typically thought to proceed through divergence of genes, proteins, and ultimately phenotypes(1-3). However, similar traits might also evolve convergently in unrelated taxa due to similar selection pressures(4,5). Adaptive phenotypic convergence is widespread in nature, and recent results from a handful of genes have suggested that this phenomenon is powerful enough to also drive recurrent evolution at the sequence level(6-9). Where homoplasious substitutions do occur these have long been considered the result of neutral processes. However, recent studies have demonstrated that adaptive convergent sequence evolution can be detected in vertebrates using statistical methods that model parallel evolution(9,10) although the extent to which sequence convergence between genera occurs across genomes is unknown. Here we analyse genomic sequence data in mammals that have independently evolved echolocation and show for the first time that convergence is not a rare process restricted to a handful of loci but is instead widespread, continuously distributed and commonly driven by natural selection acting on a small number of sites per locus. Systematic analyses of convergent sequence evolution in 805,053 amino acids within 2,326 orthologous coding gene sequences compared across 22 mammals (including four new bat genomes) revealed signatures consistent with convergence in nearly 200 loci. Strong and significant support for convergence among bats and the dolphin was seen in numerous genes linked to hearing or deafness, consistent with an involvement in echolocation. Surprisingly we also found convergence in many genes linked to vision: the convergent signal of many sensory genes was robustly correlated with the strength of natural selection. This first attempt to detect genome-wide convergent sequence evolution across divergent taxa reveals the phenomenon to be much more pervasive than previously recognised
The momentum analyticity of two-point correlators from perturbation theory and AdS/CFT
The momentum plane analyticity of two point function of a relativistic
thermal field theory at zero chemical potential is explored. A general
principle regarding the location of the singularities is extracted. In the case
of the N=4 supersymmetric Yang-Mills theory at large , a qualitative
change in the nature of the singularity (branch points versus simple poles)
from the weak coupling regime to the strong coupling regime is observed with
the aid of the AdS/CFT correspondence.Comment: 18 pages, 3 figures, typos fixed, 1 figure update
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