631 research outputs found
Searching for Gravitational Waves with a Geostationary Interferometer
We analyze the sensitivities of a geostationary gravitational wave
interferometer mission operating in the sub-Hertz band. Because of its smaller
armlength, in the lower part of its accessible frequency band ( Hz) our proposed Earth-orbiting detector will be less
sensitive, by a factor of about seventy, than the Laser Interferometer Space
Antenna (LISA) mission. In the higher part of its band instead ( Hz), our proposed interferometer will have the capability of
observing super-massive black holes (SMBHs) with masses smaller than M. With good event rates for these systems, a geostationary
interferometer will be able to accurately probe the astrophysical scenarios
that account for their formation.Comment: 33 pages, 9 eps figure
Slavnov-Taylor identities in Coulomb gauge Yang-Mills theory
The Slavnov-Taylor identities of Coulomb gauge Yang-Mills theory are derived
from the (standard, second order) functional formalism. It is shown how these
identities form closed sets from which one can in principle fully determine the
Green's functions involving the temporal component of the gauge field without
approximation, given appropriate input.Comment: 20 pages, no figure
Merger of binary neutron stars of unequal mass in full general relativity
We present results of three dimensional numerical simulations of the merger
of unequal-mass binary neutron stars in full general relativity. A -law
equation of state is adopted, where , ,
\varep, and are the pressure, rest mass density, specific internal
energy, and the adiabatic constant, respectively. We take and the
baryon rest-mass ratio to be in the range 0.85--1. The typical grid size
is for . We improve several implementations since the
latest work. In the present code, the radiation reaction of gravitational waves
is taken into account with a good accuracy. This fact enables us to follow the
coalescence all the way from the late inspiral phase through the merger phase
for which the transition is triggered by the radiation reaction. It is found
that if the total rest-mass of the system is more than times of the
maximum allowed rest-mass of spherical neutron stars, a black hole is formed
after the merger irrespective of the mass ratios. The gravitational waveforms
and outcomes in the merger of unequal-mass binaries are compared with those in
equal-mass binaries. It is found that the disk mass around the so formed black
holes increases with decreasing rest-mass ratios and decreases with increasing
compactness of neutron stars. The merger process and the gravitational
waveforms also depend strongly on the rest-mass ratios even for the range --1.Comment: 32 pages, PRD68 to be publishe
Strong Decays of Strange Quarkonia
In this paper we evaluate strong decay amplitudes and partial widths of
strange mesons (strangeonia and kaonia) in the 3P0 decay model. We give
numerical results for all energetically allowed open-flavor two-body decay
modes of all nsbar and ssbar strange mesons in the 1S, 2S, 3S, 1P, 2P, 1D and
1F multiplets, comprising strong decays of a total of 43 resonances into 525
two-body modes, with 891 numerically evaluated amplitudes. This set of
resonances includes all strange qqbar states with allowed strong decays
expected in the quark model up to ca. 2.2 GeV. We use standard nonrelativistic
quark model SHO wavefunctions to evaluate these amplitudes, and quote numerical
results for all amplitudes present in each decay mode. We also discuss the
status of the associated experimental candidates, and note which states and
decay modes would be especially interesting for future experimental study at
hadronic, e+e- and photoproduction facilities. These results should also be
useful in distinguishing conventional quark model mesons from exotica such as
glueballs and hybrids through their strong decays.Comment: 69 pages, 5 figures, 39 table
Expansion and further delineation of the SETD5 phenotype leading to global developmental delay, variable dysmorphic features, and reduced penetrance
Diagnostic exome sequencing (DES) has aided delineation of the phenotypic spectrum of rare genetic etiologies of intellectual disability (ID). A SET domain containing 5 gene (SETD5) phenotype of ID and dysmorphic features has been previously described in relation to patients with 3p25.3 deletions and in a few individuals with de novo sequence alterations. Herein, we present additional patients with pathogenic SETD5 sequence alterations. The majority of patients in this cohort and previously reported have developmental delay, behavioral/psychiatric issues, and variable hand and skeletal abnormalities. We also present an apparently unaffected carrier mother of an affected individual and a carrier mother with normal intelligence and affected twin sons. We suggest that the phenotype of SETD5 is more complex and variable than previously presented. Therefore, many features and presentations need to be considered when evaluating a patient for SETD5 alterations through DES
Recommended from our members
The power of popular publicity: new social media and the affective dynamics of the sport racism scandal
Sociologists have tended to take insufficient account of the importance of emotions to the social power of the institution of media, particularly as altered by the emergence of social media in the current media ecology. This paper compensates for this neglect by means of a brief illustrative case study of the effect of social media on the public reception of the 2011 Sepp Blatter racism scandal and of other ârace-relatedâ scandals in the UK. In proposing media scandalsâ wider sociological significance regarding the dynamic, multi-accented relationships between emotions and power, it analyses how Englandâs prevailing climate of âpostcolonial guiltâ was reinforced and conveyed through social media networks
SUFU haploinsufficiency causes a recognisable neurodevelopmental phenotype at the mild end of the Joubert syndrome spectrum.
Joubert syndrome (JS) is a recessively inherited ciliopathy characterised by congenital ocular motor apraxia (COMA), developmental delay (DD), intellectual disability, ataxia, multiorgan involvement, and a unique cerebellar and brainstem malformation. Over 40 JS-associated genes are known with a diagnostic yield of 60%-75%.In 2018, we reported homozygous hypomorphic missense variants of the SUFU gene in two families with mild JS. Recently, heterozygous truncating SUFU variants were identified in families with dominantly inherited COMA, occasionally associated with mild DD and subtle cerebellar anomalies.
We reanalysed next generation sequencing (NGS) data in two cohorts comprising 1097 probands referred for genetic testing of JS genes.
Heterozygous truncating and splice-site SUFU variants were detected in 22 patients from 17 families (1.5%) with strong male prevalence (86%), and in 8 asymptomatic parents. Patients presented with COMA, hypotonia, ataxia and mild DD, and only a third manifested intellectual disability of variable severity. Brain MRI showed consistent findings characterised by vermis hypoplasia, superior cerebellar dysplasia and subtle-to-mild abnormalities of the superior cerebellar peduncles. The same pattern was observed in two out of three tested asymptomatic parents.
Heterozygous truncating or splice-site SUFU variants cause a novel neurodevelopmental syndrome encompassing COMA and mild JS, which likely represent overlapping entities. Variants can arise de novo or be inherited from a healthy parent, representing the first cause of JS with dominant inheritance and reduced penetrance. Awareness of this condition will increase the diagnostic yield of JS genetic testing, and allow appropriate counselling about prognosis, medical monitoring and recurrence risk
Risks to carbon storage from land-use change revealed by peat thickness maps of Peru
This work was funded by NERC (grant ref. NE/R000751/1) to I.T.L., A.H., K.H.R., E.T.A.M., C.M.A., T.R.B., G.D. and E.C.D.G.; Leverhulme Trust (grant ref. RPG-2018-306) to K.H.R., L.E.S.C. and C.E.W.; Gordon and Betty Moore Foundation (grant no. 5439, MonANPeru network) to T.R.B., E.N.H.C. and G.F.; Wildlife Conservation Society to E.N.H.C.; Concytec/British Council/Embajada BritĂĄnica Lima/Newton Fund (grant ref. 220â2018) to E.N.H.C. and J.D.; Concytec/NERC/Embajada BritĂĄnica Lima/Newton Fund (grant ref. 001â2019) to E.N.H.C. and N.D.; the governments of the United States (grant no. MTO-069018) and Norway (grant agreement no. QZA-12/0882) to K.H.; and NERC Knowledge Exchange Fellowship (grant ref no. NE/V018760/1) to E.N.H.C.Tropical peatlands are among the most carbon-dense ecosystems but land-use change has led to the loss of large peatland areas, associated with substantial greenhouse gas emissions. To design effective conservation and restoration policies, maps of the location and carbon storage of tropical peatlands are vital. This is especially so in countries such as Peru where the distribution of its large, hydrologically intact peatlands is poorly known. Here field and remote sensing data support the model development of peatland extent and thickness for lowland Peruvian Amazonia. We estimate a peatland area of 62,714âkm2 (5th and 95th confidence interval percentiles of 58,325 and 67,102âkm2, respectively) and carbon stock of 5.4 (2.6â10.6)âPgC, a value approaching the entire above-ground carbon stock of Peru but contained within just 5% of its land area. Combining the map of peatland extent with national land-cover data we reveal small but growing areas of deforestation and associated CO2 emissions from peat decomposition due to conversion to mining, urban areas and agriculture. The emissions from peatland areas classified as forest in 2000 represent 1â4% of Peruvian CO2 forest emissions between 2000 and 2016. We suggest that bespoke monitoring, protection and sustainable management of tropical peatlands are required to avoid further degradation and CO2 emissions.PostprintPeer reviewe
- âŠ