Positive follow-up blood cultures identify high mortality risk among patients with Gram-negative bacteraemia

Objectives: The role of follow-up blood cultures (FUBCs) in the management of Gram-negative bacteraemia (GNB) is poorly understood. We aimed to determine the utility of FUBCs in identifying patients with increased mortality risk. Methods: An observational study with a prospectively enrolled cohort of adult inpatients with GNB was conducted at Duke University Health System from 2002 to 2015. FUBCs were defined as blood cultures performed from 24 hours to 7 days from initial positive blood culture. Results: Among 1702 patients with GNB, 1164 (68%) had FUBCs performed. When performed, FUBCs were positive in 20% (228/1113) of cases. FUBC acquisition was associated with lower all-cause in-hospital mortality (108/538, 20%, vs. 176/1164, 15%; p 0.01) and attributable in-hospital mortality (78/538, 15%, vs. 98/1164, 8%; p < 0.0001). Propensity score–weighted Cox proportional hazards models revealed that obtaining FUBCs was associated with reductions in all-cause (hazard ratio (HR) 0.629; 95% confidence interval (CI), 0.511–0.772; p < 0.0001) and attributable mortality (HR 0.628; 95% CI, 0.480–0.820; p 0.0007). Positive FUBCs were associated with increased all-cause mortality (49/228, 21%, vs. 110/885, 11%; p 0.0005) and attributable mortality (27/228, 12%, vs. 61/885, 7%; p 0.01) relative to negative FUBCs. Propensity score–weighted Cox proportional hazards models revealed that positive FUBCs were associated with increased all-cause (HR 2.099; 95% CI, 1.567–2.811; p < 0.0001) and attributable mortality (HR 1.800; 95% CI, 1.245–2.603; p 0.002). In a calibration analysis, a scoring system accurately identified patients at high risk of positive FUBCs. Conclusions: Rates of positive FUBCs were high and identified patients at increased risk for mortality. Clinical variables can identify patients at high risk for positive FUBCs. FUBCs should be considered in the management of GNB

A Measurement of the Proton Structure Function F ⁣2(x,Q2)F_{\!2}(x,Q^2)

A measurement of the proton structure function $F_{\!2}(x,Q^2)$ is reported for momentum transfer squared $Q^2$ between 4.5 $GeV^2$ and 1600 $GeV^2$ and for Bjorken $x$ between $1.8\cdot10^{-4}$ and 0.13 using data collected by the HERA experiment H1 in 1993. It is observed that $F_{\!2}$ increases significantly with decreasing $x$, confirming our previous measurement made with one tenth of the data available in this analysis. The $Q^2$ dependence is approximately logarithmic over the full kinematic range covered. The subsample of deep inelastic events with a large pseudo-rapidity gap in the hadronic energy flow close to the proton remnant is used to measure the "diffractive" contribution to $F_{\!2}$.Comment: 32 pages, ps, appended as compressed, uuencoded fil

Inclusive charged particle cross-sections in photoproduction at HERA

Cross sections are presented for the inclusive production of charged particles measured in electron-proton collisions at low Q 2 with the H1 detector at HERA. The transverse momentum distribution extends up to 8 GeV/ c . Its shape is found to be harder than that observed in p p collisions at comparable centre-of-mass energies √S γp ≈ √S p p ≈ 200 GeV , and also harder than in γp collisions at lower energies √ S γp ≈ 18 GeV. Results from quantum chromodynamics (QCD) calculations agree with the measured transverse momentum and pseudorapidity cross sections

First measurement of the deep-inelastic structure of proton diffraction

A measurement is presented, using data taken with the H1 detector at HERA, of the contribution of diffractive interactions to deep-inelastic electron-proton scattering. The diffractive contribution to the proton structure function is evaluated as a function of the appropriate deep-inelastic scattering variables using a class of deep-inelastic ep scattering events with no hadronic energy flow in an interval of pseudo-rapidity adjacent to the proton beam direction. The dependence of this contribution on x-pomeron is consistent with both a diffractive interpretation and a factorisable ep diffractive cross section. A first measurement of the deep-inelastic structure of the pomeron in the form of a factorised structure function is presented. This structure function is observed to be consistent with scale invariance

First measurement of the charged current cross-section at HERA

The cross section of the charged current process e − p → v e + hadrons is measured at HERA for transverse momenta of the hadron system larger than 25 GeV. The size of the cross section exhibits the W propagator

Measurement of the proton structure function F2 (x, Q2) in the low-x region at HERA

A measurement of the proton structure function F2 (x, Q2) is presented with about 1000 neutral current deep inelastic scattering events for Bjorken x in the range x {reversed tilde equals} 10-2 - 10-4 and Q2 > 5 GeV2. The measurement is based on an integrated luminosity of 22.5 nb-1 recorded by the H1 detector in the first year of HERA operation. The structure function F2 (x, Q2) shows a significant rise with decreasing x. © 1993.0320 auteursSCOPUS: ar.jinfo:eu-repo/semantics/publishe

Deep inelastic scattering events with a large rapidity gap at HERA

Evidence is presented using data taken with the H1 detector at HERA for a class of deep inelastic electron-proton scattering (DIS) events (5 < Q2 < 120 GeV2) at low Bjorken-x (10-4 < x < 10-2) which have almost no hadronic energy flow in a large interval of pseudo-rapidity around the proton remnant direction and which cannot be attributed to our present understanding of DIS and fluctuations in final state hadronic fragmentation. From an integrated luminosity of 273 nb-1, 734 events, that is about 5% of the total DIS sample, have no energy deposition greater than 400 MeV forward of laboratory pseudo-rapidity ηmax = 1.8 up to the largest measurable pseudo-rapidity of about 3.65. Evidence that about 10% of observed rapidity gap events are exclusive vector meson electroproduction is presented. Good descriptions of the data are obtained using models based either on a vector meson dominance like picture, which includes a large fraction of inelastic virtual photon dissociation, or on deep inelastic electron-pomeron scattering in which the partonic sub-structure of the latter is resolved. © 1994.0400 auteursSCOPUS: ar.jinfo:eu-repo/semantics/publishe

A Search for heavy leptons at HERA

A search for direct production of new leptons in the mass range from 10 GeV up to 225 GeV is presented by the H1 experiment at HERA. The data were obtained during 1993 and correspond to an integrated luminosity of 528 nb-1. The search includes heavy lepton decays to final states e (ν) γ and e (ν) W, e(ν) Z with the subsequent decay of the W and Z bosons into jets or lepton pairs. No evidence was found for the production of new massive electrons or neutrinos in any of the decay channels. Rejection limits for excited electrons and neutrinos are derived. © 1994.0400 auteursSCOPUS: ar.jinfo:eu-repo/semantics/publishe

The Gluon density of the proton at low x from a QCD analysis of F2

We present a QCD analysis of the proton structure function $F_2$ measured by the H1 experiment at HERA, combined with data from previous fixed target experiments. The gluon density is extracted from the scaling violations of $F_2$ in the range $2\cdot 10^{-4}<x<3\cdot 10^{-2}$ and compared with an approximate solution of the QCD evolution equations. The gluon density is found to rise steeply with decreasing $x$.Comment: 17 pages, latex2e, 5 figures appended as uuencoded file, hep number include