Suppression of human papillomavirus gene expression in vitro and in vivo by herpes simplex virus type 2 infection

AbstractRecent epidemiological studies have found that women infected with both herpes simplex virus type 2 (HSV-2) and human papillomavirus (HPV) type 16 or HPV-18 are at greater risk of developing cervical carcinoma compared to women infected with only one virus. However, it remains unclear if HSV-2 is a cofactor for cervical cancer or if HPV and HSV-2 interact in any way. We have studied the effect of HSV-2 infection on HPV-11 gene expression in an in vitro double-infection assay. HPV transcripts were down-regulated in response to HSV-2 infection. Two HSV-2 vhs mutants failed to reduce HPV-16 E1^E4 transcripts. We also studied the effect of HSV-2 infection on preexisting experimental papillomas in a vaginal epithelial xenograft model. Doubly infected grafts demonstrated papillomatous transformation and the classical cytopathic effect from HSV-2 infection. HPV and HSV DNA signals were mutually exclusive. These studies may have therapeutic applications for HPV infections and related neoplasms

Vortices and dynamics in trapped Bose-Einstein condensates

I review the basic physics of ultracold dilute trapped atomic gases, with emphasis on Bose-Einstein condensation and quantized vortices. The hydrodynamic form of the Gross-Pitaevskii equation (a nonlinear Schr{\"o}dinger equation) illuminates the role of the density and the quantum-mechanical phase. One unique feature of these experimental systems is the opportunity to study the dynamics of vortices in real time, in contrast to typical experiments on superfluid $^4$He. I discuss three specific examples (precession of single vortices, motion of vortex dipoles, and Tkachenko oscillations of a vortex array). Other unusual features include the study of quantum turbulence and the behavior for rapid rotation, when the vortices form dense regular arrays. Ultimately, the system is predicted to make a quantum phase transition to various highly correlated many-body states (analogous to bosonic quantum Hall states) that are not superfluid and do not have condensate wave functions. At present, this transition remains elusive. Conceivably, laser-induced synthetic vector potentials can serve to reach this intriguing phase transition.Comment: Accepted for publication in Journal of Low Temperature Physics, conference proceedings: Symposia on Superfluids under Rotation (Lammi, Finland, April 2010

Organisational innovation facilitators as drivers for international trade between China and European Union

This paper analyses the role of innovation policy and the main facilitators to promote China's international trade in the European Union. The theme Innovation Policy of China to potentiate their international trade in the European Union (EU), from 2014 to 2019. To undertake this, research was established the literature survey. The results show that regarding the research areas there is a multiplicity of themes, including Trade Policy, Digital Trade, International negotiations, Multilateral relations, Leadership, China – Politics & Government, Digital Trade Apps, International Trade, Trade Balance, and Goods balance. Also, the US–China trade war has consequences on the GTC because China, but also the EU and other countries are focussing their trade interest in other regions, especially consumers in Asia, Eurasia, Africa, and South America. For future studies, it is suggested to expand the search for articles concerning China and EU Trade on other databases.info:eu-repo/semantics/publishedVersio