Cirurgia bariátrica em indivíduos com déficits cognitivos graves: relato de dois casos

sem informaçãoBariatric surgery has become the gold-standard treatment for refractory morbid obesity. Obesity is frequently associated with certain syndromes that include coexisting cognitive deficits. However, the outcomes from bariatric surgery in this group of indiv13618488sem informaçãosem informaçãosem informaçã

Nutritional characteristics of meat from lambs fed diets containing mulberry hay

The objective of this study was to evaluate the nutritional characteristics of meat from lambs fed diets containing 0%, 12.5% and 25.0% (dry matter (DM)) mulberry hay as a substitute for the concentrate. Twenty-four feedlot Île-de-France lambs with an average age of 60 days and bodyweight (BW) of 15 kg were fed in individual stalls and slaughtered at 32 kg BW, at approximately 130 days old. The chemical composition of the experimental diets contained, respectively, 584.4, 569.4 and 571.8 g DM/kg; 188.8, 185.1 and 184 g crude protein (CP)/kg and 29.9, 29.5 and 25.5 Mcal/kg DM for the mulberry hay inclusion levels of 0%, 12.5% and 25.0%, with a dietary forage to concentrate ratio of 50 : 50. The chemical composition of the meat was 757.9 g moisture/kg DM, 208.6 g CP/kg DM, 22.9 g crude fat/kg DM and 10.5 g ash/kg DM. Cholesterol concentration (36.07 mg/100 g) in the meat was not influenced by mulberry hay inclusion of the diet. An increase was observed in the concentrations of saturated pentadecanoic, heptadecanoic and arachidic acids; monounaturated heptadecenoic acid; and polyunsaturated α-linolenic, ɣ-linolenic and eicosapentaenoic acids. Nervonic and conjugated linoleic acid (CLA) concentrations responded quadratically, representing 3.7 g/kg and 5.9 g/kg of the meat when mulberry hay was included at 16.98% and 12.56%. Omega-3 acid concentrations increased, while the omega-3 : omega-6 ratio decreased in the meat of mulberry hay-fed animals. Inclusion of mulberry hay in lamb diets increases the amount of desirable fatty acids in their meat, whose nutritional characteristics are improved.Keywords: Chemical composition, fatty acids, feedlot, sheep mea

Co-infection Trypanosoma Cruzi/hiv: Systematic Review (1980 - 2010) [coinfecção Trypanosoma Cruzi/hiv: Revisão Sistemática (1980 - 2010)]

Introduction: The co-infection Trypanosoma cruzi/HIV has been described as a clinical event of great relevance. The objective of this study was to describe clinical and epidemiological aspects published in literature. Methods: It is a systematic review of a descriptive nature from the databases Medline, Lilacs, SciELO, Scopus, from 1980 to 2010. Results: There were 83 articles (2.8 articles/year) with a total of 291 cases. The co-infection was described in 1980 and this situation has become the defining AIDS clinical event in Brazil. This is the country with the highest number of publication (51.8%) followed by Argentina (27.7%). The majority of cases are amongst adult men (65.3%) native or from endemic regions with serological diagnosis in the chronic stage (97.9%) and indeterminate form (50.8%). Both diseases follow the normal course, but in 41% the reactivation of the Chagas disease occurs. The most severe form is the meningoencephalitis, with 100% of mortality without specific and early treatment of the T. cruzi. The medication of choice was the benznidazole on doses and duration normally used for the acute phase. The high parasitemia detected by direct or indirect quantitative methods indicated reactivation and its elevation is the most important predictive factor. The lower survival rate was related to the reactivation of the Chagas disease and the natural complications of both diseases. The role of the antiretroviral treatment on the co-infection cannot yet be defined by the knowledge currently existent. Conclusions: Despite the relevance of this clinical event there are still gaps to be filled.446762770Dias, J.C.P., Globalização, iniqüidade e doença de Chagas (2007) Cad Saude Publica, 23, pp. S513-S522Akhavan, D., (2000) Analise de custo-efetividade do programa de controle da doença de Chagas no Brasil, , Relatório final. Brasil: Organização Pan-Americana da SaúdeCastro, J.A., Mecca, M.M., Bartel, L.C., Toxic effects of drugs used to treat Chagas' disease (American trypanosomiasis) (2006) Hum Exp Toxicol, 25, pp. 471-479Urbina, J.A., Chemotherapy of Chagas' disease: The how and the why (1999) J Mol Med, 77, pp. 332-340(2006) Relatório técnico: Certificação do Brasil como área interrompida de transmissão da doença de chagas pelo T. infestans, , Ministério da Saúde, Brasilia: MS/OMS/OPASRelatório Técnico: Recomendações para diagnóstico, tratamento e acompanhamento da co-infecção Trypanosoma cruzi-vírus da imunodeficiência humana (2006) Rev Soc Bras Med Trop, 39, pp. 392-415. , Ministério da Saúdedel Castillo, M., Mendoza, G., Ovieda, J., Perez Bianco, R.P., Anselmo, A.E., Silva, M., AIDS and Chagas' disease with central nervous system tumor-like lesion (1990) Am J Med, 88, pp. 693-694Harms, G., Feldmeir, H., The impact of HIV infection on tropical disease (2005) Infect Dis Clin N Am, 19, pp. 121-135Almeida, E.A., Ramos Jr., A.N., Correia, D., Shikanai-Yasuda, M.A., Brazilian Network of Attention and Studies on Trypanosoma cruzi/HIV Co-infection and others immunossupression conditions (2009) Rev Soc Bras Med Trop, 42, pp. 605-608Ramos Jr., A.N., Correia, D., Almeida, E.A., Shikanai-Yasuda, M.A., History, Current Issues and Future of the Brazilian Network for Attending and Studying Trypanosoma cruzi/HIV Coinfection (2010) J Infect Dev Ctries, 4, pp. 682-688Spina-França, A., Livramento, J.A., Machado, L.R., Yassuda, N., Anticorpos a Trypanosoma cruzi no líquido cefalorraqueano (1988) Arq Neuro-Psiquiat, 46, pp. 374-378Ramos Jr., A.N., Inclusion of Chagas' disease reactivation as a condition for AIDS case definition to epidemiological surveillance in Brazil (2004) Rev Soc Bras Med Trop, 37, pp. 192-193Livramento, J.A., Machado, L.R., Spina-França, A., Anormalidades do líquido cefalorraqueano em 170 casos de AIDS (1989) Arq Neuropsiquiat, 47, pp. 326-327Torrealba, G.M., Acuña, G.L., Tagle, P.M., Tapia, J.I., Huete, I.L., Valor de la biopsia cerebral en pacientes com SIDA y lesions expansivas cerebrales (1990) Rev Med Chile, 118, pp. 1367-1371Ferreira, M.S., Nishioka, S.A., Rocha, A., Silva, A.M., Ferreira, R.G., Olivier, W., Acute fatal Trypanosoma cruzi meningoencephalitis in a Human Immunodeficiency Vírus-positive hemophiliac patiente (1991) Am J Trop Med Hyg, 45, pp. 723-727Gallo, P., Fabão Neto, O.M., Suarez, J.M.M., Borba, R.P., Acute central nervous system infection by Trypanosoma cruzi and AIDS (1992) Arq Neuro-Psiquiat, 50, pp. 375-377Rosemberg, S., Chaves, C.J., Higuchi, M.L., Lopes, M.B.S., Castro, L.H.M., Machado, L.R., Fatal meningoncephalitis caused by reactivation of Trypanosoma cruzi in a patient with AIDS (1992) Neurology, 42, pp. 640-642Glucklstein, D., Ciferri, F., Ruskin, J., Chagas' disease: Another cause of cerebral mass in the Acquired Immunodeficiency Syndrome (1992) Am J Med, 92, pp. 429-432Oddó, D., Casanova, M., Acuña, G., Ballesteros, J., Morales, B., Acute Chagas' disease (Trypanosomiasis americana) in Acquired Immunodeficiency Syndrome: Report of two cases (1992) Hum Pathol, 23, pp. 41-44Metze, K., Maciel, J.A., AIDS and Chagas' disease (1993) Neurology, 43, pp. 447-448Solari, A., Saavedra, H., Sepúlveda, C., Oddó, D., Acuña, G., Labarca, J., Succesful treatment of Trypanosoma cruzi encephalitis in a patient with hemophilia and AIDS (1993) Clin Infect Dis, 16, pp. 255-259Rocha, A., Ferreira, M.S., Nishioka, S.A., Silva, M., Burgarelli, K.N., Silva, A.M., Trypanosoma cruzi meningoencephalitis and myocarditis in a patient with Acquired Immunodeficiency Syndrome (1993) Rev Inst Med Trop São Paulo, 35, pp. 205-208Nishioka, S.A., Ferreira, M.S., Rocha, A., Burgarelli, M.K.N., Silva, A.M., Duarte, M.I.S., Reactivation of Chagas' disease successfully treated with benznidazole in a patient with Acquired Immunodeficiency Syndrome (1993) Mem Inst Oswaldo Cruz, 88, pp. 493-496Libaak, N.E., Gonzaléz, M.I., Gutfraind, E., Wainstein, J.M., Simone, A., Caravello, O., Mielomeningoencefalitis candidiásica asociada a meningitis por Trypanosoma cruzi en un paciente portador de SIDA (1993) Rev Assoc Med Argentina, 106, pp. 4-8Pittella, J.E.H., Central nervous system involvement in Chagas' disease. An apdating (1993) Rev Inst Med Trop São Paulo, 35, pp. 111-116Rocha, A., Meneses, A.C.O., Silva, A.M., Ferreira, M.S., Nishioka, A.S., Almeida, E., Pathology of patients with Chagas' disease and Acquired Immunodeficiency Syndrome (1994) Am J Trop Med Hyg, 50, pp. 261-268Sartori, A.M.C., Lopes, M.H., Caramelli, B., Duarte, M.I.S., Pinto, P.L.S., Shikanai-Yassuda, M.A., Simultaneous occurence of acute myocarditis and reactivated Chagas' disease in a patient with AIDS (1995) Clin Infect Dis, 21, pp. 1297-1299Robinson, R.D., Parasitic infections associated with HIV/AIDS in the Caribbean (1995) Bull PAHO, 29, pp. 129-137Freilij, H., Altcheh, J., Muchinik, G., Perinatal human immunodeficiency virus infection and congenital Chagas' disease (1995) Pediatric Infect Dis J, 14, pp. 161-162Pimentel, P.C.A., Handfas, B.W., Carmignani, M., Trypanosoma cruzi meningoencephalitis in AIDS mimicking cerebral metastases. Case Report (1996) Arq Neuro-Psiquitr, 54, pp. 102-106di Lorenzo, G.A., Pagano, M.A., Taratuto, A.L., Garau, M.L., Meli, F.J., Pomsztein, M.D., Chagasic granulomatous encephalitis in immunosuppressed patients (1996) J Neuroimaging, 6, pp. 94-97Ferreira, M.S., Nishioka, A.S., Silvestre, M.T.A., Borges, A.S., Nunes-Araújo, F.R.F., Rocha, A., Reactivation of Chagas' disease in patients with AIDS: Report of three new cases and review of the literature (1997) Clin Infect Dis, 25, pp. 1397-1400Montero, A., Cohen, J.E., Martinez, D.P., Giovannoni, A.G., Tratamiento empirico anti-toxoplasma en SIDA y Chagas cerebral. Relato de dos casos, revision de la bibliografia y propuesta de un algoritmo (1998) Medicina (Buenos Aires), 58, pp. 504-506Sartori, A.M.C., Lopes, M.H., Benvenuti, L.A., Caramelli, B., di Pietro, A.O., Nunes, E.V., Reactivation of Chagas' disease in a human immunodeficenc virus-infected patient leading to severe heart disease with a late positive direct microscopic examination of the blood (1998) Am J Trop Med Hyg, 59, pp. 784-786Manigot, D.A., SIDA y Chagas: La dificultad de globalizar los protocolos (1998) Medicina (Buenos Aires), 58, pp. 522-524Pacheco, R.S., Ferreira, M.S., Machado, M.I., Brito, C.M.M., Pires, M.Q., da-Cruz, A.M., Chagas' disease and HIV co-infection: Genotypic characterization of the Tripanosoma cruzi strain (1998) Mem Inst Oswaldo Cruz, 93, pp. 165-169Lazo, J.E., Meneses, A.C.O., Rocha, A., Frenkel, J.K., Marquez, J.O., Lopes, E.R., Meningoencefalites toxoplásmica e chagásica em pacientes com infecção pelo vírus da imunodeficiência humana: Diagnóstico diferencial anatomopatológico e tomográfico (1998) Rev Soc Bras Med Trop, 31, pp. 163-171Lazo, J., Meneses, A.C.O., Rocha, A., Ferreira, M.S., Marquez, J.O., Lopes, E.R., Chagasic meningoencephalitis in the immunodeficient (1998) Arq Neuropsiquiat, 56, pp. 93-97Cohen, J.H., Tsai, E.C., Ginsberg, H.J., Godes, J., Pseudotumoral chagasic meningoencephalitis as the first manifestation of Acquired Immunodeficiency syndrome (1998) Surg Neurol, 49, pp. 324-327Iliovich, E., Lopez, R., Kum, M., Uzandizaga, G., Peritonitis espontanea chagasica en un enfermo de SIDA (1998) Medicina (Buenos Aires), 58, pp. 507-508Bisugo, M.C., Araújo, M.F.L., Nunes, E.V., Cunha, E.A., Oliveira Jr., O.C., Guilherme, C.S., Isolamento de Trypanosoma cruzi por xenocultura após aplicação de xenodiagnóstico in vivo e/ou in vitro em pacientes na fase crônica da doença de Chagas e na co-infecção pelo HIV (1998) Rev Inst Adolfo Lutz, 57, pp. 89-96Sartori, A.M.C., Shikanai-Yasuda, M.A., Amato Neto, V., Lopes, M.H., Follow-up of 18 patients with Human Immunodeficiency Vírus infection and chronic Chagas' disease, with reactivation of Chagas' disease causing cardiac disease in three patients (1998) Clin Infect Dis, 26, pp. 177-179Aguiar, J.I., Aguiar, E.S., Serologic testing for Chagas' disease and HIV in counseling programs and blood banks in midwest Brazil (1999) Braz J Infect Dis, 3, pp. 176-179Perez-Ramirez, L., Barnabé, C., Sartori, A.M.C., Ferreira, M.S., Tolezano, J.E., Nunes, E.V., Clinical analysis and parasite genetic diversity in Human Immunodeficiency Vírus/Chagas' disease coinfections in Brazil (1999) Am J Trop Med Hyg, 64, pp. 198-206Galhardo, M.C.G., Martins, I.A., Hasslocher-Moreno, A., Xavier, S.S., Coelho, J.M.C., Vasconcelos, A.C.V., Reativação da infecção por Trypanosoma cruzi em paciente com Síndrome de Imunodeficiência Adquirida (1999) Rev Soc Bras Med Trop, 32, pp. 291-294Pagano, M.A., Segura, M.J., di Lorenzo, G.A., Garau, M.L., Molina, H.A., Cahb, P., Cerebral tumor-like american trypanosomiasis in Acquired Immunodeficiency Syndrome (1999) Ann Neurol, 45, pp. 403-406Santos, S.S., Almeida, G.M.D., Monteiro, M.L.R., Gemignani, P., Duarte, M.I.S., Toscano, C.M., Ocular myositis and diffuse meningoencephalitis from Trypanosoma cruzi in an AIDS patient (1999) Trans R Soc Trop Med Hyg, 93, pp. 535-536Sartori, A.M.C., Sotto, M.N., Braz, L.M.A., Oliveira Jr., O.C., Patzina, R.A., Shikanai-Yassuda, M.A., Reactivation of Chagas' disease manifested by skin lesions in a patient with AIDS (1999) Trans R Soc Trop Med Hyg, 93, pp. 631-632Silva, N., O'Bryan, L., Medeiros, E., Holand, H., Suleiman, J., Mendonça, J.S., Trypanosoma cruzi meningoencephalitis in HIV-Infected patients (1999) Journal of Acquir Immune Defic Syndr & Hum Pathol, 20, pp. 342-349Morgado, M.G., Barcellos, C., Pina, M.F., Bastos, F.I., Human Immunodeficiency Vírus/Acquired Immunodeficiency Syndrome and tropical diseases: A Brazilian perspective (2000) Mem Inst Oswaldo Cruz, 95 (SUPPL. I), pp. 145-151Oeleman, W., Velásquez, J.N., Carnevale, S., Besasso, H., Teixeira, G.M., Peralta, J.M., Intestinal Chagas' disease in patients with AIDS (2000) AIDS, 14, pp. 1072-1073Corti, M., AIDS and Chagas' disease. Review (2000) AIDS patients care STDs, 14, pp. 581-588Corti, M., Trione, N., Corbera, K., Vivas, C., Enfermedad de Chagas: Otra causa de masa cerebral ocupante en pacientes com syndrome de immunodeficiencia adquirida (2000) Enfermedades Infecciosas y Microbiologia Clínica, 18, pp. 194-199Cahn, P., Belloso, W.H., Murillo, J., Prada-Trujillo, AIDS in Latin America (2000) Infec Dis Clin North Ame, 14, pp. 185-209Concetti, H., Retegui, M., Pérez, G., Pérez, H., Chagas' disease of the cervix uteri in a patient with Acquired Immunodeficiency Syndrome (2000) Hum Pathol, 31, pp. 120-122Jesus-Pedro, R., Doença de Chagas e Síndrome da Imunodeficiência Adquirida: Quantos estariam co-infectados no Brasil? (2001) JBA São Paulo, 2, pp. 5-6Antunes, A.C.M., Cecchini, F.M.L., von Bock Bolli, F., Oliveira, P.P., Rebouças, R.G., Monte, T.L., Cerebral trypanosomiasis and AIDS (2002) Arq Neuropsiquiat, 60, pp. 730-733Harms, G., Feldmeier, H., Review: HIV infection and tropical parasitic diseases-deleterious interactions in both directions? (2002) Tropical Medicine and International Health, 7, pp. 479-488Ferreira, M.S., Borges, A.S., Some aspects of protozoan infections in immunocompromised patients-A review (2002) Mem Inst Oswaldo Cruz, 97, pp. 443-457Sartori, A.M.C., Caiaffa-Filho, H.H., Bezerra, R.C., Gulherme, C.S., Lopes, M.H., Shikanai-Yassuda, M.A., Exacerbation of HIV viral load simultaneous with asymptomatic reactivation of chronic Chagas' disease (2002) Am J Trop Med Hyg, 67, pp. 521-523Sartori, A.M.C., Eluf Neto, J., Nunes, E.V., Braz, L.M.A., Caiaffa-Filho, H.H., Shikanai-Yassuda, M.A., Trypanosoma cruzi parasitemia in chronic Chagas' disease: Comparison between Human Immunodeficiency Virus (HIV)-Positive and HIV-Negative patients (2002) J Inf Dis, 186, pp. 872-875Lages-Silva, E., Ramirez, L.E., Silva-Vergera, M.L., Chiare, E., Chagasic meningoencephlitis in a patient with Acquired Immunodeficiency Syndrome: Diagnosis, follow-up and genetic characterization of Trypanosoma cruzi (2002) Clin Infect Dis, 34, pp. 118-123Santos, E.O., Canela, J.R., Monção, H.C.G., Roque, M.J.G., Reactivation of Chagas'disease leading to the diagnosis of Acquired Immunodeficiency Syndrome (2002) Braz J Infect Dis, 6, pp. 317-321Brito, C.M.M., Pires, M.Q., Pacheco, R.S., Chagas' disease and HIV co-infection: Genetic analyses of two Trypanosoma cruzi strains under experimental immunosuppression (2003) Kinetoplastid Biol Dis, 2, p. 107Corti, M., Enfermedad de Chagas y síndrome de immunodeficiencia adquirida (2003) Enf Emerg, 5, pp. 13-17Vaidian, A.K., Weiss, L.M., Tanowitz, H.B., Chagas' disease and AIDS-Review (2004) Kinetoplastid Biol Dis, 3, pp. 1-6Cruz, A.M., Igreja, R.P., Dantas, W., Junqueira, A.C.V., Pacheco, R.S., Silva-Gonçalves, A.J., Long-term follow-up of co-infected HIV and Trypanosoma cruzi brazilian patients (2004) Trans R Soc Trop Med Hyg, 98, pp. 728-733Yoo, T.W., Mlikotic, A., Cornford, M.E., Beck, C.K., Concurrent cerebral American Trypanosomiasis an Toxoplasmosis in a patient with AIDS (2004) Clin Infect Dis, 39, pp. 30-34Revera, J., Hillis, L.D., Levine, B.D., Reactivation of cardiac Chagas' disease in Acquired Immunedeficiency Syndrome (2004) Am J Cardiol, 94, pp. 1102-1103Madalosso, G., Pellini, A.C.G., Vasconcelos, M.J., Ribeiro, A.F., Weissmann, L., Oliveira Filho, G.S., Chagasic meningoencephalitis: Case report of a recently included AIDS-defining illness in Brazil (2004) Rev Inst Med Trop S Paulo, 46, pp. 199-202Parra-Piñeros, J.E., Valderrama, W., Leon-Sarmiento, F.E., Daza, N., Ramirez-Díaz, H., Leon-Sarmiento, M.E., False-positive Human Immunodeficiency Virus test and Trypanosoma cruzi infection in Eastern Colombia (2004) Southern Med J, 97, p. 423Rodrigues, D.B.R., Correia, D., Marra, M.D., Giraldo, L.E.R., Lages-Silva, E., Silva-Vergara, M.L., Cytokine serum levels in patients infected by Human Immunodeficiency Virus with and without Trypanosoma cruzi coinfection (2005) Rev Soc Bras Med Trop, 38, pp. 483-487Burgos, J.M., Begher, S.B., Freitas, J.M., Risio, M., Duffy, T., Altcheh, J., Molecular diagnosis and typing of Trypanosoma cruzi populations and lineages in cerebral Chagas' disease in a patient with AIDS (2005) Am J Trop Med Hyg, 73, pp. 1016-1018Valerga, M., Bases, O., Martin, M., Papucci, T., Encefalitis multifocal en un paciente com SIDA (2005) Enferm Infecc Microbiol Clin, 23, pp. 569-570Picco, G., Enfermedad de Chagas y SIDA, una coinfección a considerar (2005) Med Clin (Barc), 125, p. 678Auger, S.R., Storrino, R., Rosa, M., Caravello, O., González, M.J., Botaro, E., Chagas y SIDA, la importancia del diagnóstico precoz (2005) Rev Argent Cardiol, 73, pp. 439-445Corti, M., Yampolsky, C., Prolonged survival and immune reconstitution after chagasic meningoencephlaitis in a patient with Acquired Immunodeficiency Syndrome (2006) Rev Soc Bras Med Trop, 39, pp. 85-88Lambert, N., Metha, B., Walters, R., Eron, J., Chagasic encephalitis as the initial manifestation of AIDS (2006) Ann Int Med, 144, pp. 941-943Pereira, R.E., Pimentel, R.A., Canela, J.R., Santos, E.O., Meningoencefalite chagásica em portadores de HIV (2006) JBM, 90, pp. 18-21Scapellato, P.G., Boltaro, E.G., Scapellato, J.I., Vidal, G.I., Es posible la transmision de la enfermedad de Chagas mediante el hábito de compartir jeringas entre pacientes HIV+ adictos a drogas? (2006) Medicina (Buenos Aires), 66, pp. 595-596Sartori, A.M.C., Ibrahim, D.Y., Westphalen, E.V.N., Braz, L.M.A., Oliveira Jr., O.C., Gakiya, E., Manifestations of Chagas' disease (American trypanosomiasis) in patients with HIV/AIDS (2007) Ann Trop Med Parasitol, 101, pp. 31-50Karp, C.L., Auwaerter, P.G., Coinfection with HIV and tropical infectious diseases. I. Protozoal pathogens (2007) Clin Infect Dis, 45, pp. 1208-1213Dolcini, G.L., Solana, M.E., Andreani, G., Celentano, A.M., Parodi, L.M., Donato, A.M., Trypanosoma cruzi (Chagas' disease agent) replication in human placenta (2008) Retrovirology, 5, pp. 53-66Cordova, E., Boschi, A., Ambrosioni, J., Cudos, C., Corti, M., Reactivation of Chagas' disease with central nervous involvement in HIV-infected patients in Argentina, 1992-2007 (2008) Int J Infect Dis, 12, pp. 587-592Burgos, J.M., Begher, S., Silva, H.M.V., Bisio, T., Levin, M.J., Macedo, A.M., Case report: Molecular identification of Trypanosoma cruzi I tropism for central nervous system in Chagas reactivation due to AIDS (2008) Am J Trop Med Hyg, 78, pp. 294-297Sica, R.E.P., Gargiullo, G., Papayanis, C., Tumour-like chagasic encephalitis in AIDS patients: An atypical presentation in one of them and outcome in a small series of cases (2008) Arq Neuro-Psiquiatr, 66, pp. 881-884Verdú, J., de Paz, F., Castaño, V., Torrús, D., Reus, S., Reactivation of Chagas' disease with central nervous system involvement: Peripheral blood smear evidence (2009) Internal J Infect Dis, 13, pp. e527-e528Almeida, E.A., Silva, E.L., Guariento, M.E., Souza, M.L., Aoki, F.H., Pedro, R.J., Fatal evolution of Chagas' disease/Aids co-infection: Diagnostic difficulties between myocarditis reactivation and chronic chagasic myocardiopathy (2009) Rev Soc Bras Med Trop, 42, pp. 199-202Almeida, E.A., Silva, E.L., Guariento, M.E., Aoki, F.H., Pedro, R.J., Etiological treatment with itraconazole or ketoconazole in individuals with Trypanosoma cruzi/HIV co-infection (2009) Ann Trop Med Parasitol, 103, pp. 471-476López, O.M., Three-years survival of a patient with HIV and chagasic meningoencephalitis: Case report (2010) Rev Chil Infect, 27, pp. 160-164Warley, E., Antabak, N.T., Desse, J., de Luca, A., Warley, F., Galimbert, G.F., Desarrollo de neoplasias e infecciones definitorias de sida despues de iniciar la terapia antiretroviral de alta eficacia (2010) Medicina (Buenos Aires), 70, pp. 49-52Rodríguez-Guardado, A., Alvarez, V.A., Rodríguez-Perez, M., Alvarez, P.M., Flores-Chavez, M., Alonso-Gonzaléz, P., Screening for Chagas'disease in HIVpositive inmigrants from endemic areas (2010) Epidemiol Infect, 139, pp. 539-543Almeida, E.A., Lima, J.N., Lages-Silva, E., Guariento, M.E., Aoki, F.H., Torres-Morales, A.E., Chagas' disease and HIV co-infection in patients without effective antiretroviral therapy: Prevalence, clinical presentation and natural history (2010) Trans R Soc Trop Med Hyge, 104, pp. 447-452Fonseca, M.G.P., Bastos, F.I., Twenty-five years of the AIDS epidemic in Brazil: Principal epidemiological findings, 1980-2005 (2007) Cad Saúde Pública, 23 (SUPPL. III), pp. 333-344Gomes, A.P., Santos, S.S., Martins, W.A., Siqueira-Batista, R., Oliveira, L.B., Antonio, V.E., Aspectos clínicos (2007) Moléstia de Chagas, pp. 77-90. , In: Siqueira-Batista R, Gomes AP, Corrêa AD, Geller M, editors. 2 a Ed. Rio de Janeiro: Editora Rubio(2005) Rev Soc Bras Med Trop, 38 (SUPPL. III), pp. 1-29. , Consenso Brasileiro sobre doença de ChagasBurgarelli, M.K.N., Contribuição para o estudo clínico-laboratorial e imunológico da associação entre a doença de Chagas e a Síndrome da Imunodeficiência Adquirida (1996) Rev Pat Trop, 25, pp. 81-167Schenone, H., Xenodiagnosis (1999) Mem Inst Oswaldo Cruz, 94 (SUPPL. I), pp. 289-294Aids e Hepatites Virais [Internet], , http://www.aids.gov.br/, Departamento de DST, Brasília (BR): Ministério da Saúde[cited 2010 Aug 9]. Available fromhttp://new.paho.org/, Organização Pan-Americana de Saúde [Internet], World Health Organization. [cited 2010 Aug 9]. Available fromPortela-Lindoso, A.A.B., Shikanai-Yassuda, M.A., Doença de Chagas crônica: Do xenodiagnóstico e hemocultura à reação em cadeia da polimerase (2003) Rev Saude Publica, 37, pp. 107-115Rassi Jr., A., Rassi, A., Little, W.C., Chagas' heart disease (2000) Clin Cardiol, 23, pp. 883-88

Essential oil from Ageratum fastigiatum reduces expression of the pro-inflammatory cytokine tumor necrosis factor-alpha in peripheral blood leukocytes subjected to in vitro stimulation with phorbol myristate acetate

AbstractAgeratum fastigiatum (Gardner) R.M. King & H. Rob., a member of the Asteraceae family popularly known in Brazil as “matapasto”, is indicated in folk medicine as anti-inflammatory and analgesic. Despite its popular use, little is known about its potential effect on the parameters involved in an inflammatory response. The objective of this study was to characterize the chemical composition of the essential oil from A. fastigiatum and to evaluate the frequency of tumor necrosis factor alpha and interferon gamma producing cells in peripheral blood lymphocytes stimulated with phorbol myristate acetate in the presence of essential oil from A. fastigiatum. Non-toxic concentrations of essential oil from A. fastigiatum were evaluated in cultures of peripheral blood leucocytes using the trypan blue exclusion assay by flow cytometry. GC–MS analysis revealed that the prevalent compounds identified in the essential oil from A. fastigiatum sample were α-pinene, limonene, trans-caryophyllene, α-humulene, caryophyllene oxide, 1,2-humulene-epoxide, 1,6-humulanodien-3-ol, and α-cadinol. Results showed that exposure to essential oil from A. fastigiatum at concentrations of 0.5×10−2 and 1×10−2μl/ml caused no alterations in leukocyte viability as compared to the control group. Both concentrations lowered the percentage of tumor necrosis factor alpha (+)-lymphocytes and neutrophils. There were no changes in the percentage of lymphocytes positive for the interferon gamma cytokine. Our results suggest that part of the anti-inflammatory activity attributed to A. fastigiatum may be due to the effect of some of its components in decreasing the number of cells that produce the pro-inflammatory cytokine tumor necrosis factor alpha

Identificación del índice de vulnerabilidad territorial a partir de modelos jerárquicos y heurísticos aplicando SOA

Auxiliar de InvestigaciónEn el proyecto se realiza el diseño y desarrollo de 4 servicios web implementando los modelos de toma de decisión (AHP, AHP FUZZY, ELECTRE y PROMETHEE), encargados de procesar datos obtenidos en campo en la primera fase del proyecto que se realizó a través de encuestas, formatos de entrevistas, talleres y metodologías de análisis. Los datos se procesaran de acuerdo al modelo de toma de decisión seleccionado, generando como resultado final un indicador de vulnerabilidad territorial.PregradoIngeniero de Sistema

Scalable and accurate causality tracking for eventually consistent stores

Lecture Notes in Computer Science 8460, 2014In cloud computing environments, data storage systems often rely on optimistic replication to provide good performance and availability even in the presence of failures or network partitions. In this scenario, it is important to be able to accurately and efficiently identify updates executed concurrently. Current approaches to causality tracking in optimistic replication have problems with concurrent updates: they either (1) do not scale, as they require replicas to maintain information that grows linearly with the number of writes or unique clients; (2) lose information about causality, either by removing entries from client-id based version vectors or using server-id based version vectors, which cause false conflicts. We propose a new logical clock mechanism and a logical clock framework that together support a traditional key-value store API, while capturing causality in an accurate and scalable way, avoiding false conflicts. It maintains concise information per data replica, only linear on the number of replica servers, and allows data replicas to be compared and merged linear with the number of replica servers and versions.(undefined

Estudos sobre a nutrição mineral do arroz: XV. absorção radicular e foliar do radiofosforo pelas variedades IAC-47 e IAC-435

Foram estudados os efeitos do tempo e da concentração iônica externa na absorção do radiofósforo por raízes destacadas e por plantas inteiras de arroz das variedades IAC-47 (sequeiro) e IAC-435 (irrigado). No intervalo de 30 a 180 min. houve linearidade na absorção. O valor de km para as duas variedades foi o mesmo sendo, porém, menor quando se empregaram raízes destacadas. Não se encontrou diferença significativa na absorção foliar do fosfato monoamônico ou diamônico em ausência ou em presença de uréia.Root uptake either by excised roots or by intact young plants (3-4 week old) showed linearity in the period from 30 to 180 minutes of contact with the solution. Km values were the same for both varieties being, however, slightly lower in the case of excised roots. Foliar uptake was affect neither by source (monoammonium against diammonium phosphate) nor by the presence of urea in the same solution