2,053 research outputs found
Risk of cancer after assisted reproduction: a review of the available evidences and guidance to fertility counselors
Infertile women requiring ovarian stimulation and assisted reproduction techniques (ART) are faced with difficult issues. The fear that using hormones could increase their risk of cancer is the most significant. One of the main challenges for assessing cancer risk after ART is the difficulty to separate it from the underlying condition of infertility per se. The delay or the inability to achieve a pregnancy is an important risk factor for breast, endometrial and ovarian cancer. We analyzed the current literature on the topic
Freeze/thaw stress induces organelle remodeling and membrane recycling in cryopreserved human mature oocytes
Purpose: Our aim was to evaluate the ultrastructure of human metaphase II oocytes subjected to slow freezing and fixed after thawing at different intervals during post-thaw rehydration. Methods: Samples were studied by light and transmission electron microscopy. Results: We found that vacuolization was present in all cryopreserved oocytes, reaching a maximum in the intermediate stage of rehydration. Mitochondria-smooth endoplasmic reticulum (M-SER) aggregates decreased following thawing, particularly in the first and intermediate stages of rehydration, whereas mitochondria-vesicle (MV) complexes augmented in the same stages. At the end of rehydration, vacuoles and MV complexes both diminished and M-SER aggregates increased again. Cortical granules (CGs) were scarce in all cryopreserved oocytes, gradually diminishing as rehydration progressed. Conclusions: This study also shows that such a membrane remodeling is mainly represented by a dynamic process of transition between M-SER aggregates and MV complexes, both able of transforming into each other. Vacuoles and CG membranes may take part in the membrane recycling mechanism
Connecting Galaxy Evolution, Star Formation and the X-ray Background
As a result of deep hard X-ray observations by Chandra and XMM-Newton a
significant fraction of the cosmic X-ray background (CXRB) has been resolved
into individual sources. These objects are almost all active galactic nuclei
(AGN) and optical followup observations find that they are mostly obscured Type
2 AGN, have Seyfert-like X-ray luminosities (i.e., L_X ~ 10^{43-44} ergs
s^{-1}), and peak in redshift at z~0.7. Since this redshift is similar to the
peak in the cosmic star-formation rate, this paper proposes that the obscuring
material required for AGN unification is regulated by star-formation within the
host galaxy. We test this idea by computing CXRB synthesis models with a ratio
of Type 2/Type 1 AGN that is a function of both z and 2-10 keV X-ray
luminosity, L_X. The evolutionary models are constrained by parameterizing the
observed Type 1 AGN fractions from the recent work by Barger et al. The
parameterization which simultaneously best accounts for Barger's data, the CXRB
spectrum and the X-ray number counts has a local, low-L_X Type 2/Type 1 ratio
of 4, and predicts a Type 2 AGN fraction which evolves as (1+z)^{0.3}. Models
with no redshift evolution yielded much poorer fits to the Barger Type 1 AGN
fractions. This particular evolution predicts a Type 2/Type 1 ratio of 1-2 for
log L_X > 44, and thus the deep X-ray surveys are missing about half the
obscured AGN with these luminosities. These objects are likely to be Compton
thick. Overall, these calculations show that the current data strongly supports
a change to the AGN unification scenario where the obscuration is connected
with star formation in the host galaxy rather than a molecular torus alone. The
evolution of the obscuration implies a close relationship between star
formation and AGN fueling, most likely due to minor mergers or interactions.Comment: 36 pages, 8 figures, ApJ in press. Minor changes to match published
versio
ISO investigates the nature of extremely-red hard X-ray sources responsible for the X-ray background
We analyse very deep X-ray and mid-IR surveys in common areas of the Lockman
Hole and the HDF North to study the sources of the X-ray background (XRB) and
to test the standard obscured accretion paradigm. We detect with ISO a rich
population of X-ray luminous sources with red optical colours, including a
fraction identified with Extremely Red Objects (R-K > 5) and galaxies with SEDs
typical of normal massive ellipticals or spirals at z ~ 1. The high 0.5-10 keV
X-ray luminosities of these objects (1E43-1E45 erg/s) indicate that the
ultimate energy source is gravitational accretion, while the X-ray to IR flux
ratios and the X-ray spectral hardness show evidence of photoelectric
absorption at low X-ray energies. An important hint on the physics comes from
the mid-IR data at 6.7 and 15 um, well reproduced by model spectra of
completely obscured quasars under standard assumptions and l.o.s. optical
depths tau ~ 30-40. Other predictions of the standard XRB picture, like the
distributions of intrinsic bolometric luminosities and the relative fractions
of type-I and -II objects (1:3), are also consistent with our results. Obscured
gravitational accretion is then confirmed as being responsible for the bulk of
the X-ray background, since we detect in the IR the down-graded energy
photoelectrically absorbed in X-rays: 63% of the faint 5-10 keV XMM sources are
detected in the mid-IR by Fadda et al. (2001). However, although as much as 90%
of the X-ray energy production could be converted to IR photons, no more than
20% of the Cosmic IR Background can be attributed to X-ray loud AGNs.Comment: 7 pages, 5 postscript figures, ApJ submitte
The First INTEGRAL AGN Catalog
We present the first INTEGRAL AGN catalog, based on observations performed
from launch of the mission in October 2002 until January 2004. The catalog
includes 42 AGN, of which 10 are Seyfert 1, 17 are Seyfert 2, and 9 are
intermediate Seyfert 1.5. The fraction of blazars is rather small with 5
detected objects, and only one galaxy cluster and no star-burst galaxies have
been detected so far. A complete subset consists of 32 AGN with a significance
limit of 7 sigma in the INTEGRAL/ISGRI 20-40 keV data. Although the sample is
not flux limited, the distribution of sources shows a ratio of obscured to
unobscured AGN of 1.5 - 2.0, consistent with luminosity dependent unified
models for AGN. Only four Compton-thick AGN are found in the sample. Based on
the INTEGRAL data presented here, the Seyfert 2 spectra are slightly harder
(Gamma = 1.95 +- 0.01) than Seyfert 1.5 (Gamma = 2.10 +- 0.02) and Seyfert 1
(Gamma = 2.11 +- 0.05).Comment: 17 pages, 12 figures, accepted for publication in Ap
Rubbing effects on the structural and optical properties of poly(3Âhexylthiophene) films
International audienc
Reachability problems for PAMs
Piecewise affine maps (PAMs) are frequently used as a reference model to show
the openness of the reachability questions in other systems. The reachability
problem for one-dimentional PAM is still open even if we define it with only
two intervals. As the main contribution of this paper we introduce new
techniques for solving reachability problems based on p-adic norms and weights
as well as showing decidability for two classes of maps. Then we show the
connections between topological properties for PAM's orbits, reachability
problems and representation of numbers in a rational base system. Finally we
show a particular instance where the uniform distribution of the original orbit
may not remain uniform or even dense after making regular shifts and taking a
fractional part in that sequence.Comment: 16 page
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