539 research outputs found
Suzaku Confirms NGC~3660 is an Unabsorbed Seyfert 2
An enigmatic group of objects, unabsorbed Seyfert 2s may have intrinsically
weak broad line regions, obscuration in the line of sight to the BLR but not to
the X-ray corona, or so much obscuration that the X-ray continuum is completely
suppressed and the observed spectrum is actually scattered into the line of
sight from nearby material. NGC 3660 has been shown to have weak broad
optical/near infrared lines, no obscuration in the soft X-ray band, and no
indication of "changing look" behavior. The only previous hard X-ray detection
of this source by Beppo-SAX seemed to indicate that the source might harbor a
heavily obscured nucleus. However, our analysis of a long-look Suzaku
observation of this source shows that this is not the case, and that this
source has a typical power law X-ray continuum with normal reflection and no
obscuration. We conclude that NGC 3660 is confirmed to have no unidentified
obscuration and that the anomolously high Beppo-SAX measurement must be due to
source confusion or similar, being inconsistent with our Suzaku measurements as
well as non-detections from Swift-BAT and RXTE.Comment: Accepted to PAS
Inferring Compton-thick AGN candidates at z>2 with Chandra using the >8 keV restframe spectral curvature
To fully understand cosmic black hole growth we need to constrain the
population of heavily obscured active galactic nuclei (AGN) at the peak of
cosmic black hole growth (1-3). Sources with obscuring column densities
higher than atoms , called Compton-thick
(CT) AGN, can be identified by excess X-ray emission at 20-30 keV, called
the "Compton hump". We apply the recently developed Spectral Curvature (SC)
method to high-redshift AGN (2<z<5) detected with Chandra. This method
parametrizes the characteristic "Compton hump" feature cosmologically
redshifted into the X-ray band at observed energies <10 keV. We find good
agreement in CT AGN found using the SC method and bright sources fit using
their full spectrum with X-ray spectroscopy. In the Chandra deep field south,
we measure a CT fraction of (3/17) for sources with
observed luminosity erg . In the
Cosmological evolution survey (COSMOS), we find an observed CT fraction of
(40/272) or when corrected for
the survey sensitivity. When comparing to low redshift AGN with similar X-ray
luminosities, our results imply the CT AGN fraction is consistent with having
no redshift evolution. Finally, we provide SC equations that can be used to
find high-redshift CT AGN (z>1) for current (XMM-Newton) and future (eROSITA
and ATHENA) X-ray missions.Comment: 10 pages, 8 figure
Broadband Observations of the Compton-thick Nucleus of NGC 3393
We present new NuSTAR and Chandra observations of NGC 3393, a galaxy reported
to host the smallest separation dual AGN resolved in the X-rays. While past
results suggested a 150 pc separation dual AGN, three times deeper Chandra
imaging, combined with adaptive optics and radio imaging suggest a single,
heavily obscured, radio-bright AGN. Using VLA and VLBA data, we find an AGN
with a two-sided jet rather than a dual AGN and that the hard X-ray, UV,
optical, NIR, and radio emission are all from a single point source with a
radius <0.2". We find that the previously reported dual AGN is most likely a
spurious detection resulting from the low number of X-ray counts (<160) at 6-7
keV and Gaussian smoothing of the data on scales much smaller than the PSF
(0.25" vs. 0.80" FWHM). We show that statistical noise in a single Chandra PSF
generates spurious dual peaks of the same separation (0.550.07" vs. 0.6")
and flux ratio (399% vs. 32% of counts) as the purported dual AGN. With
NuSTAR, we measure a Compton-thick source (NH=
cm) with a large torus half-opening angle, {\theta}=79 which we
postulate results from feedback from strong radio jets. This AGN shows a 2-10
keV intrinsic to observed flux ratio of 150. Using simulations, we find that
even the deepest Chandra observations would severely underestimate the
intrinsic luminosity of NGC 3393 above z>0.2, but would detect an unobscured
AGN of this luminosity out to high redshift (z=5).Comment: Accepted for publication in ApJ. 15 Figures and 4 table
The nature of the torus in the heavily obscured AGN Markarian 3: an X-ray study
In this paper we report the results of an X-ray monitoring campaign on the
heavily obscured Seyfert galaxy Markarian 3 carried out between the fall of
2014 and the spring of 2015 with NuSTAR, Suzaku and XMM-Newton. The hard X-ray
spectrum of Markarian 3 is variable on all the time scales probed by our
campaign, down to a few days. The observed continuum variability is due to an
intrinsically variable primary continuum seen in transmission through a large,
but still Compton-thin column density (N_H~0.8-1.110 cm).
If arranged in a spherical-toroidal geometry, the Compton scattering matter has
an opening angle ~66 degrees and is seen at a grazing angle through its upper
rim (inclination angle ~70 degrees). We report a possible occultation event
during the 2014 campaign. If the torus is constituted by a system of clouds
sharing the same column density, this event allows us to constrain their number
(175) and individual column density, [~(4.91.5)10
cm]. The comparison of IR and X-ray spectroscopic results with
state-of-the art "torus" models suggests that at least two thirds of the X-ray
obscuring gas volume might be located within the dust sublimation radius. We
report also the discovery of an ionized absorber, characterised by variable
resonant absorption lines due to He- and H-like iron. This discovery lends
support to the idea that moderate column density absorbers could be due to
clouds evaporated at the outer surface of the torus, possibly accelerated by
the radiation pressure due to the central AGN emission leaking through the
patchy absorber.Comment: Accepted for publication in MNRAS, 17 pages, 11 figures, 5 table
The multi-layer variable absorbers in NGC 1365 revealed by XMM-Newton and <i>NuSTAR</i>
Between 2012 July and 2013 February, NuSTAR and XMM-Newton performed four long-look joint observations of the type 1.8 Seyfert, NGC 1365. We have analyzed the variable absorption seen in these observations in order to characterize the geometry of the absorbing material. Two of the observations caught NGC 1365 in an unusually low absorption state, revealing complexity in the multi-layer absorber that had previously been hidden. We find the need for three distinct zones of neutral absorption in addition to the two zones of ionized absorption and the Compton-thick torus previously seen in this source. The most prominent absorber is likely associated with broad-line region clouds with column densities of around approximately 10 (sup 23) per square centimeter and a highly clumpy nature as evidenced by an occultation event in 2013 February. We also find evidence of a patchy absorber with a variable column around approximately 10 (sup 22) per square centimeter and a line-of-sight covering fraction of 0.3-0.9, which responds directly to the intrinsic source flux, possibly due to a wind geometry. A full-covering, constant absorber with a low column density of approximately 1 by 10 (sup 22) per square centimeter is also present, though the location of this low density haze is unknown
The 2-79 keV X-ray Spectrum of the Circinus Galaxy with NuSTAR, XMM-Newton and Chandra: a Fully Compton-Thick AGN
The Circinus galaxy is one of the nearest obscured AGN, making it an ideal
target for detailed study. Combining archival Chandra and XMM-Newton data with
new NuSTAR observations, we model the 2-79 keV spectrum to constrain the
primary AGN continuum and to derive physical parameters for the obscuring
material. Chandra's high angular resolution allows a separation of nuclear and
off-nuclear galactic emission. In the off-nuclear diffuse emission we find
signatures of strong cold reflection, including high equivalent-width neutral
Fe lines. This Compton-scattered off-nuclear emission amounts to 18% of the
nuclear flux in the Fe line region, but becomes comparable to the nuclear
emission above 30 keV. The new analysis no longer supports a prominent
transmitted AGN component in the observed band. We find that the nuclear
spectrum is consistent with Compton-scattering by an optically-thick torus,
where the intrinsic spectrum is a powerlaw of photon index ,
the torus has an equatorial column density of cm and the intrinsic AGN keV luminosity is
erg/s. These values place Circinus along the same
relations as unobscured AGN in accretion rate-vs- and -vs-
phase space. NuSTAR's high sensitivity and low background allow us to study the
short time-scale variability of Circinus at X-ray energies above 10 keV for the
first time. The lack of detected variability favors a Compton-thick absorber,
in line with the the spectral fitting results.Comment: Accepted for publication in Ap
The Chandra COSMOS Legacy Survey: Compton thick AGN at high redshift
The existence of a large population of Compton thick (CT; N-H > 10(24)
cm(-2) ) active galactic nuclei (AGN) is a key ingredient of most cosmic
X-ray background synthesis models. However, direct identification of
these sources, especially at high redshift, is difficult due to flux
suppression and complex spectral shape produced by CT obscuration. We
explored the Chandra Cosmological Evolution Survey (COSMOS) Legacy point
source catalogue, comprising 1855 sources to select, via X-ray
spectroscopy, a large sample of CT candidates at high redshift. Adopting
a physical model to reproduce the toroidal absorber and a Monte-Carlo
sampling method, we selected 67 individual sources with >5 per cent
probability of being CT, in the redshift range 0.04 less than or similar
to z less than or similar to 3.5. The sum of the probabilities above N-H
> 10(24) cm(-2) gives a total of 41.9 effective CT, corrected for
classification bias. We derive number counts in the 2-10 keV band in
three redshift bins. The observed log N-log S is consistent with an
increase of the intrinsic CT fraction (f(CT)) from similar to 0.30 to
similar to 0.55 from low to high redshift. When resealed to a common
luminosity (log(L-X/ erg s(-1)) = 44.5), we find an increase from f(CT)
= 0.191(-0.06)(+0.07) to 0.30(-0.08)(+0.10) and f(CT )=
0.49(-0.11)(+0.12) from low to high z. This evolution can be
parametrized as f(CT) = 0.11(-0.04)(+0.05)(1 + z)(1.11 +/- 0.13). T
hanks to Hubble Space Mlescope-Advanced Camera for Surveys deep imaging,
we find that the fraction of CT AGN in mergers/interacting systems
increases with luminosity and redshift and is significantly higher than
for non-CT AGN hosts
The Chandra COSMOS Legacy Survey: Compton Thick AGN at high redshift
The existence of a large population of Compton thick (CT, ) AGN is a key ingredient of most Cosmic X-ray background synthesis
models. However, direct identification of these sources, especially at high
redshift, is difficult due to the flux suppression and complex spectral shape
produced by CT obscuration. We explored the Chandra COSMOS Legacy point source
catalog, comprising 1855 sources, to select via X-ray spectroscopy, a large
sample of CT candidates at high redshift. Adopting a physical model to
reproduce the toroidal absorber, and a Monte-Carlo sampling method, we selected
67 individual sources with >5% probability of being CT, in the redshift range
, gives
a total of 41.9 effective CT, corrected for classification bias. We derive
number counts in the 2-10 keV band in three redshift bins. The observed
logN-logS is consistent with an increase of the intrinsic CT fraction
() from to from low to high redshift. When
rescaled to a common luminosity (log(L/erg/s)) we find an
increase from to
and from low to high z. This evolution can be
parametrized as . Thanks to
HST-ACS deep imaging, we find that the fraction of CT AGN in
mergers/interacting systems increases with luminosity and redshift and is
significantly higher than for non-CT AGN hosts.Comment: 15 pages, 13 figures. Published in MNRAS 31 July 201
Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from the plasma membrane to the nucleus. Deregulation of the EGFR/ERK pathway due to alterations affecting the expression or function of a number of pathway components has long been associated with numerous forms of cancer. Under normal conditions, Epidermal Growth Factor (EGF) stimulates a rapid but transient activation of ERK as the signal is rapidly shutdown. Whereas, under cancerous mutation conditions the ERK signal cannot be shutdown and is sustained resulting in the constitutive activation of ERK and continual cell proliferation. In this study, we have used computational modelling techniques to investigate what effects various cancerous alterations have on the signalling flow through the ERK pathway. RESULTS: We have generated a new model of the EGFR activated ERK pathway, which was verified by our own experimental data. We then altered our model to represent various cancerous situations such as Ras, B-Raf and EGFR mutations, as well as EGFR overexpression. Analysis of the models showed that different cancerous situations resulted in different signalling patterns through the ERK pathway, especially when compared to the normal EGF signal pattern. Our model predicts that cancerous EGFR mutation and overexpression signals almost exclusively via the Rap1 pathway, predicting that this pathway is the best target for drugs. Furthermore, our model also highlights the importance of receptor degradation in normal and cancerous EGFR signalling, and suggests that receptor degradation is a key difference between the signalling from the EGF and Nerve Growth Factor (NGF) receptors. CONCLUSION: Our results suggest that different routes to ERK activation are being utilised in different cancerous situations which therefore has interesting implications for drug selection strategies. We also conducted a comparison of the critical differences between signalling from different growth factor receptors (namely EGFR, mutated EGFR, NGF, and Insulin) with our results suggesting the difference between the systems are large scale and can be attributed to the presence/absence of entire pathways rather than subtle difference in individual rate constants between the systems.This work was funded by the Department of Trade and Industry (DTI), under their Bioscience Beacon project programme. AG was funded by an industrial PhD studentship from Scottish Enterprise and Cyclacel
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