Suzaku Confirms NGC~3660 is an Unabsorbed Seyfert 2

An enigmatic group of objects, unabsorbed Seyfert 2s may have intrinsically weak broad line regions, obscuration in the line of sight to the BLR but not to the X-ray corona, or so much obscuration that the X-ray continuum is completely suppressed and the observed spectrum is actually scattered into the line of sight from nearby material. NGC 3660 has been shown to have weak broad optical/near infrared lines, no obscuration in the soft X-ray band, and no indication of "changing look" behavior. The only previous hard X-ray detection of this source by Beppo-SAX seemed to indicate that the source might harbor a heavily obscured nucleus. However, our analysis of a long-look Suzaku observation of this source shows that this is not the case, and that this source has a typical power law X-ray continuum with normal reflection and no obscuration. We conclude that NGC 3660 is confirmed to have no unidentified obscuration and that the anomolously high Beppo-SAX measurement must be due to source confusion or similar, being inconsistent with our Suzaku measurements as well as non-detections from Swift-BAT and RXTE.Comment: Accepted to PAS

Inferring Compton-thick AGN candidates at z>2 with Chandra using the >8 keV restframe spectral curvature

To fully understand cosmic black hole growth we need to constrain the population of heavily obscured active galactic nuclei (AGN) at the peak of cosmic black hole growth ($z\sim$1-3). Sources with obscuring column densities higher than $\mathrm{10^{24}}$ atoms $\mathrm{cm^{-2}}$, called Compton-thick (CT) AGN, can be identified by excess X-ray emission at $\sim$20-30 keV, called the "Compton hump". We apply the recently developed Spectral Curvature (SC) method to high-redshift AGN (2<z<5) detected with Chandra. This method parametrizes the characteristic "Compton hump" feature cosmologically redshifted into the X-ray band at observed energies <10 keV. We find good agreement in CT AGN found using the SC method and bright sources fit using their full spectrum with X-ray spectroscopy. In the Chandra deep field south, we measure a CT fraction of $\mathrm{17^{+19}_{-11}\%}$ (3/17) for sources with observed luminosity $\mathrm{>5\times 10^{43}}$ erg $\mathrm{s^{-1}}$. In the Cosmological evolution survey (COSMOS), we find an observed CT fraction of $\mathrm{15^{+4}_{-3}\%}$ (40/272) or $\mathrm{32\pm11 \%}$ when corrected for the survey sensitivity. When comparing to low redshift AGN with similar X-ray luminosities, our results imply the CT AGN fraction is consistent with having no redshift evolution. Finally, we provide SC equations that can be used to find high-redshift CT AGN (z>1) for current (XMM-Newton) and future (eROSITA and ATHENA) X-ray missions.Comment: 10 pages, 8 figure

Broadband Observations of the Compton-thick Nucleus of NGC 3393

We present new NuSTAR and Chandra observations of NGC 3393, a galaxy reported to host the smallest separation dual AGN resolved in the X-rays. While past results suggested a 150 pc separation dual AGN, three times deeper Chandra imaging, combined with adaptive optics and radio imaging suggest a single, heavily obscured, radio-bright AGN. Using VLA and VLBA data, we find an AGN with a two-sided jet rather than a dual AGN and that the hard X-ray, UV, optical, NIR, and radio emission are all from a single point source with a radius <0.2". We find that the previously reported dual AGN is most likely a spurious detection resulting from the low number of X-ray counts (<160) at 6-7 keV and Gaussian smoothing of the data on scales much smaller than the PSF (0.25" vs. 0.80" FWHM). We show that statistical noise in a single Chandra PSF generates spurious dual peaks of the same separation (0.55$\pm$0.07" vs. 0.6") and flux ratio (39$\pm$9% vs. 32% of counts) as the purported dual AGN. With NuSTAR, we measure a Compton-thick source (NH=$2.2\pm0.4\times10^{24}$ cm$^{-2}$) with a large torus half-opening angle, {\theta}=79 which we postulate results from feedback from strong radio jets. This AGN shows a 2-10 keV intrinsic to observed flux ratio of 150. Using simulations, we find that even the deepest Chandra observations would severely underestimate the intrinsic luminosity of NGC 3393 above z>0.2, but would detect an unobscured AGN of this luminosity out to high redshift (z=5).Comment: Accepted for publication in ApJ. 15 Figures and 4 table

The nature of the torus in the heavily obscured AGN Markarian 3: an X-ray study

In this paper we report the results of an X-ray monitoring campaign on the heavily obscured Seyfert galaxy Markarian 3 carried out between the fall of 2014 and the spring of 2015 with NuSTAR, Suzaku and XMM-Newton. The hard X-ray spectrum of Markarian 3 is variable on all the time scales probed by our campaign, down to a few days. The observed continuum variability is due to an intrinsically variable primary continuum seen in transmission through a large, but still Compton-thin column density (N_H~0.8-1.1$\times$10$^{24}$ cm$^{-2}$). If arranged in a spherical-toroidal geometry, the Compton scattering matter has an opening angle ~66 degrees and is seen at a grazing angle through its upper rim (inclination angle ~70 degrees). We report a possible occultation event during the 2014 campaign. If the torus is constituted by a system of clouds sharing the same column density, this event allows us to constrain their number (17$\pm$5) and individual column density, [~(4.9$\pm$1.5)$\times$10$^{22}$ cm$^{-2}$]. The comparison of IR and X-ray spectroscopic results with state-of-the art "torus" models suggests that at least two thirds of the X-ray obscuring gas volume might be located within the dust sublimation radius. We report also the discovery of an ionized absorber, characterised by variable resonant absorption lines due to He- and H-like iron. This discovery lends support to the idea that moderate column density absorbers could be due to clouds evaporated at the outer surface of the torus, possibly accelerated by the radiation pressure due to the central AGN emission leaking through the patchy absorber.Comment: Accepted for publication in MNRAS, 17 pages, 11 figures, 5 table

The multi-layer variable absorbers in NGC 1365 revealed by XMM-Newton and <i>NuSTAR</i>

Between 2012 July and 2013 February, NuSTAR and XMM-Newton performed four long-look joint observations of the type 1.8 Seyfert, NGC 1365. We have analyzed the variable absorption seen in these observations in order to characterize the geometry of the absorbing material. Two of the observations caught NGC 1365 in an unusually low absorption state, revealing complexity in the multi-layer absorber that had previously been hidden. We find the need for three distinct zones of neutral absorption in addition to the two zones of ionized absorption and the Compton-thick torus previously seen in this source. The most prominent absorber is likely associated with broad-line region clouds with column densities of around approximately 10 (sup 23) per square centimeter and a highly clumpy nature as evidenced by an occultation event in 2013 February. We also find evidence of a patchy absorber with a variable column around approximately 10 (sup 22) per square centimeter and a line-of-sight covering fraction of 0.3-0.9, which responds directly to the intrinsic source flux, possibly due to a wind geometry. A full-covering, constant absorber with a low column density of approximately 1 by 10 (sup 22) per square centimeter is also present, though the location of this low density haze is unknown

The 2-79 keV X-ray Spectrum of the Circinus Galaxy with NuSTAR, XMM-Newton and Chandra: a Fully Compton-Thick AGN

The Circinus galaxy is one of the nearest obscured AGN, making it an ideal target for detailed study. Combining archival Chandra and XMM-Newton data with new NuSTAR observations, we model the 2-79 keV spectrum to constrain the primary AGN continuum and to derive physical parameters for the obscuring material. Chandra's high angular resolution allows a separation of nuclear and off-nuclear galactic emission. In the off-nuclear diffuse emission we find signatures of strong cold reflection, including high equivalent-width neutral Fe lines. This Compton-scattered off-nuclear emission amounts to 18% of the nuclear flux in the Fe line region, but becomes comparable to the nuclear emission above 30 keV. The new analysis no longer supports a prominent transmitted AGN component in the observed band. We find that the nuclear spectrum is consistent with Compton-scattering by an optically-thick torus, where the intrinsic spectrum is a powerlaw of photon index $\Gamma = 2.2-2.4$, the torus has an equatorial column density of $N_{\rm H} = (6-10)\times10^{24}$cm$^{-2}$ and the intrinsic AGN $2-10$ keV luminosity is $(2.3-5.1)\times 10^{42}$ erg/s. These values place Circinus along the same relations as unobscured AGN in accretion rate-vs-$\Gamma$ and $L_X$-vs-$L_{IR}$ phase space. NuSTAR's high sensitivity and low background allow us to study the short time-scale variability of Circinus at X-ray energies above 10 keV for the first time. The lack of detected variability favors a Compton-thick absorber, in line with the the spectral fitting results.Comment: Accepted for publication in Ap

The Chandra COSMOS Legacy Survey: Compton thick AGN at high redshift

The existence of a large population of Compton thick (CT; N-H &gt; 10(24) cm(-2) ) active galactic nuclei (AGN) is a key ingredient of most cosmic X-ray background synthesis models. However, direct identification of these sources, especially at high redshift, is difficult due to flux suppression and complex spectral shape produced by CT obscuration. We explored the Chandra Cosmological Evolution Survey (COSMOS) Legacy point source catalogue, comprising 1855 sources to select, via X-ray spectroscopy, a large sample of CT candidates at high redshift. Adopting a physical model to reproduce the toroidal absorber and a Monte-Carlo sampling method, we selected 67 individual sources with &gt;5 per cent probability of being CT, in the redshift range 0.04 less than or similar to z less than or similar to 3.5. The sum of the probabilities above N-H &gt; 10(24) cm(-2) gives a total of 41.9 effective CT, corrected for classification bias. We derive number counts in the 2-10 keV band in three redshift bins. The observed log N-log S is consistent with an increase of the intrinsic CT fraction (f(CT)) from similar to 0.30 to similar to 0.55 from low to high redshift. When resealed to a common luminosity (log(L-X/ erg s(-1)) = 44.5), we find an increase from f(CT) = 0.191(-0.06)(+0.07) to 0.30(-0.08)(+0.10) and f(CT )= 0.49(-0.11)(+0.12) from low to high z. This evolution can be parametrized as f(CT) = 0.11(-0.04)(+0.05)(1 + z)(1.11 +/- 0.13). T hanks to Hubble Space Mlescope-Advanced Camera for Surveys deep imaging, we find that the fraction of CT AGN in mergers/interacting systems increases with luminosity and redshift and is significantly higher than for non-CT AGN hosts

The Chandra COSMOS Legacy Survey: Compton Thick AGN at high redshift

The existence of a large population of Compton thick (CT, $N_{H}>10^{24} cm^{-2}$) AGN is a key ingredient of most Cosmic X-ray background synthesis models. However, direct identification of these sources, especially at high redshift, is difficult due to the flux suppression and complex spectral shape produced by CT obscuration. We explored the Chandra COSMOS Legacy point source catalog, comprising 1855 sources, to select via X-ray spectroscopy, a large sample of CT candidates at high redshift. Adopting a physical model to reproduce the toroidal absorber, and a Monte-Carlo sampling method, we selected 67 individual sources with >5% probability of being CT, in the redshift range $0.0410^{24} cm^{-2}$, gives a total of 41.9 effective CT, corrected for classification bias. We derive number counts in the 2-10 keV band in three redshift bins. The observed logN-logS is consistent with an increase of the intrinsic CT fraction ($f_{CT}$) from $\sim0.30$ to $\sim0.55$ from low to high redshift. When rescaled to a common luminosity (log(L$_{\rm X}$/erg/s)$=44.5$) we find an increase from $f_{CT}=0.19_{-0.06}^{+0.07}$ to $f_{CT}=0.30_{-0.08}^{+0.10}$ and $f_{CT}=0.49_{-0.11}^{+0.12}$ from low to high z. This evolution can be parametrized as $f_{CT}=0.11_{-0.04}^{+0.05}(1+z)^{1.11\pm0.13}$. Thanks to HST-ACS deep imaging, we find that the fraction of CT AGN in mergers/interacting systems increases with luminosity and redshift and is significantly higher than for non-CT AGN hosts.Comment: 15 pages, 13 figures. Published in MNRAS 31 July 201

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway

This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell signalling pathway that relays the signal for a cell to proliferate from the plasma membrane to the nucleus. Deregulation of the EGFR/ERK pathway due to alterations affecting the expression or function of a number of pathway components has long been associated with numerous forms of cancer. Under normal conditions, Epidermal Growth Factor (EGF) stimulates a rapid but transient activation of ERK as the signal is rapidly shutdown. Whereas, under cancerous mutation conditions the ERK signal cannot be shutdown and is sustained resulting in the constitutive activation of ERK and continual cell proliferation. In this study, we have used computational modelling techniques to investigate what effects various cancerous alterations have on the signalling flow through the ERK pathway. RESULTS: We have generated a new model of the EGFR activated ERK pathway, which was verified by our own experimental data. We then altered our model to represent various cancerous situations such as Ras, B-Raf and EGFR mutations, as well as EGFR overexpression. Analysis of the models showed that different cancerous situations resulted in different signalling patterns through the ERK pathway, especially when compared to the normal EGF signal pattern. Our model predicts that cancerous EGFR mutation and overexpression signals almost exclusively via the Rap1 pathway, predicting that this pathway is the best target for drugs. Furthermore, our model also highlights the importance of receptor degradation in normal and cancerous EGFR signalling, and suggests that receptor degradation is a key difference between the signalling from the EGF and Nerve Growth Factor (NGF) receptors. CONCLUSION: Our results suggest that different routes to ERK activation are being utilised in different cancerous situations which therefore has interesting implications for drug selection strategies. We also conducted a comparison of the critical differences between signalling from different growth factor receptors (namely EGFR, mutated EGFR, NGF, and Insulin) with our results suggesting the difference between the systems are large scale and can be attributed to the presence/absence of entire pathways rather than subtle difference in individual rate constants between the systems.This work was funded by the Department of Trade and Industry (DTI), under their Bioscience Beacon project programme. AG was funded by an industrial PhD studentship from Scottish Enterprise and Cyclacel