69 research outputs found
ОСНОВНЫЕ ПРИОРИТЕТЫ РАЗВИТИЯ МЕЖРЕГИОНАЛЬНЫХ И МЕЖГОСУДАРСТВЕННЫХ ПРОДОВОЛЬСТВЕННЫХ СВЯЗЕЙ РЕГИОНОВ СИБИРИ
Methodical positions for priority development of interregional and interstate food relations are justified. They include estimation of the current state and layout of AIC industries; definition of efficiency of existing interregional and interstate food relations and their influence upon functioning of agrofood market; justification for the system of measures to improve the formed food relations subject to Russia’s membership in WTO. Stemming from the methodical positions, Siberia’s regions are determined which have the opportunity to export grain and livestock output beyond their territories. It is established that the level of interdependence of Siberia’s regions on goods exchange operations is quite high. It is revealed that at the present time there is no strategy of development of foreign-economic relations of Siberia’s regions to frontier countries. Insufficiently developed is the regulatory-legal base of interstate cooperation, there are no special programs for the development of regional export potential, personnel training and infrastructure development. The study resulted in perspective directions suggested for the development of foreign-economic activity in Siberia.Обоснованы методические положения по приоритетному развитию межрегиональных и межгосударственных продовольственных связей. Они включают в себя оценку современного состояния и размещения отраслей АПК; определение эффективности сложившихся межрегиональных и межгосударственных продовольственных связей и их влияния на функционирование агропродовольственного рынка; обоснование системы мер по улучшению сложившихся продовольственных связей с учетом членства России в ВТО. Исходя из методических положений определены регионы Сибири, имеющие возможность вывозить зерно и продукты животноводства за пределы своих территорий. Установлено, что уровень взаимозависимости регионов Сибири от товарообменных операций весьма высок. Выявлено, что в настоящее время отсутствует стратегия развития внешнеэкономических связей регионов Сибири с приграничными странами. Недостаточно развита нормативно-правовая база межгосударственного сотрудничества, отсутствуют специальные программы по развитию экспортного потенциала регионов, по подготовке кадров, по развитию инфраструктуры. В результате исследования предложены перспективные направления развития внешнеэкономической деятельности Сибири
Existence of an optimal size of a delaminated rigid inclusion embedded in the Kirchhoff-Love plate
Involvement of Noradrenergic Neurotransmission in the Stress- but not Cocaine-Induced Reinstatement of Extinguished Cocaine-Induced Conditioned Place Preference in Mice: Role for β-2 Adrenergic Receptors
The responsiveness of central noradrenergic systems to stressors and cocaine poses norepinephrine as a potential common mechanism through which drug re-exposure and stressful stimuli promote relapse. This study investigated the role of noradrenergic systems in the reinstatement of extinguished cocaine-induced conditioned place preference by cocaine and stress in male C57BL/6 mice. Cocaine- (15 mg/kg, i.p.) induced conditioned place preference was extinguished by repeated exposure to the apparatus in the absence of drug and reestablished by a cocaine challenge (15 mg/kg), exposure to a stressor (6-min forced swim (FS); 20–25°C water), or administration of the α-2 adrenergic receptor (AR) antagonists yohimbine (2 mg/kg, i.p.) or BRL44408 (5, 10 mg/kg, i.p.). To investigate the role of ARs, mice were administered the nonselective β-AR antagonist, propranolol (5, 10 mg/kg, i.p.), the α-1 AR antagonist, prazosin (1, 2 mg/kg, i.p.), or the α-2 AR agonist, clonidine (0.03, 0.3 mg/kg, i.p.) before reinstatement testing. Clonidine, prazosin, and propranolol failed to block cocaine-induced reinstatement. The low (0.03 mg/kg) but not high (0.3 mg/kg) clonidine dose fully blocked FS-induced reinstatement but not reinstatement by yohimbine. Propranolol, but not prazosin, blocked reinstatement by both yohimbine and FS, suggesting the involvement of β-ARs. The β-2 AR antagonist ICI-118551 (1 mg/kg, i.p.), but not the β-1 AR antagonist betaxolol (10 mg/kg, i.p.), also blocked FS-induced reinstatement. These findings suggest that stress-induced reinstatement requires noradrenergic signaling through β-2 ARs and that cocaine-induced reinstatement does not require AR activation, even though stimulation of central noradrenergic neurotransmission is sufficient to reinstate
Disinfection of Surfaces Contaminated with SARS-CoV-2 Coronavirus by UV Radiation of Low-Pressure Mercury-Vapour Lamp
The aim of the work was to determine the effective ultraviolet (UV) doses required for the disinfection of surfaces contaminated with the SARS-CoV-2 coronavirus using a low-pressure mercury lamp. Materials and methods. To carry out prompt disinfection of surfaces, a specially designed source of UV radiation with a power of 7.5 W at a wavelength of 254 nm in the form of a portable flashlight was employed, which has a high efficiency of UV radiation output and the possibility of long-term autonomous operation from a compact battery. In the studies, a suspension culture of the SARS-CoV-2 coronavirus with biological activity of 5.3∙106 PFU/ml was used. The objects of testing were plastic Petri dishes (disposable) and office paper (grade C, density 80 g/m2 ). Results and discussion. Doses of UV radiation that provide disinfection of surfaces contaminated with the COVID-19 pathogen with an efficiency of 99.0 % (paper) to 99.95 % (plastic) have been determined. The results obtained make it possible to recommend a portable UV irradiator for use in the practice of preventive measures to combat the spread of the disease caused by the SARS-CoV-2 coronavirus
Evidence for the Re-Enactment of a Recently Learned Behavior during Sleepwalking
Animal studies have shown that sequenced patterns of neuronal activity may be replayed during sleep. However, the existence of such replay in humans has not yet been directly demonstrated. Here we studied patients who exhibit overt behaviors during sleep to test whether sequences of movements trained during the day may be spontaneously reenacted by the patients during sleep
Does Sleep Improve Your Grammar? : Preferential Consolidation of Arbitrary Components of New Linguistic Knowledge
We examined the role of sleep-related memory consolidation processes in learning new form-meaning mappings. Specifically, we examined a Complementary Learning Systems account, which implies that sleep-related consolidation should be more beneficial for new hippocampally dependent arbitrary mappings (e.g. new vocabulary items) relative to new systematic mappings (e.g. grammatical regularities), which can be better encoded neocortically. The hypothesis was tested using a novel language with an artificial grammatical gender system. Stem-referent mappings implemented arbitrary aspects of the new language, and determiner/suffix+natural gender mappings implemented systematic aspects (e.g. tib scoiffesh + ballerina, tib mofeem + bride; ked jorool + cowboy, ked heefaff + priest). Importantly, the determiner-gender and the suffix-gender mappings varied in complexity and salience, thus providing a range of opportunities to detect beneficial effects of sleep for this type of mapping. Participants were trained on the new language using a word-picture matching task, and were tested after a 2-hour delay which included sleep or wakefulness. Participants in the sleep group outperformed participants in the wake group on tests assessing memory for the arbitrary aspects of the new mappings (individual vocabulary items), whereas we saw no evidence of a sleep benefit in any of the tests assessing memory for the systematic aspects of the new mappings: Participants in both groups extracted the salient determiner-natural gender mapping, but not the more complex suffix-natural gender mapping. The data support the predictions of the complementary systems account and highlight the importance of the arbitrariness/systematicity dimension in the consolidation process for declarative memories
Automated Force Volume Image Processing for Biological Samples
Atomic force microscopy (AFM) has now become a powerful technique for investigating on a molecular level, surface forces, nanomechanical properties of deformable particles, biomolecular interactions, kinetics, and dynamic processes. This paper specifically focuses on the analysis of AFM force curves collected on biological systems, in particular, bacteria. The goal is to provide fully automated tools to achieve theoretical interpretation of force curves on the basis of adequate, available physical models. In this respect, we propose two algorithms, one for the processing of approach force curves and another for the quantitative analysis of retraction force curves. In the former, electrostatic interactions prior to contact between AFM probe and bacterium are accounted for and mechanical interactions operating after contact are described in terms of Hertz-Hooke formalism. Retraction force curves are analyzed on the basis of the Freely Jointed Chain model. For both algorithms, the quantitative reconstruction of force curves is based on the robust detection of critical points (jumps, changes of slope or changes of curvature) which mark the transitions between the various relevant interactions taking place between the AFM tip and the studied sample during approach and retraction. Once the key regions of separation distance and indentation are detected, the physical parameters describing the relevant interactions operating in these regions are extracted making use of regression procedure for fitting experiments to theory. The flexibility, accuracy and strength of the algorithms are illustrated with the processing of two force-volume images, which collect a large set of approach and retraction curves measured on a single biological surface. For each force-volume image, several maps are generated, representing the spatial distribution of the searched physical parameters as estimated for each pixel of the force-volume image
The association between alcohol use, alcohol use disorders and tuberculosis (TB). A systematic review
<p>Abstract</p> <p>Background</p> <p>In 2004, tuberculosis (TB) was responsible for 2.5% of global mortality (among men 3.1%; among women 1.8%) and 2.2% of global burden of disease (men 2.7%; women 1.7%). The present work portrays accumulated evidence on the association between alcohol consumption and TB with the aim to clarify the nature of the relationship.</p> <p>Methods</p> <p>A systematic review of existing scientific data on the association between alcohol consumption and TB, and on studies relevant for clarification of causality was undertaken.</p> <p>Results</p> <p>There is a strong association between heavy alcohol use/alcohol use disorders (AUD) and TB. A meta-analysis on the risk of TB for these factors yielded a pooled relative risk of 2.94 (95% CI: 1.89-4.59). Numerous studies show pathogenic impact of alcohol on the immune system causing susceptibility to TB among heavy drinkers. In addition, there are potential social pathways linking AUD and TB. Heavy alcohol use strongly influences both the incidence and the outcome of the disease and was found to be linked to altered pharmacokinetics of medicines used in treatment of TB, social marginalization and drift, higher rate of re-infection, higher rate of treatment defaults and development of drug-resistant forms of TB. Based on the available data, about 10% of the TB cases globally were estimated to be attributable to alcohol.</p> <p>Conclusion</p> <p>The epidemiological and other evidence presented indicates that heavy alcohol use/AUD constitute a risk factor for incidence and re-infection of TB. Consequences for prevention and clinical interventions are discussed.</p
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