5,736 research outputs found
The Effect of Changing Government Subsidy Programs: An Analysis of Revenue at the Farm level
Producer revenue is simultaneously simulated for several hundred county-specific representative farms. The effects of current and alternative commodity programs are analyzed. In particular, two variations of revenue-triggered programs similar to plans proposed by the National Corn Growers Association are evaluated.Risk, commodity policy, simulation, Agricultural and Food Policy, Risk and Uncertainty, Q180,
Functional characterization of synthetic leukotriene B and its stereochemical isomers.
Leukotriene B (LTB), a potent lipid chemotactic factor for neutrophils, is 5S,12R-dihydroxy-6,14-cis,8,10-trans-eicosatetraenoic acid (Fig 1), based upon direct comparison of natural LTB with synthetic 5S,12R-dihydroxy-6,8,10,14-eicosatetraenoic acid (5,12-di-HETE) stereoisomers in three biological assays. Of the six synthetic stereoisomers evaluated, only the 5S,12R,6,14-cis,8,10-trans compound had chemotactic potency for human neutrophils in vitro that was comparable to that of natural LTB, with a concentration of 3 X 10(9-9) M eliciting a one-half maximum response. In contrast, the racemic mixture of 5R,12R- and 5S,12S-6,10-trans,8,14-cis, the racemic mixture of 5S,12R- and 5R,12S-6,10-trans,8,14-cis, the 5S,12R-6,8-trans,10,14-cis, the 5S,12R-6,8,10-trans,14-cis, and the 5S,12S-6,8,10-trans,14-cis stereoisomers required concentrations of 3 X 10(-7) to 1 X 10(-6) M to elicit comparable responses. Only natural LTB and its synthetic counterpart elicited a local neutrophil infiltration when injected into the skin of the rhesus monkey at 10 ng and 100 ng per site. Natural and synthetic LTB at a concentration of 3 X 10(-8) M each provoked an EC25 contractile response of guinea pig pulmonary parenchymal strips in vitro, whereas the other four tested stereoisomers of 5,12-di-HETE were inactive at this concentration. Structure-function analyses suggest that the neutrophil chemotactic activity depends critically upon the C-1 to C-12 domain, including the stereochemistry of the 6-,8-,and 10-olefinic bonds and the presence of both hydroxyl groups
Do Gender Differences in Perceived Prototypical Computer Scientists and Engineers Contribute to Gender Gaps in Computer Science and Engineering?
Women are vastly underrepresented in the fields of computer science and engineering (CS&E). We examined whether women might view the intellectual characteristics of prototypical individuals in CS&E in more stereotype-consistent ways than men might and, consequently, show less interest in CS&E. We asked 269 U.S. college students (187, 69.5% women) to describe the prototypical computer scientist (Study 1) or engineer (Study 2) through open-ended descriptions as well as through a set of trait ratings. Participants also rated themselves on the same set of traits and rated their similarity to the prototype. Finally, participants in both studies were asked to describe their likelihood of pursuing future college courses and careers in computer science (Study 1) or engineering (Study 2). Across both studies, we found that women offered more stereotype-consistent ratings than did men of the intellectual characteristics of prototypes in CS (Study 1) and engineering (Study 2). Women also perceived themselves as less similar to the prototype than men did. Further, the observed gender differences in prototype perceptions mediated the tendency for women to report lower interest in CS&E fields relative to men. Our work highlights the importance of prototype perceptions for understanding the gender gap in CS&E and suggests avenues for interventions that may increase women’s representation in these vital fields
Tuning Jammed Frictionless Disk Packings from Isostatic to Hyperstatic
We perform extensive computational studies of two-dimensional static
bidisperse disk packings using two distinct packing-generation protocols. The
first involves thermally quenching equilibrated liquid configurations to zero
temperature over a range of thermal quench rates and initial packing
fractions followed by compression and decompression in small steps to reach
packing fractions at jamming onset. For the second, we seed the system
with initial configurations that promote micro- and macrophase-separated
packings followed by compression and decompression to . We find that
amorphous, isostatic packings exist over a finite range of packing fractions
from in the large-system limit,
with . In agreement with previous calculations,
we obtain for , where is the rate
above which is insensitive to rate. We further compare the structural
and mechanical properties of isostatic versus hyperstatic packings. The
structural characterizations include the contact number, bond orientational
order, and mixing ratios of the large and small particles. We find that the
isostatic packings are positionally and compositionally disordered, whereas
bond-orientational and compositional order increase with contact number for
hyperstatic packings. In addition, we calculate the static shear modulus and
normal mode frequencies of the static packings to understand the extent to
which the mechanical properties of amorphous, isostatic packings are different
from partially ordered packings. We find that the mechanical properties of the
packings change continuously as the contact number increases from isostatic to
hyperstatic.Comment: 11 pages, 15 figure
Single-Shot Electron Diffraction using a Cold Atom Electron Source
Cold atom electron sources are a promising alternative to traditional
photocathode sources for use in ultrafast electron diffraction due to greatly
reduced electron temperature at creation, and the potential for a corresponding
increase in brightness. Here we demonstrate single-shot, nanosecond electron
diffraction from monocrystalline gold using cold electron bunches generated in
a cold atom electron source. The diffraction patterns have sufficient signal to
allow registration of multiple single-shot images, generating an averaged image
with significantly higher signal-to-noise ratio than obtained with unregistered
averaging. Reflection high-energy electron diffraction (RHEED) was also
demonstrated, showing that cold atom electron sources may be useful in
resolving nanosecond dynamics of nanometre scale near-surface structures.Comment: This is an author-created, un-copyedited version of an article
published in Journal of Physics B: Atomic, Molecular and Optical Physics. IOP
Publishing Ltd is not responsible for any errors or omissions in this version
of the manuscript or any version derived from it. The Version of Record is
available online at http://dx.doi.org/10.1088/0953-4075/48/21/21400
Reconciling Semiclassical and Bohmian Mechanics: II. Scattering states for discontinuous potentials
In a previous paper [J. Chem. Phys. 121 4501 (2004)] a unique bipolar
decomposition, Psi = Psi1 + Psi2 was presented for stationary bound states Psi
of the one-dimensional Schroedinger equation, such that the components Psi1 and
Psi2 approach their semiclassical WKB analogs in the large action limit.
Moreover, by applying the Madelung-Bohm ansatz to the components rather than to
Psi itself, the resultant bipolar Bohmian mechanical formulation satisfies the
correspondence principle. As a result, the bipolar quantum trajectories are
classical-like and well-behaved, even when Psi has many nodes, or is wildly
oscillatory. In this paper, the previous decomposition scheme is modified in
order to achieve the same desirable properties for stationary scattering
states. Discontinuous potential systems are considered (hard wall, step, square
barrier/well), for which the bipolar quantum potential is found to be zero
everywhere, except at the discontinuities. This approach leads to an exact
numerical method for computing stationary scattering states of any desired
boundary conditions, and reflection and transmission probabilities. The
continuous potential case will be considered in a future publication.Comment: 18 pages, 8 figure
Amish Population Pyramids: Demographic Patterns across Affiliations in the Holmes County, Ohio, Settlement
Research indicates demographic trends within the Amish community remain stable over time, even as Amish populations proliferate. However, most of the research on demographic trends fails to examine variation across affiliations. We use data from Ohio Amish Directory, Holmes County and Vicinity, 2010 to construct age-sex population pyramids for three different affiliations. Population pyramids render the growth, decline, and stability of populations visible. Andy Weaver (or Dan) and Old Order churches present expanding pyramids implying rapid growth, while New Order churches render a stationary pyramid indicating slower growth. Sociologists of religion consistently find that strict churches, cultivating separation from the outside world, tend to grow faster than those that foster accommodation with the outside world. We argue that the data presented in this article suggests a similar dynamic at work in Plain Anabaptist communities
The calcium current in inner segments of rods from the salamander (Ambystoma tigrinum) retina.
Solitary rod inner segments were isolated from salamander retinae. Their Ca current was studied with the 'whole-cell, gigaseal' technique (Hamill, Marty, Neher, Sakmann & Sigworth, 1981). The soluble constituents of the cytoplasm exchanged with the solution in the pipette. The external solution could be changed during continuous perfusion. Membrane voltage was controlled with a voltage clamp. After permeant ions other than Ca were replaced with impermeant ions (i.e. tetraethylammonium as a cation, and aspartate or methanesulphonate as an anion), an inward current remained. It activated at approximately -40 mV, reached a maximum at approximately 0 mV, and decreased as the membrane was further depolarized. The size of the current increased when Ba was substituted for external Ca. The current was blocked when Ca was replaced with Co. The voltage at which the current was half-maximum shifted from approximately -22 to -31 mV during the initial 3 min of an experiment. The maximum amplitude of the current continuously declined during the entire course of an experiment. The time course for activation of the Ca current following a step of depolarization could be described by the sum of two exponentials. The time constant of the slower exponential was voltage dependent. Deactivation following repolarization could also be described by the sum of two exponentials. Both time constants for deactivation were independent of voltage (between -30 and 0 mV) and faster than the slower time constant for activation. When the internal Ca concentration was buffered by 10 mM-EGTA, the Ca current did not inactivate during several seconds of maintained depolarization. When the concentration of EGTA was reduced to 0.1 mM, the Ca current declined and the membrane conductance decreased during several seconds of maintained depolarization. This inactivation was incomplete and only occurred after a substantial quantity of Ca entered. Following repolarization the Ca conductance recovered from inactivation. In contrast, the continuous decline observed during the course of an experiment (item 3) was not reversible. The difference suggests that inactivation and the decline are distinct processes
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