457 research outputs found
Examination of evidence for collinear cluster tri-partition
In a series of the experiments at different time-of-flight spectrometers of
heavy ions we have observed manifestations of a new at least ternary decay
channel of low excited heavy nuclei. Due to specific features of the effect, it
was called collinear cluster tri-partition (CCT). The experimental results
obtained initiated a number of theoretical articles dedicated to different
aspects of the CCT. We compare theoretical predictions with our experimental
data, only partially published so far. The model of one of the most populated
CCT modes that gives rise to the so called "Ni-bump" is discussed. Detection of
the 68-72Ni fission fragments with a kinetic energy E<25 MeV at the
mass-separator Lohengrin is proposed for an independent experimental
verification of the CCT.Comment: 16 pages, 14 figure
Structure, stability, and mobility of small Pd clusters on the stoichiometric and defective TiO (110) surfaces
We report on the structure and adsorption properties of Pd ()
clusters supported on the rutile TiO (110) surfaces with the possible
presence of a surface oxygen vacancy or a subsurface Ti-interstitial atom. As
predicted by the density functional theory, small Pd clusters prefer to bind to
the stoichiometric titania surface or at sites near subsurface Ti-interstitial
atoms. The adsorption of Pd clusters changes the electronic structure of the
underlying surface. For the surface with an oxygen vacancy, the charge
localization and ferromagnetic spin states are found to be largely attenuated
owing to the adsorption of Pd clusters. The potential energy surfaces of the Pd
monomer on different types of surfaces are also reported. The process of
sintering is then simulated via the Metropolis Monte Carlo method. The presence
of oxygen vacancy likely leads to the dissociation of Pd clusters. On the
stoichiometric surface or surface with Ti-interstitial atom, the Pd monomers
tend to sinter into larger clusters, whereas the Pd dimer, trimer and tetramer
appear to be relatively stable below 600 K. This result agrees with the
standard sintering model of transition metal clusters and experimental
observations.Comment: 27 pages, 11 figure
Influence of detection of pretreatment cytogenetic abnormalities on first complete remission and survival in adult acute lymphoblastic leukemia
Objective: Treatment of acute lymphoblastic leukemia (ALL) in adults focuses on the initial assessment of the prognostic relevant cytogenetic features as well as a response-guided therapy based on molecular data. We examined the importance of molecular-cytogenetic abnormalities for complete remission (CR) rates and the overall survival (OS) in adult ALLs.Materials and Methods: Conventional cytogenetics and fluorescence in situ hybridization were performed on bone marrow cells from 33 newly-diagnosed ALL adults. Two karyotype categories [standard- risk group- normal karyotype, hyperdiplody and other structural aberrations, and high-risk group-t(11q23)/MLL, t(9;22)/bcr-abl, t(1;19), t(8;14), C-MYC and complex karyotype] and the biologically and clinically relevant ALL ploidy subgroups were prospectively defined.Results: Chromosomal abnormalities were found in 52% of the cases with a high rate of poor-risk translocations - t(9;22), t(8q24), t(11q23), t(1;19). The total CR rate was 67% and the median time for achievement 2.33 months. Male sex, an age below 35 years and the absence of high risk translocations might have contributed to the high CR rates. Female patients, hyperdiplody, low white blood cells (WBC), and random cytogenetic aberrations had the longest OS. OS, 3- and 5-years survival periods were significantly shorter for poor-risk than standard risk group (p=.015, p=.001 and p=.005, respectively).Conclusion: This study emphasizes the lack of influence of cytogenetic aberrations on the CR and the time to achieve CR. However, our observations show that these aberrations are an independent prognostic factor in adult ALL - they allow predicting therapy resistance and the OS time after intensetreatment
Aromaticity in a Surface Deposited Cluster: Pd on TiO (110)
We report the presence of \sigma-aromaticity in a surface deposited cluster,
Pd on TiO (110). In the gas phase, Pd adopts a tetrahedral
structure. However, surface binding promotes a flat, \sigma-aromatic cluster.
This is the first time aromaticity is found in surface deposited clusters.
Systems of this type emerge as a promising class of catalyst, and so
realization of aromaticity in them may help to rationalize their reactivity and
catalytic properties, as a function of cluster size and composition.Comment: 4 pages, 3 figure
Ostwald ripening in the presence of simultaneous occurrence of various mass transfer mechanisms: An extension of the Lifshitz-Slyozov theory
The Ostwald ripening stage of a phase transformation process with allowance for synchronous operation of various mass transfer mechanisms (volume diffusion and diffusion along the block boundaries and dislocations) and the initial condition for the particle-radius distribution function is theoretically studied. The initial condition is taken from the analytical solution describing the intermediate stage of a phase transition process. The present theory focuses on relaxation dynamics from the beginning of the ripening process to its final asymptotic state, which is described by the previously constructed theories (Slezov VV. et al. 1978 J. Phys. Chem. Solids 39, 705-709. (doi:10.1016/0022-3697(78)90002-1) and Alexandrov & Alexandrova 2020 Phil. Trans. R. Soc. A 378, 20190247. (doi:10.1098/rsta.2019.0247)). An evolutionary behaviour of particle growth rates dependent on various mass transfer mechanisms and time is analytically described. The boundaries of the transition layer, which surround the blocking point, are found. The fundamental and relaxation contributions to the particle-radius distribution function are derived for the simultaneous occurrence of various mass transfer mechanisms. The left branch of this function is shifted to smaller particle radii whereas its right branch extends to the right of the blocking point as compared with the asymptotic universal distribution function. The theory under consideration well agrees with experimental data. This article is part of the theme issue 'Transport phenomena in complex systems (part 1)'. © 2021 The Author(s).Russian Science Foundation, RSF, (18-19-00008)Data accessibility. This article has no additional data. Authors’ contributions. All authors contributed equally to the present research article. Competing interests. We declare we have no competing interests. Funding. This work was supported by the Russian Science Foundation (grant no. 18-19-00008)
Immunological efficacy of Vaccination against Measles in Children with Down syndrome
The data of current vaccination process of cellular, humoral immunity and specific antibody formation in 41 children with Down syndrome at the age of 1 year to 6 years old is observed. To prevent easles used measles vaccine (n=12), divaccine -measles-mumps (n=21) and or Priorix vaccine (n=8). The comparison group consisted of 63 children without Down syndrome. The post-vaccination period in 97,6% of children with Down syndrome cases are asymptomatic, only 2,4% of children mentioned layering of intercurrent diseases. The immunological status in children with Down syndrome is characterized by a significant decrease in the umber leucocytes, lymphocytes, CD3+, CD4+, CD8+ and absolute number of CD20+, but functional activity of the cells is preserved. By 30 days after immunization they have increased leucocytes, lymphocytes, CD 95+cells. The number of antibodies significantly increased (6,63±0,33 compared to 5,79±0,32 log2, р < 0,05)
Scission Point Calculations and Physical Treating of the 'Ni-bump' in 252Cf (sf)
In a series of the experiments at different time-of-flight spectrometers of heavy ions we have observed manifestations of a new at least ternary decay channel of low excited heavy nuclei. Due to specific features of the effect, it was called collinear cluster tri-partition (CCT). The experimental results obtained initiated a number of theoretical articles dedicated to different aspects of the CCT. In the report we compare the theoretical predictions with our experimental data, only partially published so far. The developed model of one of the most populated CCT modes that gives rise to the so called “Ni-bump” is discussed
Evolution of a Polydisperse Ensemble of Spherical Particles in a Metastable Medium with Allowance for Heat and Mass Exchange with the Environment
Motivated by a wide range of applications in various fields of physics and materials science, we consider a generalized approach to the evolution of a polydisperse ensemble of spherical particles in metastable media. An integrodifferential system of governing equations, consisting of a kinetic equation for the particle-size distribution function (Fokker–Planck type equation) and a balance equation for the temperature (concentration) of a metastable medium, is formulated. The kinetic equation takes into account fluctuations in the growth/reduction rates of individual particles, the velocity of particles in a spatial direction, the withdrawal of particles of a given size from the metastable medium, and their source/sink term. The heat (mass) balance equation takes into account the growth/reduction of particles in a metastable system as well as heat (mass) exchange with the environment. A generalized system of equations describes various physical and chemical processes of phase transformations, such as the growth and dissolution of crystals, the evaporation of droplets, the boiling of liquids and the combustion of a polydisperse fuel. The ways of analytical solution of the formulated integrodifferential system of equations based on the saddle-point technique and the separation of variables method are considered. The theory can be applied when describing the evolution of an ensemble of particles at the initial and intermediate stages of phase transformation when the distances between the particles are large enough, and interactions between them can be neglected. © 2022 by the authors. Licensee MDPI, Basel, Switzerland.Russian Foundation for Basic Research, РФФИ: 20-08-00199; Ministry of Education and Science of the Russian Federation, Minobrnauka: FEUZ-2020-0057Funding: This paper comprises two parts of research studies, including (i) the model generalization and discussion of governing equations, analytical solutions, analysis of the results obtained, and (ii) checking the mathematics, numerical calculations, visualization, and discussion of the functions obtained. Two parts of this review article were supported by two financial sources. The first part was supported by the Russian Foundation for Basic Research (grant no. 20-08-00199). At the same time, the authors are grateful to the Ministry of Science and Higher Education of the Russian Federation (grant no. FEUZ-2020-0057) for the support of the second part of the research studies
Prognostic value of left ventricular global longitudinal strain and mechanical dispersion by speckle tracking echocardiography in patients with ischemic and nonischemic cardiomyopathy: a systematic review and meta-analysis
Aim. To conduct a systematic review and meta-analysis in order to evaluate the prognostic value of left ventricular global longitudinal strain (LV GLS) and LV mechanical dispersion (LVMD) in ischemic and nonischemic cardiomyopathy.Material and methods. We searched PubMed, Google Scholar and Embase for studies on the prognostic value of LV GLS and LVMD in ischemic and nonischemic cardiomyopathy. Hazard ratios (HR) from included studies were pooled for metaanalysis.Results. Twelve studies were selected from 314 publications for this systematic review and meta-analysis. In total, 2624 patients (mean age, 57,3 years; mean follow-up, 40,8 months) were included in the analysis. Meta-analysis showed that decreased LV GLS was associated with an increased risk of ventricular arrhythmias (VAs) (adjusted HR: 1,10 per 1% of GLS; 95% CI: 1,01-1,19; p=0,03) and major adverse cardiovascular events (MACE): adjusted HR: 1,22 per 1% of GLS; 95% CI: 1,11-1,33; p<0,0001). Patients with VAs had greater LVMD than those without it (weighted mean difference, 33,69 ms; 95% CI: -41,32 to -26,05; p<0,0001). Each 10 ms increment of LVMD was significantly and independently associated with VA episodes (adjusted HR: 1,18; 95% CI: 1,08-1,29; p=0,0002).Conclusions. LV GLS and LVMD assessed using speckle tracking provides important predictive value and can be used as an effective tool for stratifying risk in patients with ischemic and nonischemic cardiomyopathy
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