274 research outputs found
An Analysis of Factors Affecting the Effective Use of Knowledge Management in Counter Improvised Explosive Device (C-IED) Operations
Improvised Explosive Device (IED) is a weapon of choice and is likely to remain a major component of the Global War on Terrorism. It is critical that gaps in knowledge transfer are quickly addressed in order to more effectively equip personnel to counter IED (C-IED) threat. Therefore, the military must analyze the current Knowledge Management (KM) programs in C-IED arena in order to maximize transfer of knowledge derived from experience and skill to staffs and finally to commanders. This study investigates the factors that influence effective use of KM in C-IED operations in the military. The study suggests that effective KM program is determined by the interaction of three organizational capabilities: knowledge infrastructure, knowledge process, and leadership orientation. A self-administrated survey was conducted on 300 NATO staff officers who have served in C-IED environments. A structural equation modeling technique was used to test a set of hypotheses using 118 completed responses collected from the survey. The results suggest that out of the 11 constructs within the model; two are rated as àttribute needs immediate attention (i.e. Culture and Traditional Leadership), eight are rated as àttribute needs further enhancement (i.e. Overall Organizational Capability, Knowledge Process, Knowledge Infrastructure, Acquisition, Transfer, Application, Structure and Transformational Leadership) and one is rated as àttribute runs satisfactorily (i.e. Technology). The results of this research have particular value to engineering management researchers and practitioners operating in military domains because it proposes, empirically tests and justifies a conceptual model that explains KM in C-IED operations in the military
Effect of Long-Term Marine Omega-3 Fatty Acids Supplementation on the Risk of Atrial Fibrillation in Randomized Controlled Trials of Cardiovascular Outcomes: A Systematic Review and Meta-Analysis.
Background: Some, but not all, large-scale randomized controlled trials (RCTs) investigating the effects of marine omega-3 fatty acids supplementation on cardiovascular outcomes have reported increased risks of atrial fibrillation (AF). The potential reasons for disparate findings may be dose related. Methods: The MEDLINE and Embase databases were searched for articles and abstracts published between January 1, 2012 and December 31, 2020 in addition to a meta-analysis of large cardiovascular RCTs published in 2019. RCTs of cardiovascular outcomes of marine omega-3 fatty acids that reported results for AF, either as pre-specified outcome, adverse event, or a cause for hospitalization, with a minimum sample size of 500 patients and a median followup of at least one year were included. RCTs specifically examining shorter term effects of omega-3 fatty acids on recurrent AF in patients with established AF or post-operative AF were not included. The hazard ratio (HR) for the reported AF outcomes within each trial was metaanalyzed using random-effects model with Knapp-Hartung adjustment and evaluated a doseresponse relationship with a meta-regression model. Results: Of 4049 screened records, seven studies were included in the meta-analysis. Of those, five were already detected in a previous meta-analysis of cardiovascular RCTs. Among the 81,210 patients from 7 trials, 58,939 (72.6%) were enrolled in trials testing ≤1gram per day (g/d) and 22,271 (27.4%) in trials testing >1g/d of omega-3 fatty acids. The mean age was 65 years and 31,842 (39%) were female. The weighted average follow-up was 4.9 years. In meta-analysis, the use of marine omega-3 fatty acid supplements was associated with an increased risk of AF (n=2,905; HR 1.25, 95%CI 1.07-1.46, P=0.013). In analyses stratified by dose, the HR was greater in the trials testing >1g/d (HR 1.49, 95%CI 1.04-2.15, P=0.042) as compared with those testing ≤1 g/d (HR 1.12, 95%CI 1.03-1.22, P=0.024, P for interaction1g/d
Electrical Impedance Tomography of Translationally Uniform Cylindrical Objects with General Cross-Sectional Boundaries
An algorithm is developed for electrical impedance tomography (EIT) of finite cylinders with general cross-sectional boundaries and translationally uniform conductivity distributions. The electrodes for data collection are assumed to be placed around a cross-sectional plane,- therefore the axial variation of the boundary conditions and also the potential field are expanded in Fourier series. For each Fourier component a two-dimensional (2-D) partial differential equation is derived. Thus the 3-D forward problem is solved as a succession of 2-D problems and it is shown that the Fourier series can be truncated to provide substantial saving in computation time. The finite element method is adopted and the accuracy of the boundary potential differences (gradients) thus calculated is assessed by comparison to results obtained using cylindrical harmonic expansions for circular cylinders. A 1016-element and 541-node mesh is found to be optimal. For a given cross-sectional boundary, the ratios of the gradients calculated for both 2-D and 3-D homogeneous objects are formed. The actual measurements from the 3-D object are multiplied by these ratios and thereafter the tomographic image is obtained by the 2-D iterative equipotential lines method. The algorithm is applied to data collected from phantoms, and the errors incurred from the several assumptions of the method are investigated. The method is also applied to humans and satisfactory images are obtained. It is argued that the method finds an “equivalent” translationally uniform object, the calculated gradients for which are the same as the actual measurements collected. In the absence of any other information about the translational variation of conductance this method is especially suitable for body parts with some translational uniformity. © 1990 IEE
Test of 6-kVA three-phase flux transfer-type current-limiting transformer
A 6-kVA three-phase model of the flux transfer-type current-limiting transformer was developed and tested. In this device, the winding loops of YBCO superconducting tapes couple magnetically two independent iron cores: the primary-side iron core and the secondary-side iron core. The former and the latter are equipped with copper primary and secondary windings, respectively. Because the magnetic fluxes linked to the superconducting winding loops must be kept constant, the magnetic flux is transferred by the superconducting YBCO loops between the two iron cores in order to couple magnetically the primary and secondary coils. While the YBCO loops are superconducting, 100% of the magnetic flux is transferred and the device shows the similar function as usual transformers. Once the YBCO loops become normal by a fault current in any of the windings, the power transfer between two iron cores is limited and the current in the secondary winding is limited naturally on a result of decoupling the iron cores
System for monitoring and supporting the treatment of sleep apnea using IoT and big data
[EN] Sleep apnea has become in the sleep disorder that causes greater concern in recent years due to its morbidity and mortality, higher medical care costs and poor people quality of life. Some proposals have addressed sleep apnea disease in elderly people, but they have still some technical limitations. For these reasons, this paper presents an innovative system based on fog and cloud computing technologies which in combination with IoT and big data platforms offers new opportunities to build novel and innovative services for supporting the sleep apnea and to overcome the current limitations. Particularly, the system is built on several low-power wireless networks with heterogeneous smart devices (i.e, sensors and actuators). In the fog, an edge node (Smart IoT Gateway) provides IoT connection and interoperability and pre-processing IoT data to detect events in real-time that might endanger the elderly's health and to act accordingly. In the cloud, a Generic Enabler Context Broker manages, stores and injects data into the big data analyzer for further processing and analyzing. The system's performance and subjective applicability are evaluated using over 30 GB size datasets and a questionnaire fulfilled by medicals specialist, respectively. Results show that the system data analytics improve the health professionals' decision making to monitor and guide sleep apnea treatment, as well as improving elderly people's quality of life. (C) 2018 Elsevier B.V. All rights reserved.This research was supported by the Ecuadorian Government through the Secretary of Higher Education, Science, Technology, and Innovation (SENESCYT) and has received funding from the European Union's "Horizon 2020'' research and innovation program as part of the ACTIVAGE project under Grant 732679 and the Interoperability of Heterogeneous IoT Platforms project (INTER-IoT) under Grant 687283.Yacchirema-Vargas, DC.; Sarabia-Jácome, DF.; Palau Salvador, CE.; Esteve Domingo, M. (2018). System for monitoring and supporting the treatment of sleep apnea using IoT and big data. Pervasive and Mobile Computing. 50:25-40. https://doi.org/10.1016/j.pmcj.2018.07.007S25405
Subclinical thyroid dysfunction and the risk of heart failure events: an individual participant data analysis from 6 prospective cohorts.
BACKGROUND: American College of Cardiology/American Heart Association guidelines for the diagnosis and management of heart failure recommend investigating exacerbating conditions such as thyroid dysfunction, but without specifying the impact of different thyroid-stimulation hormone (TSH) levels. Limited prospective data exist on the association between subclinical thyroid dysfunction and heart failure events.
METHODS AND RESULTS: We performed a pooled analysis of individual participant data using all available prospective cohorts with thyroid function tests and subsequent follow-up of heart failure events. Individual data on 25 390 participants with 216 248 person-years of follow-up were supplied from 6 prospective cohorts in the United States and Europe. Euthyroidism was defined as TSH of 0.45 to 4.49 mIU/L, subclinical hypothyroidism as TSH of 4.5 to 19.9 mIU/L, and subclinical hyperthyroidism as TSH <0.45 mIU/L, the last two with normal free thyroxine levels. Among 25 390 participants, 2068 (8.1%) had subclinical hypothyroidism and 648 (2.6%) had subclinical hyperthyroidism. In age- and sex-adjusted analyses, risks of heart failure events were increased with both higher and lower TSH levels (P for quadratic pattern <0.01); the hazard ratio was 1.01 (95% confidence interval, 0.81-1.26) for TSH of 4.5 to 6.9 mIU/L, 1.65 (95% confidence interval, 0.84-3.23) for TSH of 7.0 to 9.9 mIU/L, 1.86 (95% confidence interval, 1.27-2.72) for TSH of 10.0 to 19.9 mIU/L (P for trend <0.01) and 1.31 (95% confidence interval, 0.88-1.95) for TSH of 0.10 to 0.44 mIU/L and 1.94 (95% confidence interval, 1.01-3.72) for TSH <0.10 mIU/L (P for trend=0.047). Risks remained similar after adjustment for cardiovascular risk factors.
CONCLUSION: Risks of heart failure events were increased with both higher and lower TSH levels, particularly for TSH ≥10 and <0.10 mIU/L
Transcription Factors in Light and Circadian Clock Signaling Networks Revealed by Genomewide Mapping of Direct Targets for Neurospora White Collar Complex
Light signaling pathways and circadian clocks are inextricably linked and have profound effects on behavior in most organisms. Here, we used chromatin immunoprecipitation (ChIP) sequencing to uncover direct targets of the Neurospora crassa circadian regulator White Collar Complex (WCC). The WCC is a blue-light receptor and the key transcription factor of the circadian oscillator. It controls a transcriptional network that regulates ∼20% of all genes, generating daily rhythms and responses to light. We found that in response to light, WCC binds to hundreds of genomic regions, including the promoters of previously identified clock- and light-regulated genes. We show that WCC directly controls the expression of 24 transcription factor genes, including the clock-controlled adv-1 gene, which controls a circadian output pathway required for daily rhythms in development. Our findings provide links between the key circadian activator and effectors in downstream regulatory pathways
Association between income and control of cardiovascular risk factors after acute coronary syndromes: an observational study.
The role of income in cardiovascular disease prevention after an acute coronary syndrome (ACS) remains unclear. We aimed to assess the association between income and control of cardiovascular risk factors one year after an ACS in a country with universal health insurance.
Between 2013 and 2014, we studied 255 consecutive patients with ACS in an observational study in a university hospital in Switzerland in which self-reported household income was assessed. We classified patients into two categories based on the median income in Switzerland: higher than CHF 6000 (&euro; 5300) or less than or equal to CHF 6000 (&euro; 5300) per month. One year after discharge, patients were evaluated for the achievement of lipid and blood pressure targets, smoking cessation and drug adherence. Multivariate odds ratios (OR) were adjusted for age, sex, education, living status and working status.
Overall, 52.2% (n = 133) of patients with ACS were in the low-income category and 47.8% (n = 122) were in the high-income category. One year after discharge, high-income patients had higher rates of smoking cessation (64.2 vs 30.1%, multivariate-adjusted odds ratio (OR) 3.82, 95% confidence interval (CI) 1.58&ndash;9.24) and blood pressure target achievement (78.6 vs 60.2%, multivariate-adjusted OR 2.19, 95% CI 1.09&ndash;4.41) compared to those in the low-income category. There were no differences regarding adherence to drugs or lipid control between the two income groups.
A high household income was associated with a higher rate of smoking cessation and better control of blood pressure one year after ACS, independently of education, living status and working status
Global Assessment Report on Disaster Risk Reduction 2019
The Global Assessment Report on Disaster Risk Reduction (GAR) is the flagship report of the United Nations on worldwide efforts to reduce disaster risk
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