Development and Testing of a Real-Time LoRawan Sniffer Based on GNU-Radio

En este documento se muestran las vulnerabilidades presentes en una red de sensores inalámbricas implementada sobre una red de área amplia de largo alcance (LoRaWAN por sus siglas en inglés) LoRaWAN y se identifican los posibles ataques que se podrían realizar a la red usando sniffing y/o replay. Los ataques a la red se realizaron implementando un analizador de protocolos (Sniffer) para capturar los paquetes. El Sniffer se implementó utilizando el hardware RTL2832U y se visualizó en Wireshark, a través de GNU-Radio. Las pruebas mostraron que se pueden amenazar la disponibilidad y confidencialidad de los datos a través de ataques de replay con verificación en el LoRa server utilizando hardware HackRF One y GNU-Radio. Aunque la especificación LoRaWAN tiene contadores para evitar ataques de replay, bajo condiciones adecuadas se lograría vulnerar la red llegando a realizar la denegación del servicio del nodo en el servidor.This paper shows the vulnerabilities present in a wireless sensor network implemented over a long-range wide area network (LoRaWAN) LoRaWAN, and identifies possible attacks that could be made to the network using sniffing and/or replay. Attacks on the network were performed by implementing a protocol analyzer (Sniffer) to capture packets. The Sniffer was implemented using the RTL2832U hardware and visualized in Wireshark, through GNU-Radio. Tests showed that data availability and confidentiality could be threatened through replay attacks with LoRa server verification using HackRF One and GNU-Radio hardware. Although the LoRaWAN specification has, frame counters to avoid replay attacks, under given the right conditions, this measure could be violated even deny service to the node on the server

Fibrosarcoma esplénico primario en un perro

Se describe un caso de fibrosarcoma esplénico primario, con metástasis múltiples, en un perro mestizo macho, de ocho años de edad. Clínicamente el animal presentaba un cuadro de insuficiencia hepática. Mediante la necropsia y el estudio histológico se llegó al diagnóstico definitivo.A case of primary splenic fibrosarcoma, with multiple metastasis, in a male eight-year old mixed-breed dog is described. The animal showed clinical signs corresponding with an hepatic failure. Necropsy and a subsequent histopathologic study lead to the final diagnosis

Establishment of criteria for the selection and adaptation of objectives and indicators in ISO9001:2008 quality system in a university pharmaceutical pilot plant

The authors want to thank Álex López from LOUFARM, S.L. for his support in drafting the article.Aims: The aim of this work is the correct establishment and follow-up of quality objectives and indicators as the cornerstones of a quality assurance system, in this case focused on ISO9001. Materials and methods: In this work, the authors present the criteria that, in their view, an organization must follow for a better selection and adaptation of the ISO9001:2008 quality system objectives and indicators applied to a university pharmaceutical pilot plant. The evolution of errors in setting objectives and indicators is assessed. Results: Based on the experience of several years at the SDM (Service of Development of Medicines) at the Faculty of Pharmacy of the University of Barcelona, the results show that the establishing of appropriate objectives and indicators is not an easy task. A careful selection of both objectives and indicators must be a compulsory step prior to the establishment of a robust, reliable quality assurance system through years. Conclusions: Experience over time proves to be a powerful tool to end up selecting the right quality objectives and indicators for such quality system. Since this task is not always easy to carry out, is necessary to set a selection of criteria in order to obtain useful information that contributes to the continuous improvement of the quality system.Objetivos: El objetivo de este trabajo es el correcto establecimiento y seguimiento de los objetivos de calidad y sus indicadores, como pilar fundamental de un sistema de garantía de calidad, en este caso centrado en ISO9001. Material y métodos: En este trabajo, los autores presentan los criterios que, a su juicio, una organización debe seguir para una mejor selección y adaptación de objetivos e indicadores en el marco de la norma de calidad ISO9001:2008, aplicada a una planta piloto farmacéutica universitaria. Se realiza una evaluación de los errores en el establecimiento de objetivos e indicadores. Resultados: En base a la experiencia de varios años en SDM (Servicio de Desarrollo del Medicamento) en la Facultad de Farmacia de la Universidad de Barcelona, los resultados muestran que el establecimiento de objetivos e indicadores apropiados no resulta una tarea sencilla. Una cuidadosa selección tanto de objetivos como de indicadores debe ser un paso obligado para el establecimiento de un sistema de aseguramiento de calidad robusto y fiable a lo largo del tiempo. Conclusiones: El aprendizaje basado en la experiencia de años demuestra ser una herramienta poderosa para acabar seleccionando los objetivos e indicadores correctos que se adapten al sistema de calidad en cuestión. Dado que este hecho no siempre resulta fácil, es necesario establecer unos criterios con el objetivo de obtener información útil que contribuya a la mejora continua del sistema de calidad

Adult cocaine-induced brain metabolic activation is altered in a sex-dependent manner by chronic periadolescent cannabinoid exposure in rats

[Poster] 4th European Molecular Imaging Meeting, Barcelona, Spain, May 27 - 30, 2009Cannabinoid exposure during the periadolescent period has been shown to augment the rates of cocaine self-administration in female but not male Wistar rats. However, how this cannabinoid history alters cocaine-induced brain activation remains unknownPublicad

MicroRNA-mediated differential expression of TRMU, GTPBP3 and MTO1 in cell models of mitochondrial-DNA diseases

Mitochondrial diseases due to mutations in the mitochondrial (mt) DNA are heterogeneous in clinical manifestations but usually include OXPHOS dysfunction. Mechanisms by which OXPHOS dysfunction contributes to the disease phenotype invoke, apart from cell energy deficit, maladaptive responses to mitochondria-to-nucleus retrograde signaling. Here we used five different cybrid models of mtDNA diseases to demonstrate that the expression of the nuclear-encoded mt-tRNA modification enzymes TRMU, GTPBP3 and MTO1 varies in response to specific pathological mtDNA mutations, thus altering the modification status of mt-tRNAs. Importantly, we demonstrated that the expression of TRMU, GTPBP3 and MTO1 is regulated by different miRNAs, which are induced by retrograde signals like ROS and Ca2+ via different pathways. Our data suggest that the up- or down-regulation of the mt-tRNA modification enzymes is part of a cellular response to cope with a stoichiometric imbalance between mtDNA- and nuclear-encoded OXPHOS subunits. However, this miRNA-mediated response fails to provide full protection from the OXPHOS dysfunction; rather, it appears to aggravate the phenotype since transfection of the mutant cybrids with miRNA antagonists improves the energetic state of the cells, which opens up options for new therapeutic approaches

Bose-Einstein condensate dark matter phase transition from finite temperature symmetry breaking of Klein-Gordon fields

In this paper the thermal evolution of scalar field dark matter particles at finite cosmological temperatures is studied. Starting with a real scalar field in a thermal bath and using the one loop quantum corrections potential, we rewrite Klein-Gordon's (KG) equation in its hydrodynamical representation and study the phase transition of this scalar field due to a Z_2 symmetry breaking of its potential. A very general version of a nonlinear Schr\"odinger equation is obtained. When introducing Madelung's representation, the continuity and momentum equations for a non-ideal SFDM fluid are formulated, and the cosmological scenario with the SFDM described in analogy to an imperfect fluid is then considered where dissipative contributions are obtained in a natural way.Additional terms appear compared to those obtained in the classical version commonly used to describe the \LambdaCDM model, i.e., the ideal fluid. The equations and parameters that characterize the physical properties of the system such as its energy, momentum and viscous flow are related to the temperature of the system, scale factor, Hubble's expansion parameter and the matter energy density. Finally, some details on how galaxy halos and smaller structures might be able to form by condensation of this SF are given.Comment: Substantial changes have been made to the paper, following the referees recommendations. 16 pages. Published in Classical and Quantum Gravit

Long-term effectiveness of sustainable land management practices to control runoff, soil erosion, and nutrient loss and the role of rainfall intensity in Mediterranean rainfed agroecosystems

Mediterranean environments are especially susceptible to soil erosion and to inappropriate soil management, leading to accelerated soil loss. Sustainable Land Management (SLM) practices (such as reduced tillage, no-tillage, cover crops, etc.,) have the potential to reduce soil, organic carbon (OC), and nutrient losses by erosion. However, the effectivity of these practices is site-dependent and varies under different rainfall conditions. The objective of this paper was to evaluate the effects of SLM practices in two rainfed systems (a wheat field and an almond orchard) representative of a large area of the driest Mediterranean regions - on runoff, soil erosion, particle size distribution, and OC and nutrient (N and P) contents in sediments. The influence of the rainfall characteristics on the effectiveness of the SLM practices was also evaluated. The SLM implemented were: reduced tillage (RT) in the wheat field and almond orchard and reduced tillage combined with green manure (RTG) in the almond orchard; these were compared to conventional tillage, the usual practice in the area. Open erosion plots were set up to monitor the effects of SLM on soil carbon and nutrients and on soil erosion after each rainfall event over six years (2010 2016). The results show that the SLM practices evaluated resulted in increased organic carbon (OC) and nutrients (N and P) contents in the soil, and reduced runoff, erosion, and mobilization of organic carbon and nutrients in sediments. Reductions in runoff of 30% and 65% and decreases in erosion of 65 and 85% were found in the wheat field and almond orchards, respectively. In addition, the total OC, N, and P losses in the wheat field were reduced by 56%, 45%, and 64%, respectively, while in the almond field the OC, N, and P losses were reduced by 90% under RT and by 85% under RTG. The beneficial effect of the SLM practices on soil erosion was observed within 18 months of their implementation and continued throughout the six years of the study. Furthermore, the effectiveness of tillage reduction with respect to erosion control and carbon and nutrients mobilization was highest during the most intense rainfall events, which are responsible for the highest erosion rates in Mediterranean areas. Our results support the key role of SLM practices under semiarid conditions as useful tools for climate change mitigation and adaptation, given the expected increase in high-intensity rainfall events in semiarid areas. © 2019 The AuthorsThis study site has been funded by several national (CYCIT AGL201125069//CICYT AGL2010-20941//CGL2013-42009-R//CGL2014-55-405-R), Regional (Séneca Foundation: 08757/PI/08//19350/PI/14), and European Commission H2020 (F6 DG RTD 037046 and Grant 728003, DIVERFARMING projects). Joris de Vente acknowledges support from a Ramón y Cajal research grant (RYC-2012-10375) and María Almagro was supported by the Juan de la Cierva Program (IJCI-2015-23500)

Lack of sex-related analysis and reporting in Cochrane Reviews : a cross-sectional study

Background: Sex-specific analysis and reporting may allow a better understanding of intervention effects and can support the decision-making process. Well-conducted systematic reviews (SRs), like those carried out by the Cochrane Collaboration, provide clinical responses transparently and stress gaps of knowledge. This study aimed to describe the extent to which sex is analysed and reported in a cross-section of Cochrane SRs of interventions, and assess the association with the gender of main authorships. Methods: We searched SRs published during 2018 within the Cochrane Database of Systematic Reviews. An investigator appraised the sex-related analysis and reporting across sections of SRs and collected data on gender and country of affiliation of the review first and last authors, and a second checked for accuracy. We conducted descriptive statistics and bivariate logistic regression to explore the association between the gender of the authors and sex-related analysis and reporting. Results: Six hundred and ten Cochrane SRs were identified. After removing those that met no eligibility criteria, 516 reviews of interventions were included. Fifty-six reviews included sex-related reporting in the abstract, 90 considered sex in their design, 380 provided sex-disaggregated descriptive data, 142 reported main outcomes or performed subgroup analyses by sex, and 76 discussed the potential impact of sex or the lack of such on the interpretations of findings. Women represented 53.1 and 42.2% of first and last authorships, respectively. Women authors (in first and last position) had a higher possibility to report sex in at least one of the review sections (OR 2.05; CI 95% 1.12-3.75, P=0.020) than having none. Conclusions: Sex consideration amongst Cochrane SRs was frequently missing. Structured guidance to sex-related analysis and reporting is needed to enhance the external validity of findings. Likewise, including gender diversity within the research workforce and relevant authorship positions may foster equity in the evidence generated