Seismotectonic setting at the North Anatolian Fault Zone after the 1999 Mw=7.4 Izmit earthquake based on high-resolution aftershock locations

International audienceThe most recent devastating earthquakes that occurred along the North Anatolian Fault Zone (NAFZ) in northwestern Turkey were the 1999 Izmit (Mw=7.4) and Düzce (Mw=7.1) events. In this study we present a catalog of Izmit aftershock hypocenters that was deduced from a network covering the entire 140 km long rupture of the mainshock. 7348 events with a location accuracy better than 5 km are analysed. Aftershocks were observed along the entire ruptured segment along a 20 km wide band of activity. Events are clustered in distinct regions and dominantly occur at 5 to 15 km depth. The eastern termination of the Izmit rupture is characterized by a sharp and steeply dipping boundary exactly where the Düzce mainshock initiated 87 days after the Izmit event. Relocation of the events using double-difference technology results in 4696 high-resolution hypocenters that allow resolving the internal structure of the seismically active areas with a resolution of 300 m (horizontal) and 400m (vertical). Below the Akyazi Plain, representing a small pull-apart structure at a triple junction of the NAFZ, we identify planes of activity that can be correlated with nodal planes of EW extensional normal faulting aftershocks. Along the easternmost Karadere-Düzce segment we identify the down-dip extension of the Karadere fault that hosted about 1 m of right-lateral coseismic slip. At the easternmost rupture we correlate a cloud-type distribution of seismic activity with the largest aftershocks in this area, a subevent of the Izmit mainshock and the Düzce mainshock that all have an almost identical focal mechanism. This part of the NAFZ is interpreted as a classical example of a seismic barrier along the fault

ML scale in Northwestern Turkey from 1999 Izmit aftershocks: updates

We present an update of the local magnitude scale previously calibrated for Northwestern Turkey by Baumbach et al. (2003). The path coverage in the westernmost part of the analysed area has been increased, as well as the number of amplitudes for distance greater than 110 km. Furthermore, a set of recordings from accelerometric stations operated by the Kandilli Observatory and Earthquake Research Institute (KOERI) has been merged with the recordings by the Sapanca-Bolu and GermanTaskForce seismological networks. In all, 4047 recordings from 528 earthquakes recorded by 31 seismometers and 23 accelerometers are considered to calibrate the local magnitude scale over a hypocentral distance range from 10 to 190 km. By analyzing the unit covariance matrix and the resolution matrix, we show how the source-to-station geometries of the seismic and strong motion networks affect the uncertainties of the computed station corrections, attenuation coefficients, and magnitudes. The assumptions made concerning the reference station correction, and the change in the amplification for the Wood-Anderson torsion seismograph from 2800 to 2080 (Uhrhammer and Collins, 1990) introduced an offset of about 0.34 in the magnitudes with respect to Baumbach et al. (2003), with the updated local magnitude scale ranges from 0.50 to 5.91. The distribution of the residuals with distance confirms that the extension of both the magnitude and distance ranges and the improved path coverage have preserved the high quality that characterized the data set analyzed by Baumbach et al. (2003)

ML scale in Northwestern Turkey from 1999 Izmit aftershock: updates

Abstract We present an update of the local magnitude scale previously calibrated for northwestern Turkey by Baumbach et al. (2003). The path coverage in the westernmost part of the analyzed area has been increased, as well as the number of amplitudes for distance greater than 110 km. Furthermore, a set of recordings from accelerometric stations operated by the Kandilli Observatory and Earthquake Research Institute (KOERI) has been merged with the recordings by the Sapanca-Bolu and German Task Force seismological networks. In all, 4047 recordings from 528 earthquakes recorded by 31 seismometers and 23 accelerometers are considered to calibrate the local magnitude scale over a hypocentral distance range from 10 to 190 km. By analyzing the unit covariance matrix and the resolution matrix, we show how the source-to-station geometries of the seismic and strong-motion networks affect the uncertainties of the computed station corrections, attenuation coefficients, and magnitudes. The assumptions made concerning the reference station correction, and the change in the amplification for the Wood–Anderson torsion seismograph from 2800 to 2080 (Uhrhammer and Collins, 1990) introduced an offset of about 0.34 in the magnitudes with respect to Baumbach et al. (2003), with the updated local magnitude scale ranges from 0.50 to 5.91. The distribution of the residuals with distance confirms that the extension of both the magnitude and distance ranges and the improved path coverage have preserved the high quality that characterized the data set analyzed by Baumbach et al. (2003)

Macrophage mal1 deficiency suppresses atherosclerosis in low-density lipoprotein receptor-null mice by activating peroxisome proliferator-activated receptor-γ-regulated genes

Objective- The adipocyte/macrophage fatty acid-binding proteins aP2 (FABP4) and Mal1 (FABP5) are intracellular lipid chaperones that modulate systemic glucose metabolism, insulin sensitivity, and atherosclerosis. Combined deficiency of aP2 and Mal1 has been shown to reduce the development of atherosclerosis, but the independent role of macrophage Mal1 expression in atherogenesis remains unclear. Methods and Results- We transplanted wild-type (WT), Mal1, or aP2 bone marrow into low-density lipoprotein receptor-null (LDLR) mice and fed them a Western diet for 8 weeks. Mal1→LDLR mice had significantly reduced (36%) atherosclerosis in the proximal aorta compared with control WT→LDLR mice. Interestingly, peritoneal macrophages isolated from Mal1-deficient mice displayed increased peroxisome proliferator-activated receptor-γ (PPARγ) activity and upregulation of a PPARγ-related cholesterol trafficking gene, CD36. Mal1 macrophages showed suppression of inflammatory genes, such as COX2 and interleukin 6. Mal1→LDLR mice had significantly decreased macrophage numbers in the aortic atherosclerotic lesions compared with WT→LDLR mice, suggesting that monocyte recruitment may be impaired. Indeed, blood monocytes isolated from Mal1→LDLR mice on a high-fat diet had decreased CC chemokine receptor 2 gene and protein expression levels compared with WT monocytes. Conclusion- Taken together, our results demonstrate that Mal1 plays a proatherogenic role by suppressing PPARγ activity, which increases expression of CC chemokine receptor 2 by monocytes, promoting their recruitment to atherosclerotic lesions. © 2011 American Heart Association, Inc

Deep generative modeling for single-cell transcriptomics.

Single-cell transcriptome measurements can reveal unexplored biological diversity, but they suffer from technical noise and bias that must be modeled to account for the resulting uncertainty in downstream analyses. Here we introduce single-cell variational inference (scVI), a ready-to-use scalable framework for the probabilistic representation and analysis of gene expression in single cells ( https://github.com/YosefLab/scVI ). scVI uses stochastic optimization and deep neural networks to aggregate information across similar cells and genes and to approximate the distributions that underlie observed expression values, while accounting for batch effects and limited sensitivity. We used scVI for a range of fundamental analysis tasks including batch correction, visualization, clustering, and differential expression, and achieved high accuracy for each task

Comparison of Characteristics and Outcomes of Trial Participants and Nonparticipants: Example of Blood and Marrow Transplant Clinical Trials Network 0201 Trial

Controversy surrounds the question of whether clinical trial participants have better outcomes than comparable patients who are not treated on a trial. We explored this question using a recent large, randomized, multi-center study comparing peripheral blood (PB) with bone marrow (BM) transplantation from unrelated donors (URD), conducted by the Blood and Marrow Transplant Clinical Trials Network (BMT CTN)

Estimation of hazardous waste factors

The first step of establishing a reliable waste inventory is the determination of waste factors. This study presents a detailed survey for the estimation of waste factors from different manufacturing sectors. Waste factors were obtained in units of “tons of hazardous waste generated per 1 ton of production of related industry” using waste generation figures given by Turkish Statistics Institute (TURKSTAT) and production figures given by The Union of Chambers and Commodity Exchanges of Turkey (TOBB). Estimated waste factors were cross-checked with the information obtained from field surveys conducted for basic metal and metal finishing industries. The hazardous waste factors obtained from TURSTAT and TOBB data for Basic Metal Industries (37) and Manufacture of Fabricated Metal Products, Machinery and Equipment (38) are 0.0035 and 0.0068, respectively. From the field surveys, the average hazardous waste factor of eight facilities in category (37) is estimated as 0.054 and that for six facilities in category (38) is determined as 0.007. In a parallel evaluation, hazardous waste factors obtained from production and waste generation figures declared by nine facilities in Basic Metal category (37) and 16 facilities in Metal Finishing category (38) are calculated as 0.017 and 0.012, respectively. These varying results indicate that for reliable waste factors estimation, hazardous waste generation and production figures of the industries should be attained correctly and checked with various data obtained from different sources before they are used for establishing the waste inventories. © 2011 Taylor & Francis Group, LLC

Seismotectonic setting at the North Anatolian Fault Zone after the 1999 Mw=7.4 Izmit earthquake based on high-resolution aftershock locations

The most recent devastating earthquakes that occurred along the North Anatolian Fault Zone (NAFZ) in northwestern Turkey were the 1999 Izmit (Mw=7.4) and Düzce (Mw=7.1) events. In this study we present a catalog of Izmit aftershock hypocenters that was deduced from a network covering the entire 140 km long rupture of the mainshock. 7348 events with a location accuracy better than 5 km are analysed. Aftershocks were observed along the entire ruptured segment along a 20 km wide band of activity. Events are clustered in distinct regions and dominantly occur at 5 to 15 km depth. The eastern termination of the Izmit rupture is characterized by a sharp and steeply dipping boundary exactly where the Düzce mainshock initiated 87 days after the Izmit event. Relocation of the events using double-difference technology results in 4696 high-resolution hypocenters that allow resolving the internal structure of the seismically active areas with a resolution of 300 m (horizontal) and 400m (vertical). Below the Akyazi Plain, representing a small pull-apart structure at a triple junction of the NAFZ, we identify planes of activity that can be correlated with nodal planes of EW extensional normal faulting aftershocks. Along the easternmost Karadere-Düzce segment we identify the down-dip extension of the Karadere fault that hosted about 1 m of right-lateral coseismic slip. At the easternmost rupture we correlate a cloud-type distribution of seismic activity with the largest aftershocks in this area, a subevent of the Izmit mainshock and the Düzce mainshock that all have an almost identical focal mechanism. This part of the NAFZ is interpreted as a classical example of a seismic barrier along the fault