589 research outputs found
The bactericidal activity of moxifloxacin in patients with pulmonary tuberculosis
Patients in whom acid-fast bacilli smear-positive pulmonary tuberculosis was newly diagnosed were randomized to receive 400 mg moxifloxacin, 300 mg isonaizid, or 600 mg rifampin daily for 5 days. Sixteen-hour overnight sputa collections were made for the 2 days before and for 5 days of monotherapy. Bactericidal activity was estimated by the time taken to kill 50% of viable bacilli (vt(50)) and the fall in sputum viable count during the first 2 days designated as the early bactericidal activity (EBA). The mean vt(50) of moxifloxacin was 0.88 days (95% confidence interval [Cl], 0.43-1.33 days) and the mean EBA was 0.53 (95% CI 0.28-0.79). For the isoniazid group, the mean vt(50) was 0.46 days (95% Cl, 0.31-0.61 days) and the mean EBA was 0.77 (95% Cl, 0.54-1.00). For rifampin, the mean vt(50) was 0.71 days (95% Cl, 0.48-0.95 days) and the mean EBA was 0.28 (95% Cl, 0.15-0.41). Using the EBA method, isoniazid was significantly more active than rifampin (p < 0.01) but not moxifloxacin. Using the vt(50) method, isoniazid was more active than both rifampin and moxifloxacin (p = 0.03). Moxifloxacin has an activity similar to rifampin in human subjects with pulmonary tuberculosis, suggesting that it should undergo further assessment as part of a short course regimen for the treatment of drug-susceptible tuberculosis
Quantitative Spectroscopy of Supernovae for Dark Energy Studies
Detailed quantitative spectroscopy of Type Ia supernovae (SNe~Ia) provides
crucial information needed to minimize systematic effects in both ongoing SNe
Ia observational programs such as the Nearby Supernova Factory, ESSENCE, and
the SuperNova Legacy Survey (SNLS) and in proposed JDEM missions such as SNAP,
JEDI, and DESTINY.
Quantitative spectroscopy is mandatory to quantify and understand the
observational strategy of comparing ``like versus like''. It allows us to
explore evolutionary effects, from variations in progenitor metallicity to
variations in progenitor age, to variations in dust with cosmological epoch. It
also allows us to interpret and quantify the effects of asphericity, as well as
different amounts of mixing in the thermonuclear explosion.Comment: White paper submitted to the Dark Energy Task Force, 13 pages, 5
figure
Multi-layered Spectral Formation in SNe Ia Around Maximum Light
We use the radiative transfer code PHOENIX to study the line formation of the
wavelength region 5000-7000 Angstroms. This is the region where the SNe Ia
defining Si II feature occurs. This region is important since the ratio of the
two nearby silicon lines has been shown to correlate with the absolute blue
magnitude. We use a grid of LTE synthetic spectral models to investigate the
formation of line features in the spectra of SNe Ia. By isolating the main
contributors to the spectral formation we show that the ions that drive the
spectral ratio are Fe III, Fe II, Si II, and S II. While the first two strongly
dominate the flux transfer, the latter two form in the same physical region
inside of the supernova. We also show that the naive blackbody that one would
derive from a fit to the observed spectrum is far different than the true
underlying continuum.Comment: 35 pages, 15 figures, ApJ (2008) 684 in pres
Effects of Age and Gender on Physical Performance
Our purpose was to examine the effects of age and gender on physical performance. We assessed a one-hour swimming performance and participation of 4,271 presumably healthy men and women, aged 19–91 years, from the 2001–2003 United States Masters Swimming long-distance (1 h) national competition. The decline in performance with increasing age was found to be quadratic rather than linear. The equation which best fit variation in 1 h swimming distance in meters (m) according to variations in age in years (y) in men was: distance (m) = 4058 + 2.18 age−0.29 age (http://www.acsmmsse.org/pt/re/msse/positionstandards.htm;jsessionid=DiRVACC7YS3mq27s5kV3vwpEVSokmmD1ZJLC7pdnol3KcfoSu0t!1096311956!-949856145!9001!-1), with the same equation for women except that 380 m needed to be subtracted from the calculated value at all ages (about a 10% difference). There was a large overlap in performance between men and women. The overall mean decline in performance with age was about 50% and was parallel in men and women. The mean difference in distance for a 1-year increment in age was −9.7 m at 21 y of age, −21.3 m at 40 y, and −44.5 m at 80 y. Far greater declines of about 96% in numbers participating with advanced age (80 y and over, 4% of peak numbers) were observed than in the 40–49 y age group. In conclusion, the declines in performance were parallel in men and women at all ages, and the 1-year age-related declines in performance were about twice as great at 40 y and more than four-times as great at 80 y than at 20 y of age, with even greater age-related declines in participation being noted for both men and women
Time-dependent radiative transfer with PHOENIX
Aims. We present first results and tests of a time-dependent extension to the
general purpose model atmosphere code PHOENIX. We aim to produce light curves
and spectra of hydro models for all types of supernovae. Methods. We extend our
model atmosphere code PHOENIX to solve time-dependent non-grey, NLTE, radiative
transfer in a special relativistic framework. A simple hydrodynamics solver was
implemented to keep track of the energy conservation of the atmosphere during
free expansion. Results. The correct operation of the new additions to PHOENIX
were verified in test calculations. Conclusions. We have shown the correct
operation of our extension to time-dependent radiative transfer and will be
able to calculate supernova light curves and spectra in future work.Comment: 7 pages, 12 figure
State-Dependent Computation Using Coupled Recurrent Networks
Although conditional branching between possible behavioral states is a hallmark of intelligent behavior, very little is known about the neuronal mechanisms that support this processing. In a step toward solving this problem, we demonstrate by theoretical analysis and simulation how
networks of richly interconnected neurons, such as those observed in the superficial layers of the neocortex, can embed reliable, robust finite state machines. We show how a multistable neuronal network containing a number of states can be created very simply by coupling two recurrent
networks whose synaptic weights have been configured for soft winner-take-all (sWTA) performance. These two sWTAs have simple, homogeneous, locally recurrent connectivity except for a small fraction of recurrent cross-connections between them, which are used to embed the required states. This coupling between the maps allows the network to continue to express the current state even after the input that elicited that state iswithdrawn. In addition, a small number of transition neurons implement the necessary input-driven transitions between the embedded states. We provide simple rules to systematically design and construct neuronal state machines of this kind. The significance of our finding is that it offers a method whereby the cortex could construct networks supporting a broad range of sophisticated processing by applying only small specializations to the same generic neuronal circuit
Evolving Monolithic Robot Controllers through Incremental Shaping
Evolutionary robotics has been shown to be an effective technique for generating robot behaviors that are difficult to derive analytically from the robot’s mechanics and task environment. Moreover, augmenting evolutionary algorithms with environmental scaffolding via an incremental shaping method makes it possible to evolve controllers for complex tasks that would otherwise be infeasible. In this paper we present a summary of two recent publications in the evolutionary robotics literature demonstrating how these methods can be used to evolve robot controllers for non-trivial tasks, what the obstacles are in evolving controllers in this way, and present a novel research question that can be investigated under this framework
Spectral Modeling of SNe Ia Near Maximum Light: Probing the Characteristics of Hydro Models
We have performed detailed NLTE spectral synthesis modeling of 2 types of 1-D
hydro models: the very highly parameterized deflagration model W7, and two
delayed detonation models. We find that overall both models do about equally
well at fitting well observed SNe Ia near to maximum light. However, the Si II
6150 feature of W7 is systematically too fast, whereas for the delayed
detonation models it is also somewhat too fast, but significantly better than
that of W7. We find that a parameterized mixed model does the best job of
reproducing the Si II 6150 line near maximum light and we study the differences
in the models that lead to better fits to normal SNe Ia. We discuss what is
required of a hydro model to fit the spectra of observed SNe Ia near maximum
light.Comment: 29 pages, 14 figures, ApJ, in pres
Environmental Influence on the Evolution of Morphological Complexity in Machines
Whether, when, how, and why increased complexity evolves in biological populations is a longstanding open question. In this work we combine a recently developed method for evolving virtual organisms with an information-theoretic metric of morphological complexity in order to investigate how the complexity of morphologies, which are evolved for locomotion, varies across different environments. We first demonstrate that selection for locomotion results in the evolution of organisms with morphologies that increase in complexity over evolutionary time beyond what would be expected due to random chance. This provides evidence that the increase in complexity observed is a result of a driven rather than a passive trend. In subsequent experiments we demonstrate that morphologies having greater complexity evolve in complex environments, when compared to a simple environment when a cost of complexity is imposed. This suggests that in some niches, evolution may act to complexify the body plans of organisms while in other niches selection favors simpler body plans
The DICE calibration project: design, characterization, and first results
We describe the design, operation, and first results of a photometric
calibration project, called DICE (Direct Illumination Calibration Experiment),
aiming at achieving precise instrumental calibration of optical telescopes. The
heart of DICE is an illumination device composed of 24 narrow-spectrum,
high-intensity, light-emitting diodes (LED) chosen to cover the
ultraviolet-to-near-infrared spectral range. It implements a point-like source
placed at a finite distance from the telescope entrance pupil, yielding a flat
field illumination that covers the entire field of view of the imager. The
purpose of this system is to perform a lightweight routine monitoring of the
imager passbands with a precision better than 5 per-mil on the relative
passband normalisations and about 3{\AA} on the filter cutoff positions. The
light source is calibrated on a spectrophotometric bench. As our fundamental
metrology standard, we use a photodiode calibrated at NIST. The radiant
intensity of each beam is mapped, and spectra are measured for each LED. All
measurements are conducted at temperatures ranging from 0{\deg}C to 25{\deg}C
in order to study the temperature dependence of the system. The photometric and
spectroscopic measurements are combined into a model that predicts the spectral
intensity of the source as a function of temperature. We find that the
calibration beams are stable at the level -- after taking the slight
temperature dependence of the LED emission properties into account. We show
that the spectral intensity of the source can be characterised with a precision
of 3{\AA} in wavelength. In flux, we reach an accuracy of about 0.2-0.5%
depending on how we understand the off-diagonal terms of the error budget
affecting the calibration of the NIST photodiode. With a routine 60-mn
calibration program, the apparatus is able to constrain the passbands at the
targeted precision levels.Comment: 25 pages, 27 figures, accepted for publication in A&
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