528 research outputs found
Review of Clinical Trials Using Neural Stem Cells
The use of stem cells in clinical trials started several years ago for regenerativebased therapies or for the treatment of tumours. After brain injuries or neurodegenerative diseases, neural stem cells represent a promising strategy to repair the affected tissue and to replace degenerative cells. Neural stem cells can migrate and differentiate into neurons, astrocytes and oligodendrocytes, and thus could serve as promising therapeutic solutions. However, these cells can represent a potential source of cancer stem cells in tumour brain where they are responsible of recurrence, invasiveness and resistance to current treatments. Thus, few clinical trials involving endogenous, genetically modifiedor derived-neural stem cells have been conducted in the world to treat brain disorders. According to the website www.clinicaltrials.gov only 37 clinical trials involving neural stem cells are listed. Most of them use derived-neural stem cells to treat brain disorders (neurodegenerative diseases, injuries or tumours). For the future, a better approach would be to target directly endogenous stem cells.
Composition-Dependent Passivation Efficiency at the CdS/CuIn1-xGaxSe2 Interface
International audienc
Cu(In,Ga)Se2 absorber thinning and the homo-interface model: Influence of Mo back contact and 3-stage process on device characteristics
Thinning the absorber layer is one of the possibilities envisaged to further decrease the production costs of Cu(In,Ga)Se2 (CIGSe) thin films solar cell technology. In the present study, the electronic transport in submicron CIGSe-based devices has been investigated and compared to that of standard devices. It is observed that when the absorber is around 0.5 μm-thick, tunnelling enhanced interface recombination dominates, which harms cells energy conversion efficiency. It is also shown that by varying either the properties of the Mo back contact or the characteristics of 3-stage growth processing, one can shift the dominating recombination mechanism from interface to space charge region and thereby improve the cells efficiency. Discussions on these experimental facts led to the conclusions that 3-stage process implies the formation of a CIGSe/CIGSe homo-interface, whose location as well as properties rule the device operation; its influence is enhanced in submicron CIGSe based solar cells
Two-nucleon knockout contributions to the C reaction in the dip and {}(1232) regions
The contributions from C and C to the
semi-exclusive C cross section have been calculated in an
unfactorized model for two-nucleon emission. We assume direct two-nucleon
knockout after virtual photon coupling with the two-body pion-exchange currents
in the target nucleus. Results are presented at several kinematical conditions
in the dip and (1232) regions. The calculated two-nucleon knockout
strength is observed to account for a large fraction of the measured
strength above the two-nucleon emission threshold.Comment: 12 Revtex pages, 4 postscript figures (available upon request),
University of Gent preprint SSF94-02-0
Inelastic nucleon contributions in nuclear response functions
We estimate the contribution of inelastic nucleon excitations to the
inclusive cross section in the CEBAF kinematic range.
Calculations are based upon parameterizations of the nucleon structure
functions measured at SLAC. Nuclear binding effects are included in a
vector-scalar field theory, and are assumed have a minimal effect on the
nucleon excitation spectrum. We find that for q\lsim 1 GeV the elastic and
inelastic nucleon contributions to the nuclear response functions are
comparable, and can be separated, but with roughly a factor of two uncertainty
in the latter from the extrapolation from data. In contrast, for q\rsim 2 GeV
this uncertainty is greatly reduced but the elastic nucleon contribution is
heavily dominated by the inelastic nucleon background.Comment: 20 pages, 7 figures available from the authors at Department of
Physics and Astronomy, University of Rochester, Rochester NY 1462
Nuclear model effects in Charged Current neutrino--nucleus quasielastic scattering
The quasielastic scattering of muon neutrinos on oxygen 16 is studied for
neutrino energies between 200 MeV and 1 GeV using a relativistic shell model.
Final state interactions are included within the distorted wave impulse
approximation, by means of a relativistic optical potential, with and without
imaginary part, and of a relativistic mean field potential. For comparison with
experimental data the inclusive charged--current quasielastic cross section for
-- scattering in the kinematical conditions of the LSND
experiment at Los Alamos is also presented and briefly discussed.Comment: 4 pages, 5 figures, two-column format. Accepted as brief report in
Phys. Rev.
Extended Superscaling of Electron Scattering from Nuclei
An extended study of scaling of the first and second kinds for inclusive
electron scattering from nuclei is presented. Emphasis is placed on the
transverse response in the kinematic region lying above the quasielastic peak.
In particular, for the region in which electroproduction of resonances is
expected to be important, approximate scaling of the second kind is observed
and the modest breaking of it is shown probably to be due to the role played by
an inelastic version of the usual scaling variable.Comment: LaTeX, 36 pages including 5 color postscript figures and 4 postscript
figure
What makes re-finding information difficult? A study of email re-finding
Re-nding information that has been seen or accessed before is a task which can be relatively straight-forward, but often it can be extremely challenging, time-consuming and frustrating. Little is known, however, about what makes one re-finding task harder or easier than another. We performed a user study to learn about the contextual factors that influence users' perception of task diculty in the context of re-finding email messages. 21 participants were issued re-nding tasks to perform on their own personal collections. The participants' responses to questions about the tasks combined with demographic data and collection statistics for the experimental population provide a rich basis to investigate the variables that can influence the perception of diculty. A logistic regression model was developed to examine the relationships be- tween variables and determine whether any factors were associated with perceived task diculty. The model reveals strong relationships between diculty and the time lapsed since a message was read, remembering when the sought-after email was sent, remembering other recipients of the email, the experience of the user and the user's ling strategy. We discuss what these findings mean for the design of re-nding interfaces and future re-finding research
High-spin states with seniority v=4,4,6 in 119-126Sn
The 119-126Sn nuclei have been produced as fission fragments in two reactions
induced by heavy ions: 12C+238U at 90 MeV bombarding energy, 18O+208Pb at 85
MeV. Their level schemes have been built from gamma rays detected using the
Euroball array. High-spin states located above the long-lived isomeric states
of the even- and odd-A 120-126Sn nuclei have been identified. Moreover isomeric
states lying around 4.5 MeV have been established in 120,122,124,126Sn from the
delayed coincidences between the fission fragment detector SAPhIR and the
Euroball array. The states located above 3-MeV excitation energy are ascribed
to several broken pairs of neutrons occupying the nu h11/2 orbit. The maximum
value of angular momentum available in such a high-j shell, i.e. for
mid-occupation and the breaking of the three neutron pairs, has been
identified. This process is observed for the first time in spherical nuclei.Comment: 20 pages, 22 figures, 12 tables, accepted for publication in Physical
Review
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