Obesity Induces Hypothalamic Endoplasmic Reticulum Stress and Impairs Proopiomelanocortin (POMC) Post-translational Processing

It was shown previously that abnormal prohormone processing or inactive proconverting enzymes that are responsible for this processing cause profound obesity. Our laboratory demonstrated earlier that in the diet-induced obesity (DIO) state, the appetite-suppressing neuropeptide -melanocyte-stimulating hormone ( -MSH) is reduced, yet the mRNA of its precursor protein proopiomelanocortin (POMC) remained unaltered. It was also shown that the DIO condition promotes the development of endoplasmic reticulum (ER) stress and leptin resistance. In the current study, using an in vivo model combined with in vitro experiments, we demonstrate that obesity-induced ER stress obstructs the post-translational processing of POMC by decreasing proconverting enzyme 2, which catalyzes the conversion of adrenocorticotropin to -MSH, thereby decreasing -MSH peptide production. This novel mechanism of ER stress affecting POMC processing in DIO highlights the importance of ER stress in regulating central energy balance in obesity.Fil: Cakir, Isin. Brown University; Estados UnidosFil: Cyr, Nicole E.. Brown University; Estados UnidosFil: Perello, Mario. Brown University; Estados Unidos. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Litvinov, Bogdan Patedakis. Brown University; Estados UnidosFil: Romero, Amparo. Brown University; Estados UnidosFil: Stuart, Ronald C.. Brown University; Estados UnidosFil: Nillni, Eduardo A.. Brown University; Estados Unido

Observation of Non-Exponential Orbital Electron Capture Decays of Hydrogen-Like 140^{140}Pr and 142^{142}Pm Ions

We report on time-modulated two-body weak decays observed in the orbital electron capture of hydrogen-like $^{140}$Pr$^{59+}$ and $^{142}$Pm$^{60+}$ ions coasting in an ion storage ring. Using non-destructive single ion, time-resolved Schottky mass spectrometry we found that the expected exponential decay is modulated in time with a modulation period of about 7 seconds for both systems. Tentatively this observation is attributed to the coherent superposition of finite mass eigenstates of the electron neutrinos from the weak decay into a two-body final state.Comment: 12 pages, 5 figure

On differential equation on four-point correlation function in the Conformal Toda Field Theory

The properties of completely degenerate fields in the Conformal Toda Field Theory are studied. It is shown that a generic four-point correlation function that contains only one such field does not satisfy ordinary differential equation in contrast to the Liouville Field Theory. Some additional assumptions for other fields are required. Under these assumptions we write such a differential equation and solve it explicitly. We use the fusion properties of the operator algebra to derive a special set of three-point correlation function. The result agrees with the semiclassical calculations.Comment: 5 page

Application of the RMF mass model to the r-process and the influence of mass uncertainties

A new mass table calculated by the relativistic mean field approach with the state-dependent BCS method for the pairing correlation is applied for the first time to study r-process nucleosynthesis. The solar r-process abundance is well reproduced within a waiting-point approximation approach. Using an exponential fitting procedure to find the required astrophysical conditions, the influence of mass uncertainty is investigated. R-process calculations using the FRDM, ETFSI-Q and HFB-13 mass tables have been used for that purpose. It is found that the nuclear physical uncertainty can significantly influence the deduced astrophysical conditions for the r-process site. In addition, the influence of the shell closure and shape transition have been examined in detail in the r-process simulations.Comment: to be published in Phys. Rev. C, 22 pages, 9 figure

q-Legendre Transformation: Partition Functions and Quantization of the Boltzmann Constant

In this paper we construct a q-analogue of the Legendre transformation, where q is a matrix of formal variables defining the phase space braidings between the coordinates and momenta (the extensive and intensive thermodynamic observables). Our approach is based on an analogy between the semiclassical wave functions in quantum mechanics and the quasithermodynamic partition functions in statistical physics. The basic idea is to go from the q-Hamilton-Jacobi equation in mechanics to the q-Legendre transformation in thermodynamics. It is shown, that this requires a non-commutative analogue of the Planck-Boltzmann constants (hbar and k_B) to be introduced back into the classical formulae. Being applied to statistical physics, this naturally leads to an idea to go further and to replace the Boltzmann constant with an infinite collection of generators of the so-called epoch\'e (bracketing) algebra. The latter is an infinite dimensional noncommutative algebra recently introduced in our previous work, which can be perceived as an infinite sequence of "deformations of deformations" of the Weyl algebra. The generators mentioned are naturally indexed by planar binary leaf-labelled trees in such a way, that the trees with a single leaf correspond to the observables of the limiting thermodynamic system

Oil-free control systems of steam turbines

В статье рассмотрены перспективные системы автоматического регулирования паровых турбин на базе электромеханических приводов. Описано применение клапана с электромеханическим приводом в качестве регулирующего органа на лини дополнительного отбора пара из турбины. Рассмотрена возможность применения электромеханических приводов в качестве привода стопорного и регулирующих клапанов высокого давления.In article perspective control systems of steam turbines on the basis of electromechanical drives are considered. Use of the valve with the electromechanical drive as regulator on additional steam extraction from the turbine is described. The possibility of use of electromechanical drives as drive for high pressure stop and control valves is considered

Optical Conductivity of Ferromagnetic Semiconductors

The dynamical mean field method is used to calculate the frequency and temperature dependent conductivity of dilute magnetic semiconductors. Characteristic qualitative features are found distinguishing weak, intermediate, and strong carrier-spin coupling and allowing quantitative determination of important parameters defining the underlying ferromagnetic mechanism

The Experimental WSN Network for Underground Monitoring H2 Abundance in the Mine Atmosphere Karnasurt Mine Lovozero Layered Alkaline Intrusion

We have developed specialized equipment based on mini-MDM hydrogen sensors and the WSN telecommunication technology for long-term monitoring of hydrogen content in the environment. Unlike existing methods, the developed equipment makes it possible to carry out measurements directly in the explosion zone with high discreteness in time. This equipment was tested at a large rare-earth deposit of the Lovozero Alkaline Pluton Karnasurt in the underground mining tunnel. We observed a short time very high concentration of hydrogen in the atmosphere (more than 3 orders of normal atmosphere concentration). This discovery is very important because at the time of the explosion one can create abnormally high concentrations of explosive mixtures of hydrocarbon gases that can lead to accidents. The high resolving power of the measurement equipment makes it possible to determine the shape of the anomaly hydrogen of such a concentration and to calculate the volumes of hydrogen released from the rocks, at first time in the practice. The shape of the anomaly usually consists of 2-3 additional peaks of the shape - "dragon-head-like peak". We make an first attempt is made to explain this form of anomaly in the article. The aim of the work in the estimation hydrogen emission in mining ore deposit rare earth elements