234 research outputs found
The role of the genetic counsellor: a systematic review of research evidence
In Europe, genetic counsellors are employed in specialist genetic centres or other specialist units. According to the European Board of Medical Genetics, the genetic counsellor must fulfil a range of roles, including provision of information and facilitation of psychosocial adjustment of the client to their genetic status and situation. To evaluate the extent to which genetic counsellors fulfil their prescribed roles, we conducted a systematic review of the published relevant scientific evidence. We searched five relevant electronic databases (Medline, CINAHL, SocIndex, AMED and PsychInfo) using relevant search terms and handsearched four subject-specific journals for research-based papers published in English between 1 January 2000 and 30 June 2013. Of 419 potential papers identified initially, seven satisfied the inclusion criteria for the review. Themes derived from the thematic analysis of the data were: (i) rationale for genetic counsellors to provide care, (ii) appropriate roles and responsibilities and (iii) the types of conditions included in the genetic counsellor caseload. The findings of this systematic review indicate that where genetic counsellors are utilised in specialist genetic settings, they undertake a significant workload associated with direct patient care and this appears to be acceptable to patients. With the burden on genetic services, there is an argument for the increased use of genetic counsellors in countries where they are under-utilised. In addition, roles undertaken by genetic counsellors in specialist genetic settings could be adapted to integrate genetic counsellors into multi-disciplinary teams in other specialisms
A Dispersive Backend Design for the 'Double-Fourier' Interferometer BETTII
BETTII (Balloon Experimental Twin Telescope for Infra-red Interferometry) is designed to provide high angular resolution spectroscopic data in the far-infrared (FIR) wavelengths. The most significant limitation for BETTII is its sensitivity; obtaining spectral signal-to-noise ratio greater than 5 in less than 10 minutes requires sources greater than 13 Janskys (Jy). One possible way to improve the signal-to-noise ratio (SNR) for future BETTII flights is by reducing the spectral bandwidth post beam-combination. This involves using a dispersive element to spread out a polychromatic point source PSF (Point Spread Function) on the detector array, such that each pixel corresponds to a small fraction of the bandwidth. This results in a broader envelope of the interferometric fringe pattern allowing more fringes to be detected, and thereby improving the spectral SNR. Here we present the analysis and optical design of the dispersive backend, discussing the tradeoffs and how it can be combined with the existing design
The Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII): First Flight
The Balloon Experimental Twin Telescope for Infrared Interferometry (BETTII) is an 8-meter far-infrared (30-100 m) double-Fourier Michelson interferometer designed to fly on a high altitude scientific balloon. The project began in 2011, and the payload was declared ready for flight in September 2016. Due to bad weather, the first flight was postponed until June 2017; BETTII was successfully launched on June 8, 2017 for an engineering flight. Over the course of the one night flight, BETTII acquired a large amount of technical data that we are using to characterize the payload. Unfortunately, the flight ended with an anomaly that resulted in destruction of the payload. In this paper, we will discuss the path to BETTII flight, the results of the first flight, and some of the plans for the future
Measurements of the Temperature and E-Mode Polarization of the CMB from 500 Square Degrees of SPTpol Data
We present measurements of the -mode polarization angular auto-power
spectrum () and temperature--mode cross-power spectrum () of the
cosmic microwave background (CMB) using 150 GHz data from three seasons of
SPTpol observations. We report the power spectra over the spherical harmonic
multipole range , and detect nine acoustic peaks in the
spectrum with high signal-to-noise ratio. These measurements are the most
sensitive to date of the and power spectra at and , respectively. The observations cover 500 deg, a fivefold increase
in area compared to previous SPTpol analyses, which increases our sensitivity
to the photon diffusion damping tail of the CMB power spectra enabling tighter
constraints on \LCDM model extensions. After masking all sources with
unpolarized flux mJy we place a 95% confidence upper limit on residual
polarized point-source power of at , suggesting that the damping tail
dominates foregrounds to at least with modest source masking. We
find that the SPTpol dataset is in mild tension with the model
(), and different data splits prefer parameter values that differ
at the level. When fitting SPTpol data at we
find cosmological parameter constraints consistent with those for
temperature. Including SPTpol data at results in a preference for
a higher value of the expansion rate (H_0 = 71.3 \pm
2.1\,\mbox{km}\,s^{-1}\mbox{Mpc}^{-1} ) and a lower value for present-day
density fluctuations ().Comment: Updated to match version accepted to ApJ. 34 pages, 17 figures, 6
table
Targeting of radiolabeled J591 antibody to PSMA-expressing tumors: optimization of imaging and therapy based on non-linear compartmental modeling
Fourier Analysis of Correlated Monte Carlo Importance Sampling
International audienceFourier analysis is gaining popularity in image synthesis, as a tool for the analysis of error in Monte Carlo (MC) integration. Still, existing tools are only able to analyze convergence under simplifying assumptions (such as randomized shifts) which are not applied in practice during rendering. We reformulate the expressions for bias and variance of sampling-based integrators to unify non-uniform sample distributions (importance sampling) as well as correlations between samples while respecting finite sampling domains. Our unified formulation hints at fundamental limitations of Fourier-based tools in performing variance analysis for MC integration. This non-trivial exercise also provides exciting insight into the effects of importance sampling on the convergence rate of estimators because of the introduction or removal of discontinuities. Specifically, we demonstrate that the convergence of multiple importance sampling (MIS) is determined by the strategy that converges slowest. We propose two simple and practical approaches to limit the impact of discontinuities on the convergence rate of estimators: The first one involves mirroring the integrand to cancel out the effect of boundary discontinuities. This is followed by two novel mirror sampling techniques for MC estimation in this mirrored domain. The second approach improves direct illumination light sampling by smoothing out discontinuities within the domain at the cost of introducing a small amount of bias. Our approaches are simple, practical and can be easily incorporated in production renderers
TGF-beta(2)- and H2O2-Induced Biological Changes in Optic Nerve Head Astrocytes Are Reduced by the Antioxidant Alpha-Lipoic Acid
Background/Aims: The goal of the present study was to determine whether transforming growth factor-beta(2) (TGF-beta(2))- and oxidative stress-induced cellular changes in cultured human optic nerve head (ONH) astrocytes could be reduced by pretreatment with the antioxidant alpha-lipoic acid (LA). Methods: Cultured ONH astrocytes were treated with 1.0 ng/ml TGF-beta(2) for 24 h or 200 mu M hydrogen peroxide (H2O2) for 1 h. Lipid peroxidation was measured by a decrease in cis-pari-naric acid fluorescence. Additionally, cells were pretreated with different concentrations of LA before TGF-beta 2 or H2O2 exposure. Expressions of the heat shock protein (Hsp) alpha B-crystallin and Hsp27, the extracellular matrix (ECM) component fibronectin and the ECM-modulating protein connective tissue growth factor (CTGF) were examined with immunohistochemistry and real-time PCR analysis. Results: Both TGF-beta(2) and H2O2 increased lipid peroxidation. Treatment of astrocytes with TGF-beta(2) and H2O2 upregulated the expression of alpha B-crystallin, Hsp27, fibronectin and CTGF. Pretreatment with different concentrations of LA reduced the TGF-beta(2)- and H2O2-stimulated gene expressions. Conclusion: We showed that TGF-beta(2)- and H2O2-stimulated gene expressions could be prevented by pretreatment with the antioxidant LA in cultured human ONH astrocytes. Therefore, it is tempting to speculate that the use of antioxidants could have protective effects in glaucomatous optic neuropathy. Copyright (C) 2012 S. Karger AG, Base
- …