Ice polyamorphism in the minimal Mercedes-Benz model of water

We investigate ice polyamorphism in the context of the two-dimensional Mercedes-Benz model of water. We find a first-order phase transition between a crystalline phase and a high-density amorphous phase. Furthermore, we find a reversible transformation between two amorphous structures of high and low density; however, we find this to be a continuous and not an abrupt transition, as the low-density amorphous phase does not show structural stability. We discuss the origin of this behavior and its implications with regard to the minimal generic modeling of polyamorphism. © 2012 American Institute of Physics.Simulations were performed at the IFISC’s Nuredduna highthroughput computing clusters, supported by the projects GRID-CSIC and FISICOS (FIS2007-60327, funded by the Spanish MINCNN and the ERDF). J.H.E.C. acknowledges MINCINN (Spain) Project No. FIS2010-22322-528C02-02. O.P. and P.A.S. acknowledge MINCINN (Spain) Project No. FIS2010-22322-528C02-01.Peer Reviewe

Exploiting the neutronization burst of a galactic supernova

One of the robust features found in simulations of core-collapse supernovae (SNe) is the prompt neutronization burst, i.e. the first $\sim 25$ milliseconds after bounce when the SN emits with very high luminosity mainly $\nu_e$ neutrinos. We examine the dependence of this burst on variations in the input of current SN models and find that recent improvements of the electron capture rates as well as uncertainties in the nuclear equation of state or a variation of the progenitor mass have only little effect on the signature of the neutronization peak in a megaton water Cherenkov detector for different neutrino mixing schemes. We show that exploiting the time-structure of the neutronization peak allows one to identify the case of a normal mass hierarchy and large 13-mixing angle $\theta_{13}$, where the peak is absent. The robustness of the predicted total event number in the neutronization burst makes a measurement of the distance to the SN feasible with a precision of about 5%, even in the likely case that the SN is optically obscured.Comment: 14 pages, 17 eps figures, revtex4 style, minor comments adde

The genomic distribution of intraspecific and interspecific sequence divergence of human segmental duplications relative to human/chimpanzee chromosomal rearrangements

Background: It has been suggested that chromosomal rearrangements harbor the molecular footprint of the biological phenomena which they induce, in the form, for instance, of changes in the sequence divergence rates of linked genes. So far, all the studies of these potential associations have focused on the relationship between structural changes and the rates of evolution of singlecopy DNA and have tried to exclude segmental duplications (SDs). This is paradoxical, since SDs are one of the primary forces driving the evolution of structure and function in our genomes and have been linked not only with novel genes acquiring new functions, but also with overall higher DNA sequence divergence and major chromosomal rearrangements. Results: Here we take the opposite view and focus on SDs. We analyze several of the features of SDs, including the rates of intraspecific divergence between paralogous copies of human SDs and of interspecific divergence between human SDs and chimpanzee DNA. We study how divergence measures relate to chromosomal rearrangements, while considering other factors that affect evolutionary rates in single copy DNA. Conclusion: We find that interspecific SD divergence behaves similarly to divergence of singlecopy DNA. In contrast, old and recent paralogous copies of SDs do present different patterns of intraspecific divergence. Also, we show that some relatively recent SDs accumulate in regions that carry inversions in sister lineages.This research was supported by a grant to A.N. from the Ministerio de Ciencia y Tecnologia (Spain, BFU2006 15413-C02-01) and by BE2005 and BP2006 fellowships to T.M.B from the "Departament d'Educacio i Universitats de la Generalitat de Catalunya"

High energy neutrino yields from astrophysical sources II: Magnetized sources

We calculate the yield of high energy neutrinos produced in astrophysical sources for arbitrary interaction depths $\tau_0$ and magnetic field strengths $B$. We take into account energy loss processes like synchrotron radiation and diffusion of charged particles in turbulent magnetic fields as well as the scattering of secondaries on background photons and the direct production of charm neutrinos. Meson-photon interactions are simulated with an extended version of the SOPHIA model. Diffusion leads to an increased path-length before protons leave the source of size R_s and therefore magnetized sources lose their transparency below the energy $E\sim 10^{18}{\rm eV} (R_s/{\rm pc}) (B/{\rm mG}) \tau_0^{1/\alpha}$, with $\alpha=1/3$ and 1 for Kolmogorov and Bohm diffusion, respectively. Moreover, the neutrino flux is suppressed above the energy where synchrotron energy losses become important for charged particles. As a consequence, the energy spectrum and the flavor composition of neutrinos are strongly modified both at low and high energies even for sources with \tau_0\lsim 1.Comment: 15 pages, 16 figure

High-Throughput Task to Study Memory Recall During Spatial Navigation in Rodents

© Copyright © 2020 Morales, Tomàs, Dalmau, de la Rocha and Jercog. Spatial navigation is one of the most frequently used behavioral paradigms to study memory formation in rodents. Commonly used tasks to study memory are labor-intensive, preventing the simultaneous testing of multiple animals with the tendency to yield a low number of trials, curtailing the statistical power. Moreover, they are not tailored to be combined with neurophysiology recordings because they are not based on overt stereotyped behavioral responses that can be precisely timed. Here we present a novel task to study long-term memory formation and recall during spatial navigation. The task consists of learning sessions during which mice need to find the rewarding port that changes from day to day. Hours after learning, there is a recall session during which mice search for the location of the memorized rewarding port. During the recall sessions, the animals repeatedly poke the remembered port over many trials (up to ∼20) without receiving a reward (i.e., no positive feedback) as a readout of memory. In this task, mice show memory of port locations learned on up to three previous days. This eight-port maze task requires minimal human intervention, allowing for simultaneous and unsupervised testing of several mice in parallel, yielding a high number of recall trials per session over many days, and compatible with recordings of neural activity

Signatures of supernova neutrino oscillations in the Earth mantle and core

The Earth matter effects on supernova (SN) neutrinos can be identified at a single detector through peaks in the Fourier transform of their ``inverse energy'' spectrum. The positions of these peaks are independent of the SN models and therefore the peaks can be used as a robust signature of the Earth matter effects, which in turn can distinguish between different neutrino mixing scenarios. Whereas only one genuine peak is observable when the neutrinos traverse only the Earth mantle, traversing also the core gives rise to multiple peaks. We calculate the strengths and positions of these peaks analytically and explore their features at a large scintillation detector as well as at a megaton water Cherenkov detector through Monte Carlo simulations. We propose a simple algorithm to identify the peaks in the actual data and quantify the chances of a peak identification as a function of the location of the SN in the sky.Comment: 17 pages, 9 figure

Excess hospitalizations and mortality associated with seasonal influenza in Spain, 2008–2018

Hospitalization; Influenza; MortalityHospitalització; Grip; MortalitatHospitalización; Gripe; MortalidadBackground Influenza may trigger complications, particularly in at-risk groups, potentially leading to hospitalization or death. However, due to lack of routine testing, influenza cases are infrequently coded with influenza-specific diagnosis. Statistical models using influenza activity as an explanatory variable can be used to estimate annual hospitalizations and deaths associated with influenza. Our study aimed to estimate the clinical and economic burden of severe influenza in Spain, considering such models. Methods The study comprised ten epidemic seasons (2008/2009–2017/2018) and used two approaches: (i) a direct method of estimating the seasonal influenza hospitalization, based on the number of National Health Service hospitalizations with influenza-specific International Classification of Diseases (ICD) codes (ICD-9: 487–488; ICD-10: J09-J11), as primary or secondary diagnosis; (ii) an indirect method of estimating excess hospitalizations and deaths using broader groups of ICD codes in time-series models, computed for six age groups and four groups of diagnoses: pneumonia or influenza (ICD-9: 480–488, 517.1; ICD-10: J09–J18), respiratory (ICD-9: 460–519; ICD-10: J00–J99), respiratory or cardiovascular (C&R, ICD-9: 390–459, 460–519; ICD-10: I00–I99, J00–J99), and all-cause. Means, excluding the H1N1pdm09 pandemic (2009/2010), are reported in this study. Results The mean number of hospitalizations with a diagnosis of influenza per season was 13,063, corresponding to 28.1 cases per 100,000 people. The mean direct annual cost of these hospitalizations was €45.7 million, of which 65.7% was generated by patients with comorbidities. Mean annual influenza-associated C&R hospitalizations were estimated at 34,894 (min: 16,546; max: 52,861), corresponding to 75.0 cases per 100,000 (95% confidence interval [CI]: 63.3–86.3) for all ages and 335.3 (95% CI: 293.2–377.5) in patients aged ≥ 65 years. We estimate 3.8 influenza-associated excess C&R hospitalizations for each hospitalization coded with an influenza-specific diagnosis in patients aged ≥ 65 years. The mean direct annual cost of the estimated excess C&R hospitalizations was €142.9 million for all ages and €115.9 million for patients aged ≥ 65 years. Mean annual influenza-associated all-cause mortality per 100,000 people was estimated at 27.7 for all ages. Conclusions Results suggest a relevant under-detected burden of influenza mostly in the elderly population, but not neglectable in younger people.The BARI study was funded by Sanofi. Martinón-Torres F has received support for the present work from the Instituto de Salud Carlos III (Proyecto de Investigación en Salud, Acción Estratégica en Salud): Fondo de Investigación Sanitaria (FIS; PI070069/PI1000540/PI1601569/PI1901090) del plan nacional de I + D + I and ‘fondos FEDER’ and Proyectos GAIN Rescata-Covid_IN845D 2020/23 (GAIN, Xunta de Galicia)

Experimental study of the effect of temperature on the strength of ready-mixed concrete : theory

En este artículo se presenta un estudio sobre los efectos de la temperatura ambiental sobre las prestaciones del hormigón, en estado fresco y endurecido, y sobre las propiedades de los materiales constituyentes del mismo, desde una perspectiva industrial. El objetivo principal es el de optimizar la dosificación del hormigón en climas cálidos y al mismo tiempo, establecer medidas de actuación a nivel industrial para minimizar los efectos adversos en plantas de producción de hormigón preparado. En la primera parte del artículo, se muestran los resultados de varias campañas experimentales cuyo propósito ha sido determinar la influencia de las temperaturas ambientales extremas sobre las propiedades térmicas, de trabajabilidad y mecánicas del hormigón, así como de morteros, pastas de cemento y áridos. Las conclusiones apuntan al árido como un factor de gran importancia, no sólo por las características específicas de su comportamiento con la temperatura, sino también, porque es el componente presente en mayor contenido en el hormigón. En la segunda parte del artículo, se presentan las bases de una formulación metodológica para llevar a cabo la optimización del hormigón en climas cálidos

Addressing influenza’s underestimated burden – Iberian experts call to action

Hospitalization; Influenza; PreventionHospitalització; Grip; PrevencióHospitalización; Gripe; PrevenciónHaving a proper understanding of the impact of influenza is a fundamental step towards improved preventive action. This paper reviews findings from the Burden of Acute Respiratory Infections study on the burden of influenza in Iberia, and its potential underestimation, and proposes specific measures to lessen influenza’s impact.The BARI study was funded by Sanofi