1,667 research outputs found
Historical and new spectral indicators from the Nearby Supernova Factory
International audienceFrom a sample of 58 SNe~Ia spectra obtained by the Nearby Supernova Factory with the SuperNovae Integral Field Spectrograph (SNIFS), we present measurements of spectral indicators proposed in the literature. In addition, we probe the direct correlation of spectral indicators to the Hubble diagram residuals and the relevance of such indicators as substitutes to stretch and colour
Expression of Protease-Activated Receptor 1 and 2 and Anti-Tubulogenic Activity of Protease-Activated Receptor 1 in Human Endothelial Colony-Forming Cells
Endothelial colony-forming cells (ECFCs) are obtained from the culture of human peripheral blood mononuclear cell (hPBMNC) fractions and are characterised by high proliferative and pro-vasculogenic potential, which makes them of great interest for cell therapy. Here, we describe the detection of protease-activated receptor (PAR) 1 and 2 amongst the surface proteins expressed in ECFCs. Both receptors are functionally coupled to extracellular signal-regulated kinase (ERK) 1 and 2, which become activated and phosphorylated in response to selective PAR1- or PAR2-activating peptides. Specific stimulation of PAR1, but not PAR2, significantly inhibits capillary-like tube formation by ECFCs in vitro, suggesting that tubulogenesis is negatively regulated by proteases able to stimulate PAR1 (e.g. thrombin). The activation of ERKs is not involved in the regulation of tubulogenesis in vitro, as suggested by use of the MEK inhibitor PD98059 and by the fact that PAR2 stimulation activates ERKs without affecting capillary tube formation. Both qPCR and immunoblotting showed a significant downregulation of vascular endothelial growth factor 2 (VEGFR2) in response to PAR1 stimulation. Moreover, the addition of VEGF (50–100 ng/ml) but not basic Fibroblast Growth Factor (FGF) (25–100 ng/ml) rescued tube formation by ECFCs treated with PAR1-activating peptide. Therefore, we propose that reduction of VEGF responsiveness resulting from down-regulation of VEGFR2 is underlying the anti-tubulogenic effect of PAR1 activation. Although the role of PAR2 remains elusive, this study sheds new light on the regulation of the vasculogenic activity of ECFCs and suggests a potential link between adult vasculogenesis and the coagulation cascade
Multi-layered Spectral Formation in SNe Ia Around Maximum Light
We use the radiative transfer code PHOENIX to study the line formation of the
wavelength region 5000-7000 Angstroms. This is the region where the SNe Ia
defining Si II feature occurs. This region is important since the ratio of the
two nearby silicon lines has been shown to correlate with the absolute blue
magnitude. We use a grid of LTE synthetic spectral models to investigate the
formation of line features in the spectra of SNe Ia. By isolating the main
contributors to the spectral formation we show that the ions that drive the
spectral ratio are Fe III, Fe II, Si II, and S II. While the first two strongly
dominate the flux transfer, the latter two form in the same physical region
inside of the supernova. We also show that the naive blackbody that one would
derive from a fit to the observed spectrum is far different than the true
underlying continuum.Comment: 35 pages, 15 figures, ApJ (2008) 684 in pres
Venous-right atrial bypass for superior vena cava thrombosis during orthotopic liver transplantation
Type Ia Supernova Spectral Line Ratios as Luminosity Indicators
Type Ia supernovae have played a crucial role in the discovery of the dark
energy, via the measurement of their light curves and the determination of the
peak brightness via fitting templates to the observed lightcurve shape. Two
spectroscopic indicators are also known to be well correlated with peak
luminosity. Since the spectroscopic luminosity indicators are obtained directly
from observed spectra, they will have different systematic errors than do
measurements using photometry. Additionally, these spectroscopic indicators may
be useful for studies of effects of evolution or age of the SNe Ia progenitor
population. We present several new variants of such spectroscopic indicators
which are easy to automate and which minimize the effects of noise. We show
that these spectroscopic indicators can be measured by proposed JDEM missions
such as SNAP and JEDI.Comment: 50 pages, 19 figures, 24 tables, submitted to Ap
Initial Hubble Diagram Results from the Nearby Supernova Factory
The use of Type Ia supernovae as distance indicators led to the discovery of
the accelerating expansion of the universe a decade ago. Now that large second
generation surveys have significantly increased the size and quality of the
high-redshift sample, the cosmological constraints are limited by the currently
available sample of ~50 cosmologically useful nearby supernovae. The Nearby
Supernova Factory addresses this problem by discovering nearby supernovae and
observing their spectrophotometric time development. Our data sample includes
over 2400 spectra from spectral timeseries of 185 supernovae. This talk
presents results from a portion of this sample including a Hubble diagram
(relative distance vs. redshift) and a description of some analyses using this
rich dataset.Comment: Short version of proceedings for ICHEP08, Philadelphia PA, July 2008;
see v1 for full-length versio
The Nearby Supernova Factory
The Nearby Supernova Factory (SNfactory) is an ambitious project to find and
study in detail approximately 300 nearby Type Ia supernovae (SNe~Ia) at
redshifts 0.03<z<0.08. This program will provide an exceptional data set of
well-studied SNe in the nearby smooth Hubble flow that can be used as
calibration for the current and future programs designed to use SNe to measure
the cosmological parameters. The first key ingredient for this program is a
reliable supply of Hubble-flow SNe systematically discovered in unprecedented
numbers using the same techniques as those used in distant SNe searches. In
2002, 35 SNe were found using our test-bed pipeline for automated SN search and
discovery. The pipeline uses images from the asteroid search conducted by the
Near Earth Asteroid Tracking group at JPL. Improvements in our subtraction
techniques and analysis have allowed us to increase our effective SN discovery
rate to ~12 SNe/month in 2003.Comment: 7 pages, 3 figures to be published in New Astronomy Review
Atmospheric extinction properties above Mauna Kea from the Nearby Supernova Factory spectro-photometric data set
We present a new atmospheric extinction curve for Mauna Kea spanning
3200--9700 \AA. It is the most comprehensive to date, being based on some 4285
standard star spectra obtained on 478 nights spread over a period of 7 years
obtained by the Nearby SuperNova Factory using the SuperNova Integral Field
Spectrograph. This mean curve and its dispersion can be used as an aid in
calibrating spectroscopic or imaging data from Mauna Kea, and in estimating the
calibration uncertainty associated with the use of a mean extinction curve. Our
method for decomposing the extinction curve into physical components, and the
ability to determine the chromatic portion of the extinction even on cloudy
nights, is described and verified over the wide range of conditions sampled by
our large dataset. We demonstrate good agreement with atmospheric science data
obtain at nearby Mauna Loa Observatory, and with previously published
measurements of the extinction above Mauna Kea.Comment: 22 pages, 24 figures, 6 table
Host Galaxy Properties and Hubble Residuals of Type Ia Supernovae from the Nearby Supernova Factory
We examine the relationship between Type Ia Supernova (SN Ia) Hubble
residuals and the properties of their host galaxies using a sample of 115 SNe
Ia from the Nearby Supernova Factory (SNfactory). We use host galaxy stellar
masses and specific star-formation rates fitted from photometry for all hosts,
as well as gas-phase metallicities for a subset of 69 star-forming (non-AGN)
hosts, to show that the SN Ia Hubble residuals correlate with each of these
host properties. With these data we find new evidence for a correlation between
SN Ia intrinsic color and host metallicity. When we combine our data with those
of other published SN Ia surveys, we find the difference between mean SN Ia
brightnesses in low and high mass hosts is 0.077 +- 0.014 mag. When viewed in
narrow (0.2 dex) bins of host stellar mass, the data reveal apparent plateaus
of Hubble residuals at high and low host masses with a rapid transition over a
short mass range (9.8 <= log(M_*/M_Sun) <= 10.4). Although metallicity has been
a favored interpretation for the origin of the Hubble residual trend with host
mass, we illustrate how dust in star-forming galaxies and mean SN Ia progenitor
age both evolve along the galaxy mass sequence, thereby presenting equally
viable explanations for some or all of the observed SN Ia host bias.Comment: 20 pages, 11 figures, accepted for publication in Ap
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