Use of a tyrosine kinase inhibitor as neoadjuvant therapy for non-small cell lung cancer: A case report

We report here a 66-year-old woman diagnosed with bronchioloalveolar carcinoma of the right lung cT4N2M0. The patient was from the Philippines, had never smoked, and tested positive for an EGFR mutation. She received gefitinib as neoadjuvant therapy for two months and displayed a partial response. The tumour was resected by performing a right pneumonectomy. The residual viable tumour accounted for less than 10%. Adjuvant chemotherapy with carboplatin-taxol was administered for four cycles. Fifteen months post-surgery, two brain metastases were found. Gefitinib was prescribed, and one month later complete radiological response was assessed. The patient remains asymptomatic and without visible disease four months later. Controlled randomised trials are needed to clarify the role of these target therapies in the neoadjuvant settin

From circular paths to elliptic orbits: A geometric approach to Kepler's motion

The hodograph, i.e. the path traced by a body in velocity space, was introduced by Hamilton in 1846 as an alternative for studying certain dynamical problems. The hodograph of the Kepler problem was then investigated and shown to be a circle, it was next used to investigate some other properties of the motion. We here propose a new method for tracing the hodograph and the corresponding configuration space orbit in Kepler's problem starting from the initial conditions given and trying to use no more than the methods of synthetic geometry in a sort of Newtonian approach. All of our geometric constructions require straight edge and compass only.Comment: 9 pages, 4 figure

Slow growth of magnetic domains helps fast evolution routes for out-of-equilibrium dynamics

Cooling and heating faster a system is a crucial problem in science, technology, and industry. Indeed, choosing the best thermal protocol to reach a desired temperature or energy is not a trivial task. Noticeably, we find that the phase transitions may speed up thermalization in systems where there are no conserved quantities. In particular, we show that the slow growth of magnetic domains shortens the overall time that the system takes to reach a final desired state. To prove that statement, we use intensive numerical simulations of a prototypical many-body system, namely, the two-dimensional Ising model. © 2021 Published by the American Physical Societ

Uclacyanin Proteins Are Required for Lignified Nanodomain Formation within Casparian Strips

© 2020 The Author(s) Casparian strips (CSs) are cell wall modifications of vascular plants restricting extracellular free diffusion into and out of the vascular system [1]. This barrier plays a critical role in controlling the acquisition of nutrients and water necessary for normal plant development [2–5]. CSs are formed by the precise deposition of a band of lignin approximately 2 μm wide and 150 nm thick spanning the apoplastic space between adjacent endodermal cells [6, 7]. Here, we identified a copper-containing protein, Uclacyanin1 (UCC1), that is sub-compartmentalized within the CS. UCC1 forms a central CS nanodomain in comparison with other CS-located proteins that are found to be mainly accumulated at the periphery of the CS. We found that loss-of-function of two uclacyanins (UCC1 and UCC2) reduces lignification specifically in this central CS nanodomain, revealing a nano-compartmentalized machinery for lignin polymerization. This loss of lignification leads to increased endodermal permeability and, consequently, to a loss of mineral nutrient homeostasis

Leprosy. An Update: Definition, Pathogenesis, Classification, Diagnosis, and Treatment

Abstract Leprosy is a chronic granulomatous disease caused by the bacillus Mycobacterium leprae. It primarily affects the skin and peripheral nerves and is still endemic in various regions of the world. Clinical presentation depends on the patient's immune status at the time of infection and during the course of the disease. Leprosy is associated with disability and marginalization. Diagnosis is clinical and is made when the patient has at least 1 of the following cardinal signs specified by the World Health Organization: hypopigmented or erythematous macules with sensory loss; thickened peripheral nerves; or positive acid-fast skin smear or skin biopsy with loss of adnexa at affected sites. Leprosy is treated with a multidrug combination of rifampicin, clofazimine, and dapsone. Two main regimens are used depending on whether the patient has paucibacillary or multibacillary disease. © 2011 Elsevier España, S.L. and AEDV. All rights reserved. Resumen La lepra es una enfermedad granulomatosa crónica causado por una micobacteria (M. leprae) que presenta predisposición por la piel y nervios periféricos. La lepra continúa siendo endémica en distintas regiones del mundo. La presentación clínica de la enfermedad depende del estado inmunológico del paciente al adquirirla y durante la evolución de la misma. Es una infección que se asocia a discapacidad y marginación. PALABRAS CLAVE El diagnóstico de lepra es clínico y se hace al tener uno o más de los signos cardinales establecidos por la OMS; máculas hipopigmentadas o eritematosas con disminución de la sensibilidad, engrosamiento de los nervios periféricos y la demostración de bacilos ácido alcohol resistente en una baciloscopia o biopsia de piel, con pérdida de anexos en los sitios afectados. Leprosy. An Update: Definition, Pathogenesis, Classification, Diagnosis, and Treatment 555 El tratamiento es con tres drogas; rifampicina, clofazimina y dapsona. Existen principalmente dos modalidades de tratamiento dependiendo de la presentación clínica del paciente como paucibacilar o multibacilar

Towards new insights in the phylogeny of the Spermacoce clade: an integrative taxonomic approach using morphology, anatomy, ecology and phylogenetics reveáis the new genus Leonoria

Phylogenetic inference analyses o f two nuclear and four plastid DNA markers from 82 accessions representing 19 genera o f the Spermacoce clade (Spermacoceae-Rubiaceae) confirm that the Brazilian genus Denscantia is biphyletic. By the analyses o f reproductive morphological characters, foliar morpho-anatomy and histochemical, geographical distribution ranges, and ecological niche derived from climatic space, Denscantia caldcóla is shown as a distinct lineage from the other Denscantia species, indicating its taxonomic segregation into a new monospecific genus Leonoria. Significant morphological diíferences o f Leonoria with Denscantia were found in inflorescence organization, stigma shape, fruit dehiscence, and pollen morphology. Morphoanatomical variation among leaf traits were found in epidemial cells, occurrence o f trichomes, mesophyll histochemical, and vascular organization. Analysis o f occurrence records o f 205 specimens demonstrates a clear ecological distinction between o f Denscantia s.s. and Leonoria, which is ecologically confined to limestone outcrops associated with seasonally dry forests. The current study demonstrates the importance of an integrative taxonomic approach - in which múltiple disciplines are combined - to the unravel complex taxonomic pattems within Rubiaceae. The genus Leonoria, to be newly described, is dedicated to Professor Elsa Leonor Cabral

"The Ising model on spherical lattices: dimer versus Monte Carlo approach"

We study, using dimer and Monte Carlo approaches, the critical properties and finite size effects of the Ising model on honeycomb lattices folded on the tetrahedron. We show that the main critical exponents are not affected by the presence of conical singularities. The finite size scaling of the position of the maxima of the specific heat does not match, however, with the scaling of the correlation length, and the thermodynamic limit is attained faster on the spherical surface than in corresponding lattices on the torus.Comment: 25 pages + 6 figures not included. Latex file. FTUAM 93-2

Mitochondrial echoes of first settlement and genetic continuity in El Salvador

Background: From Paleo-Indian times to recent historical episodes, the Mesoamerican isthmus played an important role in the distribution and patterns of variability all around the double American continent. However, the amount of genetic information currently available on Central American continental populations is very scarce. In order to shed light on the role of Mesoamerica in the peopling of the New World, the present study focuses on the analysis of the mtDNA variation in a population sample from El Salvador. Methodology/Principal Findings: We have carried out DNA sequencing of the entire control region of the mitochondrial DNA (mtDNA) genome in 90 individuals from El Salvador. We have also compiled more than 3,985 control region profiles from the public domain and the literature in order to carry out inter-population comparisons. The results reveal a predominant Native American component in this region: by far, the most prevalent mtDNA haplogroup in this country (at ~90%) is A2, in contrast with other North, Meso- and South American populations. Haplogroup A2 shows a star-like phylogeny and is very diverse with a substantial proportion of mtDNAs (45%; sequence range 16090–16365) still unobserved in other American populations. Two different Bayesian approaches used to estimate admixture proportions in El Salvador shows that the majority of the mtDNAs observed come from North America. A preliminary founder analysis indicates that the settlement of El Salvador occurred about 13,400±5,200 Y.B.P.. The founder age of A2 in El Salvador is close to the overall age of A2 in America, which suggests that the colonization of this region occurred within a few thousand years of the initial expansion into the Americas. Conclusions/Significance: As a whole, the results are compatible with the hypothesis that today's A2 variability in El Salvador represents to a large extent the indigenous component of the region. Concordant with this hypothesis is also the observation of a very limited contribution from European and African women (~5%). This implies that the Atlantic slave trade had a very small demographic impact in El Salvador in contrast to its transformation of the gene pool in neighbouring populations from the Caribbean facade

Puberty in the Bronze Age: First application of a puberty estimation method to a prehistoric population

This is the peer reviewed version of the following article: Doe, Danielle M., et al. "Puberty in the Bronze Age: First application of a puberty estimation method to a prehistoric population". International Journal of Osteoarchaeology 29.6 (2019): 1091-1099, which has been published in final form at https://doi.org/10.1002/oa.2822. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived VersionsPuberty and adolescence represent a significant period of physical growth and maturation and a critical life stage in which children transition into adults within their societies. Numerous studies have observed a secular trend and have determined that puberty is now occurring earlier than in the past. This investigation represents the first application of a methodology for assessing the pubertal status of osteological remains to a prehistoric skeletal sample. Six Bronze Age adolescent skeletons from the Cerro de La Encantada archaeological site (Ciudad Real, Spain) were analysed. Prepubescence was observed at age 9 and the transition phase of the pubertal growth spurt at 15 years of age. These results were similar to those obtained from medieval, Industrial Revolution, and modern populations, both within and outside of the Iberian Peninsula. The similarity in the development of the Bronze Age adolescents to that of other past and contemporary populations suggests that the pubertal process has remained essentially unchanged across millennia until recent times. However, other interpretations, including the influence of a subpar developmental environment and potential methodological artefacts, are possible. Nevertheless, studies of this type provide important information about a crucial transitory period in human developmentThe Laboratorio de Poblaciones del Pasado (LAPP) has been supported by Projects HAR2016‐78036‐P, HAR2016‐74846‐P, HAR2017‐82755‐P, and HAR2017‐83004‐P (Spanish Government) and a grant (Ref. 38360) from the Leakey Foundatio

Exact renormalization-group analysis of first order phase transitions in clock models

We analyze the exact behavior of the renormalization group flow in one-dimensional clock-models which undergo first order phase transitions by the presence of complex interactions. The flow, defined by decimation, is shown to be single-valued and continuous throughout its domain of definition, which contains the transition points. This fact is in disagreement with a recently proposed scenario for first order phase transitions claiming the existence of discontinuities of the renormalization group. The results are in partial agreement with the standard scenario. However in the vicinity of some fixed points of the critical surface the renormalized measure does not correspond to a renormalized Hamiltonian for some choices of renormalization blocks. These pathologies although similar to Griffiths-Pearce pathologies have a different physical origin: the complex character of the interactions. We elucidate the dynamical reason for such a pathological behavior: entire regions of coupling constants blow up under the renormalization group transformation. The flows provide non-perturbative patterns for the renormalization group behavior of electric conductivities in the quantum Hall effect.Comment: 13 pages + 3 ps figures not included, TeX, DFTUZ 91.3