Current profiles and AC losses of a superconducting strip with elliptic cross-section in perpendicular magnetic field

The case of a hard type II superconductor in the form of strip with elliptic cross-section when placed in transverse magnetic field is studied. We approach the problem in two steps, both based on the critical-state model. First we calculate numerically the penetrated current profiles that ensure complete shielding in the interior, without assuming an a priori form for the profiles. In the second step we introduce an analytical approximation that asumes that the current profiles are ellipses. Expressions linking the sample magnetization to the applied field are derived covering the whole range of applied fields. The theoretical predictions are tested by the comparison with experimental data for the imaginary part of AC susceptibility.Comment: 12 pages; 3 figure

Influence of health literacy on acceptance of influenza and pertussis vaccinations: a cross-sectional study among Spanish pregnant women.

OBJECTIVES: Immunisations against influenza and Bordetella pertussis infection are recommended to pregnant women in Valencia (Spain), yet vaccination rates remain low. Health literacy (HL) appears as a crucial factor in vaccination decision-making. We explored the relation between HL of pregnant women and decisions to receive influenza and pertussis immunisations. SETTING: University hospital in Valencia (Spain). PARTICIPANTS: 119 women who gave birth at a hospital in Valencia (Spain) between November 2015 and May 2016. Women in the immediate postpartum period (more than 27 weeks of gestation), between November 2015 and May 2016 were included in the study. Women with impairments, language barriers or illiteracy which prevented completion of the questionnaires, or those who were under 18 years were excluded from enrolment. PRIMARY AND SECONDARY OUTCOME MEASURES: HL level; influenza and pertussis immunisation rate; reasons for rejection of vaccination. RESULTS: 119 participants were included (mean age 32.3±5.5 years, 52% primiparous, 95% full-term deliveries). A higher education level was associated with Short Assessment of Health Literacy for Spanish Adults _50 (adjusted R2=0.22, p=0.014) and Newest Vital Sign (adjusted R2=0.258, p=0.001) scores. Depending on the scale, 56%-85% of participants had adequate HL. 52% (62/119) and 94% (112/119) of women received influenza and pertussis immunisation, respectively. Women rejecting influenza vaccine had a higher HL level (measured by SALHSA_50 tool) than those accepting it (Kruskal-Wallis test p=0.022). 24% of women who declined influenza vaccination felt the vaccine was unnecessary, and 23% claimed to have insufficient information. CONCLUSIONS: Influenza vaccination rate was suboptimal in our study. Women with high HL were more likely to decline immunisation. Information from professionals needs to match patients' HL levels to reduce negative perceptions of vaccination

Patients with Schizophrenia Showed Worse Cognitive Performance than Bipolar and Major Depressive Disorder in a Sample with Comorbid Substance Use Disorders

Comorbidity of substance use disorders (SUD) and severe mental illness (SMI) is highly frequent in patients, the most common diagnoses being schizophrenia (SZ), bipolar disorder (BD) and major depressive disorder (MDD). Since comorbidity has its own clinical features, and neurocognitive functioning is not always similar to psychiatric symptoms the present study explores the cognitive performance of patients with dual disorders. A neuropsychological battery of tests was used to assess 120 under treatment male patients, 40 for each group considered (SZ + SUD, BD + SUD and MDD + SUD) who were mainly polyconsumers. Significant differences (with premorbid IQ as a covariate) were found among the groups, with SZ + SUD having a worse performance in attention, verbal learning, short term memory and recognition. The consideration of a global Z score for performance evidenced an impaired neurocognitive pattern for SZ + SUD compared with BD + SUD and MDD + SUD. According to norms, all patients showed difficulties in verbal learning, short-term memory and recognition. Our research indicated that the neurocognitive functioning of dual disorder patients was influenced by the comorbid SMI, with SZ + SUD presenting major difficulties. Future studies should thoroughly explore the role of such difficulties as indicators or endophenotypes for dual schizophrenia disorders, and their usefulness for prevention and treatment.This research was funded by the grant PID2020-117767GB-I00 of Spanish Ministry of Science and Innovation (MCIN/AEI/10.13039/501100011033) and the Generalitat de Catalunya (2017SGR-748). Partial funding for open access charge: Universidad de Málag

Constraints on dark matter particles from theory, galaxy observations and N-body simulations

Mass bounds on dark matter (DM) candidates are obtained for particles decoupling in or out of equilibrium with {\bf arbitrary} isotropic and homogeneous distribution functions. A coarse grained Liouville invariant primordial phase space density $\mathcal D$ is introduced. Combining its value with recent photometric and kinematic data on dwarf spheroidal satellite galaxies in the Milky Way (dShps), the DM density today and $N$-body simulations, yields upper and lower bounds on the mass, primordial phase space densities and velocity dispersion of the DM candidates. The mass of the DM particles is bound in the few keV range. If chemical freeze out occurs before thermal decoupling, light bosonic particles can Bose-condense. Such Bose-Einstein {\it condensate} is studied as a dark matter candidate. Depending on the relation between the critical($T_c$)and decoupling($T_d$)temperatures, a BEC light relic could act as CDM but the decoupling scale must be {\it higher} than the electroweak scale. The condensate tightens the upper bound on the particle's mass. Non-equilibrium scenarios that describe particle production and partial thermalization, sterile neutrinos produced out of equilibrium and other DM models are analyzed in detail obtaining bounds on their mass, primordial phase space density and velocity dispersion. Light thermal relics with $m \sim \mathrm{few} \mathrm{keV}$ and sterile neutrinos lead to a primordial phase space density compatible with {\bf cored} dShps and disfavor cusped satellites. Light Bose condensed DM candidates yield phase space densities consistent with {\bf cores} and if $T_c\gg T_d$ also with cusps. Phase space density bounds from N-body simulations suggest a potential tension for WIMPS with $m \sim 100 \mathrm{GeV},T_d \sim 10 \mathrm{MeV}$.Comment: 27 pages 8 figures. Version to appear in Phys. Rev.

INTERVENCIÓN CON MENORES EN RECURSOS DE ACOGIDA

Extracto del informe inéditoEl análisis de los trabajos sobre intervención con madres maltratadas y sus hijos, nos ha permitido estructurar las áreas que se pueden desarrollar utilizando como instrumento mediador la lectura, sin olvidar fomentar el hábito lector y las lecturas compartidas madres-hijos. El trabajo se ha concentrado en la elaboración de materiales a partir de libros infantiles. Estos materiales están dirigidos a los educadores de las casas de acogida y a las madres. Se han seleccionado dos álbumes de literatura infantil para cada una de las áreas de intervención. Las propuestas de trabajo de los álbumes pretenden emplear la lectura como herramienta para poder entrar en el mundo interior de los hijos e hijas de las mujeres maltratadas y abrir una puerta para que puedan expresarse libremente

Unleashing the power of shark variable single domains (VNARs): broadly neutralizing tools for combating SARS-CoV-2

The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) generated a joint global effort to develop vaccines and other treatments that could mitigate the negative effects and the rapid spread of the virus. Single-domain antibodies derived from various sources, including cartilaginous fish, camelids, and humans, have gained attention as promising therapeutic tools against coronavirus disease 2019. Shark-derived variable new antigen receptors (VNARs) have emerged as the smallest naturally occurring antigen-binding molecules. Here, we compile and review recent published studies on VNARs with the capacity to recognize and/or neutralize SARS-CoV-2. We found a close balance between the use of natural immune libraries and synthetic VNAR libraries for the screening against SARS-CoV-2, with phage display being the preferred display technology for the selection of VNARs against this virus. In addition, we discuss potential modifications and engineering strategies employed to improve the neutralization potential of VNARs, such as exploring fusion with the Fc domain of human Immunoglobulin G (IgG) to increase avidity and therapeutic potential. This research highlights the potential of VNARs as powerful molecular tools in the fight against infectious diseases

Reference interval for immature platelet fraction on Sysmex XN haematology analyser in adult population

Introduction: The Sysmex XN-series haematology analyser has newly adopted a fluorescent channel to measure immature platelet fraction (IPF). To promote the clinical utility of this promising parameter, establishing a reliable reference interval is mandatory. According to previous studies, IPF values may be affected by the employed analyser and the ethnic background of the individual, but no differences seem to be found between individuals’ genders. Therefore, this study aimed to define the reference interval for IPF in a Spanish population following Clinical and Laboratory Standard Institute (CLSI) guidelines. Materials and methods: A total of 153 healthy Caucasian adults from Spain met the inclusion criteria. IPF measurement was performed by means of a Sysmex XN-2000 haematology analyser. A non-parametric percentile method was used to calculate the reference intervals in accordance with CLSI guidelines. Results: The obtained reference interval for IPF on the Sysmex XN-2000 was 1.6–9.6% (90% confidence intervals (CIs) were 1.5–1.8 and 9.3–11.5, respectively). No significant gender difference in IPF reference intervals was observed (P = 0.101). Conclusions: This study provides, for the first time, a reference interval for IPF using a Sysmex XN-2000 in a Spanish population, ranging from 1.6 to 9.6%. These data are needed to evaluate platelet production in several conditions such as thrombocytopenia, inflammatory states and cardiovascular diseases, as well as for future research