On the Hardy-type integral operators in Banach function spaces

Characterization of the mapping properties such as boundedness, compactness, measure of non-compactness and estimates of the approximation numbers of Hardy-type integral operators in Banach function spaces are given

The role of self-esteem in the development and self-development of a student’s personality

This article uses the concept of self-esteem and its impact on the development of a student's personality. The analysis of the views of some domestic and foreign scientists in this field of scientific knowledge is given. The ways of organizing the evaluative activity of the teacher are indicate

The use of microarrays for the identification of the origin of genes of avian influenza viruses in wild birds

Forty-two strains of avian influenza viruses were isolated from the wild waterfowls’ feces in the city of Moscow. These viruses, as well as reference strains and some experimental reassortants, were analyzed by microarrays. The microarrays contained 176 probes to the different segments of influenza virus genome. The microarray helps to determine 1) the hemagglutinin and neuraminidase proteins subtype; 2) the primary structure of the C-terminal sequence of the viral NS1 protein, which serves as a ligand for the PDZ domain; 3) the presence of stop codons in the reading frame of PB1-F2 as well as the N66S substitution in the PB1-F2 viral protein; 4) the presence of the polybasic site for hemagglutinin cleavage. The viruses of the H3N1, H3N6, H3N8, H4N6, H1N1, H5N3, and H11N9 subtypes were identified from the group of wild birds’ isolates. All isolates contained the ESEV sequence at the C-terminus of the NS1 protein and the full-length reading frame for the PB1-F2 protein. The replacement of N66S in PB1-F2 was found in six strains. However, the presence of the ESEV sequence (ligand of PDZ domain) in the NS1 virus protein and the N66S substitution in PB1-F2 did not lead to the pathogenicity of these viruses for mice. All isolates demonstrated high yield growth in chicken embryos and were infectious and immunogenic for mice, but did not induce any clinical symptoms.Forty-two strains of avian influenza viruses were isolated from the wild waterfowls’ feces in the city of Moscow. These viruses, as well as reference strains and some experimental reassortants, were analyzed by microarrays. The microarrays contained 176 probes to the different segments of influenza virus genome. The microarray helps to determine 1) the hemagglutinin and neuraminidase proteins subtype; 2) the primary structure of the C-terminal sequence of the viral NS1 protein, which serves as a ligand for the PDZ domain; 3) the presence of stop codons in the reading frame of PB1-F2 as well as the N66S substitution in the PB1-F2 viral protein; 4) the presence of the polybasic site for hemagglutinin cleavage. The viruses of the H3N1, H3N6, H3N8, H4N6, H1N1, H5N3, and H11N9 subtypes were identified from the group of wild birds’ isolates. All isolates contained the ESEV sequence at the C-terminus of the NS1 protein and the full-length reading frame for the PB1-F2 protein. The replacement of N66S in PB1-F2 was found in six strains. However, the presence of the ESEV sequence (ligand of PDZ domain) in the NS1 virus protein and the N66S substitution in PB1-F2 did not lead to the pathogenicity of these viruses for mice. All isolates demonstrated high yield growth in chicken embryos and were infectious and immunogenic for mice, but did not induce any clinical symptoms

Inferring on the intentions of others by hierarchical Bayesian learning

Inferring on others' (potentially time-varying) intentions is a fundamental problem during many social transactions. To investigate the underlying mechanisms, we applied computational modeling to behavioral data from an economic game in which 16 pairs of volunteers (randomly assigned to "player" or "adviser" roles) interacted. The player performed a probabilistic reinforcement learning task, receiving information about a binary lottery from a visual pie chart. The adviser, who received more predictive information, issued an additional recommendation. Critically, the game was structured such that the adviser's incentives to provide helpful or misleading information varied in time. Using a meta-Bayesian modeling framework, we found that the players' behavior was best explained by the deployment of hierarchical learning: they inferred upon the volatility of the advisers' intentions in order to optimize their predictions about the validity of their advice. Beyond learning, volatility estimates also affected the trial-by-trial variability of decisions: participants were more likely to rely on their estimates of advice accuracy for making choices when they believed that the adviser's intentions were presently stable. Finally, our model of the players' inference predicted the players' interpersonal reactivity index (IRI) scores, explicit ratings of the advisers' helpfulness and the advisers' self-reports on their chosen strategy. Overall, our results suggest that humans (i) employ hierarchical generative models to infer on the changing intentions of others, (ii) use volatility estimates to inform decision-making in social interactions, and (iii) integrate estimates of advice accuracy with non-social sources of information. The Bayesian framework presented here can quantify individual differences in these mechanisms from simple behavioral readouts and may prove useful in future clinical studies of maladaptive social cognition

Spin and orbital mechanisms of the magneto-gyrotropic photogalvanic effects in GaAs/AlGaAs quantum well structures

We report on the study of the linear and circular magneto-gyrotropic photogalvanic effect (MPGE) in GaAs/AlGaAs quantum well structures. Using the fact that in such structures the Land\'e-factor g* depends on the quantum well (QW) width and has different signs for narrow and wide QWs, we succeeded to separate spin and orbital contributions to both MPGEs. Our experiments show that, for most quantum well widths, the PGEs are mainly driven by spin-related mechanisms, which results in a photocurrent proportional to the g* factor. In structures with a vanishingly small g* factor, however, linear and circular MPGE are also detected, proving the existence of orbital mechanisms.Comment: 10 pages, 10 figure

On the minima and convexity of Epstein Zeta function

Let $Z_n(s; a_1,..., a_n)$ be the Epstein zeta function defined as the meromorphic continuation of the function \sum_{k\in\Z^n\setminus\{0\}}(\sum_{i=1}^n [a_i k_i]^2)^{-s}, \text{Re} s>\frac{n}{2} to the complex plane. We show that for fixed $s\neq n/2$, the function $Z_n(s; a_1,..., a_n)$, as a function of $(a_1,..., a_n)\in (\R^+)^n$ with fixed $\prod_{i=1}^n a_i$, has a unique minimum at the point $a_1=...=a_n$. When $\sum_{i=1}^n c_i$ is fixed, the function $$(c_1,..., c_n)\mapsto Z_n(s; e^{c_1},..., e^{c_n})$$ can be shown to be a convex function of any $(n-1)$ of the variables $\{c_1,...,c_n\}$. These results are then applied to the study of the sign of $Z_n(s; a_1,..., a_n)$ when $s$ is in the critical range $(0, n/2)$. It is shown that when $1\leq n\leq 9$, $Z_n(s; a_1,..., a_n)$ as a function of $(a_1,..., a_n)\in (\R^+)^n$, can be both positive and negative for every $s\in (0,n/2)$. When $n\geq 10$, there are some open subsets $I_{n,+}$ of $s\in(0,n/2)$, where $Z_{n}(s; a_1,..., a_n)$ is positive for all $(a_1,..., a_n)\in(\R^+)^n$. By regarding $Z_n(s; a_1,..., a_n)$ as a function of $s$, we find that when $n\geq 10$, the generalized Riemann hypothesis is false for all $(a_1,...,a_n)$.Comment: 27 page

ВИЗУАЛЬНОЕ ТЕСТ-ОПРЕДЕЛЕНИЕ Pb(II) С ИСПОЛЬЗОВАНИЕМ ИНДИКАТОРНОЙ ЖЕЛАТИНОВОЙ ПЛЕНКИ

A hardened gelatin gel deposited on a transparent polymeric matrix is of interest for the development of highly sensitive methods which combine concentration and subsequent determination of the analyte in the solid phase.For visual test for determination of lead (II) commercial photographic film with immobilized indikator bromopyrogallol red is proposed to use. The optimal conditions for the immobilization of the reagent and the metal complex in the film are determined. The composition and stability of the indicator reaction products are evaluated in solution and heterogeneous water / gelatin film. On the basis of  these studies the technique of visual test determination of lead, based on the formation of complex compounds of Pb (II) c bromopyrogallol red in the medium hardened gelatin gel are found. Metrological characteristics of the proposed method of visual test determination of Pb (II) with the use of the indicator film are developed. Correctness of the methodology for determination of lead was tested on model solutions and real objects.Keywords: bromopyrogallol red, lead (II), the indicator gelatin film, immobilization, visual colorimetry.(Russian)DOI: http://dx.doi.org/10.15826/analitika.2014.18.3.009 P.V Anisimovich1,  Z.A Temerdashev1,  T.B Pochinok1, E.A. Reshetniak2, T.S. Smolenskaya1,  O.Iu. Lomakina1  1Federal state budget educational institution of higher professional education "Kuban State University", Krasnodar, Russian Federation2V.N. Karazin Kharkiv National University, Kharkiv, UkraineСреди прозрачных полимерных сорбентов, используемых  для концентрирования и последующего определения аналита непосредственно в твердой фазе, особый интерес представляет желатиновый отвержденный гель, нанесенный на прозрачную полимерную матрицу.Для визуально-тестового определения свинца(II) предложено использовать коммерческую фотопленку с иммобилизованным металлоиндикатором бромпирогаллоловым красным. Найдены оптимальные условия иммобилизации реагента и металлокомплекса в пленке. Установлен состав и оценена устойчивость продуктов индикаторной реакции в растворе и в гетерогенной системе вода/желатиновая пленка. На основе проведенных исследований разработана методика визуального тест-определения свинца, основанная на образовании комплексного соединения Pb(II) c  бромпирогаллоловым красным в среде  отвержденного желатинового геля. Оценены метрологические характеристики предложенной методики визуального тест-определения Pb(II) с использованием индикаторной пленки: интервал ненадежности обнаружения Pb(II) (1.9-3.7 мкМ), предел обнаружения (3.2 мкМ) и предел определения (3.9 мкМ) металла по цветовой шкале. Правильность определения в модельных растворах и реальных объектах доказана методом «введено-найдено» и независимым методом.Ключевые слова: бромпирогаллоловый красный, свинец(II), индикаторная желатиновая пленка, иммобилизация, визуальная колориметрия.DOI: http://dx.doi.org/10.15826/analitika.2014.18.3.009

Uncertainty in perception and the Hierarchical Gaussian Filter

In its full sense, perception rests on an agent's model of how its sensory input comes about and the inferences it draws based on this model. These inferences are necessarily uncertain. Here, we illustrate how the Hierarchical Gaussian Filter (HGF) offers a principled and generic way to deal with the several forms that uncertainty in perception takes. The HGF is a recent derivation of one-step update equations from Bayesian principles that rests on a hierarchical generative model of the environment and its (in)stability. It is computationally highly efficient, allows for online estimates of hidden states, and has found numerous applications to experimental data from human subjects. In this paper, we generalize previous descriptions of the HGF and its account of perceptual uncertainty. First, we explicitly formulate the extension of the HGF's hierarchy to any number of levels; second, we discuss how various forms of uncertainty are accommodated by the minimization of variational free energy as encoded in the update equations; third, we combine the HGF with decision models and demonstrate the inversion of this combination; finally, we report a simulation study that compared four optimization methods for inverting the HGF/decision model combination at different noise levels. These four methods (Nelder-Mead simplex algorithm, Gaussian process-based global optimization, variational Bayes and Markov chain Monte Carlo sampling) all performed well even under considerable noise, with variational Bayes offering the best combination of efficiency and informativeness of inference. Our results demonstrate that the HGF provides a principled, flexible, and efficient-but at the same time intuitive-framework for the resolution of perceptual uncertainty in behaving agents

Experience of the successful treatment with canakinumab of a patient with NLPC4-associated autoinflammatory syndrome with enterocolitis

The article shows the observation of rare NLPC4-associated autoinflammatory syndrome with enterocolitis and familial cold urticaria. Diagnosis is confirmed molecularly-genetically: previously not described mutation c.928C>T in the heterozygous state in NLRC4 gene is discovered by a method of the new generation sequencing. The use of a monoclonal antibody to the interleukin 1 canakinumab provided complete relief of fever and skin and intestinal symptoms in just 1 week of treatment. Later the signs of inflammation have disappeared completely; the patient’s quality of life improved and life-threatening complications were prevented. The above example demonstrates the high clinical efficacy of canakinumab in the patient with NLRC4-associated autoinflammatory syndrome and suggests promising therapeutic use of interleukin 1 blockers in such patients. There were no adverse events during canakinumab therapy

High Efficiency of Kanakinumabum for a Patient with a Late Diagnosed Chronic Infantile Neurological Cutaneous Articular Syndrome (CINCA)

The article presents the monitoring of a severe course of CINCA/NOMID syndrome diagnosed at late stages. The use of monoclonal antibodies to IL 1 — kanakinumabum — in a patient with chronic neurological cutaneous and articular syndrome was successful: fever, cutaneous and pain syndromes were completely stopped, joint contractures decreased after one week of therapy. Laboratory parameters of the child’s disease activity (ESR and CRP) became normal after 8 weeks of treatment. Movements in the affected joints recovered completely after 24 weeks; the audiologist noted an improvement in hearing. The above clinical example demonstrates the high efficiency of kanakinumabum for a patient with chronic neurological cutaneous and articular syndrome, and shows the perspective of therapeutic application of IL 1 blocker for patients with CINCA syndrome including advanced stages of the disease. No adverse effects were noted during kanakinumabum therapy