GEO INFORMATION EXTRACTION AND PROCESSING FROM TRAVEL NARRATIVES

Travel narratives published in electronic formats can be very important especially to the tourism community because of the great amount of knowledge that can be extracted. However, the low exploitation of these documents opens a new area of opportunity to the computing community. In this way, this article explores new ways to visualize travel narratives in a map in order to take advantage of experiences of individuals to recommend and describe travel places. Our approach is based on the use of a Geoparsing Web Service to extract geographic coordinates from travel narratives. Once geographic coordinates are extracted by using eXtensible Markup Language (XML) we draw the geo-positions and link the documents into a map image in order to visualize textual information

Treatment patterns for metastatic colorectal cancer in Spain

Abstract Purpose The primary aim of this retrospective study was to describe the treatment patterns according to the type of treatment received by patients with metastatic colorectal cancer (mCRC) in Spain. Methods This was a retrospective, observational, multicenter study performed by 33 sites throughout Spain that included consecutive patients aged 18 years or older who had received or were receiving treatment for mCRC. Results At the time of inclusion, of the 873 evaluable patients, 507 (58%) had received two lines, 235 (27%) had received three lines, 106 (12%) had received four lines, and the remaining patients had received up to ten lines. The most frequent chemotherapy schemes were the FOLFOX or CAPOX regimens (66%) for frst-line treatment, FOLFOX, CAPOX or FOLFIRI (70%) for second-line treatment, and FOLFOX, FOLFIRI or other fuoropyrimidine-based regimens for third- and fourth-line (over 60%) treatment. Sixty percent of patients received targeted therapy as part of their frst-line treatment, and this proportion increased up to approximately 70% of patients as part of the second-line of treatment. A relevant proportion of patients were treated with unknown KRAS, and especially the BRAF, mutation statuses. Conclusions This study reveals inconsistencies regarding adherence to the recommendations of the ESMO guidelines for the management of mCRC in Spain. Improved adherence to the standard practice described in such guidelines for the determination of RAS and BRAF mutation statuses and the use of targeted therapies in frst-line treatment should be considered to guarantee that patients can beneft from the best therapeutic approaches available. Keywords Colorectal cancer · Metastatic · Treatment patterns · KRAS/BRAF mutation status · Clinical practice guidelin

Long-term effectiveness of sustainable land management practices to control runoff, soil erosion, and nutrient loss and the role of rainfall intensity in Mediterranean rainfed agroecosystems

Mediterranean environments are especially susceptible to soil erosion and to inappropriate soil management, leading to accelerated soil loss. Sustainable Land Management (SLM) practices (such as reduced tillage, no-tillage, cover crops, etc.,) have the potential to reduce soil, organic carbon (OC), and nutrient losses by erosion. However, the effectivity of these practices is site-dependent and varies under different rainfall conditions. The objective of this paper was to evaluate the effects of SLM practices in two rainfed systems (a wheat field and an almond orchard) representative of a large area of the driest Mediterranean regions - on runoff, soil erosion, particle size distribution, and OC and nutrient (N and P) contents in sediments. The influence of the rainfall characteristics on the effectiveness of the SLM practices was also evaluated. The SLM implemented were: reduced tillage (RT) in the wheat field and almond orchard and reduced tillage combined with green manure (RTG) in the almond orchard; these were compared to conventional tillage, the usual practice in the area. Open erosion plots were set up to monitor the effects of SLM on soil carbon and nutrients and on soil erosion after each rainfall event over six years (2010 2016). The results show that the SLM practices evaluated resulted in increased organic carbon (OC) and nutrients (N and P) contents in the soil, and reduced runoff, erosion, and mobilization of organic carbon and nutrients in sediments. Reductions in runoff of 30% and 65% and decreases in erosion of 65 and 85% were found in the wheat field and almond orchards, respectively. In addition, the total OC, N, and P losses in the wheat field were reduced by 56%, 45%, and 64%, respectively, while in the almond field the OC, N, and P losses were reduced by 90% under RT and by 85% under RTG. The beneficial effect of the SLM practices on soil erosion was observed within 18 months of their implementation and continued throughout the six years of the study. Furthermore, the effectiveness of tillage reduction with respect to erosion control and carbon and nutrients mobilization was highest during the most intense rainfall events, which are responsible for the highest erosion rates in Mediterranean areas. Our results support the key role of SLM practices under semiarid conditions as useful tools for climate change mitigation and adaptation, given the expected increase in high-intensity rainfall events in semiarid areas. © 2019 The AuthorsThis study site has been funded by several national (CYCIT AGL201125069//CICYT AGL2010-20941//CGL2013-42009-R//CGL2014-55-405-R), Regional (Séneca Foundation: 08757/PI/08//19350/PI/14), and European Commission H2020 (F6 DG RTD 037046 and Grant 728003, DIVERFARMING projects). Joris de Vente acknowledges support from a Ramón y Cajal research grant (RYC-2012-10375) and María Almagro was supported by the Juan de la Cierva Program (IJCI-2015-23500)

Be abundances in cool main-sequence stars with exoplanets

We present new UVES spectra of a sample of 15 cool unevolved stars with and without detected planetary companions. Together with previous determinations, we study Be depletion and possible differences in Be abundances between both groups of stars. We obtain a final sample of 89 and 40 stars with and without planets, respectively, which covers a wide range of effective temperatures, from 4700 K to 6400 K, and includes several cool dwarf stars for the first time. We determine Be abundances for these stars and find that for most of them (the coolest ones) the BeII resonance lines are often undetectable, implying significant Be depletion. While for hot stars Be abundances are aproximately constant, with a slight fall as Teff decreases and the Li-Be gap around 6300 K, we find a steep drop of Be content as Teff decreases for Teff < 5500 K, confirming the results of previous papers. Therefore, for these stars there is an unknown mechanism destroying Be that is not reflected in current models of Be depletion. Moreover, this strong Be depletion in cool objects takes place for all the stars regardless of the presence of planets, thus, the effect of extra Li depletion in solar-type stars with planets when compared with stars without detected planets does not seem to be present for Be, although the number of stars at those temperatures is still small to reach a final conclusion.Comment: Accepted for publication in Ap

Active study: undetected prevalence and clinical inertia in the treatment of breakthrough cancer pain (BTcP)

Aims To prove if there is clinical inertia in the identification and treatment of episodes of breakthrough cancer pain (BTcP), comparing actual results from clinical practice with clinical oncologists’ prior perception. Design Observational and descriptive study, using information collected by practising medical oncologists, at three moments: (a) questionnaire regarding their professional judgement of the handling of patients with BTcP in their practice, (b) cross-sectional clinical screening, to detect possible existing cases of BTcP in a representative sample of their patients, (c) retrospective self-audit of clinical case histories of patients diagnosed with BTcP to find out about how it has been handled. Participants and study period A random sample on a state level of 108 specialists in medical oncology. 540 patients who suffer some type of cancer pain on the designated study date for each specialist (July–December 2016). Results The global prevalence of BTcP in the study sample covered 91.3% of the patients who were suffering some type of cancer pain. Barely 2% of the doctors surveyed suspected figures around this mark. 40.9% of the cases had not been previously detected as BTcP by their doctors. Although 90% of the patients who had previously been diagnosed with BTcP received a specific analgesic treatment for the symptoms, 42% of those patients with known BTcP were not able to control their episodes of pain. Conclusions Clinical inertia is a serious problem in the handling of BTcP in medical oncology services, where it is the subject of a significantly low level of detection and treatment, despite the contrasting perception of specialists.pre-print339 K

Oncologist’s knowledge and implementation of guidelines for breakthrough cancer pain in Spain: CONOCE study

[Purpose]: Breakthrough cancer pain (BTcP) has been shown to be a prevalent and poor prognostic factor for oncologic patients, which remain under diagnosed and undertreated. In 2012, the Spanish Society of Medical Oncology (SEOM) published a clinical practice guideline (CPG) for the treatment of cancer pain which specifically addressed the management of BTcP.[Methods]: Fundación ECO designed a qualitative study using an Internet-based survey to investigate the attitudes toward, compliance with, and use of SEOM Guideline.[Results]: A total of 83 oncologists with a mean experience of 13 years responded. Overall, 82% were aware of different guidelines to manage BTcP. Notably, attitudes toward guidelines were highly positive and there was nearly unanimous agreement that CPG provided the best scientific evidence available (99%), on the minimum information to be gathered for the medical history (100%), on the need for a specific treatment for BTcP (100%), and fentanyl as the first-choice drug (99%). Interestingly, there were discrepancies between what oncologists agreed with and what they do in clinical practice. In fact, 87.6% declare full compliance with SEOM guideline, although adherence to registration of BTcP data in medical records ranged from 30.1 to 91.6% (mean 64.5%); therapeutic management compliance was higher ranging from 75.9 to 91.6%. Main barriers identified were time pressure together with vague statements and limited dissemination of the guidelines.[Conclusion]: Despite oncologist’s clinical practice is increasingly guided by GPC, it suffers from limited compliance, at least in part due to suboptimal statements. Improved dissemination and education are needed to enhance guideline implementation.This study was funded by Kyowa Kirin Farmacéutica S. L.U. through Fundación ECO

Movilización de carbono orgánico por distintos procesos erosivos en la conexión ladera-cauce

With the purpose of analysing the type (labile or stable) and quantity of organic carbon (OC) mobilized by different erosive processes identified at the slope-bed connection, the erosion deposits of gullies, sheet erosion, bank erosion and tillage erosion were studied in a small catchment (10 ha) and compared to the characteristics of the catchment soils. Selectivity upon soil detachment and transport was associated to different OC content and types in the erosion deposits. Enrichment ratios of organic carbon sediment/soil were low (~0,40 ± 0,26), even though a slight enrichment was described for fine particles (positively correlated to CO). These results were attributed to mineralization processes prevailing over OC burial in a very active channel where depositional sites are scarce.Con el fin de caracterizar la cantidad y tipo (lábil o recalcitrante) de carbono orgánico (CO) movilizado por distintos procesos erosivos identificados en las conexiones ladera-cauce, se estudiaron las características de los depósitos de erosión concentrada en cárcavas, erosión hídrica laminar, erosión lateral-gravitacional y erosión por laboreo en el contacto ladera-cauce de una cuenca de pequeño tamaño (10 ha) y se relacionaron con las características de los suelos-fuentes originales de donde procedían. La selectividad en el arranque y transporte de suelo de los distintos procesos se pudo asociar a diferentes contenidos y tipos de CO en los depósitos. Las razones de enriquecimiento de carbono orgánico sedimento/suelo fueron bajas (~0,40 ± 0,26), a pesar de haber un ligero enriquecimiento en partículas finas (correlacionadas positivamente con el CO) en los depósitos. Todo ello se atribuyó a los efectos de la mineralización en un cauce muy activo con pocas zonas de deposición y abundantes procesos de erosión no selectiva

Light elements in stars with exoplanets

It is well known that stars orbited by giant planets have higher abundances of heavy elements when compared with average field dwarfs. A number of studies have also addressed the possibility that light element abundances are different in these stars. In this paper we will review the present status of these studies. The most significant trends will be discussed.Comment: 10 pages, 6 figures. Submitted to the proceedings of IAU symposium 268: Light elements in the universe