Room temperature stretch forming of scale space shuttle external tank dome gores. Volume 1: Technical

An account of activities and data gathered in the Room Temperature Stretch Forming of One-third Scale External Tank Bulkhead Gores for space shuttle study, and a tooling design and production cost study are reported. The following study phases are described: (1) the stretch forming of three approximately one-third scale external tank dome gores from single sheets of 2219-T37 aluminum alloy; (2) the designing of a full scale production die, including a determination of tooling requirements; and (3) the determination of cost per gore at the required production rates, including manufacturing, packaging, and shipping

The design of on-line computer systems

It is the intent of this paper to analyze and evaluate the advantages of on-line computer systems and identity the principles by which a system might be conceived and assembled

An investigation on vibration-based damage detection in circular plates

This study aims at the development of vibration-based health monitoring (VHM) methodology for thin circular plates. The possibility of using the first several natural frequencies of a circular plate for damage detection purposes is investigated first. The study then suggests a damage detection method, which considers a vibrating plate as a dynamic system and uses its time domain response represented in a new phase (state) space to extract damage sensitive characteristics. The paper introduces the idea of using large amplitude vibrations and nonlinear time series analysis for damage detection purposes. The suggested damage detection approach explores the possibility to use certain characteristics of the distribution of phase space points on the attractor of the system. It studies the histograms of this distribution and attempts to extract damage sensitive features. Three damage features are suggested and they are shown to detect damage at a rather low level using a finite element model of the plate. The method suggested is rather generic and permits development and application to more complex structures and real data

A study of the Present State of Oyster Statistics in Chesapeake Bay and Suggested Remedial Measure

Accurate, detailed and timely information on oyster landings are essential to the efficient management of the oyster resources of Chesapeake Bay. Basic types of i_nformation needed are volumes of oysters harvested on: a) designated public beds; b) unassigned bottoms; and c) leased areas. These data need to be as site specific as possible and include the type of harvest gear. Moreover, it is essential to know the portion of harvest which results from state repletion activities (planted shells or seed) and that part originating from natural production. Price, method of harvest, the buyers and sellers identifi_cation, and other similar data are also needed. However, there are today several major problems in the collections of accurate oyster statistics in the Chesapeake Bay region. Accurate oyster statistics are not being collected. Part of the reason for this is that the data base is oriented toward tax collection rather than the collection of biological statistics about the oyster population.https://scholarworks.wm.edu/vimsbooks/1150/thumbnail.jp

Eutrophication

Eutrophication is a syndrome of [../152248/index.html ecosystem]] responses to human activities that fertilize water bodies with nitrogen (N) and phosphorus (P), often leading to changes in animal and plant populations and degradation of water and habitat quality. Nitrogen and phosphorus are essential components of structural proteins, enzymes, cell membranes, nucleic acids, and molecules that capture and utilize light and chemical energy to support life. The biologically available forms of N and P are present at low concentrations in pristine lakes, rivers, estuaries, and in vast regions of the upper ocean.https://inspire.redlands.edu/oh_chapters/1160/thumbnail.jp

Time Course of Changes in Peripheral Blood Gene Expression During Medication Treatment for Major Depressive Disorder.

Changes in gene expression (GE) during antidepressant treatment may increase understanding of the action of antidepressant medications and serve as biomarkers of efficacy. GE changes in peripheral blood are desirable because they can be assessed easily on multiple occasions during treatment. We report here on GE changes in 68 individuals who were treated for 8 weeks with either escitalopram alone, or escitalopram followed by bupropion. GE changes were assessed after 1, 2, and 8 weeks of treatment, with significant changes observed in 156, 121, and 585 peripheral blood gene transcripts, respectively. Thirty-one transcript changes were shared between the 1- and 8-week time points (seven upregulated, 24 downregulated). Differences were detected between the escitalopram- and bupropion-treated subjects, although there was no significant association between GE changes and clinical outcome. A subset of 18 genes overlapped with those previously identified as differentially expressed in subjects with MDD compared with healthy control subjects. There was statistically significant overlap between genes differentially expressed in the current and previous studies, with 10 genes overlapping in at least two previous studies. There was no enrichment for genes overexpressed in nervous system cell types, but there was a trend toward enrichment for genes in the WNT/β-catenin pathway in the anterior thalamus; three genes in this pathway showed differential expression in the present and in three previous studies. Our dataset and other similar studies will provide an important source of information about potential biomarkers of recovery and for potential dysregulation of GE in MDD

Loss of vesicular dopamine release precedes tauopathy in degenerative dopaminergic neurons in a Drosophila model expressing human tau.

While a number of genome-wide association studies have identified microtubule-associated protein tau as a strong risk factor for Parkinson's disease (PD), little is known about the mechanism through which human tau can predispose an individual to this disease. Here, we demonstrate that expression of human wild-type tau is sufficient to disrupt the survival of dopaminergic neurons in a Drosophila model. Tau triggers a synaptic pathology visualized by vesicular monoamine transporter-pHGFP that precedes both the age-dependent formation of tau-containing neurofibrillary tangle-like pathology and the progressive loss of DA neurons, thereby recapitulating the pathological hallmarks of PD. Flies overexpressing tau also exhibit progressive impairments of both motor and learning behaviors. Surprisingly, contrary to common belief that hyperphosphorylated tau could aggravate toxicity, DA neuron degeneration is alleviated by expressing the modified, hyperphosphorylated tau(E14). Together, these results show that impairment of VMAT-containing synaptic vesicle, released to synapses before overt tauopathy may be the underlying mechanism of tau-associated PD and suggest that correction or prevention of this deficit may be appropriate targets for early therapeutic intervention

Concepts in Animal Parasitology, Chapter 67: Acari (Order): Mites

Chapter 67 in Concepts in Animal Parasitology on mites (order Acari) by David Evans Walter, Gerald W. Krantz, and Evert E. Lindquist. 2024. S. L. Gardner and S. A. Gardner, editors. Zea Books, Lincoln, Nebraska, United States. doi: 10.32873/unl.dc.ciap06