New disazo pyrazole disperse dyes: Synthesis, spectroscopic studies and tautomeric structures

5-amino-4-arylazo-3-methyl-1-phenylpyrazoles (2a-k)were diazotised and coupledwith 5-hydroxy-3-methyl-1H-pyrazole and 5-hydroxy-3-methyl-1-phenylpyrazole to generate two series disazo pyrazole disperse dyes (3a-k and 4a-k). These novel synthesized disazo pyrazole disperse dyes were characterized by elemental analysis and spectral methods. Absorption ability and tautomeric structure of synthesized disazo pyrazole disperse dyes substituted with electron-withdrawing and electron-donating groups at their o, m- and p-positions were also examined in detail. © 2015 Published by Elsevier B.V

Synthetic Fiber Dyeing with New Pyrazole Disperse Dyes and Their Colorimetric and Fastness Properties

A series of disazo pyrazole disperse dyes were synthesized and reported at our previous work. These 8 synthesized disazo pyrazole disperse dyes (3a-3h) were applied to poly(lactic acid) (PLA), poly(ethylene terephthalate) (PET), and polyamide 6.6 fibers. Their colorimetric and color fastness properties were investigated. All studied fibers dyed with these synthesized dyes exhibited yellow-red shades. 3c (p-Cl), 3e (m-Cl), and 3h (o-Cl) disazo disperse dyes, having auxochrome -Cl, led to the lowest color yield values for all three studied fibers. The same dyes resulted in higher color strength with darker shades on the PET and PLA fabrics in comparison PA 6.6 fabrics. 3a (p-NO2), 3b (p-OCH3), 3d (m-NO2), 3f (o-NO2), and 3g (o-OCH3) disazo disperse dyes can be recommended for PLA and PET dyeing from the color point of view leading to medium to heavy depth of shades. The wash, alkaline and acidic perspiration, dry and wet rub, water and sea water fastness levels of PLA, PET, and PA 6.6 samples dyed with 3a-3h dyes were generally quite high and in the commercially acceptable range with few exceptions. Dyed PLA fabrics displayed better sublimation fastness levels than dyed PET and PA 6.6 fabrics. Synthesized disperse dyes resulted in high light fastness performance on especially PET and PLA fibers. Light fastness level was better for dyed PET samples by comparison with dyed PLA and PA 6.6 fabrics. © 2018, The Korean Fiber Society and Springer Science+Business Media B.V., part of Springer Nature

Synthesis and investigations of the absorption spectra of hetarylazo disperse dyes derived from 2,4-quinolinediol

Synthesis of some novel hetarylazoquinoline dyes was achieved by diazotisation of nine heterocyclic amines using nitrosyl sulphuric acid, coupling with 2,4-quinolinediol. These dyes were characterized by UV-vis, FT-IR and 1H NMR spectroscopic techniques and elemental analysis. Visible absorption spectra of the dyes are discussed, both the effects of varying pH and solvent upon the absorption ability of azoquinolines. The colour of the dyes was discussed with respect to the nature of the heterocyclic ring and to the substituents therein. Temperature and concentration effects on the visible absorption maxima of the dyes are also reported. © 2005 Elsevier Ltd. All rights reserved

Abuse and neglect in children and adolescent who applied to mental disability report [Özürlü sağlık kurulu raporu için başvuran çocuk ve ergenlerde ihmal ve istismar]

Objective: The aim of this study was to examine abuse and neglect in children and adolescent who applied to Child and Adolescents Psychiatry Clinic and Hospital Health Report Committee for disability reports. Method: Children and adolescents who admitted to our Child and Adolescent Psychiatry Clinic for disability reports between November 2015 and April 2016 were included in the study. Data were collected by retrospective chart review. Results: Of the 193 cases evaluated, disability detected in %47.7 of patients. Physical punishment by parents was found in %24.8, and poor hygiene in %51.5 of disabled group (p:0.0001). Previous admission to emergency service for fall, accident, burn, corrosive matter ingestion was reported by %30,7 of disabled group, and %16,3 of not disabled group (p:0.019). Parental undergraduate degree in the not disabled group was lower than the disabled group (p0.05). In addition, unemployed fathers were more frequent in not disabled group (p<0.05). Conclusions: Child and adolescent psychiatrists and also all healthcare providers should be sensitive to child abuse and neglect that is an important community health problem. This is the first study in Turkey investigating child abuse and neglect in children and adolescents who applied to Child and Adolescent Psychiatry Clinic for disability reports. Our results suggest that to evaluate histories of childhood abuse and neglect can have a positive impact on reporting processes. © 2017, Istanbul Universitesi. All rights reserved

The Management of Traumatic Brain Injury in Children

Among all age groups, young children have one of the highest rates of Traumatic Brain Injury (TBI) related emergency department (ED) visits

Dyeing of poly(lactic acid) fibres with synthesised novel heterocyclic disazo disperse dyes

Poly(lactic acid) (PLA) is the first melt-processable, renewable, sustainable and biodegradable natural-based synthetic fibre. It has a broad range of uses and combines ecological advantages with outstanding performance in textiles. PLA fibre, as an aliphatic polyester, can be dyed with disperse dyes. Apart from the limited number of commercial disperse dyes, disperse dye exhaustion on PLA is generally lower than that on poly(ethylene terephthalate) (PET). In this study, new heterocyclic disazo disperse dyes, substituted with methyl, nitro and chloro groups at their ortho-, meta- and para- positions, synthesised in our previous study, were applied to PLA and PET fibres to examine their dyeing performance, and colour fastness and dye exhaustion properties. Different shades of yellow, orange, reddish brown and brown were obtained. Most of the synthesised novel heterocyclic disazo disperse dyes exhibited good build-up properties with high K/S levels on both fibres. Para- bonding substituent provided higher K/S values than meta- and ortho- positions for –NO2 and –Cl substituents for both fibres. Overall, the most synthesised novel heterocyclic disazo disperse dyes in this study exhibited good build-up properties with high K/S, exhaustion and wet fastness levels on both PLA and PET fibres. © 2020 Society of Dyers and Colourist

Is Change in Hemoglobin Level a Predictive Biomarker of Tyrosine Kinase Efficacy in Metastatic Renal Cell Carcinoma? A Turkish Oncology Group Study

PMID = 2833356

The acromegaly registry of ten different centers in Turkey.

OBJECTIVES: To describe biochemical and clinical features, and therapeutic outcomes of acromegaly patients in Turkey. METHODS: Retrospective multicenter epidemiological study of 547 patients followed in 10 centers of the Turkish Acromegaly registry. RESULTS: A total of 547 acromegaly patients (55% female) with a median age of 41 was included in this study. Majority of patients had a macroadenoma (78%). Transsphenoidal surgery was performed as primary treatment in 92% of the patients (n = 503). Surgical remission rate was 39% (197/503) in all operated patients. Overall disease control was achieved in 70% of patients. Remission group were significantly older than non-remission group (p = .002). Patients with microadenomas had significantly higher remission rates than patients with macroadenomas (p < .001). Patients with microadenomas were significantly older at the time of diagnosis when compared to patients with macroadenomas (p < .001). Preoperative growth hormone (GH) and insulin-like growth factor 1 (IGF-1) levels were significantly lower in the remission group (p < .001). Initial IGF-1 and GH levels were significantly higher in macroadenomas compared to microadenomas (p < .001). Medical treatment was administered as a second-line treatment (97%) in almost all patients without remission. Radiotherapy was preferred in 21% of the patients mostly as a third line treatment. CONCLUSIONS: This is one of the largest real life studies evaluating the epidemiological characteristics and treatment outcomes of patients with acromegaly who were followed in different centers in Turkey. Transsphenoidal surgery in the treatment of acromegaly still remains the most valid method. Medical treatment options may improve long-term disease outcomes in patients who cannot be controlled with surgical treatment (up to 70%)

Worse patient–physician relationship is associated with more fear of cancer recurrence (Deimos Study): A study of the Palliative Care Working Committee of the Turkish Oncology Group (TOG)

Objective: Fear of cancer recurrence (FCR) is an important psychological trauma associated with reduction in the quality of life, disruptions in the level of adjustment, emotional distress and anxiety. The purpose of the study was to evaluate the impact of patient–physician relationship on FCR. Methods: The study was designed as a multicentre survey study. The cancer survivors, who were under remission, were evaluated with structured questionnaires. Patient–physician relationship (PPR) scale in which higher scores indicate better relationship and FCR inventory was used. Results: Between January and April 2019, 1,580 patients were evaluated. The median age was 57.0 (19–88), and 66% were female. There was high level of FCR scores in 51% of participants. There was a negative correlation between PPR and FCR scores (r = −.134, p <.001). In multivariate analysis, young age, female gender, history of metastasectomy and worse PPR were associated with high levels of FCR. Conclusion: It is the first data showing the adverse impact of worse PPR on FCR. The strategies to improve the PPR should be practised. In addition, the cancer survivors, who are under the risk of FCR, should be evaluated and managed. © 2020 John Wiley & Sons Lt