Blockchain use cases across entire lifecycle of a built asset: A review

Blockchain is a key enabling technology towards the 4th industrial revolution of the construction industry. The aim of this paper is to map uses of blockchain technology across the various phases in the lifecycle of built assets. Of interest to this paper is a new classification of blockchain solutions in combination with other key enabling technologies, like Building Information Modelling and Internet of Things. The literature indicates that blockchain shows high potential for solving challenges across the entire lifecycle of a project and has an especially high potential to influence and possibly improve management in the Operation and Maintenance phase

Pulmonary Carcinoid Surface Receptor Modulation Using Histone Deacetylase Inhibitors

Study describes the use of a non-cytotoxic dose of histone deacetylase (HDAC) inhibitors to induce pulmonary carcinoid somatostatin receptor subtype 2 (SSTR2) expression to diagnose pulmonary carcinoids

The High-Acceptance Dielectron Spectrometer HADES

HADES is a versatile magnetic spectrometer aimed at studying dielectron production in pion, proton and heavy-ion induced collisions. Its main features include a ring imaging gas Cherenkov detector for electron-hadron discrimination, a tracking system consisting of a set of 6 superconducting coils producing a toroidal field and drift chambers and a multiplicity and electron trigger array for additional electron-hadron discrimination and event characterization. A two-stage trigger system enhances events containing electrons. The physics program is focused on the investigation of hadron properties in nuclei and in the hot and dense hadronic matter. The detector system is characterized by an 85% azimuthal coverage over a polar angle interval from 18 to 85 degree, a single electron efficiency of 50% and a vector meson mass resolution of 2.5%. Identification of pions, kaons and protons is achieved combining time-of-flight and energy loss measurements over a large momentum range. This paper describes the main features and the performance of the detector system

HADES experiment: di-lepton spectroscopy in p + p (2.2 GeV) and C+C (1 and 2 A GeV) collisions

The HADES (High Acceptance Di-Electron Spectrometer) is a tool designed for lepton pair (e+e−) spectroscopy in pion, proton and heavy ion induced reactions in the 1–2AGeV energy range. One of the goals of the HADES experiment is to study in-medium modifications of hadron properties like effective masses, decay widths, electromagnetic form factors etc. Such effects can be probed with vector mesons ( ρ,ω,ɸ ) decaying into e+e− channel. The identification of vector mesons by means of a HADES spectrometer is based on invariant mass reconstruction of e+e− pairs. The combined information from all spectrometer sub-detectors is used to reconstruct the di-lepton signal. The recent results from 2.2GeV p + p, 1AGeV and 2AGeV C+C experiments are presented.Diaz Medina, Jose, [email protected]

Study of e+,e− production in elementary and nuclear collisions near the production threshold with HADES

HADES is a second generation experiment designed to study dielectron production in proton, pion, and heavy ion induced reactions at the GSI accelerator facility in Darmstadt. The physics programme of HADES is focused on in-medium properties of the light vector mesons. In this contribution we present status of the HADES experiment, demonstrate its capability to identify rare dielectron signal, show first experimental results obtained from C+C reactions at 2 A GeV and shortly discuss physics programme of up-coming experimental runs. © 2004 Elsevier B.V. All rights reserved. 53 1 49 58 Cited By :1

Electrochemical Methods for Lithium Recovery: A Comprehensive and Critical Review

Due to the ubiquitous presence of lithium‐ion batteries in portable applications, and their implementation in the transportation and large‐scale energy sectors, the future cost and availability of lithium is currently under debate. Lithium demand is expected to grow in the near future, up to 900 ktons per year in 2025. Lithium utilization would depend on a strong increase in production. However, the currently most extended lithium extraction method, the lime‐soda evaporation process, requires a period of time in the range of 1–2 years and depends on weather conditions. The actual global production of lithium by this technology will soon be far exceeded by market demand. Alternative production methods have recently attracted great attention. Among them, electrochemical lithium recovery, based on electrochemical ion‐pumping technology, offers higher capacity production, it does not require the use of chemicals for the regeneration of the materials, reduces the consumption of water and the production of chemical wastes, and allows the production rate to be controlled, attending to the market demand. Here, this technology is analyzed with a special focus on the methodology, materials employed, and reactor designs. The state‐of‐the‐art is reevaluated from a critical perspective and the viability of the different proposed methodologies analyzed.The financial support of the European Union's Horizon 2020 research and innovation programme under the Marie Skłodowska‐Curie (Grant Agreement No. 665919) are gratefully acknowledged. The authors acknowledge the free distribution of VESTA software.Peer reviewe

Superresolution optical magnetic imaging and spectroscopy using individual electronic spins in diamond.

Nitrogen vacancy (NV) color centers in diamond are a leading modality for both superresolution optical imaging and nanoscale magnetic field sensing. In this work, we address the key challenge of performing optical magnetic imaging and spectroscopy selectively on multiple NV centers that are located within a diffraction-limited field-of-view. We use spin-RESOLFT microscopy to enable precision nanoscale mapping of magnetic field patterns with resolution down to ~20 nm, while employing a low power optical depletion beam. Moreover, we use a shallow NV to demonstrate the detection of proton nuclear magnetic resonance (NMR) signals exterior to the diamond, with 50 nm lateral imaging resolution and without degrading the proton NMR linewidth

Synthetic Makaluvamine Analogs Decrease c-Kit Expression and Are Cytotoxic to Neuroendocrine Tumor Cells

In an effort to discover viable systemic chemotherapeutic agents for neuroendocrine tumors (NETs), we screened a small library of 18 drug-like compounds obtained from the Velu lab against pulmonary (H727) and thyroid (MZ-CRC-1 and TT) neuroendocrine tumor-derived cell lines. Two potent lead compounds (DHN-II-84 and DHN-III-14) identified from this screening were found to be analogs of the natural product makaluvamine. We further characterized the antitumor activities of these two compounds using pulmonary (H727), thyroid (MZ-CRC-1) and pancreatic (BON) neuroendocrine tumor cell lines. Flow cytometry showed a dose-dependent increase in apoptosis in all cell lines. Induction of apoptosis with these compounds was also supported by the decrease in myeloid cell leukemia-1 (MCL-1) and X-chromosome linked inhibitor of apoptosis (XIAP) detected by Western blot. Compound treatment decreased NET markers chromogranin A (CgA) and achaete-scute homolog 1 (ASCL1) in a dose-dependent manner. Moreover, the gene expression analysis showed that the compound treatment reduced c-Kit proto-oncogene expression in the NET cell lines. Induction of apoptosis could also have been caused by the inhibition of c-Kit expression, in addition to the known mechanisms such as damage of DNA by topoisomerase II inhibition for this class of compounds. In summary, makaluvamine analogs DHN-II-84 and DHN-III-14 induced apoptosis, decreased neuroendocrine tumor markers, and showed promising antitumor activity in pulmonary, thyroid, and pancreatic NET cell lines, and hold potential to be developed as an effective treatment to combat neuroendocrine tumors