259 research outputs found
A systematic review of the safety of lisdexamfetamine dimesylate
BACKGROUND: Here we review the safety and tolerability profile of lisdexamfetamine dimesylate (LDX), the first long-acting prodrug stimulant for the treatment of attention-deficit/hyperactivity disorder (ADHD). METHODS: A PubMed search was conducted for English-language articles published up to 16 September 2013 using the following search terms: (lisdexamfetamine OR lisdexamphetamine OR SPD489 OR Vyvanse OR Venvanse OR NRP104 NOT review [publication type]). RESULTS: In short-term, parallel-group, placebo-controlled, phase III trials, treatment-emergent adverse events (TEAEs) in children, adolescents, and adults receiving LDX were typical for those reported for stimulants in general. Decreased appetite was reported by 25-39 % of patients and insomnia by 11-19 %. The most frequently reported TEAEs in long-term studies were similar to those reported in the short-term trials. Most TEAEs were mild or moderate in severity. Literature relating to four specific safety concerns associated with stimulant medications was evaluated in detail in patients receiving LDX. Gains in weight, height, and body mass index were smaller in children and adolescents receiving LDX than in placebo controls or untreated norms. Insomnia was a frequently reported TEAE in patients with ADHD of all ages receiving LDX, although the available data indicated no overall worsening of sleep quality in adults. Post-marketing survey data suggest that the rate of non-medical use of LDX was lower than that for short-acting stimulants and lower than or equivalent to long-acting stimulant formulations. Small mean increases were seen in blood pressure and pulse rate in patients receiving LDX. CONCLUSIONS: The safety and tolerability profile of LDX in individuals with ADHD is similar to that of other stimulants
Continuous symmetry of C60 fullerene and its derivatives
Conventionally, the Ih symmetry of fullerene C60 is accepted which is
supported by numerous calculations. However, this conclusion results from the
consideration of the molecule electron system, of its odd electrons in
particular, in a close-shell approximation without taking the electron spin
into account. Passing to the open-shell approximation has lead to both the
energy and the symmetry lowering up to Ci. Seemingly contradicting to a
high-symmetry pattern of experimental recording, particularly concerning the
molecule electronic spectra, the finding is considered in the current paper
from the continuous symmetry viewpoint. Exploiting both continuous symmetry
measure and continuous symmetry content, was shown that formal Ci symmetry of
the molecule is by 99.99% Ih. A similar continuous symmetry analysis of the
fullerene monoderivatives gives a reasonable explanation of a large variety of
their optical spectra patterns within the framework of the same C1 formal
symmetry exhibiting a strong stability of the C60 skeleton.Comment: 11 pages. 5 figures. 6 table
Toward a global description of the nucleus-nucleus interaction
Extensive systematization of theoretical and experimental nuclear densities
and of optical potential strengths exctracted from heavy-ion elastic scattering
data analyses at low and intermediate energies are presented.The
energy-dependence of the nuclear potential is accounted for within a model
based on the nonlocal nature of the interaction.The systematics indicate that
the heavy-ion nuclear potential can be described in a simple global way through
a double-folding shape,which basically depends only on the density of nucleons
of the partners in the collision.The poissibility of extracting information
about the nucleon-nucleon interaction from the heavy-ion potential is
investigated.Comment: 12 pages,12 figure
The ENIGMA Stroke Recovery Working Group: Big data neuroimaging to study brain–behavior relationships after stroke
The goal of the Enhancing Neuroimaging Genetics through Meta‐Analysis (ENIGMA) Stroke Recovery working group is to understand brain and behavior relationships using well‐powered meta‐ and mega‐analytic approaches. ENIGMA Stroke Recovery has data from over 2,100 stroke patients collected across 39 research studies and 10 countries around the world, comprising the largest multisite retrospective stroke data collaboration to date. This article outlines the efforts taken by the ENIGMA Stroke Recovery working group to develop neuroinformatics protocols and methods to manage multisite stroke brain magnetic resonance imaging, behavioral and demographics data. Specifically, the processes for scalable data intake and preprocessing, multisite data harmonization, and large‐scale stroke lesion analysis are described, and challenges unique to this type of big data collaboration in stroke research are discussed. Finally, future directions and limitations, as well as recommendations for improved data harmonization through prospective data collection and data management, are provided
Improved +He potentials by inversion, the tensor force and validity of the double folding model
Improved potential solutions are presented for the inverse scattering problem
for +He data. The input for the inversions includes both the data of
recent phase shift analyses and phase shifts from RGM coupled-channel
calculations based on the NN Minnesota force. The combined calculations provide
a more reliable estimate of the odd-even splitting of the potentials than
previously found, suggesting a rather moderate role for this splitting in
deuteron-nucleus scattering generally. The approximate parity-independence of
the deuteron optical potentials is shown to arise from the nontrivial
interference between antisymmetrization and channel coupling to the deuteron
breakup channels. A further comparison of the empirical potentials established
here and the double folding potential derived from the M3Y effective NN force
(with the appropriate normalisation factor) reveals strong similarities. This
result supports the application of the double folding model, combined with a
small Majorana component, to the description even of such a loosely bound
projectile as the deuteron. In turn, support is given for the application of
iterative-perturbative inversion in combination with the double folding model
to study fine details of the nucleus-nucleus potential. A -He tensor
potential is also derived to reproduce correctly the negative Li quadrupole
moment and the D-state asymptotic constant.Comment: 22 pages, 12 figures, in Revte
Socially impaired robots: Human social disorders and robots’ socio-emotional intelligence
© Springer International Publishing Switzerland 2014. Social robots need intelligence in order to safely coexist and interact with humans. Robots without functional abilities in understanding others and unable to empathise might be a societal risk and they may lead to a society of socially impaired robots. In this work we provide a survey of three relevant human social disorders, namely autism, psychopathy and schizophrenia, as a means to gain a better understanding of social robots’ future capability requirements.We provide evidence supporting the idea that social robots will require a combination of emotional intelligence and social intelligence, namely socio-emotional intelligence. We argue that a robot with a simple socio-emotional process requires a simulation-driven model of intelligence. Finally, we provide some critical guidelines for designing future socio-emotional robots
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Sensory over-responsivity: parent report, direct assessment measures, and neural architecture
BACKGROUND:
Sensory processing difficulties are common across neurodevelopmental disorders. Thus, reliable measures are needed to understand the biological underpinnings of these differences. This study aimed to define a scoring methodology specific to auditory (AOR) and tactile (TOR) over-responsivity. Second, in a pilot cohort using MRI Diffusion Tensor Imaging, we performed a proof of concept study of whether children with AOR showed measurable differences in their white matter integrity.
METHODS:
This study included children with AOR and TOR from a mixed neurodevelopmental disorder cohort including autism and sensory processing dysfunction (n = 176) as well as neurotypical children (n = 128). We established cohorts based on sensory over-responsivity using parent report (Short Sensory Profile (SSP)) and direct assessment (Sensory Processing-Three Dimensions: Assessment (SP-3D:A)) measures. With a subset of the children (n = 39), group comparisons, based on AOR phenotype, were conducted comparing the white matter fractional anisotropy in 23 regions of interest.
RESULTS:
Using direct assessment, 31% of the children with neurodevelopmental disorders had AOR and 27% had TOR. The inter-test agreement between SSP and SP-3D:A for AOR was 65% and TOR was 50%. Children with AOR had three white matter tracts showing decreased fractional anisotropy relative to children without AOR.
CONCLUSIONS:
This study identified cut-off scores for AOR and TOR using the SSP parent report and SP-3D:A observation. A combination of questionnaire and direct observation measures should be used in clinical and research settings. The SSP parent report and SP-3D:A direct observation ratings overlapped moderately for sensory related behaviors. Based on these preliminary structural neuroimaging results, we suggest a putative neural network may contribute to AOR
Cross-cultural regularities in the cognitive architecture of pride
Pride occurs in every known culture, appears early in development, is reliably triggered by achievements and formidability, and causes a characteristic display that is recognized everywhere. Here, we evaluate the theory that pride evolved to guide decisions relevant to pursuing actions that enhance valuation and respect for a person in the minds of others. By hypothesis, pride is a neurocomputational program tailored by selection to orchestrate cognition and behavior in the service of: (i) motivating the costeffective pursuit of courses of action that would increase others' valuations and respect of the individual, (ii) motivating the advertisement of acts or characteristics whose recognition by others would lead them to enhance their evaluations of the individual, and (iii) mobilizing the individual to take advantage of the resulting enhanced social landscape. To modulate how much to invest in actions that might lead to enhanced evaluations by others, the pride system must forecast the magnitude of the evaluations the action would evoke in the audience and calibrate its activation proportionally. We tested this prediction in 16 countries across 4 continents (n = 2,085), for 25 acts and traits. As predicted, the pride intensity for a given act or trait closely tracks the valuations of audiences, local (mean r = +0.82) and foreign (mean r = +0.75). This relationship is specific to pride and does not generalize to other positive emotions that coactivate with pride but lack its audience-recalibrating function
Vertical transportation systems embedded on shuffled frog leaping algorithm for manufacturing optimisation problems in industries
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