Allevamento, transumanza, lanificio: tracce dall'alto e dal pieno Medioevo veneto

All the research on the Venetoâs medieval sheep farm are based on few evidences, provided mostly by written documentation (available just for the Veronese territory). Furthermore, the existence of mountain pasture on the Lessini, the possession of tools for the sheep shearing, inventories of possessions (including animals), archeozoological data (thanks to recent excavations) help to build a picture of the Veneto farming situation for the late Middle Ages. More problematic is, however, the reconstruction of the âmanufacturing processâ before the 12th and 13th centuries. For the late Medieval ages the availability of documentation allowed, and still allows, more exhaustive researches on the Venetian Mainland sheep farm. These studies demonstrate a strong evolution of the wool mill, that became at this time a manufacture of international standards. Despite that, it is difficult to interrelate information regarding the antique era and High Medieval Ages with those present for the following centuries, even if some elements of continuity are present and may suggest some kind of continuity. These elements of permanence may be found in a wide use of sedentary farming since the antique era to the Early Modern Ages (as demonstrated by some recent research for the Padua territory). Therefore, the sheep farm is characterised not only by transhumance, but even by sedentary raised herds

Seed potato quality improvement through positive selection by smallholder farmers in Kenya

In Kenya, seed potato quality is often a major yield constraint in potato production as smallholder farmers use farm-saved seed without proper management of seed-borne pests and diseases. Farm-saved seed is therefore often highly degenerated. We carried out on-farm research to assess whether farmer-managed positive seed selection could improve yield. Positive selection gave an average yield increase in farmer-managed trials of 34%, corresponding to a 284-€ increase in profit per hectare at an additional production cost of only 6€/ha. Positive selection can be an important alternative and complementary technology to regular seed replacement, especially in the context of imperfect rural economies characterized by high risks of production and insecure markets. It does not require cash investments and is thus accessible for all potato producers. It can also be applied where access to highquality seed is not guaranteed. The technology is also suitable for landraces and not recognized cultivars that cannot be multiplied formally. Finally, the technology fits seamlessly within the seed systems of Sub-Saharan Africa, which are dominated by self-supply and neighbour supply of seed potatoes

Gender norms and the marketing of seeds and ware potatoes in Malawi.

Gender dynamics shape and influence the nature of participation in, as well as the ability to benefit from, seed and ware potato markets in Malawi. 35 sex-disaggregated focus group discussions with farmers and 4 interviews with extension officers were conducted in Dedza and Ntcheu districts. Data on seed marketing and purchase, ware potato marketing, affordability, marketing decisions, and clients, as well as social norms and values that influence market participation by men and women were collected and analyzed using the Real Markets Approach focusing on social relations within markets. Results demonstrate that agricultural market interventions that do not address underlying social structures - such as those related to gender relations and access to key resources - will benefit one group of people over another; in this case men over women

Similarity transformations approach for a generalized Fokker-Planck equation

By using similarity transformations approach, the exact propagator for a generalized one-dimensional Fokker-Planck equation, with linear drift force and space-time dependent diffusion coefficient, is obtained. The method is simple and enables us to recover and generalize special cases studied through the Lie algebraic approach and the Green function technique.Comment: 8 pages, no figure

Structure-guided design and optimization of small molecules targeting the protein-protein interaction between the von hippel-lindau (VHL) E3 ubiquitin ligase and the hypoxia inducible factor (HIF) alpha subunit with in vitro nanomolar affinities

E3 ubiquitin ligases are attractive targets in the ubiquitin-proteasome system, however, the development of small-molecule ligands has been rewarded with limited success. The von Hippel-Lindau protein (pVHL) is the substrate recognition subunit of the VHL E3 ligase that targets HIF-1α for degradation. We recently reported inhibitors of the pVHL:HIF-1α interaction, however they exhibited moderate potency. Herein, we report the design and optimization, guided by X-ray crystal structures, of a ligand series with nanomolar binding affinities

Early parenting intervention: Family risk and first-time parenting related to intervention effectiveness

The effects of cumulative risk and parity on the effectiveness of a home based parenting intervention were tested in a randomized controlled trial with 237 families with 1- to 3-year-old children screened for high levels of externalizing behavior. The intervention was aimed at enhancing positive parenting and decreasing externalizing behaviors. The results showed that cumulative risk was not associated with either change in child externalizing behaviors or change in positive parenting. When intervention effectiveness was compared for primiparas (i.e., first-time mothers) versus multiparas (i.e., mothers with more than one child), we found that intervention mothers of first-born children displayed an increase in their use of positive discipline strategies as compared to first-time mothers in the control group, whereas a similar effect for multiparas was absent. Among multiparas we found an intervention effect on sensitivity, with control group mothers showing an increase in sensitivity, whereas the intervention group showed a constant level of sensitivity over time. These results suggest that parity may be a moderator of intervention effectiveness. Implications for investigating moderators of intervention effectiveness are discussed. © 2007 Springer Science+Business Media, LLC