Spatially-resolved magnetic resonance study of the dissolution interface between soaps and water

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Thyroid: Papillary Carcinoma with inv(7)(q21q34)

Review on Thyroid: Papillary Carcinoma with inv(7)(q21q34), with data on clinics, and the genes involved

AKAP9 (A kinase (PRKA) anchor protein (yotiao) 9)

Review on AKAP9 (A kinase (PRKA) anchor protein (yotiao) 9), with data on DNA, on the protein encoded, and where the gene is implicated

Validação de marcadores moleculares do tipo microssatélites em bananeira.

A banana é um dos produtos alimentares mais produzidos no mundo atualmente, com mais de 130 países produtores. Torna-se muito importante pois é grande geradora de fonte e renda empregando milhões de pessoas em todo o território nacional, principalmente no Nordeste do pais, onde a maioria dos produtores são de baixa renda. Dentre os fatores limitantes da cultura está o cultivo de variedades pouco resistentes a pragas e doenças; e uma estratégia para a solução deste problema é a do programa de melhoramento na busca de variedades mais produtivas e resistentes. Sendo assim os marcadores moleculares torna-se uma ferramenta acessória aos programas de melhoramento. Dentre os marcadores moleculares mais utilizados nos estudos genéticos em bananeira, os marcadores microssatélites, destacam-se por serem altamente informativos, multialélicos e por apresentarem alta reprodutibilidade. Este trabalho objetivou a validação de marcadores moleculares microssatélites EST e BAC ? SSRs para auxílio ao programa de mapeamento genético da bananeira, em diplóides de bananeira contrastantes para resistência a Sigatoka amarela e negra.PDF. 033

Morphological and molecular characteristics do not confirm popular classification of the Brazil nut tree in Acre, Brazil.

In the State of Acre, the Brazil nut tree, Bertholletia excelsa (Lecythidaceae), is classified by the local population into two types according to morphological characteristics, including color and quality of wood, shape of the trunk and crown, and fruit production. We examined thereliability of this classification by comparing morphological and molecular data of four populations of Brazil nut trees from Vale do Rio Acre in the Brazilian Amazon. For the morphological analysis, we evaluated qualitative and quantitative information of the trees, fruits, and seeds. The molecular analysis was performed using RAPD and ISSR markers, with cluster analysis. Significant differences were found between the two types of Brazil nut trees for the characters diameter at breast height, fruit yield, fruit size,and number of seeds per fruit. Despite the significant correlation between the morphological characteristics and the popular classification, we observed all possible combinations of morphological characteristics in both types of Brazil nut trees. In some individuals, the classification did not correspond to any of the characteristics. The results obtained with molecular markers showed that the two locally classified types of Brazil nut trees did not differ genetically, indicating that there is no consistent separation between them

Validação de marcadores est-ssrs em diplóides de bananeira contrastantes para resistência à sigatoka amarela e negra.

A cultura da bananeira é considerada uma importante fonte de alimento e de renda para muitas famílias, sendo a maior parte produzida por pequenos produtores. O Brasil é o quarto maior produtor de banana no mundo com produção de aproximadamente 7 milhões de toneladas em 2009. O principal fator limitante para a baixa produção é a deficiência de cultivares resistentes às principais pragas e doenças. Uma das estratégias para contornar esse problema é a liberação de novas variedades resistentes, por meio do melhoramento genético. Sendo assim, o aumento pelo interesse da utilização da tecnologia de marcadores moleculares vem crescendo, pois permite a seleção de genótipos com maior confiabilidade e redução no tempo para lançamento de uma nova cultivar, tornando-se uma ferramenta fundamental para os programas de melhoramento. Para a utilização desta ferramenta é necessário o desenvolvimento de marcadores que apresentem grande conteúdo de informação para serem utilizados em trabalhos futuros. Portanto, o objetivo do trabalho foi validar e otimizar marcadores EST - SSR identificados em clones de BAC e ESTs de Musa acuminata Burmanicoides var. Calcutta 4 e validados em 22 genótipos de Musa spp. variando de diplóides melhorados a selvagens. O valor médio do PIC e da heterozigosidade foi de 0,5

Evaluation of integrated daylighting and electric lighting design projects: Lessons learned from international case studies

This article presents and discusses the lessons learned from the monitoring of 25 integrated daylighting and electric lighting international case study projects. The case studies consist of real occupied buildings that have been monitored as part of the International Energy Agency (IEA) SHC Task 61/EBC Annex 77 Programme. The general goal of the case studies was to balance lighting energy use with occupants’ visual and non-visual requirements. This was achieved using innovative solutions for daylighting and electric lighting with advanced controls, but also implementing simple and out-of-the-box strategies. The findings suggest that energy demands for lighting can significantly be reduced by combining sensible daylight provision, efficient lighting sources, and advances in controls. Yet, the effective achievement of project goals requires adequate monitoring, fine-tuning, and verification. The findings also suggest that the adoption of “integrative” lighting – that is, lighting systems that address both visual and non-visual responses – is getting increasingly popular. Catering to non-visual requirements will likely drive further innovation in lighting technology. Currently, there is limited investment available for developing daylighting systems for integrative lighting, and the current related electric strategies often come at the risk of energy rebound effects. Overall, providing daylighting and understanding user requirements are fundamental steps towards achieving quality projects, with potential benefits beyond saving energy

Left atrial volume during stress is associated with increased risk of arrhythmias in patients with hypertrophic cardiomyopathy

Introduction: In patients affected by hypertrophic cardiomyopathy (HCM), left atrial volume index (LAVi) is associated with an increased risk of tachyarrhythmias and major clinical events. To date, the clinical meaning of LAVi measured during exercise (stress LAVi [sLAVi]) has not yet been investigated in HCM. This study sought to evaluate the correlation between LAVi/sLAVi and clinical outcome (risk of arrhythmias and heart failure [HF]) in patients with HCM. Methods and Results: We enrolled a total of 51 consecutive patients with HCM (39 men; mean age: 39.41 ± 17.9 years) who underwent standard and stress echocardiography, following a common protocol. During follow-up (median follow-up was 1.82 years), the following composite endpoints were collected: ARRHYT endpoint (atrial fibrillation, paroxysmal supraventricular tachycardia, nonsustained ventricular tachycardia (VT), sustained VT, ventricular fibrillation, syncope of likely cardiogenic nature, and sudden cardiac death) and HF endpoint (worsening of functional class and left ventricular ejection fraction, hospitalization, and death for end-stage HF). Eight patients were lost at follow-up. ARRHYT endpoint occurred in 13 (30.2%) patients (8, 18.6%, supraventricular and 10, 23.2%, ventricular arrhythmias), whereas HF endpoint occurred in 5 (11.6%) patients. sLAVi (mean value of 31.16 ± 10.15 mL/m2) performed better than rLAVi as a predictor of ARRHYT endpoint (Akaike Information Criterion: 48.37 vs. 50.37, if dichotomized according to the median values). A sLAVi value of 30 mL/m2 showed a predictive accuracy of 72.1% (C-statistics of 0.7346), with a high negative predictive value (87.5%). Conclusion: These findings encourage future studies on sLAVi, as a potential predictor of arrhythmias and adverse outcome in patients with HCM