M. B. Cossío y la desjerarquización docente

El presente trabajo va a ceñirse a algo tan palpitante y tan extentóreamente pedido por todas las fuerzas democráticas como es el cuerpo único de enseñantes y, en suma, la desjerarquización docente de que nos habla el longevo director del Museo Pedagógico Nacional, don M. Bartolomé Cossío . Este gran miembro de la Institución Libre de Enseñanza dio en Bilbao, en 1905, una conferencia que portaba el siguiente título: «El maestro, la escuela y el material de enseñanza». La vigencia del asunto tratado por Cossío era tan innegable en la época primorriverista que la seria y profunda «Revista de Pedagogía» consideró conveniente la publicación del texto con el título de «El maestro» en su número 86 de febrero de 1929

Nicotine self-administration and ERK signaling are altered in RasGRF2 knockout mice

Ras/Raf/MEK/ERK (Ras-ERK) signaling has been demonstrated to play a role in the effects of drugs of abuse such as cocaine and alcohol, but has not been extensively examined in nicotine-related reward behaviors. We examined the role of Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2), an upstream mediator of the Ras-ERK signaling pathway, on nicotine self-administration (SA) in RasGRF2 KO and WT mice. We first demonstrated that acute nicotine exposure (0.4 mg/kg) resulted in an increase in phosphorylated ERK1/2 (pERK1/2) in the striatum, consistent with previous reports. We also demonstrated that increases in pERK1/2 resulting from acute (0.4 mg/kg) and repeated (0.4 mg/kg, 10 daily injections) exposure to nicotine in WT mice were not present in RasGRF2 KO mice, confirming that RasGRF2 at least partly regulates the activity of the Ras-ERK signaling pathway following nicotine exposure. We then performed intravenous nicotine SA (0.03 mg/kg/infusion for 10 days) in RasGRF2 KO and WT mice. Consistent with a previous report using cocaine SA, RasGRF2 KO mice demonstrated an increase in nicotine SA relative to WT controls. These findings suggest a role for RasGRF2 in the reinforcing effects of nicotine, and implicate the Ras-ERK signaling pathway as a common mediator of the response to drugs of abuse

Certification prerequisites for activities related to the trading of demand response resources

Certification according to international standards brings many benefits to the society, including technical, economic and environmental aspects. In this context, this paper highlights the benefits of certification of Demand Response, including the additional credibility which provides to the trading of flexibility and higher confidence between different players. The consequence is a dynamic environment which facilitates the market acceptance of Demand Response services and products, providing significant benefits to providers and users of such services. A methodology for the systematic certification of different activities related to the transaction of Demand Response resources has been developed and it is presented here. In particular, three types of certificate have been specified, considering the certification of the entity providing the resource (Demand Response Provider), the contractual framework between the provider and the requester (Demand Response Product) and the physical platform to enable and guarantee such transaction (Demand Response Energy Service Trader). The results of this paper may help regulators and standardization bodies in the design and specification of a future norm to allow the certification of the above-mentioned activities, or a further development of existing regulation for certification of energy efficiency systems (like ISO 50001), where certification of Demand Response activities could be complementary.This work was completed in the framework of the DRIP project (11ENV/DE/340) co-funded by the European Commission through the LIFE Environment Programme. The authors deeply thank all the participants in the project for their help and support that made possible this work.Alcázar-Ortega, M.; Calpe Esteve, CM.; Theisen, T.; Rodríguez-García, J. (2015). Certification prerequisites for activities related to the trading of demand response resources. Energy. 93:705-715. doi:10.1016/j.energy.2015.09.082S7057159

Metabolite Profiling Identifies Candidate Markers Reflecting the Clinical Adaptations Associated with Roux-en-Y Gastric Bypass Surgery

Background: Roux-en-Y gastric bypass (RYGB) surgery is associated with weight loss, improved insulin sensitivity and glucose homeostasis, and a reduction in co-morbidities such as diabetes and coronary heart disease. To generate further insight into the numerous metabolic adaptations associated with RYGB surgery, we profiled serum metabolites before and after gastric bypass surgery and integrated metabolite changes with clinical data. Methodology and Principal Findings: Serum metabolites were detected by gas and liquid chromatography-coupled mass spectrometry before, and 3 and 6 months after RYGB in morbidly obese female subjects (n = 14; BMI = 46.261.7). Subjects showed decreases in weight-related parameters and improvements in insulin sensitivity post surgery. The abundance of 48 % (83 of 172) of the measured metabolites changed significantly within the first 3 months post RYGB (p,0.05), including sphingosines, unsaturated fatty acids, and branched chain amino acids. Dividing subjects into obese (n = 9) and obese/ diabetic (n = 5) groups identified 8 metabolites that differed consistently at all time points and whose serum levels changed following RYGB: asparagine, lysophosphatidylcholine (C18:2), nervonic (C24:1) acid, p-Cresol sulfate, lactate, lycopene, glucose, and mannose. Changes in the aforementioned metabolites were integrated with clinical data for body mass index (BMI) and estimates for insulin resistance (HOMA-IR). Of these, nervonic acid was significantly and negatively correlated with HOMA-IR (p = 0.001, R = 20.55)

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

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Role of B-cell receptors for B-cell development and antigen-induced differentiation

B-cell development is characterized by a number of tightly regulated selection processes. Signals through the B-cell receptor (BCR) guide and are required for B-cell maturation, survival, and fate decision. Here, we review the role of the BCR during B-cell development, leading to the emergence of B1, marginal zone, and peripheral follicular B cells. Furthermore, we discuss BCR-derived signals on activated B cells that lead to germinal center and plasma cell differentiation

Effects of Partial Replacement of Fish Meal by Fermented Copra Meal on the Growth and Feed Efficiency in Black Tiger Shrimp, Penaeus monodon

The potential of fermented copra meal (FCM) as an alternative to fish meal as a protein source for tiger shrimp, Penaeus monodon practical diet was evaluated. Five isonitrogenous (41% crude protein) diets with 0, 10, 20, 30 and 40% fish meal protein replaced with protein from FCM were formulated. P. monodon (average weight 0.38 ± 0.02 g) were distributed in 100 L capacity fiberglass tanks at 20 shrimp each. The diets were fed 4 times daily for 9 weeks initially at 15% of the shrimp ABW and reduced to 8%. The experiment was conducted in triplicate in a flow-through culture system. The parameters examined include growth, feed conversion ratio (FCR), survival, whole body nutrient composition, protein efficiency ratio (PER), and protein productive value (PPV) as a measure of protein retention. After the feeding trial, results demonstrated that regardless of the FCM replacement level in the diet, no significant differences were observed in all the parameters (growth, FCR, survival, whole body nutrient composition, PER and PPV) measured. Thus, fermented copra meal can be used as alternative protein source and can replace up to 40% of the fish meal protein in black tiger shrimp practical diet