The combined effect of prostaglandin administration and ram introduction in multiparous and nulliparous sheep in anestrous period on prolificacy

In the study it was aimed to investigate and compare the combined effectiveness of ram introduction (ram effect) and prostaglandin F2 alpha (PGF2α) administration in multiparous and nulliparous Kangal White Karaman ewes during the out of breeding season. The ewes were first divided into two main groups: non-lactating multiparous (Group M, n=104) and nulliparous (Group N, n=101). The multiparous and nulliparous animals were further divided in to two subgroups. Group MRP (n=50 multiparous) and NRP (n=51 nulliparous) were injected with a single dose of PGF2α on the first day of ram introduction. And the Group MR (n= 54) and NR (n= 50) served as controls with ram introduction but no PGF2α injection. In all of the groups, adult, purebred and fertile rams stayed with the ewes for 45 days. The blood samples were collected at 3-day intervals for 18 days after ram introduction from subsets of ewes (n=17 per group) to monitor the serum progesterone concentration. The total lambing ratios in multiparous and nulliparous animals were 72.1% (75/104) and 44.6% (45/101), respectively (P<0.001). Among the PGF2α and non-PGF2α subgroups of multiparous and nulliparous ewes, the lowest lambing rate was observed in Group NR (36.0%). In multiparous ewes (Groups MR and MRP), the mean progesterone level varied significantly among the days (P<0.001). In contrast, in Group NRP, the progesterone levels varied significantly over the tested time course (P0.05). We concluded that being multiparous contributes to the success of PGF2α administration in combination with ram introduction in the anestrous period in ewes. Furthermore, PGF2α administration together with ram introduction positively affects the lambing rate in nulliparous ewes

Molecular gated nanoporous anodic alumina for the detection of cocaine

[EN] We present herein the use of nanoporous anodic alumina (NAA) as a suitable support to implement molecular gates for sensing applications. In our design, a NAA support is loaded with a fluorescent reporter (rhodamine B) and functionalized with a short single-stranded DNA. Then pores are blocked by the subsequent hybridisation of a specific cocaine aptamer. The response of the gated material was studied in aqueous solution. In a typical experiment, the support was immersed in hybridisation buffer solution in the absence or presence of cocaine. At certain times, the release of rhodamine B from pore voids was measured by fluorescence spectroscopy. The capped NAA support showed poor cargo delivery, but presence of cocaine in the solution selectively induced rhodamine B release. By this simple procedure a limit of detection as low as 5 × 10&#8722;7 M was calculated for cocaine. The gated NAA was successfully applied to detect cocaine in saliva samples and the possible re-use of the nanostructures was assessed. Based on these results, we believe that NAA could be a suitable support to prepare optical gated probes with a synergic combination of the favourable features of selected gated sensing systems and NAA.We thank Projects MAT2015-64139-C4-1-R and TEC2015-71324-R (MINECO/FEDER), the Catalan Government (Project 2014 SGR 1344), the ICREA (ICREA2014 Academia Award) and the Generalitat Valenciana (Project PROMETEOII/2014/047) for support. We also thank to the Agencia Espanola del Medicamento y Productos Sanitarios for its concessions. A.R. thanks the UPV for her predoctoral fellowship. The authors also thank the Electron Microscopy Service at UPV for support.Ribes, À.; Xifre Perez, E.; Aznar, E.; Sancenón Galarza, F.; Pardo Vicente, MT.; Marsal, LF.; Martínez-Máñez, R. (2016). Molecular gated nanoporous anodic alumina for the detection of cocaine. 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Reconciling the stratigraphy and depositional history of the Lycian orogen-top basins, SW Anatolia

Terrestrial fossil records from the SWAnatolian basins are crucial both for regional correlations and palaeoenvironmental reconstructions. By reassessing biostratigraphic constraints and incorporating new fossil data, we calibrated and reconstructed the late Neogene andQuaternary palaeoenvironments within a regional palaeogeographical framework. The culmination of the Taurides inSWAnatolia was followed by a regional crustal extension from the late Tortonian onwards that created a broad array of NE-trending orogen-top basins with synchronic associations of alluvial fan, fluvial and lacustrine deposits. The terrestrial basins are superimposed on the upper Burdigalian marine units with a c. 7 myr of hiatus that corresponds to a shift from regional shortening to extension. The initial infill of these basins is documented by a transition from marginal alluvial fans and axial fluvial systems into central shallow-perennial lakes coinciding with a climatic shift from warm/humid to arid conditions. The basal alluvial fan deposits abound in fossil macro-mammals of an early Turolian (MN11–12; late Tortonian) age. The Pliocene epoch in the region was punctuated by subhumid/humid conditions resulting in a rise of local base levels and expansion of lakes as evidenced by marsh-swamp deposits containing diverse fossilmammal assemblages indicating late Ruscinian (lateMN15; late Zanclean) ageWe are grateful for the support of the international bilateral project between The Scientific and Technological Research Council of Turkey (TUBITAK) and The Russian Scientific Foundation (RFBR) with grant a number of 111Y192. M.C.A. is grateful to the Turkish Academy of Sciences (TUBA) for a GEBIP (Young Scientist Award) grant. T.K. and S.M. are grateful to the Ege University Scientific Research Center for the TTM/002/2016 and TTM/001/2016 projects. M.C.A., H.A., S.M. and M.B. have obtained Martin and Temmick Fellowships at Naturalis Biodiversity Center (Leiden). F.A.D. is supported by a Mehmet Akif Ersoy University Scientific Research Grant. T.A.N. is supported by an Alexander-von-Humboldt Scholarship. L.H.O. received support from TUBITAK under the 2221 program for visiting scientists

Kıyı Alanlarının Rekreasyonel Amaçlı Alternatif Kullanımının Artvin Örneğinde İrdelenmesi

Geçmişten günümüze daima insanoğlunun ilgisini çeken kıyı alanları, rekreasyonel kullanım ve etkinlik çeşitliliği açısından oldukça zengin kaynak değerlerine sahiptir. Su kenarları, tarih boyunca yerleşim, ulaşım, rekreasyon ve turizm gibi çeşitli kullanım amaçlarına hizmet ederek ilgili amaçlar doğrultusunda planlanmış ve tasarlanmıştır. Bu bağlamda halkın kıyılardan aktif ve serbestçe yararlanması ve kıyı alanlarının sürdürülebilir kullanımı ve planlanmasına yönelik çalışmalar birçok araştırmanın hedefi olmuştur. Bu çalışmanın amacı, Artvin ilinin Karadeniz kıyısında yer alan Hopa ve Arhavi ilçelerine ait kıyı ve sahil şeridinin ilk bölümünde yer alan kullanımların yasal ve teknik açıdan irdelenerek kıyıların rekreasyonel kullanım potansiyelinin belirlenmesidir. Söz konusu çalışmada Artvin İli’ne ait toplamda 36,2 km olan kıyı bandı, idari sınırlar ve planlı/plansız alan durumu dikkate alınarak yedi bölüm altında ele alınmıştır. Çalışmada materyal olarak, 1/1000 ölçekli onaylı Uygulama İmar Planları, dolgu alanlarına yönelik hazırlanan planlar, 1/1000 ölçekli halihazır haritalar ve arazi çalışmalarıyla elde edilen veriler ve fotoğraflar kullanılmıştır. Çalışma alanındaki mevcut kıyı kullanımlarının belirlenmesi ve analizi ile haritaların üretilmesi ve düzenlenmesi sürecinde ise ArcMap 10.2, Google Earth ve Photoshop CS6 programlarından yararlanılmıştır. Yapılan tüm bu inceleme ve değerlendirmeler sonucunda, çalışma alanındaki arazi yapısının elverişsiz koşullarının, kıyı alanını ve dolayısıyla rekreasyonel kullanımı kısıtladığı,  kıyının ve kıyının tamamlayıcısı olan sahil şeridinin yanlış alan kullanımlarına maruz kaldığı belirlenmiştir. Planlı alan kapsamındaki kıyı ve sahil şeridinde rekreasyonel amaçlı kullanımların var olduğu, bununla birlikte planlı alanların plansız alanlara nazaran daha çok yanlış kıyı kullanımlarına maruz kaldığı tespit edilmiştir. Ayrıca çalışma alanındaki kıyı genişliğinin, 0,5m ile 215 m arasında değiştiği ve çoğunlukla dar kıyı niteliği taşıdığı belirlenmiştir

Anomalous origin of the left circumflex coronary artery: A case report

The anomalous origin of the left circumflex coronary artery from the right sinus of Valsalva is a relatively common anatomical variation. Difficulties may occur in the diagnostic procedure, but recognition and adequate visualization of the anomaly is essential for proper patient management, especially in patients undergoing evaluation for percutaneous coronary intervention, coronary artery surgery or prosthetic valve replacement. In the present report, a patient who had undergone percutaneous coronary intervention for a right coronary artery lesion after inferior myocardial infarction is described. The anomalous origin of the left circumflex coronary artery arising independently from the right sinus of Valsalva was previously undetected. © 2007 Pulsus Group Inc. All rights reserved