Weight preoccupation in middle school, high school and college females : the influence of self-esteem and locus of control

Much of the prior empirical and theoretical literature has focused on the impact of low self-esteem and external locus of control in the etiology of clinical eating disorders.- This study examined the influences of these variables and their impact on weight preoccupation in three different school group samples of females. Three hundred, seventy-eight female participants from middle school (N=98), high school (N=96), and college (N=184) were administered the Eating Attitudes Test (EAT-40), Rosenberg Self-Esteem Scale (RSES), and the Children\u27s Nowicki-Strickland Internal-External Locus of Control Scale (CNSIE). The EAT-40 was used to dichotomize the three school groups (i.e., middle school, high school, college) into weight preoccupied (WP) and non-weight preoccupied (NWP) groups for comparisons using the dependent variables of self-esteem \ and locus of control. Additionally, the effect of low self-esteem and external locus of control was examined for its effect on weight preoccupation. Pearson Product-Moment· correlations revealed that: (a) there was a significant relationship between female participants\u27 ratings of self-esteem and weight preoccupation at all three school group levels; and (b) there was a significant relationship between locus of control and weight preoccupation in females in the middle school and high school groups, but not at the college level. Analysis of variance (ANOV A) indicated that: (a) there were significant differences in self-esteem between WP and NWP females in the college and high school groups; (b) there were no significant differences in self-esteem within the NWP group; (c) there were significant differences in self-esteem within the WP group; (d) there was a significant difference in locus of control between WP and NWP females in the high vii school group; (e) there were no significant differences in locus of control within the NWP group; and (f) there were significant differences in locus of control within the WP group. In a supplemental regression analysis, the variables of locus of control (as measured by CNSIE), self-esteem (as measured by RSES), and weight differential, were significant predictors of weight preoccupation (as measured by the EAT-40) in the middle school and high school groups. Results from this study were discussed in relation to what is· known about age-related differences in self-esteem and locus of control in eating disordered /weight preoccupied females. It was recommended that future research explore these same variables using grade instead of school groups, and that gender comparisons also be made. The limitations of this study were discussed along with quality of obtained data and implications for parents and health education

Migración de software C/C++ a plataformas móviles a partir de MDD (Model Driven Development)

Actualmente los dispositivos móviles acompañan a los usuarios en todo momento y lugar, y se prevé que serán el principal medio de acceso a Internet en los próximos años, sin embargo, el desarrollo de aplicaciones de software móviles no está lo su cientemente maduro. La proliferación de diferentes plataformas móviles ha forzado a los desarrolladores a de nir enfoques que permitan simpli car el desarrollo de aplicaciones . Los autores remarcan que dos de los principales desafíos de la ingeniería de software de aplicaciones móviles son por un lado, la creación de interfaces de usuario que abarquen diferentes clases de dispositivos móviles y por otro, brindar aplicaciones reutilizables en múltiples plataformas. Desarrollar una aplicación de software para un dispositivo móvil implica adoptar y entender las características de estos dispositivos y sus restricciones. Si bien éstos cuentan con características avanzadas también se presentan importantes restricciones. Por ejemplo, incorporan interfaces de entrada más intuitivas, usualmente, pantallas táctiles, bases de datos integradas, soporte multimedia y mecanismos de comunicación y geolocalización. También se presentan importantes restricciones en cuanto al tamaño de la pantalla disponible, capacidad de procesamiento, la utilización de memoria primaria y las bibliotecas de desarrollo disponibles .Ingeniero en Sistema

A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection

Autoantibodies detected after kidney transplantation may contribute to chronic rejection. We and others have previously described the organization of immune effectors into functional intragraft tertiary lymphoid tissue, a site where breakdown of B-cell tolerance may occur. To test this, we performed a comprehensive analysis of 26 chronically rejected kidney grafts. Antibodies were screened by indirect immunofluorescence on HEp2 cells, a procedure that detects antibodies to intracellular antigens, and monkey kidney sections, which detects kidney tissue autoantigens. The incidence of anti-HEp2 autoantibodies was significantly higher in graft explant culture supernatants than in patient sera. Reactivity against monkey kidney sections was detected in almost half of culture supernatants with anti-HEp2 autoantibodies. A local enrichment in T helper 17 and B-cell-activating factor (CD257) correlated with intragraft production of anti-HEp2 antibodies. A decrease in Tregs and a symmetric increase of activated OX40 (CD134)-expressing CD4+ T cells were found in grafts in which anti-kidney autoantibodies were produced. Thus, a stepwise breakdown of B-cell tolerance occurs within the graft during chronic rejection. Hence, the intragraft microenvironment interferes with peripheral deletion of autoreactive immature B cells that, in turn, produce antibodies against intracellular autoantigens. When intragraft immune regulation is insufficient, spreading of the local response against kidney autoantigens is favored

Dominant role of GABAB2 and Gbetagamma for GABAB receptor-mediated-ERK1/2/CREB pathway in cerebellar neurons

gamma-aminobutyric acid type B (GABA(B)) receptor is an allosteric complex made of two subunits, GABA(B1) and GABA(B2). GABA(B2) plays a major role in the coupling to G protein whereas GABA(B1) binds GABA. It has been shown that GABA(B) receptor activates ERK(1/2) in neurons of the central nervous system, but the molecular mechanisms underlying this event are poorly characterized. Here, we demonstrate that activation of GABA(B) receptor by either GABA or the selective agonist baclofen induces ERK(1/2) phosphorylation in cultured cerebellar granule neurons. We also show that CGP7930, a positive allosteric regulator specific of GABA(B2), alone can induce the phosphorylation of ERK(1/2). PTX, a G(i/o) inhibitor, abolishes both baclofen and CGP7930-mediated-ERK(1/2) phosphorylation. Moreover, both baclofen and CGP7930 induce ERK-dependent CREB phosphorylation. Furthermore, by using LY294002, a PI-3 kinase inhibitor, and a C-term of GRK-2 that has been reported to sequester Gbetagamma subunits, we demonstrate the role of Gbetagamma in GABA(B) receptor-mediated-ERK(1/2) phosphorylation. In conclusion, the activation of GABA(B) receptor leads to ERK(1/2) phosphorylation via the coupling of GABA(B2) to G(i/o) and by releasing Gbetagamma subunits which in turn induce the activation of CREB. These findings suggest a role of GABA(B) receptor in long-term change in the central nervous system

GABAB Receptor Subunit GB1 at the Cell Surface Independently Activates ERK1/2 through IGF-1R Transactivation

BACKGROUND: Functional GABA(B) receptor is believed to require hetero-dimerization between GABA(B1) (GB1) and GABA(B2) (GB2) subunits. The GB1 extracellular domain is required for ligand binding, and the GB2 trans-membrane domain is responsible for coupling to G proteins. Atypical GABA(B) receptor responses observed in GB2-deficient mice suggested that GB1 may have activity in the absence of GB2. However the underlying mechanisms remain poorly characterized. METHODOLOGY/PRINCIPAL FINDINGS: Here, by using cells overexpressing a GB1 mutant (GB1asa) with the ability to translocate to the cell surface in the absence of GB2, we show that GABA(B) receptor agonists, such as GABA and Baclofen, can induce ERK1/2 phosphorylation in the absence of GB2. Furthermore, we demonstrate that GB1asa induces ERK1/2 phosphorylation through Gi/o proteins and PLC dependent IGF-1R transactivation. CONCLUSIONS/SIGNIFICANCE: Our data suggest that GB1 may form a functional receptor at the cell surface in the absence of GB2

Informe científico de Beca de Entrenamiento: Duthey, Maximiliano (2014-2015)

Se propone como objetivo general de este trabajo analizar procesos basados en MDA y ADM para la modernización de software orientado a objetos. En particular, se propone analizar procesos de que integren técnicas tradicionales de análisis estático y dinámico con los estándares ADM. La propuesta se validará a través de la modernización de código orientado a objetos a modelos MDA que permitan posteriormente procesos de ingeniería directa (forward engineering)

Rôle de l'hétérodimérisation dans le fonctionnement et l'adressage du récepteur GABAB /

MONTPELLIER-BU Sciences (341722106) / SudocSudocFranceF