Coverage-Based Debloating for Java Bytecode

Software bloat is code that is packaged in an application but is actually not necessary to run the application. The presence of software bloat is an issue for security, for performance, and for maintenance. In this paper, we introduce a novel technique for debloating Java bytecode, which we call coverage-based debloating. We leverage a combination of state-of-the-art Java bytecode coverage tools to precisely capture what parts of a project and its dependencies are used at runtime. Then, we automatically remove the parts that are not covered to generate a debloated version of the compiled project. We successfully generate debloated versions of 220 open-source Java libraries, which are syntactically correct and preserve their original behavior according to the workload. Our results indicate that 68.3% of the libraries' bytecode and 20.5% of their total dependencies can be removed through coverage-based debloating. Meanwhile, we present the first experiment that assesses the utility of debloated libraries with respect to client applications that reuse them. We show that 80.9% of the clients with at least one test that uses the library successfully compile and pass their test suite when the original library is replaced by its debloated version

Sharing inter-faculty teaching experiences for improved training in information literacy

audience: researcher, professiona

Progressive Structural Defects in Canine Centronuclear Myopathy Indicate a Role for HACD1 in Maintaining Skeletal Muscle Membrane Systems

Mutations in HACD1/PTPLA cause recessive congenital myopathies in humans and dogs. Hydroxyacyl-coA dehydratases are required for elongation of very long chain fatty acids, and HACD1 has a role in early myogenesis, but the functions of this striated muscle-specific enzyme in more differentiated skeletal muscle remain unknown. Canine HACD1 deficiency is histopathologically classified as a centronuclear myopathy (CNM). We investigated the hypothesis that muscle from HACD1-deficient dogs has membrane abnormalities in common with CNMs with different genetic causes. We found progressive changes in tubuloreticular and sarcolemmal membranes and mislocalized triads and mitochondria in skeletal muscle from animals deficient in HACD1. Furthermore, comparable membranous abnormalities in cultured HACD1-deficient myotubes provide additional evidence that these defects are a primary consequence of altered HACD1 expression. Our novel findings, including T-tubule dilatation and disorganization, associated with defects in this additional CNM-associated gene provide a definitive pathophysiologic link with these disorders, confirm that dogs deficient in HACD1 are relevant models, and strengthen the evidence for a unifying pathogenesis in CNMs via defective membrane trafficking and excitation-contraction coupling in muscle. These results build on previous work by determining further functional roles of HACD1 in muscle and provide new insight into the pathology and pathogenetic mechanisms of HACD1 CNM. Consequently, alterations in membrane properties associated with HACD1 mutations should be investigated in humans with related phenotypes

ArchiRuptureS : Construire-Déconstruire-Bifurquer, Semaine intensive autour de l'architecture, des enjeux climatiques et sociaux

11. Sustainable cities and communitie

Proton MR spectroscopy and diffusion MR imaging monitoring to predict tumor response to interstitial photodynamic therapy for glioblastoma

International audienceDespite recent progress in conventional therapeutic approaches, the vast majority of glioblastoma recur locally, indicating that a more aggressive local therapy is required. Interstitial photodynamic therapy (iPDT) appears as a very promising and complementary approach to conventional therapies. However, an optimal fractionation scheme for iPDT remains the indispensable requirement. To achieve that major goal, we suggested following iPDT tumor response by a non-invasive imaging monitoring. Nude rats bearing intracranial glioblastoma U87MG xenografts were treated by iPDT, just after intravenous injection of AGuIX® nanoparticles, encapsulating PDT and imaging agents. Magnetic Resonance Imaging (MRI) and Magnetic Resonance Spectroscopy (MRS) allowed us an original longitudinal follow-up of post-treatment effects to discriminate early predictive markers. We successfully used conventional MRI, T2 star (T2*), Diffusion Weighted Imaging (DWI) and MRS to extract relevant profiles on tissue cytoarchitectural alterations, local vascular disruption and metabolic information on brain tumor biology, achieving earlier assessment of tumor response. From one day post-iPDT, DWI and MRS allowed us to identify promising markers such as the Apparent Diffusion Coefficient (ADC) values, lipids, choline and myoInositol levels that led us to distinguish iPDT responders from non-responders. All these responses give us warning signs well before the tumor escapes and that the growth would be appreciated

Placing the academic library at the center of veterinary PhD students' training

For several years academic librairies have been actively involved in information literacy instruction. However, the required competences are different for PhD students and in the case of the Veterinary Faculty of the University of Liège (Belgium), good Faculty-Librarian collaborations have been developed. Specific targeted courses and training sessions concerning information literacy have been officially incorporated in the PhD curriculum, with the main objective being to help PhD students to be autonomous and efficient in the elaboration of scientific publications, an essential stage of their scientific career

Case 247: Jersey finger of the fifth finger

SCOPUS: ar.jinfo:eu-repo/semantics/publishe