Twenty years of P-splines

P-splines first appeared in the limelight twenty years ago. Since then they have become popular in applications and in theoretical work. The combination of a rich B-spline basis and a simple difference penalty lends itself well to a variety of generalizations, because it is based on regression. In effect, P-splines allow the building of a “backbone” for the “mixing and matching” of a variety of additive smooth structure components, while inviting all sorts of extensions: varying-coefficient effects, signal (functional) regressors, two-dimensional surfaces, non-normal responses, quantile (expectile) modelling, among others. Strong connections with mixed models and Bayesian analysis have been established. We give an overview of many of the central developments during the first two decades of P-splines.Peer Reviewe

Twenty years of P-splines

P-splines first appeared in the limelight twenty years ago. Since then they have become popular in applications and in theoretical work. The combination of a rich B-spline basis and a simple difference penalty lends itself well to a variety of generalizations, because it is based on regression. In effect, P-splines allow the building of a “backbone” for the “mixing and matching” of a variety of additive smooth structure components, while inviting all sorts of extensions: varying-coefficient effects, signal (functional) regressors, two-dimensional surfaces, non-normal responses, quantile (expectile) modelling, among others. Strong connections with mixed models and Bayesian analysis have been established. We give an overview of many of the central developments during the first two decades of P-splines

Actualización en odontopediatría 2007

En el presente trabajo se analizan las publicaciones relacionadas con la odontopediatría aparecidas durante el año 2007. Debido a la gran cantidad de artículos publicados, estos se han distribuido en cinco apartados: 1) control de conducta; 2) pulpa; 3) operatoria dental; 4) traumatismos; y 5) miscelánea

Twenty years of P-splines

P-splines first appeared in the limelight twenty years ago. Since then they have become popular in applications and in theoretical work. The combination of a rich B-spline basis and a simple difference penalty lends itself well to a variety of generalizations, because it is based on regression. In effect, P-splines allow the building of a “backbone” for the “mixing and matching” of a variety of additive smooth structure components, while inviting all sorts of extensions: varying-coefficient effects, signal (functional) regressors, two-dimensional surfaces, non-normal responses, quantile (expectile) modelling, among others. Strong connections with mixed models and Bayesian analysis have been established. We give an overview of many of the central developments during the first two decades of P-splines.Peer Reviewe

Twenty years of P-splines

P-splines first appeared in the limelight twenty years ago. Since then they have become popular in applications and in theoretical work. The combination of a rich B-spline basis and a simple difference penalty lends itself well to a variety of generalizations, because it is based on regression. In effect, P-splines allow the building of a "backbone" for the "mixing and matching" of a variety of additive smooth structure components, while inviting all sorts of extensions: varying-coefficient effects, signal (functional) regressors, two-dimensional surfaces, non-normal responses, quantile (expectile) modelling, among others. Strong connections with mixed models and Bayesian analysis have been established. We give an overview of many of the central developments during the first two decades of P-splines

Modelling physical activity profiles in COPD patients: a new approach to variable-domain functional regression models

Motivated by the increasingly common technology for collecting data, like cellphones, smartwatches, etc, functional data analysis has been intensively studied in recent decades, and along with it, functional regression models. However, the majority of functional data methods in general and functional regression models, in particular, are based on the fact that the observed datapresent the same domain. When the data have variable domain it needs to be aligned or registered in order to be fitted with the usual modeling techniques adding computational burden. To avoid this, a model that contemplates the variable domain features of the data is needed, but this type of models are scarce and its estimation method presents some limitations. In this article, we propose a new scalar-on-function regression model for variable domain functional data that eludes the need for alignment and a new estimation methodology that we extend to other variable domain regression models

Sustainability in sports facilities

[EN] The Consejo Superior de Deportes (Sports Council in Spain), with the technical support of Instituto de Biomecanica of Valencia, has published a new good practice guide for sports facilities, that it is entitled From Planning to Management of Sports Facilities. A way to Sustainability. By this way it is completed a cycle in the edition of support tools for the municipalities, opening a new thematic that will guide the initiatives next years: the sustainability.[ES] El Consejo Superior de Deportes (CSD), con el apoyo técnico del Instituto de Biomecánica (IBV), ha publicado un nuevo manual de buenas prácticas en instalaciones deportivas titulado " De la Planificación a la gestión de las Instalaciones Deportivas. Un camino hacia la Sostenibilidad ". Con esta publicación se completa el ciclo de ediciones de herramientas de apoyo a los municipios, que abre paso a la temática que guiará las iniciativas en los próximos años: la sostenibilidad.Pérez Durbán, V.; Gude Redondo, R.; Magraner Llavador, L.; Rosa Mañez, D.; Matey González, FJ.; Gil Guerrero, I.; Pereira Carrillo, IM.... (2012). La sostenibilidad en instalaciones deportivas. Revista de biomecánica. (58):19-20. http://hdl.handle.net/10251/38505S19205

Mild Cognitive Impairment Is Associated with Enhanced Activation of Th17 Lymphocytes in Non-Alcoholic Fatty Liver Disease

Patients with nonalcoholic fatty liver disease (NAFLD) may show mild cognitive impairment (MCI). The mechanisms involved remain unclear. The plasma concentrations of several cytokines and chemokines were measured in 71 NAFLD patients (20 with and 51 without MCI) and 61 controls. Characterization and activation of leukocyte populations and CD4+ sub-populations were carried out and analyzed by flow cytometry. We analyzed the cytokines released from CD4+ cell cultures and the mRNA expression of transcription factors and receptors in peripheral blood mononuclear cells. The appearance of MCI in NAFLD patients was associated with increased activation of CD4+ T lymphocytes, mainly of the Th17 subtype, increased plasma levels of pro-inflammatory and anti-inflammatory cytokines such as IL-17A, IL-23, IL-21, IL-22, IL-6, INF-γ, and IL-13, and higher expression of the CCR2 receptor. Constitutive expression of IL-17 was found in cultures of CD4+ cells from MCI patients, reflecting Th17 activation. High IL-13 plasma levels were predictive of MCI and could reflect a compensatory anti-inflammatory response to the increased expression of pro-inflammatory cytokines. This study identified some specific alterations of the immune system associated with the appearance of neurological alterations in MCI patients with NAFLD that could be the basis to improve and restore cognitive functions and quality of life in these patients