Gaussian Partial Information Decomposition: Bias Correction and Application to High-dimensional Data

Recent advances in neuroscientific experimental techniques have enabled us to simultaneously record the activity of thousands of neurons across multiple brain regions. This has led to a growing need for computational tools capable of analyzing how task-relevant information is represented and communicated between several brain regions. Partial information decompositions (PIDs) have emerged as one such tool, quantifying how much unique, redundant and synergistic information two or more brain regions carry about a task-relevant message. However, computing PIDs is computationally challenging in practice, and statistical issues such as the bias and variance of estimates remain largely unexplored. In this paper, we propose a new method for efficiently computing and estimating a PID definition on multivariate Gaussian distributions. We show empirically that our method satisfies an intuitive additivity property, and recovers the ground truth in a battery of canonical examples, even at high dimensionality. We also propose and evaluate, for the first time, a method to correct the bias in PID estimates at finite sample sizes. Finally, we demonstrate that our Gaussian PID effectively characterizes inter-areal interactions in the mouse brain, revealing higher redundancy between visual areas when a stimulus is behaviorally relevant

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome associated with COVID-19: An Emulated Target Trial Analysis.

RATIONALE: Whether COVID patients may benefit from extracorporeal membrane oxygenation (ECMO) compared with conventional invasive mechanical ventilation (IMV) remains unknown. OBJECTIVES: To estimate the effect of ECMO on 90-Day mortality vs IMV only Methods: Among 4,244 critically ill adult patients with COVID-19 included in a multicenter cohort study, we emulated a target trial comparing the treatment strategies of initiating ECMO vs. no ECMO within 7 days of IMV in patients with severe acute respiratory distress syndrome (PaO2/FiO2 <80 or PaCO2 ≥60 mmHg). We controlled for confounding using a multivariable Cox model based on predefined variables. MAIN RESULTS: 1,235 patients met the full eligibility criteria for the emulated trial, among whom 164 patients initiated ECMO. The ECMO strategy had a higher survival probability at Day-7 from the onset of eligibility criteria (87% vs 83%, risk difference: 4%, 95% CI 0;9%) which decreased during follow-up (survival at Day-90: 63% vs 65%, risk difference: -2%, 95% CI -10;5%). However, ECMO was associated with higher survival when performed in high-volume ECMO centers or in regions where a specific ECMO network organization was set up to handle high demand, and when initiated within the first 4 days of MV and in profoundly hypoxemic patients. CONCLUSIONS: In an emulated trial based on a nationwide COVID-19 cohort, we found differential survival over time of an ECMO compared with a no-ECMO strategy. However, ECMO was consistently associated with better outcomes when performed in high-volume centers and in regions with ECMO capacities specifically organized to handle high demand. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0/)

IRM CEREBRALE FOETALE (EXPERIENCE DIJONNAISE A PROPOS DE 78 PATIENTES)

DIJON-BU Médecine Pharmacie (212312103) / SudocPARIS-BIUM (751062103) / SudocSudocFranceF

Depth perception from pairs of overlapping cues in pictorial displays

The experiments reported herein probe the visual cortical mechanisms that control near–far percepts in response to two-dimensional stimuli. Figural contrast is found to be a principal factor for the emergence of percepts of near versus far in pictorial stimuli, especially when stimulus duration is brief. Pictorial factors such as interposition (Experiment 1) and partial occlusion Experiments 2 and 3) may cooperate, as generally predicted by cue combination models, or compete with contrast factors in the manner predicted by the FACADE model. In particular, if the geometrical con guration of an image favors activation of cortical bipole grouping cells, as at the top of a T-junction, then this advantage can cooperate with the contrast of the con guration to facilitate a near–far percept at a lower contrast than at an X-junction. Varying the exposure duration of the stimuli shows that the more balanced bipole competition in the X-junction case takes longer exposure times to resolve than the bipole competition in the T-junction case (Experiment 3)

Forest diversity reduces the prevalence of pathogens transmitted by the tick Ixodes ricinus

Tick-borne diseases represent the majority of vector-borne human diseases in Europe, with Ixodes ricinus, mostly present in forests, as the main vector. Studies show that vertebrate hosts diversification would decrease the prevalence of these pathogens. However, it is not well known whether habitat diversity can have similar impact on ticks and their infection rates. We measured the presence and abundance of different stages of I. ricinus, and the prevalence of associated pathogens in a large-scale forest experiment in which we manipulated tree diversity and moisture level. We showed that larval abundance was influenced by tree species identity, with larvae being more present in pine plots than in oak plots, while nymph abundance increased with canopy tree density. The proportion of Borrelia bugdorferi s.l.-infected nymphs decreased with increasing tree diversity. Our findings suggest that tree overstorey composition, structure and diversity, can affect tick abundance and pathogen prevalence. They support the idea that forest habitats may have “diluting” or “amplifying” effects on tick-borne diseases with direct relevance for human health

Forest diversity reduces the prevalence of pathogens transmitted by the tick Ixodes ricinus

International audienceTick-borne diseases represent the majority of vector-borne human diseases in Europe, with Ixodes ricinus, mostly present in forests, as the main vector. Studies show that vertebrate hosts diversification would decrease the prevalence of these pathogens. However, it is not well known whether habitat diversity can have similar impact on ticks and their infection rates. We measured the presence and abundance of different stages of I. ricinus, and the prevalence of associated pathogens in a large-scale forest experiment in which we manipulated tree diversity and moisture level. We showed that larval abundance was influenced by tree species identity, with larvae being more present in pine plots than in oak plots, while nymph abundance increased with canopy tree density. The proportion of Borrelia bugdorferi s.l.-infected nymphs decreased with increasing tree diversity. Our findings suggest that tree overstorey composition, structure and diversity, can affect tick abundance and pathogen prevalence. They support the idea that forest habitats may have “diluting” or “amplifying” effects on tick-borne diseases with direct relevance for human health

Response of rhizosphere and endophytic bacterial communities of hyperaccumulating plants to nickel contamination

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Synthesis and evaluation of hybrid bis-cationic salts as antimalarial drugs

International audienceA new series of hybrid bis-cations has been synthesized as potent antimalarial agents. These drugs share two different cationic heads derived from bis-thiazolium and bis-amidine salts. Structure-activity relationships has been defined and pointed out that the linker plays a prior role for antimalarial activity leading to compounds with significant oral activity

PM10 Chemical Profile during North African Dust Episodes over French West Indies

International audienceThe French West Indies are periodically affected by North African dust episodes (NADE) resulting in PM10 concentrations exceeding air quality standards. The aim of the present study was to decipher the PM10 chemical profile during NADE over Guadeloupe. PM10 samples were collected daily at a rural site and an urban site during five episodes between April and October in 2017. During these events, the median PM10 mass concentrations were, on average, 2 to 5 times higher than in the post-episode baseline period. Sampled filters were analyzed for their quantification of chemical constituents including carbonaceous fractions (elemental and organic carbon, EC/OC), anions/cations and levoglucosan, 51 elements, and 57 selected organic species. An orthogonal partial least squares discriminant analysis (OPLS-DA) was conducted to identify the specific chemical profile of PM10 during NADE: 16 elements were identified as the most discriminant between the NADE and the control samples with mass concentration levels twice as high during a NADE. Among them, only two (Mn and V) are classified as emerging pollutant while no limit values exist for the other ones. The extensive characterization of the NADE PM10 chemical profile we performed is a key step to assess the chemical exposure of French West Indies populations during such events

Regulatory B Cells with a Partial Defect in CD40 Signaling and Overexpressing Granzyme B Transfer Allograft Tolerance in Rodents

International audienceEmerging knowledge regarding B cells in organ transplantation has demonstrated that these cells can no longer be taken as mere generators of deleterious Abs but can also act as beneficial players. We previously demonstrated in a rat model of cardiac allograft tolerance induced by short-term immunosuppression an accumulation in the blood of B cells overexpressing inhibitory molecules, a phenotype also observed in the blood of patients that spontaneously develop graft tolerance. In this study, we demonstrated the presence in the spleen of regulatory B cells enriched in the CD24intCD38+CD27+IgD2IgM+/low subpopulation, which are able to transfer donor-specific tolerance via IL-10 and TGF-b1–dependent mechanisms and to suppress in vitro TNF-a secretion. Following anti-CD40 stimulation, IgD2IgM+/low B cells were blocked in their plasma cell differentiation pathway, maintained high expression of the inhibitory molecules CD23 and Bank1, and upregulated Granzyme B and Irf4, two molecules described as highly expressed by regulatory B cells. Interestingly, these B cells recognized specifically a dominant donor Ag, suggesting restricted specificity that could lead to a particular B cell response. Regulatory B cells were not required for induction of tolerance and appeared following Foxp3+CD4+CD25+ regulatory T cells, suggesting cooperation with regulatory T cells for their expansion. Nevertheless, following transfer to new recipients, these B cells migrated to the allograft, kept their regulatory profile, and promoted local accumulation of Foxp3+CD4+CD25+ regulatory T cells. Mechanisms of regulatory B cells and their cell therapy potential are important to decipher in experimental models to pave the way for future developments in the clinic