Assessment of non-contacting optical methods to measure wear and surface roughness in ceramic total disc replacements

This study presents a method for measuring the low volumetric wear expected in ceramic total disc replacements, which can be used to replace intervertebral discs in the spine, using non-contacting optical methods. Alumina-on-alumina ball-on-disc tests were conducted with test conditions approximating those of cervical (neck region of the spine) total disc replacement wear tests. The samples were then scanned using a three-dimensional non-contacting optical profilometer and the data used to measure surface roughness and develop a method for measuring the wear volume. The results showed that the magnification of the optical lens affected the accuracy of both the surface roughness and wear volume measurements. The method was able to successfully measure wear volumes of 0.0001mm3, which corresponds to a mass of 0.0001 mg, which would have been undetectable using the gravimetric method. A further advantage of this method is that with one scan the user can measure changes in surface topography, volumetric wear and the location of the wear on the implant surface. This method could also be applied to more severe wear, other types of orthopaedic implants and different materials

On an exact solution of the Thomas-Fermi equation for a trapped Bose-Einstein condensate with dipole-dipole interactions

We derive an exact solution to the Thomas-Fermi equation for a Bose-Einstein condensate which has dipole-dipole interactions as well as the usual s-wave contact interaction, in a harmonic trap. Remarkably, despite the non-local anisotropic nature of the dipolar interaction the solution is an inverted parabola, as in the pure s-wave case, but with a different aspect ratio. Various properties such as electrostriction and stability are discussed.Comment: 11 pages, 5 figure

A Sino-German 6 cm polarization survey of the Galactic plane II. The region from 129 degree to 230 degree longitude

Linearly polarized Galactic synchrotron emission provides valuable information about the properties of the Galactic magnetic field and the interstellar magneto-ionic medium, when Faraday rotation along the line of sight is properly taken into account. We aim to survey the Galactic plane at 6 cm including linear polarization. At such a short wavelength Faraday rotation effects are in general small and the Galactic magnetic field properties can be probed to larger distances than at long wavelengths. The Urumqi 25-m telescope is used for a sensitive 6 cm survey in total and polarized intensities. WMAP K-band (22.8 GHz) polarization data are used to restore the absolute zero-level of the Urumqi U and Q maps by extrapolation. Total intensity and polarization maps are presented for a Galactic plane region of 129 degree < l < 230 degree and |b| < 5 degree in the anti-centre with an angular resolution of 9'5 and an average sensitivity of 0.6 mK and 0.4 mK Tb in total and polarized intensity, respectively. We briefly discuss the properties of some extended Faraday Screens detected in the 6 cm polarization maps. The Sino-German 6 cm polarization survey provides new information about the properties of the magnetic ISM. The survey also adds valuable information for discrete Galactic objects and is in particular suited to detect extended Faraday Screens with large rotation measures hosting strong regular magnetic fields.Comment: 17 pages, 20 figures, accepted by A&amp;A. Resolutions of the figures have been significantly reduced. For version with full resolution, see http://159.226.88.6/zmtt/6cm/papers/gao.paper2.pd

Radio Observations of the Supernova Remnant Candidate G312.5-3.0

The radio images from the Parkes-MIT-NRAO (PMN) Southern Sky Survey at 4850 MHz have revealed a number of previously unknown radio sources. One such source, G312.5-3.0 (PMN J1421-6415), has been observed using the multi-frequency capabilities of the Australia Telescope Compact Array (ATCA) at frequencies of 1380 MHz and 2378 MHz. Further observations of the source were made using the Molonglo Observatory Synthesis Telescope (MOST) at a frequency of 843 MHz. The source has an angular size of 18 arcmin and has a distinct shell structure. We present the reduced multi-frequency observations of this source and provide a brief argument for its possible identification as a supernova remnant.Comment: 5 pages, 5 figures, Accepted for publication in MNRA

Osteoarthritis and the rule of halves

&lt;b&gt;Background&lt;/b&gt; Symptomatic osteoarthritis poses a major challenge to primary health care but no studies have related accessing primary care ("detection"), receiving recommended treatments ("treatment"), and achieving adequate control ("control").&lt;p&gt;&lt;/p&gt; &lt;b&gt;Objective&lt;/b&gt; To provide estimates of detection, treatment, and control within a single population adapting the approach used to determine a Rule of Halves for other long-term conditions.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Setting&lt;/b&gt; General population.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Participants&lt;/b&gt; 400 adults aged 50+ years with prevalent symptomatic knee osteoarthritis.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Design&lt;/b&gt; Prospective cohort with baseline questionnaire, clinical assessment, and plain radiographs, and questionnaire follow-up at 18 and 36 months and linkage to primary care medical records.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Outcome measures&lt;/b&gt; "Detection" was defined as at least one musculoskeletal knee-related GP consultation between baseline and 36 months. "Treatment" was self-reported use of at least one recommended treatment or physiotherapy/hospital specialist referral for their knee problem at all three measurement points. Pain was "controlled" if characteristic pain intensity &lt;5 out of 10 on at least two occasions.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Results&lt;/b&gt; In 221 cases (55.3%; 95%CI: 50.4, 60.1) there was evidence that the current problem had been detected in general practice. Of those detected, 164 (74.2% (68.4, 80.0)) were receiving one or more of the recommended treatments at all three measurement points. Of those detected and treated, 45 (27.4% (20.5, 34.3)) had symptoms under control on at least two occasions. Using narrower definitions resulted in substantially lower estimates.&lt;p&gt;&lt;/p&gt; &lt;b&gt;Conclusion&lt;/b&gt; Osteoarthritis care does not conform to a Rule of Halves. Symptom control is low among those accessing health care and receiving treatment

Tapping Environmental History to Recreate America’s Colonial Hydrology

To properly remediate, improve, or predict how hydrological systems behave, it is vital to establish their histories. However, modern-style records, assembled from instrumental data and remote sensing platforms, hardly exist back more than a few decades. As centuries of data is preferable given multidecadal fluxes of both meteorology/climatology and demographics, building such a history requires resources traditionally considered only useful in the social sciences and humanities. In this Feature, Pastore et al. discuss how they have undertaken the synthesis of historical records and modern techniques to understand the hydrology of the Northeastern U.S. from Colonial times to modern day. Such approaches could aid studies in other regions that may require heavier reliance on qualitative narratives. Further, a better insight as to how historical changes unfolded could provide a “past is prologue” methodology to increase the accuracy of predictive environmental models

Two Large HI Shells in the Outer Galaxy near l=279 degrees

As part of a survey of HI 21-cm emission in the Southern Milky Way, we have detected two large shells in the interstellar neutral hydrogen near l=279 deg. The center velocities are +36 and +59 km/s, which puts the shells at kinematic distances of 7 and 10 kpc. The larger shell is about 610 pc in diameter and very empty, with density contrast of at least 15 between the middle and the shell walls. It has expansion velocity of about 20 km/s and swept up mass of several million solar masses. The energy indicated by the expansion may be as high as 2.4 X 10^53 ergs. We estimate its age to be 15 to 20 million years. The smaller shell has diameter of about 400 pc, expansion velocity about 10 km/s and swept up mass of about 10^6 solar masses. Morphologically both regions appear to be shells, with high density regions mostly surrounding the voids, although the first appears to have channels of low density which connect with the halo above and below the HI layer. They lie on the edge of the Carina arm, which suggests that they may be expanding horizontally into the interarm region as well as vertically out of the disk. If this interpretation is correct, this is the first detection of an HI chimney which has blown out of both sides of the disk.Comment: 21 pages, 14 jpeg figures, accepted for publication in A

How does reviewing the evidence change veterinary surgeons' beliefs regarding the treatment of ovine footrot? A quantitative and qualitative study

Footrot is a widespread, infectious cause of lameness in sheep, with major economic and welfare costs. The aims of this research were: (i) to quantify how veterinary surgeons’ beliefs regarding the efficacy of two treatments for footrot changed following a review of the evidence (ii) to obtain a consensus opinion following group discussions (iii) to capture complementary qualitative data to place their beliefs within a broader clinical context. Grounded in a Bayesian statistical framework, probabilistic elicitation (roulette method) was used to quantify the beliefs of eleven veterinary surgeons during two one-day workshops. There was considerable heterogeneity in veterinary surgeons’ beliefs before they listened to a review of the evidence. After hearing the evidence, seven participants quantifiably changed their beliefs. In particular, two participants who initially believed that foot trimming with topical oxytetracycline was the better treatment, changed to entirely favour systemic and topical oxytetracycline instead. The results suggest that a substantial amount of the variation in beliefs related to differences in veterinary surgeons’ knowledge of the evidence. Although considerable differences in opinion still remained after the evidence review, with several participants having non-overlapping 95% credible intervals, both groups did achieve a consensus opinion. Two key findings from the qualitative data were: (i) veterinary surgeons believed that farmers are unlikely to actively seek advice on lameness, suggesting a proactive veterinary approach is required (ii) more attention could be given to improving the way in which veterinary advice is delivered to farmers. In summary this study has: (i) demonstrated a practical method for probabilistically quantifying how veterinary surgeons’ beliefs change (ii) revealed that the evidence that currently exists is capable of changing veterinary opinion (iii) suggested that improved transfer of research knowledge into veterinary practice is needed (iv) identified some potential obstacles to the implementation of veterinary advice by farmers

The Molonglo Galactic Plane Survey: I. Overview and Images

The first epoch Molonglo Galactic Plane Survey (MGPS1) is a radio continuum survey made using the Molonglo Observatory Synthesis Telescope (MOST) at 843 MHz with a resolution of 43" X 43" cosec |delta|. The region surveyed is 245 deg < l < 355 deg, |b| < 1.5 deg. The thirteen 9 deg X 3 deg mosaic images presented here are the superposition of over 450 complete synthesis observations, each taking 12 h and covering 70' X 70' cosec |delta|. The root-mean-square sensitivity over much of the mosaiced survey is 1-2 mJy/beam (1 sigma), and the positional accuracy is approximately 1" X 1" cosec |delta| for sources brighter than 20 mJy. The dynamic range is no better than 250:1, and this also constrains the sensitivity in some parts of the images. The survey area of 330 sq deg contains well over 12,000 unresolved or barely resolved objects, almost all of which are extra-galactic sources lying in the Zone of Avoidance. In addition a significant fraction of this area is covered by extended, diffuse emission associated with thermal complexes, discrete H II regions, supernova remnants, and other structures in the Galactic interstellar medium.Comment: Paper with 3 figures and 1 table + Table 2 + 7 jpg grayscales for Fig 4. Astrophysical Journal Supplement (in press) see also http://www.astrop.physics.usyd.edu.au/MGP

Colorectal cancer linkage on chromosomes 4q21, 8q13, 12q24, and 15q22

A substantial proportion of familial colorectal cancer (CRC) is not a consequence of known susceptibility loci, such as mismatch repair (MMR) genes, supporting the existence of additional loci. To identify novel CRC loci, we conducted a genome-wide linkage scan in 356 white families with no evidence of defective MMR (i.e., no loss of tumor expression of MMR proteins, no microsatellite instability (MSI)-high tumors, or no evidence of linkage to MMR genes). Families were ascertained via the Colon Cancer Family Registry multi-site NCI-supported consortium (Colon CFR), the City of Hope Comprehensive Cancer Center, and Memorial University of Newfoundland. A total of 1,612 individuals (average 5.0 per family including 2.2 affected) were genotyped using genome-wide single nucleotide polymorphism linkage arrays; parametric and non-parametric linkage analysis used MERLIN in a priori-defined family groups. Five lod scores greater than 3.0 were observed assuming heterogeneity. The greatest were among families with mean age of diagnosis less than 50 years at 4q21.1 (dominant HLOD = 4.51, α = 0.84, 145.40 cM, rs10518142) and among all families at 12q24.32 (dominant HLOD = 3.60, α = 0.48, 285.15 cM, rs952093). Among families with four or more affected individuals and among clinic-based families, a common peak was observed at 15q22.31 (101.40 cM, rs1477798; dominant HLOD = 3.07, α = 0.29; dominant HLOD = 3.03, α = 0.32, respectively). Analysis of families with only two affected individuals yielded a peak at 8q13.2 (recessive HLOD = 3.02, α = 0.51, 132.52 cM, rs1319036). These previously unreported linkage peaks demonstrate the continued utility of family-based data in complex traits and suggest that new CRC risk alleles remain to be elucidated. © 2012 Cicek et al