CONVERSION OF A LAMB PRODUCTION SYSTEM TO ORGANIC FARMING: HOW TO MANAGE, FOR WHICH RESULTS?

Two sheep flocks were managed organically (for two years from conversion onwards) under different lambing strategies (1 lambing/year vs. 3 lambings every two years). The second system was tested as there was a producer’s interest in high productivity that is a guarantee of good economic results in conventional. Reproduction, feeding, lamb production, carcass quality, health (particularly internal parasitism), economic return of the flock, grass production, and pasture biodiversity were evaluated. The lambs were bred under low therapeutic input. The economical advantage of increasing lambing frequency was not demonstrated, whereas this strategy complexified management and resulted in higher internal parasitic infection of the lambs, and finally showed a lower stability. There were difficulties in establishing a very high feed self-sufficiency in both systems, especially the more intensive system (4 points lower), due to harsh climatic conditions; following this five-year experiment, we are changing our strategy to provide nitrogen in the systems

CONVERSION OF A LAMB PRODUCTION SYSTEM TO ORGANIC FARMING: HOW TO MANAGE, FOR WHAT RESULTS?

Two sheep flocks were managed organically for two years from conversion under different lambing strategies (1 lambing/year vs. 3 lambings every two years). The second system was tested because pf a producer’s interest in high productivity, which is a guarantee of good economic results in conventional production.. Reproduction, feeding, lamb production, carcass quality, health (particularly internal parasitism), economic return of the flock, grass production, and pasture biodiversity were evaluated. The lambs were bred with low therapeutic inputs. No economic advantage of increasing lambing frequency was demonstrated, whereas this strategy complicated management and resulted in higher internal parasitic infection of the lambs, and finally showed lower stability. There were difficulties in establishing a very high feed self-sufficiency in both systems, especially the more intensive system (4 points lower), due to harsh climatic conditions. Following this five-year experiment, we are changing our strategy to provide nitrogen in the systems

La guerre d’Algérie dans les relations Franco-espagnoles

Comparer le retentissement de la guerre d’Algérie dans les relations de la France avec l’Espagne et l’Italie conduit à dégager une chronologie particulière dans le cas espagnol. Après avoir fait preuve d’une hostilité qui le distinguait des pays occidentaux, sur fond de rivalité des politiques arabes et de crise marocaine, le régime franquiste se rapproche de la position française en 1957, alors même que la pression internationale s’accroît ; il apporte toutefois un soutien conditionnel, d’où un constant marchandage qui lève le contentieux pendant. Paradoxalement, la guerre d’Algérie scelle ainsi la réconciliation bilatérale.A comparative study of the impact of the Algerian war on the relations of France with Spain and Italy brings a special chronology in the Spanish case to light. First, with the rivalry between Arab politics and the Moroccan crisis behind, the franquist power shows an hostility that distinguishes it from the Occidental countries. Then the regime comes close to French position in 1957, while the international pressure grows ; its support is conditional howewer, and always accompanied by bargaining which removes the pending disputes. Paradoxically, the Algerian war leads to a bilateral reconciliation

A comparison of in situ and in vitro methods to estimate in vivo fermentable organic matter of forages in ruminants

Farmers in five districts of north-eastern Uganda were interviewed to generate information on sweet potato production and constraints, with emphasis on damage by millipedes. Participatory rural appraisal methodology was used to interview 148 farmers. The peak period of planting sweet potato was from the end of May till the beginning of July in order to produce dried form food (amukeke) for storage in the dry season, which sets in around November. Vine cuttings were usually planted on mounds and weeding was mostly done only once. Osukut, Araka Red and Araka White were the most popular varieties. Many respondents obtained planting material from volunteer plants. Separation of plots over time and in space was often not practised. Sweet potato crop rotations were diverse. Millet, groundnut and maize were commonly grown after sweet potato. Cassava, sweet potato, groundnut and maize are host crops for millipedes and were often grown in succession. Millipede incidences were not statistically different for the three agro-ecological zones of north-eastern Uganda, but depended on the frequency of millipede hosts (including sweet potato) in the crop rotations. Groundnut planted after sweet potato had high levels of millipede attack. Millipede incidence was often associated with the incidence of weevils. The results of this inventory show that most farmers consider millipedes as a pest of sweet potato and other major food and cash crops, but that many farmers lack the knowledge to control them

NKG2D/NKG2-Ligand Pathway Offers New Opportunities in Cancer Treatment

The antitumor functions of NK cells are regulated by the integration of positive and negative signals triggered by numerous membrane receptors present on the NK cells themselves. Among the main activating receptors, NKG2D binds several stress-induced molecules on tumor targets. Engagement of NKG2D by its ligands (NKG2D-Ls) induces NK cell activation leading to production of cytokines and target cell lysis. These effects have therapeutic potential as NKG2D-Ls are widely expressed by solid tumors, whereas their expression in healthy cells is limited. Here, we describe the genetic and environmental factors regulating the NKG2D/NKG2D-L pathway in tumors. NKG2D-L expression is linked to cellular stress and cell proliferation, and has been associated with oncogenic mutations. Tumors have been found to alter their to NKG2D-L expression as they progress, which interferes with the antitumor function of the pathway. Nevertheless, this pathway could be advantageously exploited for cancer therapy. Various cancer treatments, including chemotherapy and targeted therapies, indirectly interfere with the cellular and soluble forms of NKG2D-Ls. In addition, NKG2D introduced into chimeric antigen receptors in T- and NK cells is a promising tumor immunotherapy approach

Estimation of the duodenal flow of microbial nitrogen in ruminants based on the chemical composition of forages: a literature review

The objective of this study was to evaluate the estimation of the duodenal flow of microbial nitrogen (N) in ruminants fed forage only, per kilogram of dry matter (DM) intake, which is the yield of microbial protein (YMP). The estimation was based on the chemical composition of forages. A data file of 62 observations was collected from in vivo studies on cattle and sheep fed diets with forage only. A statistical analysis of YMP was conducted with neutral detergent fibre (NDF), crude protein (CP), non structural carbohydrates (NSC), group of forage species (legumes or grasses), method of conservation, physical form of presentation, level of DM intake, animal species, methodology and references as parameters. After a stepwise regression, CP was significant and the most important predictor. NSC or the method of conservation had an extra effect on YMP. On the basis of these three parameters the best fit equations were found and the influence of all parameters on YMP were discussed. Using the data file of this study, the prediction of YMP from the PDI-system was also validated. The statistics of the validation of the PDI prediction were similar to the statistics of the equations from this study. In conclusion, the chemical composition of forages, with or without the method of conservation, is a poor indication for the duodenal flow of microbial N (g $\cdot$kg -1 DM intake) in ruminants fed diets with forages only

Dietary experience modifies horses' feeding behavior and selection patterns of three macronutrient rich diets

Choice feeding is often used to investigate an animal’s nutritional requirements and dietary preferences. A problem with this approach is that animals with long gut transit times, such as the horse, may find it difficult to associate a chosen food with its nutritional consequence when alternative foods are presented simultaneously. One solution is to present foods singly for a period of time before a simultaneous choice session to allow the development of learned associations. This method was used to determine if horse’s voluntary intake and feeding behavior was influenced by the macronutrient composition of the diet. Seven stabled horses, maintained on a low intensity exercise regimen, were allowed, on an ad libitum basis, haylage and 3 isocaloric forage based diets that were rich in 1 of 3 macronutrients (protein, lipid, and hydrolyzable carbohydrate). Initially, diets were presented as a 3-way choice for 5 d (self-selection a [SSa]), then singly (monadic phase) with exposure to each diet for 2 separate periods of 3 d each, and finally again as a choice for 5 d (self-selection b [SSb]). The total amount of trial diet offered differed with trial phase, with 2 to 2.5% of BW during SSa and the monadic phase, increasing to ad libitum access during SSb. To control differences in the total amount of trial diet offered, 2 measurements of voluntary intake were taken at 4 and 22 h postpresentation. Daily macronutrient and energy intakes were estimated from proximate analysis of the trial diets and batches of haylage fed. Feeding behavior was observed over a single 4-h period during both self-selection phases. Horses showed no initial preference after 4 h for any 1 diet during SSa. Following the monadic phase, horses demonstrated a preference for the protein and hydrolyzable carbohydrate rich diets over the lipid rich diet (P < 0.001). Dietary experience modified foraging behavior as the total number of visits to the diets decreased during SSb (P < 0.005). Analysis of 24 -h macronutrient consumption showed that protein and hydrolyzable carbohydrate intake increased during SSb, whereas lipid intake remained constant over both self-selection phases (P < 0.001). These data indicate for perhaps the first time that horses can respond to dietary macronutrient content and that single presentations during choice studies facilitates expression of dietary preferences

Modulation of NK cell activation by exogenous calcium from alginate dressings in vitro

Natural Killer (NK) cells participate in the defense against infection by killing pathogens and infected cells and secreting immuno-modulatory cytokines. Defects in NK cell activity have been reported in obese, diabetic, and elderly patients that are at high risk of developing infected chronic wounds. Calcium alginate dressings are indicated for the debridement during the inflammatory phase of healing. Since calcium ions are major activators of NK cells, we hypothesized that these dressings could enhance NK functions, as investigated in vitro herein. Primary human blood NK cells were freshly-isolated from healthy volunteers and exposed to conditioned media (CM) from two alginate dressings, Algosteril® (ALG, pure Ca2+ alginate) and Biatain® Alginate (BIA, Ca2+ alginate with CMC), in comparison with an exogenous 3mM calcium solution. Our results demonstrated that exogenous calcium and ALG-CM, but not BIA-CM, induced NK cell activation and enhanced their capacity to kill their targets as a result of increased degranulation. NK cell stimulation by ALG depended on the influx of extracellular Ca2+via the SOCE Ca2+ permeable plasma membrane channels. ALG-CM also activated NK cell cytokine production of IFN-γ and TNF-α through a partly Ca2+-independent mechanism. This work highlights the non-equivalence between alginate dressings for NK cell stimulation and shows that the pure calcium alginate dressing Algosteril® enhances NK cell cytotoxic and immuno-modulatory activities. Altogether, these results underline a specific property of this medical device in innate defense that is key for the cutaneous wound healing process