Enterprise Resource Planning Research: Where Are We Now and Where Should We Go From Here?

The research related to Enterprise Resource Planning (ERP) has grown over the past several years. This growing body of ERP research results in an increased need to review this extant literature with the intent of identifying gaps and thus motivate researchers to close this breach. Therefore, this research was intended to critique, synthesize and analyze both the content (e.g., topics, focus) and processes (i.e., methods) of the ERP literature, and then enumerates and discusses an agenda for future research efforts. To accomplish this, we analyzed 49 ERP articles published (1999-2004) in top Information Systems (IS) and Operations Management (OM) journals. We found an increasing level of activity during the 5-year period and a slightly biased distribution of ERP articles targeted at IS journals compared to OM. We also found several research methods either underrepresented or absent from the pool of ERP research. We identified several areas of need within the ERP literature, none more prevalent than the need to analyze ERP within the context of the supply chain

Genetic deletion of osteopontin in TRAMP mice skews prostate carcinogenesis from adenocarcinoma to aggressive human-like neuroendocrine cancers

Osteopontin (OPN) is a secreted glycoprotein, that belongs to the non-structural extracellular matrix (ECM), and its over expression in human prostate cancer has been associated with disease progression, androgen independence and metastatic ability. Nevertheless, the pathophysiology of OPN in prostate tumorigenesis has never been studied. We crossed TRansgenic Adenocarcinoma of the Mouse Prostate (TRAMP) mice with OPN deficient (OPN-/-) mice and followed tumor onset and progression in these double mutants. Ultrasound examination detected the early onset of a rapidly growing, homogeneous and spherical tumor in about 60% of OPN-/- TRAMP mice. Such neoplasms seldom occurred in parental TRAMP mice otherwise prone to adenocarcinomas and were characterized for being androgen receptor negative, highly proliferative and endowed with neuroendocrine (NE) features. Gene expression profiling showed up-regulation of genes involved in tumor progression, cell cycle and neuronal differentiation in OPN-deficient versus wild type TRAMP tumors. Downregulated genes included key genes of TGFa pathway, including SMAD3 and Filamin, which were confirmed at the protein level. Furthermore, NE genes and particularly those characterizing early prostatic lesions of OPN-deficient mice were found to correlate with those of human prostate NE tumours. These data underscore a novel role of OPN in the early stages of prostate cancer growth, protecting against the development of aggressive NE tumors

Preface: Earth Observation for Integrated Water and Basin Management: Challenges for adaptation to a changing environment

Integrated river basin management involves a sound knowledge of water and land interactions, and impacts from and feedbacks to human activity. Remote sensing has been an efficient and increasingly promising means of gathering direct information of the Earth surface, as well as information on water and energy fluxes. The recent generation of high-resolution sensors offers a huge potential for monitoring, assessing, and modelling our changing environment in a context of uncertainty about how future climate conditions will affect the current water resource and basin management framework. Moreover, large amounts of data are now available posing a challenging opportunity to the scientific community for both exploring and transforming these data into readily usable information products for different end-users in our societies

Exploring TanDEM-X Interferometric Products for Crop-Type Mapping

The application of satellite single-pass interferometric data to crop-type mapping is demonstrated for the first time in this work. A set of nine TanDEM-X dual-pol pairs of images acquired during its science phase, from June to August 2015, is exploited for this purpose. An agricultural site located in Sevilla (Spain), composed of fields of 13 different crop species, is employed for validation. Sets of input features formed by polarimetric and interferometric observables are tested for crop classification, including single-pass coherence and repeat-pass coherence formed by consecutive images. The backscattering coefficient at HH and VV channels and the correlation between channels form the set of polarimetric features employed as a reference set upon which the added value of interferometric coherence is evaluated. The inclusion of single-pass coherence as feature improves by 2% the overall accuracy (OA) with respect to the reference case, reaching 92%. More importantly, in single-pol configurations OA increases by 10% for the HH channel and by 8% for the VV channel, reaching 87% and 88%, respectively. Repeat-pass coherence also improves the classification performance, but with final scores slightly worse than with single-pass coherence. However, it improves the individual performance of the backscattering coefficient by 6–7%. Furthermore, in products evaluated at field level the dual-pol repeat-pass coherence features provide the same score as single-pass coherence features (overall accuracy above 94%). Consequently, the contribution of interferometry, both single-pass and repeat-pass, to crop-type mapping is proved.This work was funded by the Spanish Ministry of Science and Innovation, the State Agency of Research (AEI) and the European Funds for Regional Development (EFRD) under Project TEC2017-85244-C2-1-P, and by the European Commission, H2020 Programme, under Project MOSES (Managing crOp water Saving with Enterprise Services)

DNA damage and transcriptional regulation in iPSC-derived neurons from Ataxia Telangiectasia patients

Abstract Ataxia Telangiectasia (A-T) is neurodegenerative syndrome caused by inherited mutations inactivating the ATM kinase, a master regulator of the DNA damage response (DDR). What makes neurons vulnerable to ATM loss remains unclear. In this study we assessed on human iPSC-derived neurons whether the abnormal accumulation of DNA-Topoisomerase 1 adducts (Top1ccs) found in A-T impairs transcription elongation, thus favoring neurodegeneration. Furthermore, whether neuronal activity-induced immediate early genes (IEGs), a process involving the formation of DNA breaks, is affected by ATM deficiency. We found that Top1cc trapping by CPT induces an ATM-dependent DDR as well as an ATM-independent induction of IEGs and repression especially of long genes. As revealed by nascent RNA sequencing, transcriptional elongation and recovery were found to proceed with the same rate, irrespective of gene length and ATM status. Neuronal activity induced by glutamate receptors stimulation, or membrane depolarization with KCl, triggered a DDR and expression of IEGs, the latter independent of ATM. In unperturbed A-T neurons a set of genes (FN1, DCN, RASGRF1, FZD1, EOMES, SHH, NR2E1) implicated in the development, maintenance and physiology of central nervous system was specifically downregulated, underscoring their potential involvement in the neurodegenerative process in A-T patients

SPARC regulation of PMN clearance protects from pristane-induced lupus and rheumatoid arthritis

The secreted protein acidic and rich in cysteine (SPARC) is a matricellular protein with unexpected immunosuppressive function in myeloid cells. We investigated the role of SPARC in autoimmunity using the pristane-induced model of lupus that, in mice, mimics human systemic lupus erythematosus (SLE). Sparc−/− mice developed earlier and more severe renal disease, multi-organ parenchymal damage, and arthritis than the wild-type counterpart. Sparc+/- heterozygous mice showed an intermediate phenotype suggesting Sparc gene dosage in autoimmune-related events. Mechanistically, reduced Sparc expression in neutrophils blocks their clearance by macrophages, through defective delivery of don't-eat-me signals. Dying Sparc−/− neutrophils that escape macrophage scavenging become source of autoantigens for dendritic cell presentation and are a direct stimulation for γδT cells. Gene profile analysis of knee synovial biopsies from SLE-associated arthritis showed an inverse correlation between SPARC and key autoimmune genes. These results point to SPARC down-regulation as a leading event characterizing SLE and rheumatoid arthritis pathogenesis

EFFECT OF COPPER OXIDE NANOPARTICLES TO SHEEPSHEAD MINNOW (CYPRINODON VARIEGATUS) AT DIFFERENT SALINITIES

Nanotechnologies research has become a significant priority worldwide. Many engineered nano-sized materials have been increasingly used in consumer products. But the adverse effects of these nanoparticles on the environment and organisms have recently drawn much attention. The present study investigated the effects of different concentrations of copper oxide nanoparticles (CuO NPs) on the sheepshead minnow (Cyprinodon variegatus) at different salinity regimes, since it is able to withstand a wide range of salinities. The results indicated that CuO NPs could cause behavioral changes in the fish, such as increased mucus secretion, less general activity and loss of equilibrium. No mortality was observed at the presence of CuO NPs during the experiments. But higher oxidative stress was determined at half strength seawater than seawater exposure medium, which can be associated with the decreasing toxicity of CuO NPs as salinity increases. In addition, Cu contents in the tissues of the fish were significantly higher (p<0.05) in the low salinity

Use of canopy coefficients obtained from satellite data to estimate evapotranspiration over high mountain Mediterranean watersheds

This work explores the dynamics of the water consumed by the vegetation in two Mediterranean watersheds of Sierra Nevada Mountains (Southern Spain). This region has experienced an increase in the demand of water in the last years due to the growth of irrigated areas, and a new water resources plan is required. The evapotranspiration (ET) of irrigated horticultural crops and natural communities were monitored for the hydrological years 2013/14 and 2014/15, using an approach based on the concept of reference evapotranspiration (ETo) and canopy coefficients derived from the computation of vegetation indices (VIs), which we will call the VI-ETo approach. A set of Landsat-8 and MODIS images has been used as remote input data. The results were used for the spatial analysis of water consumption in terms of the main land cover types in the area. The annual runoff obtained with a simple surface water balance, using the ET values estimated by the VI-ETo approach, was comparable to that obtained by the HBV (Hydrologiska Byrans Vattenbalansavdelning) model, a precipitation-runoff generation model that reproduces the observed river discharge at the outlet of the watershed.</p

Insulin Reduces Cerebral Ischemia/Reperfusion Injury in the Hippocampus of Diabetic Rats: A Role for Glycogen Synthase Kinase-3β

OBJECTIVE—There is evidence that insulin reduces brain injury evoked by ischemia/reperfusion (I/R). However, the molecular mechanisms underlying the protective effects of insulin remain unknown. Insulin is a well-known inhibitor of glycogen synthase kinase-3β (GSK-3β). Here, we investigate the role of GSK-3β inhibition on I/R-induced cerebral injury in a rat model of insulinopenic diabetes