Determinants of Collaborative Leadership: Civic Engagement, Gender or Organizational Norms?

This analysis attempts to unravel competing explanations of collaborative leadership styles of state legislative committee chairs. Specifically, the paper considers the influence of community or volunteer experience, gender, and institutional variables. The data show that women chairs are more likely than their male peers to cite as valuable the leadership skills and experiences that they gain through community and volunteer experience. Compared to their male colleagues, women committee chairs on average also report a greater reliance on collaborative strategies in the management of their committees. Prior community or volunteer experience has little or no direct effect on collaborative styles. In contrast, institutional factors have a much stronger and countervailing influence. Legislative professionalization produces a strong negative effect on collaborative style. Results suggest that conformity to institutional norms may be a more compelling influence than prior community experience. The analysis also points to the gendered nature of organizational leadership with men's and women's styles showing different associations to style depending on the number and power of women in a legislature.Yeshttps://us.sagepub.com/en-us/nam/manuscript-submission-guideline

The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors

Orexin peptides regulate locomotor activity and sleep-wake balance by activating orexin 1 and orexin 2 receptors (OX1R and OX2R). Dual OX1R and OX2R antagonists reduce activity and promote sleep in multiple species, including man. We tested the effects of orexin A and almorexant, a dual OX1R/OX2R antagonist, in C57BL/6J mice and in mice lacking OX1Rs, OX2Rs or both to investigate the roles of the two receptors in orexin-induced locomotion and in sleep/wake regulation. Orexin A induced locomotion primarily by activating OX2Rs as locomotion was increased following intracerebroventricular orexin in OX1R-/- mice but not in OX2R-/- or OX1R-/-/OX2R-/- mice. Almorexant attenuated the orexin A-induced locomotion, demonstrating in vivo that almorexant specifically inhibits the actions of orexin. As in other species, almorexant dose-dependently increased rapid eye movement (REM) and non-REM (NREM) sleep in C57BL/6J mice. Sleep promotion by almorexant was mediated by inhibition of the known OXRs as almorexant was ineffective in OX1R-/-/OX2R-/- mice. Almorexant induced sleep in OX1R-/- mice but not in OX2R-/- mice, demonstrating that antagonism of OX2Rs is sufficient for sleep induction. When almorexant was incubated with the receptors for short periods of time, it behaved as a dual antagonist against orexin A-induced Ca2+ responses. However, with increasing incubation times, almorexant acquired OX2R selectivity confirming the findings from binding assays and further suggesting it may behave as an OX2R antagonist in vivo. Thus, OX2R activation mediates the stimulatory effects of orexin A on locomotion and antagonism of OX2R is sufficient to promote sleep in mice

Novel iGluSnFR Variants Optimised for Rapid Glutamate Imaging

The dark matter (DM) halos of field elliptical galaxies have not been well-studied and their properties appear controversial in the literature. While some galaxies appear to be nearly devoid of DM, others show clear evidence of its presence. Furthermore, modified Newtonian dynamics (MOND), which has been found to have predictive power in the domain of disk galaxies, has not yet been investigated for isolated elliptical galaxies. We study the kinematics of the isolated elliptical NGC 7507, which has been claimed as a clear example of DM presence in early-type galaxies. We obtained major and minor axis long-slit spectroscopy of NGC 7507 using the Gemini South telescope and deep imaging in Kron-Cousins R and Washington C using the CTIO/MOSAIC camera. Mean velocities, velocity dispersion and higher order moments of the velocity distribution are measured out to ∼90 . The galaxy, although almost circular, has significant rotation along the minor axis and a rapidly declining velocity dispersion along both axes. The velocity dispersion profile is modeled in the context of a spherical Jeans analysis. Models without DM provide an excellent representation of the data with a mass-to-light ratio (M/L) of 3.1 (R-band). The most massive Navarro-Frenk-White (NFW) halo the data allow has a virial mass of only 3.9+3.1 −2.1 × 1011 M , although the data are more consistent with models that have a slight radial anisotropy, which implies the galaxy has an even lower DM halo mass of 2.2+2.0 −1.2 × 1011 M . Modeling of the h4 Gauss-Hermite coefficient is inconclusive but seems to be consistent with mild radial anisotropy. A cored logarithmic DM halo with parameters r0 = 7 kpc and v0 = 100 km s−1 can also reproduce the observed velocity dispersion profile. The MOND predictions overestimate the velocity dispersion. In conclusion, we cannot easily reproduce the previous findings of a predominance of DM in NGC 7507 within a simple spherical model. DM may be present, but only in conjunction with a strong radial anisotropy, for which there are some indications.Fil: Salinas, R.. Universidad de Concepción; Chile. European Southern Observatory; ChileFil: Richtler, T.. Universidad de Concepción; ChileFil: Bassino, Lilia Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico la Plata. Instituto de Astrofísica de la Plata; Argentina. Universidad Nacional de la Plata. Facultad de Ciencias Astronómicas y Geofísicas; ArgentinaFil: Romanowsky, A. J.. California State University; Estados UnidosFil: Schuberth, Y.. Universitaet Bonn; Alemani

Utility of real-time field control in T2*-Weighted head MRI at 7T

PURPOSE: Real-time field control can serve to reduce respiratory field perturbations during T2 * imaging at high fields. This work investigates the effectiveness of this approach in relation to key variables such as patient physique, breathing patterns, slice location, and the choice of sequence. METHODS: To cover variation in physical constitution and breathing behavior, volunteers with a wide range of body-mass-indices were asked to breathe either normally or deeply during T2 *-weighted image acquisition at 7T. Ensuing field fluctuation was countered by real-time field control or merely recorded in reference experiments. The impact of the control system on image quality was assessed by classifying and grading artifacts related to field fluctuation. RESULTS: The amplitude of respiratory field changes and related artifacts were generally stronger for subjects with higher body-mass-index and for lower slices. Field control was found effective at mitigating all five types of artifacts that were studied. Overall image quality was systematically improved. Residual artifacts in low slices are attributed to insufficient spatial order of the control system. CONCLUSION: Real-time field control was found to be a robust means of countering respiratory field perturbations in variable conditions encountered in high-field brain imaging. Reducing net fluctuation, it generally expands the feasibility of high-field T2 * imaging toward challenging patients and brain regions. Magn Reson Med, 2015. © 2015 Wiley Periodicals, Inc

Cardiac image fusion from stand-alone SPECT and CT: clinical experience

Myocardial perfusion imaging with SPECT (SPECT-MPI) and 64-slice CT angiography (CTA) are both established techniques for the noninvasive evaluation of coronary artery disease (CAD). Three-dimensional (3D) SPECT/CT image fusion may offer an incremental diagnostic value by integrating both sets of information. We report our first clinical experiences with fused 3D SPECT/CT in CAD patients. METHODS: Thirty-eight consecutive patients with at least 1 perfusion defect on SPECT-MPI (1-d adenosine stress/rest SPECT with (99m)Tc-tetrofosmin) and 64-slice CTA were included. 3D volume-rendered fused SPECT/CT images were generated and compared with the findings from the side-by-side analysis with regard to coronary lesion interpretation by assigning the perfusion defects to their corresponding coronary lesion. RESULTS: The fused SPECT/CT images added information on pathophysiologic lesion severity in 27 coronary stenoses (22%) of 12 patients (29%) (P<0.001). Among 40 equivocal lesions on side-by-side analysis, the fused interpretation confirmed hemodynamic significance in 14 lesions and excluded functional relevance in 10 lesions. In 3 lesions, assignment of perfusion defect and coronary lesion appeared to be reliable on side-by-side analysis but proved to be inaccurate on fused interpretation. Added diagnostic information by SPECT/CT was more commonly found in patients with stenoses of small vessels (P=0.004) and involvement of diagonal branches (P=0.01). CONCLUSION: In addition to being intuitively convincing, 3D SPECT/CT fusion images in CAD may provide added diagnostic information on the functional relevance of coronary artery lesions

Distinct effects of orexin 2 receptor antagonism and dual orexin 1,2 receptor antagonism on sleep architecture in mice.

Dual orexin receptor (OXR) antagonists (DORAs) such as almorexant, SB-649868, suvorexant (MK-4305) and filorexant (MK-6096), have shown promise for the treatment of insomnias and sleep disorders. Whether antagonism of both OX1R and OX2R is necessary for sleep induction has been a matter of some debate. Experiments using knockout mice suggest that it may be sufficient to antagonize only OX2R. The recent identification of an orally bioavailable, brain penetrant OX2R selective antagonist 2-((1H-Indol-3-yl)methyl)-9-(4-methoxypyrimidin-2-yl)-2,9-diazaspiro[5.5]undecan-1-one (IPSU) has allowed us to directly test whether selective antagonism of OX2R may also be a viable strategy for induction of sleep. We have previously demonstrated that IPSU and suvorexant increase sleep when dosed during the mouse active phase (lights off); IPSU achieving this primarily by increasing NREM sleep, suvorexant primarily by increasing REM sleep. Here, we tested the effects of suvorexant and IPSU during the inactive phase (lights on), in order to determine their effects on sleep architecture during a phase when sleep is naturally more prevalent. At the doses tested, only suvorexant further decreased wake during the inactive period and only during the first hour after drug application. Whereas IPSU was devoid of effects on the time spent in NREM or REM, suvorexant substantially disturbed the sleep architecture by selectively increasing REM during the first 4 hours after dosing. Thus, OX2R selective antagonists may have a reduced tendency for perturbing NREM/REM architecture in comparison with DORAs. Whether this effect will prove to be a general feature of SORAs versus DORAs remains to be seen