618 research outputs found
Multi-Component Dark Matter Systems and Their Observation Prospects
Conversions and semi-annihilations of dark matter (DM) particles in addition
to the standard DM annihilations are considered in a three-component DM system.
We find that the relic abundance of DM can be very sensitive to these
non-standard DM annihilation processes, which has been recently found for
two-component DM systems. To consider a concrete model of a three-component DM
system, we extend the radiative seesaw model of Ma by adding a Majorana fermion
\chi and a real scalar boson \phi, to obtain a Z_2 \times Z'_2 DM stabilizing
symmetry, where we assume that the DM particles are the inert Higgs boson, \chi
and \phi. It is shown how the allowed parameter space, obtained previously in
the absence of \chi and \phi, changes. The semi-annihilation process in this
model produces monochromatic neutrinos. The observation rate of these
monochromatic neutrinos from the Sun at IceCube is estimated. Observations of
high energy monochromatic neutrinos from the Sun may indicate a multi-component
DM system.Comment: 27 pages, 11 figure
On the Quantitative Impact of the Schechter-Valle Theorem
We evaluate the Schechter-Valle (Black Box) theorem quantitatively by
considering the most general Lorentz invariant Lagrangian consisting of
point-like operators for neutrinoless double beta decay. It is well known that
the Black Box operators induce Majorana neutrino masses at four-loop level.
This warrants the statement that an observation of neutrinoless double beta
decay guarantees the Majorana nature of neutrinos. We calculate these
radiatively generated masses and find that they are many orders of magnitude
smaller than the observed neutrino masses and splittings. Thus, some lepton
number violating New Physics (which may at tree-level not be related to
neutrino masses) may induce Black Box operators which can explain an observed
rate of neutrinoless double beta decay. Although these operators guarantee
finite Majorana neutrino masses, the smallness of the Black Box contributions
implies that other neutrino mass terms (Dirac or Majorana) must exist. If
neutrino masses have a significant Majorana contribution then this will become
the dominant part of the Black Box operator. However, neutrinos might also be
predominantly Dirac particles, while other lepton number violating New Physics
dominates neutrinoless double beta decay. Translating an observed rate of
neutrinoless double beta decay into neutrino masses would then be completely
misleading. Although the principal statement of the Schechter-Valle theorem
remains valid, we conclude that the Black Box diagram itself generates
radiatively only mass terms which are many orders of magnitude too small to
explain neutrino masses. Therefore, other operators must give the leading
contributions to neutrino masses, which could be of Dirac or Majorana nature.Comment: 18 pages, 4 figures; v2: minor corrections, reference added, matches
journal version; v3: typo corrected, physics result and conclusions unchange
Powers of Romance: The Liminal Challenges of Managing Organizational Intimacy
© The Author(s) 2014 Problematic organizational relationships have recently been at the core of highly visible media coverage. Most analyses of sexual relations in organizations have been, however, simplistic and unidimensional, and have placed insufficient systematic emphasis on the role of governmentality in the social construction of organizational romance. In this article, we proceed in two theoretical steps. First, we elaborate a typology of organizational romance that covers different manifestations of this nuanced process. We think of these as organizational strategies of governmentality. Second, we elaborate and identify liminal cases that fall into the interstices of the four predominant ways of managing sexual relationships in organizations. We think of these as vases of liquid love and life that evade the border controls of regulation by governmentality. Finally, we relate these issues to debates about the nature of the civilizational process and suggest hypotheses for future research
Shell structure of superheavy nuclei in self-consistent mean-field models
We study the extrapolation of nuclear shell structure to the region of
superheavy nuclei in self-consistent mean-field models -- the
Skyrme-Hartree-Fock approach and the relativistic mean-field model -- using a
large number of parameterizations. Results obtained with the Folded-Yukawa
potential are shown for comparison. We focus on differences in the isospin
dependence of the spin-orbit interaction and the effective mass between the
models and their influence on single-particle spectra. While all relativistic
models give a reasonable description of spin-orbit splittings, all
non-relativistic models show a wrong trend with mass number. The spin-orbit
splitting of heavy nuclei might be overestimated by 40%-80%. Spherical
doubly-magic superheavy nuclei are found at (Z=114,N=184), (Z=120,N=172) or
(Z=126,N=184) depending on the parameterization. The Z=114 proton shell
closure, which is related to a large spin-orbit splitting of proton 2f states,
is predicted only by forces which by far overestimate the proton spin-orbit
splitting in Pb208. The Z=120 and N=172 shell closures predicted by the
relativistic models and some Skyrme interactions are found to be related to a
central depression of the nuclear density distribution. This effect cannot
appear in macroscopic-microscopic models which have a limited freedom for the
density distribution only. In summary, our findings give a strong argument for
(Z=120,N=172) to be the next spherical doubly-magic superheavy nucleus.Comment: 22 pages REVTeX, 16 eps figures, accepted for publication in Phys.
Rev.
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Effect of rAd5-Vector HIV-1 Preventive Vaccines on HIV-1 Acquisition: A Participant- Level Meta-Analysis of Randomized Trial
Background
Three phase 2b, double-blind, placebo-controlled, randomized efficacy trials have tested recombinant Adenovirus serotype-5 (rAd5)-vector preventive HIV-1 vaccines: MRKAd5 HIV-1 gag/pol/nef in Step and Phambili, and DNA/rAd5 HIV-1 env/gag/pol in HVTN505. Due to efficacy futility observed at the first interim analysis in Step and HVTN505, participants of all three studies were unblinded to their vaccination assignments during the study but continued follow–up. Rigorous meta-analysis can provide crucial information to advise the future utility of rAd5-vector vaccines.
Methods
We included participant-level data from all three efficacy trials, and three Phase 1–2 trials evaluating the HVTN505 vaccine regimen. We predefined two co-primary analysis cohorts for assessing the vaccine effect on HIV-1 acquisition. The modified-intention-to-treat (MITT) cohort included all randomly assigned participants HIV-1 uninfected at study entry, who received at least the first vaccine/placebo, and the Ad5 cohort included MITT participants who received at least one dose of rAd5-HIV vaccine or rAd5-placebo. Multivariable Cox regression models were used to estimate hazard ratios (HRs) of HIV-1 infection (vaccine vs. placebo) and evaluate HR variation across vaccine regimens, time since vaccination, and subgroups using interaction tests.
Findings
Results are similar for the MITT and Ad5 cohorts; we summarize MITT cohort results. Pooled across the efficacy trials, over all follow-up time 403 (n = 224 vaccine; n = 179 placebo) of 6266 MITT participants acquired HIV-1, with a non-significantly higher incidence in vaccine recipients (HR 1.21, 95% CI 0.99–1.48, P = 0.06). The HRs significantly differed by vaccine regimen (interaction P = 0.03; MRKAd5 HR 1.41, 95% CI 1.11–1.78, P = 0.005 vs. DNA/rAd5 HR 0.88, 95% CI 0.61–1.26, P = 0.48). Results were similar when including the Phase 1–2 trials. Exploratory analyses based on the efficacy trials supported that the MRKAd5 vaccine-increased risk was concentrated in Ad5-positive or uncircumcised men early in follow-up, and in Ad5-negative or circumcised men later. Overall, MRKAd5 vaccine-increased risk was evident across subgroups except in circumcised Ad5-negative men (HR 0.97, 95% CI 0.58−1.63, P = 0.91); there was little evidence that the DNA/rAd5 vaccine, that was tested in this subgroup, increased risk (HR 0.88, 95% CI 0.61–1.26, P = 0.48). When restricting the analysis of Step and Phambili to follow-up time before unblinding, 114 (n = 65 vaccine; n = 49 placebo) of 3770 MITT participants acquired HIV-1, with a non-significantly higher incidence in MRKAd5 vaccine recipients (HR 1.30, 95% CI 0.89–1.14, P = 0.18).
Interpretation and Significance
The data support increased risk of HIV-1 infection by MRKAd5 over all follow-up time, but do not support increased risk of HIV-1 infection by DNA/rAd5. This study provides a rationale for including monitoring plans enabling detection of increased susceptibility to infection in HIV-1 at-risk populations
Microscopic Derivation of Non-Markovian Thermalization of a Brownian Particle
In this paper, the first microscopic approach to the Brownian motion is
developed in the case where the mass density of the suspending bath is of the
same order of magnitude as that of the Brownian (B) particle. Starting from an
extended Boltzmann equation, which describes correctly the interaction with the
fluid, we derive systematicaly via the multiple time-scale analysis a reduced
equation controlling the thermalization of the B particle, i.e. the relaxation
towards the Maxwell distribution in velocity space. In contradistinction to the
Fokker-Planck equation, the derived new evolution equation is non-local both in
time and in velocity space, owing to correlated recollision events between the
fluid and particle B. In the long-time limit, it describes a non-markovian
generalized Ornstein-Uhlenbeck process. However, in spite of this complex
dynamical behaviour, the Stokes-Einstein law relating the friction and
diffusion coefficients is shown to remain valid. A microscopic expression for
the friction coefficient is derived, which acquires the form of the Stokes law
in the limit where the mean-free in the gas is small compared to the radius of
particle B.Comment: 28 pages, no figure, submitted to Journal of Statistical Physic
Comparison of contact patterns relevant for transmission of respiratory pathogens in Thailand and the Netherlands using respondent-driven sampling
Understanding infection dynamics of respiratory diseases requires the identification and quantification of behavioural, social and environmental factors that permit the transmission of these infections between humans. Little empirical information is available about contact patterns within real-world social networks, let alone on differences in these contact networks between populations that differ considerably on a socio-cultural level. Here we compared contact network data that were collected in the Netherlands and Thailand using a similar online respondent-driven method. By asking participants to recruit contact persons we studied network links relevant for the transmission of respiratory infections. We studied correlations between recruiter and recruited contacts to investigate mixing patterns in the observed social network components. In both countries, mixing patterns were assortative by demographic variables and random by total numbers of contacts. However, in Thailand participants reported overall more contacts which resulted in higher effective contact rates. Our findings provide new insights on numbers of contacts and mixing patterns in two different populations. These data could be used to improve parameterisation of mathematical models used to design control strategies. Although the spread of infections through populations depends on more factors, found similarities suggest that spread may be similar in the Netherlands and Thailand
Proceedings of the 2nd Workshop on Flavor Symmetries and Consequences in Accelerators and Cosmology (FLASY12)
These are the proceedings of the 2nd Workshop on Flavor Symmetries and
Consequences in Accelerators and Cosmology, held 30 June 2012 - 4 July 2012,
Dortmund, Germany.Comment: Order 400 pages, several figures including the group picture v2:
corrected author list and contributio
The star-forming content of the W3 giant molecular cloud
We have surveyed a ~0.9-square-degree area of the W3 giant molecular cloud
and star-forming region in the 850-micron continuum, using the SCUBA bolometer
array on the James Clerk Maxwell Telescope. A complete sample of 316 dense
clumps was detected with a mass range from around 13 to 2500 Msun. Part of the
W3 GMC is subject to an interaction with the HII region and fast stellar winds
generated by the nearby W4 OB association. We find that the fraction of total
gas mass in dense, 850-micron traced structures is significantly altered by
this interaction, being around 5% to 13% in the undisturbed cloud but ~25 - 37%
in the feedback-affected region. The mass distribution in the detected clump
sample depends somewhat on assumptions of dust temperature and is not a simple,
single power law but contains significant structure at intermediate masses.
This structure is likely to be due to crowding of sources near or below the
spatial resolution of the observations. There is little evidence of any
difference between the index of the high-mass end of the clump mass function in
the compressed region and in the unaffected cloud. The consequences of these
results are discussed in terms of current models of triggered star formation.Comment: 13 pages, 8 figures, 1 table (full source table available on
request). Accepted for publication in Monthly Notices of the Royal
Astronomical Society (Main Journal
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