325 research outputs found
Unsymmetrically-Substituted 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-dione Scaffold—A Useful Tool for Bioactive Molecules Design
Unsymmetrically N-substituted and N,N’-disubstituted 5,12-dihydrodibenzo [b,f][1,4]diazocine-6,11-diones were synthesized in the new protocol. The desired modifications of the dibenzodiazocine scaffold were introduced at the stages of proper selection of building blocks as well as post-cyclization modifications with alkylation or acylation agents, expanding the structural diversity and possible applications of synthesized molecules. The extension of developed method resulted in the synthesis of novel: tricyclic 5,10-dihydrobenzo[b]thieno[3,4-f][1,4]diazocine-4,11-dione scaffold and fused pentacyclic framework possessing two benzodiazocine rings within its structure. Additionally, the unprecedented rearrangement of 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-diones to 2-(2-aminophenyl)isoindoline-1,3-diones was observed under the basic conditions in the presence of sodium hydride for secondary dilactams. The structures of nine synthesized products have been established by single-crystal X-ray diffraction analysis. Detailed crystallographic analysis of the investigated tri- and pentacyclic systems has shed more light on their structural features. One cell line derived from non-cancerous cells (EUFA30—human fibroblasts) and three tumor cells (U87—human primary glioblastoma, HeLa—cervix adenocarcinoma, BICR18—laryngeal squamous cell carcinoma) were used to determine the cytotoxic effect of the newly synthesized compounds. Although these compounds showed a relatively weak cytotoxic effect, the framework obtained for 5,12-dihydrodibenzo[b,f][1,4]diazocine-6,11-dione could serve as a convenient privilege structure for the design and development of novel bioactive molecules suitable for drug design, development and optimization programs
Lipid peroxidation and immune biomarkers are associated with major depression and its phenotypes, including treatment-resistant depression and melancholia
Wybrane aspekty funkcjonowania Sejmu w latach 1997–2007
Praca recenzowana / peer-reviewed paperPraca naukowa finansowana ze środków na naukę w latach 2006–2008 jako projekt
badawczy własny Nr 1 H02E 052 3
The multidirectional auxeticity and negative linear compressibility of a 3D mechanical metamaterial
In this work, through the use of a theoretical model, we analyse the potential of a specific
three-dimensional mechanical metamaterial composed of arrowhead-like structural units to exhibit
a negative Poisson’s ratio for an arbitrary loading direction. Said analysis allows us to assess its
suitability for use in applications where materials must be able to respond in a desired manner to
a stimulus applied in multiple directions. As a result of our studies, we show that the analysed system
is capable of exhibiting auxetic behaviour for a broad range of loading directions, with isotropic
behaviour being shown in some planes. In addition to that, we show that there are also certain
loading directions in which the system manifests negative linear compressibility. This enhances its
versatility and suitability for a number of applications where materials exhibiting auxetic behaviour
or negative linear compressibility are normally implemented.peer-reviewe
The serum concentration of copper in bipolar disorder
Aim. Some scientific reports indicate the changes in the concentration of serum copper in
patients with bipolar disorder (BD), however the data are inconclusive. The aim of this study
was to assess the concentration of copper in the blood serum of patients in various phases of
BD compared to healthy volunteers, taking into consideration the specific clinical features,
and the stage of illness.
Methods. The study enrolled 133 patients with a diagnosis of BD (type I, II and NOS),
including 61 people in depressive episode, 23 in mania or hypomania and 49 in remission.
The control group consisted of 50 people. Atomic absorption spectrometry was used to measure
the concentration of copper. Results. There were no statistically significant differences in the serum copper concentration
between patients in various phases of BD (mania/hypomania, depression, remission),
sub-types (Type I, Type II + NOS) or stages and healthy volunteers. However, serum copper
concentrations in patients in stage 1 was significantly higher than in advanced stages (2+3+4),
(β = 0.22; p = 0.02). Serum copper concentration was also the higher, the later the age of onset
was (β = 0.33; p < 0.001), and the lower, the greater the number of illness episodes (β = – 0.23;
p = 0.02) (multiple regression model, adj R2 = 0.19, p = 0.0001).
Conclusions. The dependencies demonstrated above may reflect pathophysiological processes
that occur in the course of BD (e.g., inflammatory response and oxidative stress) with
a different intensity depending on its stage
The concentration of carbon monoxide in the breathing areas of workers during logging operations at the motor-manual level
The serum zinc concentration as a potential biological marker in patients with major depressive disorder
Despite many clinical trials assessing the role of zinc in major depressive disorder (MDD), the conclusions still remain ambiguous. The aim of the present clinical study was to determine and comparison the zinc concentration in the blood of MDD patients (active stage or remission) and healthy volunteers (controls), as well as to discuss its potential clinical usefulness as a biomarker of the disease. In this study 69 patients with current depressive episode, 45 patients in remission and 50 controls were enrolled. The zinc concentration was measured by electrothermal atomic absorption spectrometry (ET AAS). The obtained results revealed, that the zinc concentration in depressed phase were statistically lower than in the healthy volunteers [0.89 vs. 1.06 mg/L, respectively], while the zinc level in patients achieve remission was not significantly different from the controls [1.07 vs. 1.06 mg/L, respectively]. Additionally, among the patients achieve remission a significant differences in zinc concentration between group with and without presence of drug-resistance in the previous episode of depression were observed. Also, patients in remission demonstrated correlation between zinc level and the average number of depressive episodes in the last year. Serum zinc concentration was not dependent on atypical features of depression, presence of psychotic symptoms or melancholic syndrome, age, age of onset or duration of disease, number of episodes in the life time, duration of the episode/remission and severity of depression measured by the Hamilton Rating Scale for Depression (HDRS), and the Montgomery-Asberg Depression Rating Scale (MADRS). Concluding, our findings confirm the correlation between zinc deficit present in the depressive episode, and are consistent with the majority of previous studies. These results may also indicate that serum zinc concentration might be considered as a potential biological marker of MDD
Myśl i polityka: księga pamiątkowa dedykowana profesorowi Jackowi Marii Majchrowskiemu T. 3
Publikacja jubileuszowa z okazji 40-lecia pracy naukowej profesora Jacka Majchrowskieg
Multidifferential study of identified charged hadron distributions in -tagged jets in proton-proton collisions at 13 TeV
Jet fragmentation functions are measured for the first time in proton-proton
collisions for charged pions, kaons, and protons within jets recoiling against
a boson. The charged-hadron distributions are studied longitudinally and
transversely to the jet direction for jets with transverse momentum 20 GeV and in the pseudorapidity range . The
data sample was collected with the LHCb experiment at a center-of-mass energy
of 13 TeV, corresponding to an integrated luminosity of 1.64 fb. Triple
differential distributions as a function of the hadron longitudinal momentum
fraction, hadron transverse momentum, and jet transverse momentum are also
measured for the first time. This helps constrain transverse-momentum-dependent
fragmentation functions. Differences in the shapes and magnitudes of the
measured distributions for the different hadron species provide insights into
the hadronization process for jets predominantly initiated by light quarks.Comment: All figures and tables, along with machine-readable versions and any
supplementary material and additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-013.html (LHCb
public pages
Study of the decay
The decay is studied
in proton-proton collisions at a center-of-mass energy of TeV
using data corresponding to an integrated luminosity of 5
collected by the LHCb experiment. In the system, the
state observed at the BaBar and Belle experiments is
resolved into two narrower states, and ,
whose masses and widths are measured to be where the first uncertainties are statistical and the second
systematic. The results are consistent with a previous LHCb measurement using a
prompt sample. Evidence of a new
state is found with a local significance of , whose mass and width
are measured to be and , respectively. In addition, evidence of a new decay mode
is found with a significance of
. The relative branching fraction of with respect to the
decay is measured to be , where the first
uncertainty is statistical, the second systematic and the third originates from
the branching fractions of charm hadron decays.Comment: All figures and tables, along with any supplementary material and
additional information, are available at
https://cern.ch/lhcbproject/Publications/p/LHCb-PAPER-2022-028.html (LHCb
public pages
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