Case report: Psychosis and catatonia in an adolescent patient with adipsic hypernatremia and autoantibodies against the subfornical organ.

This is the first description of a patient in which adipsic hypernatremia, a rare autoimmune encephalitis, presented in combination with complex psychiatric symptomatology, including psychosis and catatonia. Adipsic hypernatremia is characterized by autoantibodies against the thirst center of the brain. These autoantibodies cause inflammation and apoptosis in key regions of water homeostasis, leading to lack of thirst and highly increased serum sodium. To date, the symptoms of weakness, fatigue and drowsiness have been associated with adipsic hypernatremia, but no psychiatric symptomatology. Here, we showcase the first description of an adolescent patient, in which severe and complex psychiatric symptoms presented along with adipsic hypernatremia. The patient experienced delusion, hallucinations, restlessness and pronounced depression. Further, he showed ritualized, aggressive, disinhibited and sexualized behavior, as well as self-harm and psychomotor symptoms. Due to his severe condition, he was hospitalized on the emergency unit of the child and adolescent psychiatry for 8 months. Key symptoms of the presented clinical picture are: childhood-onset complex and treatment-resistant psychosis/catatonia, pronounced behavioral problems, fatigue, absent thirst perception, hypernatremia and elevated prolactin levels. This case report renders first evidence speaking for a causal link between the autoimmune adipsic hypernatremia and the psychotic disorder. Moreover, it sheds light on a new form of autoimmune psychosis

SUMO User Conference 2019

SUMO2019:Editor's Preface This volume contains the papers presented at the SUMO Conference 2019 Simulating Connected Urban Mobility. The conference was held in Berlin from 13-15 May 2019. The goal of the conference was to present new results in the field of mobility simulation and modelling using traffic tools and data which are open available.There were 32 submissions. Each submission was reviewed by at least 2 program committee members. The committee decided to accept 22 papers. Traffic simulations have a high value for traffic research studies. New traffic strategies can be tested and evaluated in advance with little costs. For realistic simulation results a complex traffic simulation framework is needed. One microscopic traffic simulation for this purpose is the open source tool Eclipse SUMO (Simulation of open mobility) which is available since 2001. SUMO provides a wide range of transport planning and modelling applications. The major topic of the 7th SUMO conference is the simulation of connected vehicles. This volume contains articles about simulator coupling, connected and automated Vehicles. Furthermore, the journal includes also papers about new algorithms for traffic light systems and new applications for the simulation of other traffic modes or reinforcement learning strategies. We would like to thank EasyChair for the conference support and its helpfull conference management tool. Laura Bieker-Walz Melanie Weber Robert Hilbrich Michael Behrisch July 24, 2019 Berli