5,915 research outputs found
Pathological classification of equine recurrent laryngeal neuropathy
Recurrent Laryngeal Neuropathy (RLN) is a highly prevalent and predominantly left‐sided, degenerative disorder of the recurrent laryngeal nerves (RLn) of tall horses, that causes inspiratory stridor at exercise because of intrinsic laryngeal muscle paresis. The associated laryngeal dysfunction and exercise intolerance in athletic horses commonly leads to surgical intervention, retirement or euthanasia with associated financial and welfare implications. Despite speculation, there is a lack of consensus and conflicting evidence supporting the primary classification of RLN, as either a distal (“dying back”) axonopathy or as a primary myelinopathy and as either a (bilateral) mononeuropathy or a polyneuropathy; this uncertainty hinders etiological and pathophysiological research. In this review, we discuss the neuropathological changes and electrophysiological deficits reported in the RLn of affected horses, and the evidence for correct classification of the disorder. In so doing, we summarize and reveal the limitations of much historical research on RLN and propose future directions that might best help identify the etiology and pathophysiology of this enigmatic disorder
Using Rheo-Small-Angle Neutron Scattering to Understand How Functionalised Dipeptides Form Gels
We explore the use of rheo-small-angle neutron scattering as a method to collect structural information from neutron scattering simultaneously with rheology to understand how low-molecular-weight hydrogels form and behave under shear. We examine three different gelling hydrogel systems to assess what structures are formed and how these influence the rheology. Furthermore, we probe what is happening to the network during syneresis and why the gels do not recover after an applied strain. All this information is vital when considering gels for applications such as 3D-printing and injection
Are Ferroan Anorthosites Direct Products of the Lunar Magma Ocean?
According to Lunar Magma Ocean (LMO) theory, lunar samples that fall into the ferroan anorthosite (FAN) category represent the only samples we have of of the primordial crust of the Moon. Modeling indicates that plagioclase crystallizes after >70% LMO crystallization and formed a flotation crust, depending upon starting composition. The FAN group of highlands materials has been subdivided into mafic-magnesian, mafic-ferroan, anorthositic- sodic, and anorthositic-ferroan, although it is not clear how these subgroups are related. Recent radiogenic isotope work has suggested the range in FAN ages and isotopic systematics are inconsistent with formation of all FANs from the LMO. While an insulating lid could have theoretically extend the life of the LMO to explain the range of the published ages, are the FAN compositions consistent with crystallization from the LMO? As part of a funded Emerging Worlds proposal (NNX15AH76G), we examine this question through analysis of FAN samples. We compare the results with various LMO crystallization models, including those that incorporate the influence of garnet
ΦCrAss001 represents the most abundant bacteriophage family in the human gut and infects Bacteroides intestinalis
peer-reviewedCrAssphages are an extensive and ubiquitous family of tailed bacteriophages, predicted to infect bacteria of the order Bacteroidales. Despite being found in ~50% of individuals and representing up to 90% of human gut viromes, members of this viral family have never been isolated in culture and remain understudied. Here, we report the isolation of a CrAssphage (ΦCrAss001) from human faecal material. This bacteriophage infects the human gut symbiont Bacteroides intestinalis, confirming previous in silico predictions of the likely host. DNA sequencing demonstrates that the bacteriophage genome is circular, 102 kb in size, and has unusual structural traits. In addition, electron microscopy confirms that ΦcrAss001 has a podovirus-like morphology. Despite the absence of obvious lysogeny genes, ΦcrAss001 replicates in a way that does not disrupt proliferation of the host bacterium, and is able to maintain itself in continuous host culture during several weeks
A feasibility study of signed consent for the collection of patient identifiable information for a national paediatric clinical audit database
Objectives: To investigate the feasibility of obtaining signed consent
for submission of patient identifiable data to a national clinical
audit database and to identify factors influencing the consent process
and its success.
Design: Feasibility study.
Setting: Seven paediatric intensive care units in England.
Participants: Parents/guardians of patients, or patients aged 12-16
years old, approached consecutively over three months for signed
consent for submission of patient identifiable data to the national
clinical audit database the Paediatric Intensive Care Audit Network
(PICANet).
Main outcome measures: The numbers and proportions of admissions for
which signed consent was given, refused, or not obtained (form not
returned or form partially completed but not signed), by age, sex,
level of deprivation, ethnicity (South Asian or not), paediatric index
of mortality score, length of hospital stay (days in paediatric
intensive care).
Results: One unit did not start and one did not fully implement the
protocol, so analysis excluded these two units. Consent was obtained
for 182 of 422 admissions (43%) (range by unit 9% to 84%). Most
(101/182; 55%) consents were taken by staff nurses. One refusal (0.2%)
was received. Consent rates were significantly better for children who
were more severely ill on admission and for hospital stays of six days
or more, and significantly poorer for children aged 10-14 years. Long
hospital stays and children aged 10-14 years remained significant in a
stepwise regression model of the factors that were significant in the
univariate model.
Conclusion: Systematically obtaining individual signed consent for
sharing patient identifiable information with an externally located
clinical audit database is difficult. Obtaining such consent is
unlikely to be successful unless additional resources are specifically
allocated to training, staff time, and administrative support
Decuplet Baryon Structure from Lattice QCD
The electromagnetic properties of the SU(3)-flavor baryon decuplet are
examined within a lattice simulation of quenched QCD. Electric charge radii,
magnetic moments, and magnetic radii are extracted from the E0 and M1 form
factors. Preliminary results for the E2 and M3 moments are presented giving the
first model independent insight to the shape of the quark distribution in the
baryon ground state. As in our octet baryon analysis, the lattice results give
evidence of spin-dependent forces and mass effects in the electromagnetic
properties. The quark charge distribution radii indicate these effects act in
opposing directions. Some baryon dependence of the effective quark magnetic
moments is seen. However, this dependence in decuplet baryons is more subtle
than that for octet baryons. Of particular interest are the lattice predictions
for the magnetic moments of and for which new recent
experimental measurements are available. The lattice prediction of the
ratio appears larger than the experimental ratio, while the
lattice prediction for the magnetic moment ratio is in good
agreement with the experimental ratio.Comment: RevTeX manuscript, 34 pages plus 21 figures (available upon request
The hydrothermal system of Punta Mita (México): an example of present submarine exhalative deposit
Disk-Loss and Disk Renewal Phases in Classical Be Stars II. Detailed Analysis of Spectropolarimetric Data
In Wisniewski et al. 2010, paper I, we analyzed 15 years of spectroscopic and
spectropolarimetric data from the Ritter and Pine Bluff Observatories of 2 Be
stars, 60 Cygni and {\pi} Aquarii, when a transition from Be to B star
occurred. Here we anaylize the intrinsic polarization, where we observe
loop-like structures caused by the rise and fall of the polarization Balmer
Jump and continuum V-band polarization being mismatched temporally with
polarimetric outbursts. We also see polarization angle deviations from the
mean, reported in paper I, which may be indicative of warps in the disk, blobs
injected at an inclined orbit, or spiral density waves. We show our ongoing
efforts to model time dependent behavior of the disk to constrain the
phenomena, using 3D Monte Carlo radiative transfer codes.Comment: 2 pages, 6 figures, IAU Symposium 27
B meson form factors from HQET simulations
We use simulations of heavy quark effective field theory to calculate the
Isgur-Wise function, and we demonstrate the feasibility of calculating the
matrix element for the B \to \pi + \leptons decay in the lattice heavy quark
effective theory (HQET).Comment: 3 pages, 2 figures, talk presented at the lattice 97 conferenc
Palynological age constraint of Les Vilelles unit, Catalan Coastal Chain, Spain
The Les Vilelles unit is a detrital sequence exposes at the southwestern margin of the Catalonian Coastal Range, NE Spain, below the Carboniferous turbiditic series. Based on the palynological content, the age of this unit was initially assigned to the Middle-Late Devonian (Eifelian to Famennian). Additional radiolarian and connodont findings were considered to be Early-Middle Mississippian (Tournaisian to early Viséan). This age inconsistency and the broad time interval, especially of the first dating, produce some ambiguity in the regional interpretations of the Les Vilelles unit and the overlying Carboniferous sequence. A palynostratigraphic analysis conducted in a section representative of the Les Vilelles unit has provided an assemblage containing miospores, acritarchs, prasinophyta phycomata and chitinozoan that can be confidently assigned to a latest Frasnian interval, in contact with the Frasnian-Famennian boundary. This dating casts doubt on the radiolarian/connodont age assignment and considerably refines the Middle -Late Devonian age formerly established. This study also includes a systematic section with the description of three newly established miospore species:Dibolisporites coniugatum, Dibolisporites priorato and Rugospora spinosa
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